Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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Esomeprazole | hsa00052 | Galactose metabolism | 1.06E-03 | 2 | P06280, O43451 | GLA, MGAM | More | | Esomeprazole | hsa00071 | Fatty acid degradation | 3.50E-02 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | Esomeprazole | hsa00220 | Arginine biosynthesis | 4.40E-02 | 1 | P15104 | GLUL | More | | Esomeprazole | hsa00230 | Purine metabolism | 1.56E-02 | 3 | Q7LG56, P51828, Q9Y227 | RRM2B, ADCY7, ENTPD4 | More | | Esomeprazole | hsa00240 | Pyrimidine metabolism | 1.45E-02 | 2 | Q7LG56, Q9Y227 | RRM2B, ENTPD4 | More | | Esomeprazole | hsa00500 | Starch and sucrose metabolism | 1.80E-08 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | Esomeprazole | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | Esomeprazole | hsa00564 | Glycerophospholipid metabolism | 1.12E-02 | 1 | Q8TCT1 | PHOSPHO1 | More | | Esomeprazole | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | Esomeprazole | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | Esomeprazole | hsa00630 | Glyoxylate and dicarboxylate metabolism | 3.93E-06 | 3 | P40925, P40926, P15104 | MDH1, MDH2, GLUL | More | | Esomeprazole | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | Esomeprazole | hsa00730 | Thiamine metabolism | 1.87E-06 | 2 | P05186, P24666 | ALPL, ACP1 | More | | Esomeprazole | hsa00740 | Riboflavin metabolism | 4.77E-02 | 1 | P30043 | BLVRB | More | | Esomeprazole | hsa00830 | Retinol metabolism | 2.20E-02 | 4 | P00325, P11766, Q9BPW9, O75911 | ADH1B, ADH5, DHRS9, DHRS3 | More | | Esomeprazole | hsa00970 | Aminoacyl-tRNA biosynthesis | 5.30E-04 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | Esomeprazole | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.39E-04 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Esomeprazole | hsa00982 | Drug metabolism - cytochrome P450 | 6.39E-04 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | Esomeprazole | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | Esomeprazole | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 |
| Esomeprazole | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | Esomeprazole | hsa02010 | ABC transporters | 4.48E-02 | 1 | Q8IZY2 | ABCA7 | More | | Esomeprazole | hsa03008 | Ribosome biogenesis in eukaryotes | 4.94E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | Esomeprazole | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | | Esomeprazole | hsa03013 | RNA transport | 2.35E-05 | 19 | P62826, P52298, Q09161, O14893, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787 | RAN, NCBP2, NCBP1, GEMIN2, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P62826 | RAN | GTP-binding nuclear protein Ran | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62826 | RAN | GTP-binding nuclear protein Ran | 0.732 | P08246 | ELA2 | Neutrophil elastase | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.852 | P08246 | ELA2 | Neutrophil elastase | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.732 | P08246 | ELA2 | Neutrophil elastase | O14893 | GEMIN2 | Gem-associated protein 2 | -0.785 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.76 | O14976 | GAK | Cyclin-G-associated kinase | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.827 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.79 | P08246 | ELA2 | Neutrophil elastase | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.723 | P08246 | ELA2 | Neutrophil elastase | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.765 | O14976 | GAK | Cyclin-G-associated kinase | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.766 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | O14976 | GAK | Cyclin-G-associated kinase | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.705 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.721 | P08246 | ELA2 | Neutrophil elastase | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.722 | P08246 | ELA2 | Neutrophil elastase | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.825 | P08246 | ELA2 | Neutrophil elastase | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.795 | O14976 | GAK | Cyclin-G-associated kinase | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.711 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.704 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.758 | P08246 | ELA2 | Neutrophil elastase | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.849 | O14976 | GAK | Cyclin-G-associated kinase | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.767 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.749 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.793 | O14976 | GAK | Cyclin-G-associated kinase | P62826 | RAN | GTP-binding nuclear protein Ran | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62826 | RAN | GTP-binding nuclear protein Ran | 0.732 | P08246 | ELA2 | Neutrophil elastase | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.852 | P08246 | ELA2 | Neutrophil elastase | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.732 | P08246 | ELA2 | Neutrophil elastase | O14893 | GEMIN2 | Gem-associated protein 2 | -0.785 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.76 | O14976 | GAK | Cyclin-G-associated kinase | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.827 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.79 | P08246 | ELA2 | Neutrophil elastase | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.723 | P08246 | ELA2 | Neutrophil elastase | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.765 | O14976 | GAK | Cyclin-G-associated kinase | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.766 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | O14976 | GAK | Cyclin-G-associated kinase | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.705 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.721 | P08246 | ELA2 | Neutrophil elastase | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.722 | P08246 | ELA2 | Neutrophil elastase | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.825 | P08246 | ELA2 | Neutrophil elastase | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.795 | O14976 | GAK | Cyclin-G-associated kinase | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.711 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.704 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.758 | P08246 | ELA2 | Neutrophil elastase | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.849 | O14976 | GAK | Cyclin-G-associated kinase | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.767 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.749 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.793 |
| Esomeprazole | hsa03015 | mRNA surveillance pathway | 4.81E-02 | 2 | Q9BZI7, O94913 | UPF3B, PCF11 | More | | Esomeprazole | hsa03020 | RNA polymerase | 3.77E-07 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.749 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.724 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9Y535 | POLR3H | DNA-directed RNA polymerase III subunit RPC8 | 0.737 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.749 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.724 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9Y535 | POLR3H | DNA-directed RNA polymerase III subunit RPC8 | 0.737 |
| Esomeprazole | hsa03040 | Spliceosome | 1.05E-10 | 17 | Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.794 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.741 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.715 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.794 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.741 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.715 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| Esomeprazole | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | Esomeprazole | hsa03060 | Protein export | 2.84E-03 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | Esomeprazole | hsa04014 | Ras signaling pathway | 2.57E-04 | 10 | P42338, P20827, P49767, Q13009, Q7LDG7, Q14644, P0DP23, P63218, P50151, P19174 | PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, RASA3, CALM1, GNG5, GNG10, PLCG1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P20827 | EFNA1 | Ephrin-A1 | 0.727 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.821 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q14644 | RASA3 | Ras GTPase-activating protein 3 | 0.741 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P20827 | EFNA1 | Ephrin-A1 | 0.727 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.821 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q14644 | RASA3 | Ras GTPase-activating protein 3 | 0.741 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| Esomeprazole | hsa04015 | Rap1 signaling pathway | 1.79E-02 | 8 | P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174 | EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1 | More | | Esomeprazole | hsa04020 | Calcium signaling pathway | 5.17E-04 | 9 | Q08828, Q16566, P30679, O15399, P0DP23, P05141, P51828, P23634, P49767 | ADCY1, CAMK4, GNA15, GRIN2D, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFC | More | | Esomeprazole | hsa04022 | cGMP-PKG signaling pathway | 3.97E-04 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | Esomeprazole | hsa04024 | cAMP signaling pathway | 5.36E-04 | 10 | P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009 | GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1 | More | | Esomeprazole | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 3.83E-04 | 10 | Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375 | CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF | More | | Esomeprazole | hsa04062 | Chemokine signaling pathway | 5.65E-04 | 14 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| Esomeprazole | hsa04064 | NF-kappa B signaling pathway | 2.23E-10 | 23 | P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| Esomeprazole | hsa04070 | Phosphatidylinositol signaling system | 1.28E-03 | 6 | P0DP23, P42338, O14986, Q16760, P48426, P27987 | CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKB | More | | Esomeprazole | hsa04071 | Sphingolipid signaling pathway | 6.37E-04 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2 | More | | Esomeprazole | hsa04072 | Phospholipase D signaling pathway | 2.68E-06 | 14 | P31751, P42338, Q9UQC2, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760 | AKT2, PIK3CB, GAB2, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | Q13547 | HDAC1 | Histone deacetylase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.804 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | -0.736 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | 0.717 | O14976 | GAK | Cyclin-G-associated kinase | Q15438 | PSCD1 | Cytohesin-1 | 0.74 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q15438 | PSCD1 | Cytohesin-1 | 0.708 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | Q16760 | DGKD | Diacylglycerol kinase delta | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q16760 | DGKD | Diacylglycerol kinase delta | 0.73 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | Q13547 | HDAC1 | Histone deacetylase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.804 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | -0.736 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | 0.717 | O14976 | GAK | Cyclin-G-associated kinase | Q15438 | PSCD1 | Cytohesin-1 | 0.74 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q15438 | PSCD1 | Cytohesin-1 | 0.708 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | Q16760 | DGKD | Diacylglycerol kinase delta | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q16760 | DGKD | Diacylglycerol kinase delta | 0.73 |
| Esomeprazole | hsa04080 | Neuroactive ligand-receptor interaction | 3.11E-04 | 10 | P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P35318 | CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADM | More | | Esomeprazole | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | Esomeprazole | hsa04114 | Oocyte meiosis | 1.35E-02 | 5 | P0DP23, Q08828, P51828, Q13362, Q14738 | CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D | More | | Esomeprazole | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | Esomeprazole | hsa04120 | Ubiquitin mediated proteolysis | 4.82E-03 | 2 | Q9UBT2, Q14669 | SAE2, TRIP12 | More | | Esomeprazole | hsa04137 | Mitophagy - animal | 2.52E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | Esomeprazole | hsa04140 | Autophagy - animal | 1.71E-02 | 5 | P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | Esomeprazole | hsa04141 | Protein processing in endoplasmic reticulum | 1.91E-03 | 6 | P18848, Q15437, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | Esomeprazole | hsa04142 | Lysosome | 1.11E-03 | 9 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900, Q9Y227 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164, ENTPD4 | More | | Esomeprazole | hsa04144 | Endocytosis | 1.37E-03 | 10 | P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q14161, Q9UMY4, Q9UNH7 | HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, GIT2, SNX12, SNX6 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9H444 | CHMP4B | Charged multivesicular body protein 4b | 0.862 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.765 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.707 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62491 | RAB11A | Ras-related protein Rab-11A | 0.854 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P42566 | EPS15 | Epidermal growth factor receptor substrate 15 | 0.838 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q96B97 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | 0.716 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q15438 | PSCD1 | Cytohesin-1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15438 | PSCD1 | Cytohesin-1 | 0.756 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.77 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.817 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9UMY4 | SNX12 | Sorting nexin-12 | 0.835 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q9UNH7 | SNX6 | Sorting nexin-6 | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9H444 | CHMP4B | Charged multivesicular body protein 4b | 0.862 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.765 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.707 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62491 | RAB11A | Ras-related protein Rab-11A | 0.854 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P42566 | EPS15 | Epidermal growth factor receptor substrate 15 | 0.838 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q96B97 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | 0.716 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q15438 | PSCD1 | Cytohesin-1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15438 | PSCD1 | Cytohesin-1 | 0.756 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.77 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.817 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9UMY4 | SNX12 | Sorting nexin-12 | 0.835 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q9UNH7 | SNX6 | Sorting nexin-6 | 0.799 |
| Esomeprazole | hsa04145 | Phagosome | 1.98E-02 | 8 | Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765 | NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Esomeprazole | hsa04151 | PI3K-Akt signaling pathway | 5.37E-05 | 19 | P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281 | RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P62753 | RPS6 | 40S ribosomal protein S6 | 0.722 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P27348 | YWHAQ | 14-3-3 protein theta | 0.833 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P22105 | TNXB | Tenascin-X | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | 0.709 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P62753 | RPS6 | 40S ribosomal protein S6 | 0.722 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P27348 | YWHAQ | 14-3-3 protein theta | 0.833 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P22105 | TNXB | Tenascin-X | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | 0.709 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 |
| Esomeprazole | hsa04210 | Apoptosis | 2.68E-03 | 11 | Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | Esomeprazole | hsa04211 | Longevity regulating pathway | 5.88E-05 | 6 | P31751, Q08828, P51828, Q99941, P18848, Q96RR4 | AKT2, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2 | More | | Esomeprazole | hsa04213 | Longevity regulating pathway - multiple species | 6.63E-07 | 8 | P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | 0.852 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | -0.845 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.713 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13547 | HDAC1 | Histone deacetylase 1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | 0.852 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | -0.845 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.713 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13547 | HDAC1 | Histone deacetylase 1 | 1 |
| Esomeprazole | hsa04217 | Necroptosis | 1.44E-03 | 5 | Q9NQC7, P07900, P15104, P01584, Q9H444 | CYLD, HSP90AA1, GLUL, IL1B, CHMP4B | More | | Esomeprazole | hsa04260 | Cardiac muscle contraction | 4.20E-02 | 3 | P67936, P13073, P12074 | TPM4, COX4I1, COX6A1 | More | | Esomeprazole | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.79E-07 | 10 | P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557 | TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P67936 | TPM4 | Tropomyosin alpha-4 chain | 0.737 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 0.781 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | P67936 | TPM4 | Tropomyosin alpha-4 chain | 0.737 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 0.781 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 |
| Esomeprazole | hsa04270 | Vascular smooth muscle contraction | 5.20E-04 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | Esomeprazole | hsa04310 | Wnt signaling pathway | 4.17E-03 | 3 | P61586, P19784, P67870 | RHOA, CSNK2A2, CSNK2B | More | | Esomeprazole | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | | Esomeprazole | hsa04360 | Axon guidance | 2.47E-03 | 7 | P16333, P20827, O95631, P42338, P07332, P23528, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1 | More | | Esomeprazole | hsa04371 | Apelin signaling pathway | 1.37E-04 | 12 | P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14814 | MEF2D | Myocyte-specific enhancer factor 2D | 0.767 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.824 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.809 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14814 | MEF2D | Myocyte-specific enhancer factor 2D | 0.767 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.824 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.809 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 |
| Esomeprazole | hsa04380 | Osteoclast differentiation | 2.55E-07 | 14 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.834 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.885 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q8N149 | LILRA2 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | 0.743 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78324 | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 | 0.832 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.834 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.885 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q8N149 | LILRA2 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | 0.743 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78324 | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 | 0.832 |
| Esomeprazole | hsa04510 | Focal adhesion | 4.07E-02 | 3 | O14986, P61586, Q16363 | PIP5K1B, RHOA, LAMA4 | More | | Esomeprazole | hsa04520 | Adherens junction | 1.38E-04 | 3 | P19784, P67870, P61586 | CSNK2A2, CSNK2B, RHOA | More | | Esomeprazole | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | Esomeprazole | hsa04610 | Complement and coagulation cascades | 8.66E-04 | 4 | P01042, P09871, P0C0L4, P11215 | KNG1, C1S, C4A, ITGAM | More | | Esomeprazole | hsa04612 | Antigen processing and presentation | 1.51E-03 | 7 | P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | Esomeprazole | hsa04613 | Neutrophil extracellular trap formation | 7.76E-08 | 26 | P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05164 | MPO | Myeloperoxidase | 0.717 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.736 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.759 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P58876 | H2BC5 | Histone H2B type 1-D | 0.947 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.793 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | O60814 | H2BC12 | Histone H2B type 1-K | 0.72 | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.923 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.779 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43315 | AQP9 | Aquaporin-9 | 0.918 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05164 | MPO | Myeloperoxidase | 0.717 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.736 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.759 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P58876 | H2BC5 | Histone H2B type 1-D | 0.947 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.793 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | O60814 | H2BC12 | Histone H2B type 1-K | 0.72 | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.923 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.779 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43315 | AQP9 | Aquaporin-9 | 0.918 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 |
| Esomeprazole | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | Esomeprazole | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | Esomeprazole | hsa04621 | NOD-like receptor signaling pathway | 1.47E-05 | 15 | P01584, P07900, Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838 | IL1B, HSP90AA1, ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | Esomeprazole | hsa04623 | Cytosolic DNA-sensing pathway | 1.21E-05 | 3 | P01584, Q9Y535, Q8NHW4 | IL1B, POLR3H, CCL4L2 | More | | Esomeprazole | hsa04625 | C-type lectin receptor signaling pathway | 4.27E-06 | 11 | Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.745 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.745 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 |
| Esomeprazole | hsa04630 | JAK-STAT signaling pathway | 2.62E-03 | 4 | P31751, P23458, P16871, Q13651 | AKT2, JAK1, IL7R, IL10RA | More | | Esomeprazole | hsa04640 | Hematopoietic cell lineage | 6.79E-04 | 16 | P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P15144 | ANPEP | Aminopeptidase N | 0.851 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.71 | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P15144 | ANPEP | Aminopeptidase N | 0.851 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.71 | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| Esomeprazole | hsa04650 | Natural killer cell mediated cytotoxicity | 1.17E-07 | 13 | P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715 | PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 |
| Esomeprazole | hsa04657 | IL-17 signaling pathway | 1.36E-07 | 9 | P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.709 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.805 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.709 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.805 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| Esomeprazole | hsa04658 | Th1 and Th2 cell differentiation | 9.79E-07 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| Esomeprazole | hsa04659 | Th17 cell differentiation | 3.35E-08 | 19 | Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458 | PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| Esomeprazole | hsa04660 | T cell receptor signaling pathway | 2.85E-05 | 17 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 |
| Esomeprazole | hsa04662 | B cell receptor signaling pathway | 1.48E-05 | 6 | P42338, P60033, P13164, P07948, P21854, Q8N149 | PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2 | More | | Esomeprazole | hsa04664 | Fc epsilon RI signaling pathway | 1.36E-04 | 7 | P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917 | TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5 | More | | Esomeprazole | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 3 | P42338, P23528, P14598 | PIK3CB, CFL1, NCF1 | More | | Esomeprazole | hsa04668 | TNF signaling pathway | 1.83E-03 | 8 | P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9 | More | | Esomeprazole | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | Esomeprazole | hsa04710 | Circadian rhythm | 4.40E-02 | 1 | O15516 | CLOCK | More | | Esomeprazole | hsa04713 | Circadian entrainment | 5.44E-03 | 5 | P0DP23, P62873, Q08828, P51828, P63092 | CALM1, GNB1, ADCY1, ADCY7, GNAS | More | | Esomeprazole | hsa04714 | Thermogenesis | 3.31E-02 | 4 | P51828, P62753, P12074, O15239 | ADCY7, RPS6, COX6A1, NDUFA1 | More | | Esomeprazole | hsa04720 | Long-term potentiation | 1.15E-04 | 6 | Q16566, P0DP23, Q15418, P18848, O15399, Q08828 | CAMK4, CALM1, RPS6KA1, ATF4, GRIN2D, ADCY1 | More | | Esomeprazole | hsa04723 | Retrograde endocannabinoid signaling | 4.94E-02 | 2 | P48169, P62873 | GABRA4, GNB1 | More | | Esomeprazole | hsa04724 | Glutamatergic synapse | 3.56E-04 | 8 | O15399, P43003, P63092, P62873, P63218, P50151, P15104, Q9NSB8 | GRIN2D, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL, HOMER2 | More | | Esomeprazole | hsa04725 | Cholinergic synapse | 1.30E-04 | 5 | Q08828, P51828, P18848, Q13557, P31751 | ADCY1, ADCY7, ATF4, CAMK2D, AKT2 | More | | Esomeprazole | hsa04726 | Serotonergic synapse | 2.52E-02 | 2 | P63092, P62873 | GNAS, GNB1 | More | | Esomeprazole | hsa04728 | Dopaminergic synapse | 1.01E-03 | 7 | P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23 | AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1 | More | | Esomeprazole | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.62E-07 | 13 | P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | Q13547 | HDAC1 | Histone deacetylase 1 | P24723 | PRKCH | Protein kinase C eta type | 0.875 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | Q13547 | HDAC1 | Histone deacetylase 1 | P24723 | PRKCH | Protein kinase C eta type | 0.875 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 |
| Esomeprazole | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | Esomeprazole | hsa04911 | Insulin secretion | 4.09E-05 | 5 | Q08828, P51828, Q99941, P18848, Q13557 | ADCY1, ADCY7, CREBL1, ATF4, CAMK2D | More | | Esomeprazole | hsa04912 | GnRH signaling pathway | 5.19E-06 | 11 | Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P45985 | ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, MAP2K4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.804 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9Y6R4 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P0DP24 | CALM2 | Calmodulin-2 | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.804 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9Y6R4 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P0DP24 | CALM2 | Calmodulin-2 | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | 0.759 |
| Esomeprazole | hsa04914 | Progesterone-mediated oocyte maturation | 3.92E-02 | 3 | P42338, Q13370, P08238 | PIK3CB, PDE3B, HSP90AB1 | More | | Esomeprazole | hsa04915 | Estrogen signaling pathway | 1.80E-07 | 10 | Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788 | CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.86 | O14976 | GAK | Cyclin-G-associated kinase | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.711 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.86 | O14976 | GAK | Cyclin-G-associated kinase | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.711 |
| Esomeprazole | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | Esomeprazole | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | Esomeprazole | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | Esomeprazole | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | Esomeprazole | hsa04923 | Regulation of lipolysis in adipocytes | 9.48E-06 | 6 | Q08828, P51828, P07550, P42338, Q9Y4H2, P31751 | ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2 | More | | Esomeprazole | hsa04924 | Renin secretion | 3.77E-02 | 2 | Q13370, P0DP23 | PDE3B, CALM1 | More | | Esomeprazole | hsa04925 | Aldosterone synthesis and secretion | 7.87E-07 | 8 | Q99941, P18848, Q08828, P51828, P0DP23, Q16566, Q13557, P23634 | CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK4, CAMK2D, ATP2B4 | More | | Esomeprazole | hsa04926 | Relaxin signaling pathway | 2.12E-03 | 5 | P31751, Q99941, P18848, Q08828, P51828 | AKT2, CREBL1, ATF4, ADCY1, ADCY7 | More | | Esomeprazole | hsa04927 | Cortisol synthesis and secretion | 2.61E-05 | 4 | Q99941, P18848, Q08828, P51828 | CREBL1, ATF4, ADCY1, ADCY7 | More | | Esomeprazole | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.17E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | Esomeprazole | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | Esomeprazole | hsa04932 | Non-alcoholic fatty liver disease | 8.76E-08 | 9 | P31751, O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298 | AKT2, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.708 | O14976 | GAK | Cyclin-G-associated kinase | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.745 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.708 | O14976 | GAK | Cyclin-G-associated kinase | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.745 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 |
| Esomeprazole | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | Esomeprazole | hsa04934 | Cushing syndrome | 2.20E-04 | 5 | Q99941, P18848, Q08828, P51828, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, CAMK2D | More | | Esomeprazole | hsa04935 | Growth hormone synthesis, secretion and action | 1.32E-03 | 5 | Q08828, P51828, Q99941, P18848, P31751 | ADCY1, ADCY7, CREBL1, ATF4, AKT2 | More | | Esomeprazole | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.40E-02 | 1 | O00141 | SGK | More | | Esomeprazole | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | Esomeprazole | hsa04966 | Collecting duct acid secretion | 4.48E-02 | 1 | P00918 | CA2 | More | | Esomeprazole | hsa04970 | Salivary secretion | 4.65E-06 | 8 | Q08828, P51828, P22694, Q14643, P17252, P0DP24, P0DP23, P49913 | ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM2, CALM1, CAMP | More | | Esomeprazole | hsa04971 | Gastric acid secretion | 6.63E-05 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | Esomeprazole | hsa04972 | Pancreatic secretion | 3.65E-02 | 2 | P63092, P61586 | GNAS, RHOA | More | | Esomeprazole | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | Esomeprazole | hsa04976 | Bile secretion | 1.47E-06 | 6 | O43315, Q08828, P51828, P22694, P08183, Q14032 | AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | Esomeprazole | hsa05010 | Alzheimer disease | 3.40E-05 | 12 | O95298, P13073, P12074, Q00535, O75460, P0DP23, P01584, P18848, P67870, P31751, P05141, P28070 | NDUFC2, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, CSNK2B, AKT2, SLC25A5, PSMB4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| Esomeprazole | hsa05012 | Parkinson disease | 3.61E-02 | 8 | O95298, P13073, P12074, P05141, O75460, P18848, P28070, P0DP23 | NDUFC2, COX4I1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, CALM1 | More | | Esomeprazole | hsa05016 | Huntington disease | 1.12E-04 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.85 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | -0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.85 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | -0.703 |
| Esomeprazole | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | Esomeprazole | hsa05020 | Prion disease | 1.57E-02 | 9 | P01584, P0DMV8, O95298, P13073, P12074, P18848, P05141, P28070, P67870 | IL1B, HSPA1A, NDUFC2, COX4I1, COX6A1, ATF4, SLC25A5, PSMB4, CSNK2B | More | | Esomeprazole | hsa05022 | Pathways of neurodegeneration - multiple diseases | 5.46E-04 | 12 | P67870, O95298, P13073, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070 | CSNK2B, NDUFC2, COX4I1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.866 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.866 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| Esomeprazole | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | Esomeprazole | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | Esomeprazole | hsa05032 | Morphine addiction | 2.47E-03 | 3 | P62873, P48169, P63092 | GNB1, GABRA4, GNAS | More | | Esomeprazole | hsa05034 | Alcoholism | 1.53E-06 | 11 | O15399, Q16566, Q13547, P0DP23, P63218, Q93077, P58876, P62807, Q16778, O60814, P68431 | GRIN2D, CAMK4, HDAC1, CALM1, GNG5, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | Esomeprazole | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.39E-05 | 6 | Q16539, P09341, P19875, P19174, P25024, P25025 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | Esomeprazole | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | Esomeprazole | hsa05132 | Salmonella infection | 2.98E-02 | 11 | P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509 | IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3 | More | | Esomeprazole | hsa05133 | Pertussis | 1.94E-04 | 5 | P11215, P0DP23, P23528, P09871, P0C0L4 | ITGAM, CALM1, CFL1, C1S, C4A | More | | Esomeprazole | hsa05134 | Legionellosis | 9.73E-06 | 8 | P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | Esomeprazole | hsa05140 | Leishmaniasis | 1.18E-05 | 13 | P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | P08246 | ELA2 | Neutrophil elastase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.729 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | P08246 | ELA2 | Neutrophil elastase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.729 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 |
| Esomeprazole | hsa05144 | Malaria | 7.40E-06 | 6 | P60033, O60603, P01375, P35443, P01584, P26718 | CD81, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | Esomeprazole | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | Esomeprazole | hsa05146 | Amoebiasis | 1.19E-07 | 13 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05089 | ARG1 | Arginase-1 | 0.819 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05089 | ARG1 | Arginase-1 | 0.848 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.708 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05089 | ARG1 | Arginase-1 | 0.819 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05089 | ARG1 | Arginase-1 | 0.848 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.708 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 |
| Esomeprazole | hsa05150 | Staphylococcus aureus infection | 7.53E-06 | 10 | P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913 | C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | Esomeprazole | hsa05152 | Tuberculosis | 2.07E-02 | 9 | Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | Esomeprazole | hsa05161 | Hepatitis B | 2.41E-03 | 11 | P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765 | PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4 | More | | Esomeprazole | hsa05162 | Measles | 5.20E-04 | 6 | P23458, P31751, P0DMV8, P01584, P67870, Q9NP90 | JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9B | More | | Esomeprazole | hsa05163 | Human cytomegalovirus infection | 5.47E-09 | 21 | P31751, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769 | AKT2, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2M | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.736 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.795 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61769 | B2M | Beta-2-microglobulin | -0.711 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.736 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.795 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61769 | B2M | Beta-2-microglobulin | -0.711 |
| Esomeprazole | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | Esomeprazole | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | Esomeprazole | hsa05168 | Herpes simplex virus 1 infection | 1.95E-03 | 14 | P25963, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.825 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.703 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q9Y2A4 | ZNF443 | Zinc finger protein 443 | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P51522 | ZNF83 | Zinc finger protein 83 | 0.851 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P17038 | ZNF43 | Zinc finger protein 43 | 0.718 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P52738 | ZNF140 | Zinc finger protein 140 | 0.71 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | O75820 | ZNF189 | Zinc finger protein 189 | 0.768 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.825 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.703 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q9Y2A4 | ZNF443 | Zinc finger protein 443 | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P51522 | ZNF83 | Zinc finger protein 83 | 0.851 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P17038 | ZNF43 | Zinc finger protein 43 | 0.718 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P52738 | ZNF140 | Zinc finger protein 140 | 0.71 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | O75820 | ZNF189 | Zinc finger protein 189 | 0.768 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 |
| Esomeprazole | hsa05169 | Epstein-Barr virus infection | 4.41E-02 | 8 | P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963 | HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247 | More | | Esomeprazole | hsa05170 | Human immunodeficiency virus 1 infection | 1.06E-03 | 13 | P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5 | TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2 | More | | Esomeprazole | hsa05171 | Coronavirus disease - COVID-19 | 3.18E-03 | 7 | P01584, P62753, P36578, P62888, P61927, P61513, P62829 | IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23 | More | | Esomeprazole | hsa05200 | Pathways in cancer | 1.31E-03 | 21 | Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| Esomeprazole | hsa05202 | Transcriptional misregulation in cancer | 2.47E-06 | 21 | Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P12980 | LYL1 | Protein lyl-1 | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P12980 | LYL1 | Protein lyl-1 | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 |
| Esomeprazole | hsa05203 | Viral carcinogenesis | 9.17E-05 | 10 | Q99941, P18848, P27348, Q13547, Q15283, P61978, P58876, P62807, Q16778, O60814 | CREBL1, ATF4, YWHAQ, HDAC1, RASA2, HNRPK, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12 | More | | Esomeprazole | hsa05204 | Chemical carcinogenesis | 1.75E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Esomeprazole | hsa05212 | Pancreatic cancer | 1.45E-04 | 8 | P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293 | PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B | More | | Esomeprazole | hsa05214 | Glioma | 1.72E-02 | 3 | P0DP23, P42338, O75293 | CALM1, PIK3CB, GADD45B | More | | Esomeprazole | hsa05217 | Basal cell carcinoma | 3.50E-02 | 4 | Q13635, P49841, Q9UJU2, P24522 | PTCH1, GSK3B, LEF1, GADD45A | More | | Esomeprazole | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | Esomeprazole | hsa05220 | Chronic myeloid leukemia | 2.16E-02 | 5 | Q13547, Q13485, P84022, P42338, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B | More | | Esomeprazole | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | Esomeprazole | hsa05224 | Breast cancer | 4.75E-02 | 4 | P49841, Q92837, P04637, P24522 | GSK3B, FRAT1, TP53, GADD45A | More | | Esomeprazole | hsa05231 | Choline metabolism in cancer | 3.38E-02 | 3 | P31751, Q16760, O14986 | AKT2, DGKD, PIP5K1B | More | | Esomeprazole | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2.89E-05 | 12 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 |
| Esomeprazole | hsa05310 | Asthma | 3.88E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | Esomeprazole | hsa05321 | Inflammatory bowel disease | 4.27E-04 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B | More | | Esomeprazole | hsa05322 | Systemic lupus erythematosus | 1.52E-05 | 14 | P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | Esomeprazole | hsa05332 | Graft-versus-host disease | 9.30E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | Esomeprazole | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | Esomeprazole | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | Esomeprazole | hsa05418 | Fluid shear stress and atherosclerosis | 3.33E-06 | 12 | Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q14145 | KEAP1 | Kelch-like ECH-associated protein 1 | -0.733 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.792 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P10599 | TXN | Thioredoxin | 0.777 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P10599 | TXN | Thioredoxin | 0.749 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P10599 | TXN | Thioredoxin | 0.836 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.848 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q14145 | KEAP1 | Kelch-like ECH-associated protein 1 | -0.733 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.792 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P10599 | TXN | Thioredoxin | 0.777 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P10599 | TXN | Thioredoxin | 0.749 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P10599 | TXN | Thioredoxin | 0.836 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.848 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 |
| Omeprazole | hsa00052 | Galactose metabolism | 1.06E-03 | 2 | P06280, O43451 | GLA, MGAM | More | | Omeprazole | hsa00071 | Fatty acid degradation | 3.50E-02 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | Omeprazole | hsa00220 | Arginine biosynthesis | 4.40E-02 | 1 | P15104 | GLUL | More | | Omeprazole | hsa00230 | Purine metabolism | 1.56E-02 | 3 | Q7LG56, P51828, Q9Y227 | RRM2B, ADCY7, ENTPD4 | More | | Omeprazole | hsa00240 | Pyrimidine metabolism | 1.45E-02 | 2 | Q7LG56, Q9Y227 | RRM2B, ENTPD4 | More | | Omeprazole | hsa00500 | Starch and sucrose metabolism | 1.80E-08 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | Omeprazole | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | Omeprazole | hsa00564 | Glycerophospholipid metabolism | 1.12E-02 | 1 | Q8TCT1 | PHOSPHO1 | More | | Omeprazole | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | Omeprazole | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | Omeprazole | hsa00630 | Glyoxylate and dicarboxylate metabolism | 3.93E-06 | 3 | P40925, P40926, P15104 | MDH1, MDH2, GLUL | More | | Omeprazole | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | Omeprazole | hsa00730 | Thiamine metabolism | 1.87E-06 | 2 | P05186, P24666 | ALPL, ACP1 | More | | Omeprazole | hsa00740 | Riboflavin metabolism | 4.77E-02 | 1 | P30043 | BLVRB | More | | Omeprazole | hsa00830 | Retinol metabolism | 2.20E-02 | 4 | P00325, P11766, Q9BPW9, O75911 | ADH1B, ADH5, DHRS9, DHRS3 | More | | Omeprazole | hsa00970 | Aminoacyl-tRNA biosynthesis | 5.30E-04 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | Omeprazole | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.39E-04 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Omeprazole | hsa00982 | Drug metabolism - cytochrome P450 | 6.39E-04 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | Omeprazole | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | Omeprazole | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 |
| Omeprazole | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | Omeprazole | hsa02010 | ABC transporters | 4.48E-02 | 1 | Q8IZY2 | ABCA7 | More | | Omeprazole | hsa03008 | Ribosome biogenesis in eukaryotes | 4.94E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | Omeprazole | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | | Omeprazole | hsa03013 | RNA transport | 2.35E-05 | 19 | P62826, P52298, Q09161, O14893, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787 | RAN, NCBP2, NCBP1, GEMIN2, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P62826 | RAN | GTP-binding nuclear protein Ran | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62826 | RAN | GTP-binding nuclear protein Ran | 0.732 | P08246 | ELA2 | Neutrophil elastase | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.852 | P08246 | ELA2 | Neutrophil elastase | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.732 | P08246 | ELA2 | Neutrophil elastase | O14893 | GEMIN2 | Gem-associated protein 2 | -0.785 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.76 | O14976 | GAK | Cyclin-G-associated kinase | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.827 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.79 | P08246 | ELA2 | Neutrophil elastase | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.723 | P08246 | ELA2 | Neutrophil elastase | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.765 | O14976 | GAK | Cyclin-G-associated kinase | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.766 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | O14976 | GAK | Cyclin-G-associated kinase | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.705 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.721 | P08246 | ELA2 | Neutrophil elastase | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.722 | P08246 | ELA2 | Neutrophil elastase | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.825 | P08246 | ELA2 | Neutrophil elastase | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.795 | O14976 | GAK | Cyclin-G-associated kinase | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.711 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.704 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.758 | P08246 | ELA2 | Neutrophil elastase | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.849 | O14976 | GAK | Cyclin-G-associated kinase | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.767 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.749 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.793 | O14976 | GAK | Cyclin-G-associated kinase | P62826 | RAN | GTP-binding nuclear protein Ran | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62826 | RAN | GTP-binding nuclear protein Ran | 0.732 | P08246 | ELA2 | Neutrophil elastase | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.852 | P08246 | ELA2 | Neutrophil elastase | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.732 | P08246 | ELA2 | Neutrophil elastase | O14893 | GEMIN2 | Gem-associated protein 2 | -0.785 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.76 | O14976 | GAK | Cyclin-G-associated kinase | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.827 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.79 | P08246 | ELA2 | Neutrophil elastase | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.723 | P08246 | ELA2 | Neutrophil elastase | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.765 | O14976 | GAK | Cyclin-G-associated kinase | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.766 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | O14976 | GAK | Cyclin-G-associated kinase | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.705 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.721 | P08246 | ELA2 | Neutrophil elastase | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.722 | P08246 | ELA2 | Neutrophil elastase | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.825 | P08246 | ELA2 | Neutrophil elastase | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.795 | O14976 | GAK | Cyclin-G-associated kinase | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.711 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.704 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.758 | P08246 | ELA2 | Neutrophil elastase | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.849 | O14976 | GAK | Cyclin-G-associated kinase | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.767 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.749 | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.793 |
| Omeprazole | hsa03015 | mRNA surveillance pathway | 4.81E-02 | 2 | Q9BZI7, O94913 | UPF3B, PCF11 | More | | Omeprazole | hsa03020 | RNA polymerase | 3.77E-07 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.749 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.724 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9Y535 | POLR3H | DNA-directed RNA polymerase III subunit RPC8 | 0.737 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.749 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.724 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9Y535 | POLR3H | DNA-directed RNA polymerase III subunit RPC8 | 0.737 |
| Omeprazole | hsa03040 | Spliceosome | 1.05E-10 | 17 | Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.794 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.741 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.715 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.794 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.741 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.715 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| Omeprazole | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | Omeprazole | hsa03060 | Protein export | 2.84E-03 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | Omeprazole | hsa04014 | Ras signaling pathway | 2.57E-04 | 10 | P42338, P20827, P49767, Q13009, Q7LDG7, Q14644, P0DP23, P63218, P50151, P19174 | PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, RASA3, CALM1, GNG5, GNG10, PLCG1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P20827 | EFNA1 | Ephrin-A1 | 0.727 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.821 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q14644 | RASA3 | Ras GTPase-activating protein 3 | 0.741 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P20827 | EFNA1 | Ephrin-A1 | 0.727 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.821 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q14644 | RASA3 | Ras GTPase-activating protein 3 | 0.741 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| Omeprazole | hsa04015 | Rap1 signaling pathway | 1.79E-02 | 8 | P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174 | EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1 | More | | Omeprazole | hsa04020 | Calcium signaling pathway | 5.17E-04 | 9 | Q08828, Q16566, P30679, O15399, P0DP23, P05141, P51828, P23634, P49767 | ADCY1, CAMK4, GNA15, GRIN2D, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFC | More | | Omeprazole | hsa04022 | cGMP-PKG signaling pathway | 3.97E-04 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | Omeprazole | hsa04024 | cAMP signaling pathway | 5.36E-04 | 10 | P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009 | GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1 | More | | Omeprazole | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 3.83E-04 | 10 | Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375 | CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF | More | | Omeprazole | hsa04062 | Chemokine signaling pathway | 5.65E-04 | 14 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| Omeprazole | hsa04064 | NF-kappa B signaling pathway | 2.23E-10 | 23 | P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| Omeprazole | hsa04070 | Phosphatidylinositol signaling system | 1.28E-03 | 6 | P0DP23, P42338, O14986, Q16760, P48426, P27987 | CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKB | More | | Omeprazole | hsa04071 | Sphingolipid signaling pathway | 6.37E-04 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2 | More | | Omeprazole | hsa04072 | Phospholipase D signaling pathway | 2.68E-06 | 14 | P31751, P42338, Q9UQC2, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760 | AKT2, PIK3CB, GAB2, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | Q13547 | HDAC1 | Histone deacetylase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.804 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | -0.736 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | 0.717 | O14976 | GAK | Cyclin-G-associated kinase | Q15438 | PSCD1 | Cytohesin-1 | 0.74 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q15438 | PSCD1 | Cytohesin-1 | 0.708 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | Q16760 | DGKD | Diacylglycerol kinase delta | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q16760 | DGKD | Diacylglycerol kinase delta | 0.73 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | Q13547 | HDAC1 | Histone deacetylase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.804 | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | -0.736 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O14986 | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | 0.717 | O14976 | GAK | Cyclin-G-associated kinase | Q15438 | PSCD1 | Cytohesin-1 | 0.74 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q15438 | PSCD1 | Cytohesin-1 | 0.708 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | Q16760 | DGKD | Diacylglycerol kinase delta | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q16760 | DGKD | Diacylglycerol kinase delta | 0.73 |
| Omeprazole | hsa04080 | Neuroactive ligand-receptor interaction | 3.11E-04 | 10 | P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P35318 | CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADM | More | | Omeprazole | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | Omeprazole | hsa04114 | Oocyte meiosis | 1.35E-02 | 5 | P0DP23, Q08828, P51828, Q13362, Q14738 | CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D | More | | Omeprazole | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | Omeprazole | hsa04120 | Ubiquitin mediated proteolysis | 4.82E-03 | 2 | Q9UBT2, Q14669 | SAE2, TRIP12 | More | | Omeprazole | hsa04137 | Mitophagy - animal | 2.52E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | Omeprazole | hsa04140 | Autophagy - animal | 1.71E-02 | 5 | P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | Omeprazole | hsa04141 | Protein processing in endoplasmic reticulum | 1.91E-03 | 6 | P18848, Q15437, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | Omeprazole | hsa04142 | Lysosome | 1.11E-03 | 9 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900, Q9Y227 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164, ENTPD4 | More | | Omeprazole | hsa04144 | Endocytosis | 1.37E-03 | 10 | P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q14161, Q9UMY4, Q9UNH7 | HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, GIT2, SNX12, SNX6 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9H444 | CHMP4B | Charged multivesicular body protein 4b | 0.862 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.765 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.707 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62491 | RAB11A | Ras-related protein Rab-11A | 0.854 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P42566 | EPS15 | Epidermal growth factor receptor substrate 15 | 0.838 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q96B97 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | 0.716 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q15438 | PSCD1 | Cytohesin-1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15438 | PSCD1 | Cytohesin-1 | 0.756 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.77 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.817 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9UMY4 | SNX12 | Sorting nexin-12 | 0.835 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q9UNH7 | SNX6 | Sorting nexin-6 | 0.799 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9H444 | CHMP4B | Charged multivesicular body protein 4b | 0.862 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.765 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75351 | VPS4B | Vacuolar protein sorting-associated protein 4B | 0.707 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62491 | RAB11A | Ras-related protein Rab-11A | 0.854 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P42566 | EPS15 | Epidermal growth factor receptor substrate 15 | 0.838 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q96B97 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | 0.716 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q15438 | PSCD1 | Cytohesin-1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15438 | PSCD1 | Cytohesin-1 | 0.756 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.77 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q14161 | GIT2 | ARF GTPase-activating protein GIT2 | 0.817 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9UMY4 | SNX12 | Sorting nexin-12 | 0.835 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | Q9UNH7 | SNX6 | Sorting nexin-6 | 0.799 |
| Omeprazole | hsa04145 | Phagosome | 1.98E-02 | 8 | Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765 | NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Omeprazole | hsa04151 | PI3K-Akt signaling pathway | 5.37E-05 | 19 | P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281 | RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P62753 | RPS6 | 40S ribosomal protein S6 | 0.722 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P27348 | YWHAQ | 14-3-3 protein theta | 0.833 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P22105 | TNXB | Tenascin-X | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | 0.709 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P62753 | RPS6 | 40S ribosomal protein S6 | 0.722 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P27348 | YWHAQ | 14-3-3 protein theta | 0.833 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P22105 | TNXB | Tenascin-X | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | 0.709 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 |
| Omeprazole | hsa04210 | Apoptosis | 2.68E-03 | 11 | Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | Omeprazole | hsa04211 | Longevity regulating pathway | 5.88E-05 | 6 | P31751, Q08828, P51828, Q99941, P18848, Q96RR4 | AKT2, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2 | More | | Omeprazole | hsa04213 | Longevity regulating pathway - multiple species | 6.63E-07 | 8 | P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | 0.852 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | -0.845 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.713 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13547 | HDAC1 | Histone deacetylase 1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | 0.852 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9Y4H2 | IRS2 | Insulin receptor substrate 2 | -0.845 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.713 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13547 | HDAC1 | Histone deacetylase 1 | 1 |
| Omeprazole | hsa04217 | Necroptosis | 1.44E-03 | 5 | Q9NQC7, P07900, P15104, P01584, Q9H444 | CYLD, HSP90AA1, GLUL, IL1B, CHMP4B | More | | Omeprazole | hsa04260 | Cardiac muscle contraction | 4.20E-02 | 3 | P67936, P13073, P12074 | TPM4, COX4I1, COX6A1 | More | | Omeprazole | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.79E-07 | 10 | P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557 | TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P67936 | TPM4 | Tropomyosin alpha-4 chain | 0.737 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 0.781 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | O14976 | GAK | Cyclin-G-associated kinase | P67936 | TPM4 | Tropomyosin alpha-4 chain | 0.737 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.774 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.735 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 0.781 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 |
| Omeprazole | hsa04270 | Vascular smooth muscle contraction | 5.20E-04 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | Omeprazole | hsa04310 | Wnt signaling pathway | 4.17E-03 | 3 | P61586, P19784, P67870 | RHOA, CSNK2A2, CSNK2B | More | | Omeprazole | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | | Omeprazole | hsa04360 | Axon guidance | 2.47E-03 | 7 | P16333, P20827, O95631, P42338, P07332, P23528, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1 | More | | Omeprazole | hsa04371 | Apelin signaling pathway | 1.37E-04 | 12 | P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14814 | MEF2D | Myocyte-specific enhancer factor 2D | 0.767 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.824 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.809 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.762 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14814 | MEF2D | Myocyte-specific enhancer factor 2D | 0.767 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.824 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.809 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P0DP23 | CALM1 | Calmodulin-1 | -0.804 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 |
| Omeprazole | hsa04380 | Osteoclast differentiation | 2.55E-07 | 14 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.834 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.885 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q8N149 | LILRA2 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | 0.743 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78324 | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 | 0.832 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.834 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.885 | O14976 | GAK | Cyclin-G-associated kinase | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q8N149 | LILRA2 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | 0.743 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78324 | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 | 0.832 |
| Omeprazole | hsa04510 | Focal adhesion | 4.07E-02 | 3 | O14986, P61586, Q16363 | PIP5K1B, RHOA, LAMA4 | More | | Omeprazole | hsa04520 | Adherens junction | 1.38E-04 | 3 | P19784, P67870, P61586 | CSNK2A2, CSNK2B, RHOA | More | | Omeprazole | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | Omeprazole | hsa04610 | Complement and coagulation cascades | 8.66E-04 | 4 | P01042, P09871, P0C0L4, P11215 | KNG1, C1S, C4A, ITGAM | More | | Omeprazole | hsa04612 | Antigen processing and presentation | 1.51E-03 | 7 | P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | Omeprazole | hsa04613 | Neutrophil extracellular trap formation | 7.76E-08 | 26 | P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05164 | MPO | Myeloperoxidase | 0.717 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.736 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.759 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P58876 | H2BC5 | Histone H2B type 1-D | 0.947 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.793 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | O60814 | H2BC12 | Histone H2B type 1-K | 0.72 | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.923 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.779 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43315 | AQP9 | Aquaporin-9 | 0.918 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05164 | MPO | Myeloperoxidase | 0.717 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.736 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.759 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P58876 | H2BC5 | Histone H2B type 1-D | 0.947 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.793 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | O60814 | H2BC12 | Histone H2B type 1-K | 0.72 | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.923 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.779 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43315 | AQP9 | Aquaporin-9 | 0.918 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 |
| Omeprazole | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | Omeprazole | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | Omeprazole | hsa04621 | NOD-like receptor signaling pathway | 1.47E-05 | 15 | P01584, P07900, Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838 | IL1B, HSP90AA1, ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | Omeprazole | hsa04623 | Cytosolic DNA-sensing pathway | 1.21E-05 | 3 | P01584, Q9Y535, Q8NHW4 | IL1B, POLR3H, CCL4L2 | More | | Omeprazole | hsa04625 | C-type lectin receptor signaling pathway | 4.27E-06 | 11 | Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.745 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q9ULY5 | CLEC4E | C-type lectin domain family 4 member E | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.766 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P20749 | BCL3 | B-cell lymphoma 3 protein | 0.745 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 |
| Omeprazole | hsa04630 | JAK-STAT signaling pathway | 2.62E-03 | 4 | P31751, P23458, P16871, Q13651 | AKT2, JAK1, IL7R, IL10RA | More | | Omeprazole | hsa04640 | Hematopoietic cell lineage | 6.79E-04 | 16 | P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P15144 | ANPEP | Aminopeptidase N | 0.851 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.71 | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P15144 | ANPEP | Aminopeptidase N | 0.851 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.71 | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| Omeprazole | hsa04650 | Natural killer cell mediated cytotoxicity | 1.17E-07 | 13 | P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715 | PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 |
| Omeprazole | hsa04657 | IL-17 signaling pathway | 1.36E-07 | 9 | P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.709 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.805 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.709 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.805 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| Omeprazole | hsa04658 | Th1 and Th2 cell differentiation | 9.79E-07 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| Omeprazole | hsa04659 | Th17 cell differentiation | 3.35E-08 | 19 | Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458 | PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| Omeprazole | hsa04660 | T cell receptor signaling pathway | 2.85E-05 | 17 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 |
| Omeprazole | hsa04662 | B cell receptor signaling pathway | 1.48E-05 | 6 | P42338, P60033, P13164, P07948, P21854, Q8N149 | PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2 | More | | Omeprazole | hsa04664 | Fc epsilon RI signaling pathway | 1.36E-04 | 7 | P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917 | TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5 | More | | Omeprazole | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 3 | P42338, P23528, P14598 | PIK3CB, CFL1, NCF1 | More | | Omeprazole | hsa04668 | TNF signaling pathway | 1.83E-03 | 8 | P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9 | More | | Omeprazole | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | Omeprazole | hsa04710 | Circadian rhythm | 4.40E-02 | 1 | O15516 | CLOCK | More | | Omeprazole | hsa04713 | Circadian entrainment | 5.44E-03 | 5 | P0DP23, P62873, Q08828, P51828, P63092 | CALM1, GNB1, ADCY1, ADCY7, GNAS | More | | Omeprazole | hsa04714 | Thermogenesis | 3.31E-02 | 4 | P51828, P62753, P12074, O15239 | ADCY7, RPS6, COX6A1, NDUFA1 | More | | Omeprazole | hsa04720 | Long-term potentiation | 1.15E-04 | 6 | Q16566, P0DP23, Q15418, P18848, O15399, Q08828 | CAMK4, CALM1, RPS6KA1, ATF4, GRIN2D, ADCY1 | More | | Omeprazole | hsa04723 | Retrograde endocannabinoid signaling | 4.94E-02 | 2 | P48169, P62873 | GABRA4, GNB1 | More | | Omeprazole | hsa04724 | Glutamatergic synapse | 3.56E-04 | 8 | O15399, P43003, P63092, P62873, P63218, P50151, P15104, Q9NSB8 | GRIN2D, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL, HOMER2 | More | | Omeprazole | hsa04725 | Cholinergic synapse | 1.30E-04 | 5 | Q08828, P51828, P18848, Q13557, P31751 | ADCY1, ADCY7, ATF4, CAMK2D, AKT2 | More | | Omeprazole | hsa04726 | Serotonergic synapse | 2.52E-02 | 2 | P63092, P62873 | GNAS, GNB1 | More | | Omeprazole | hsa04728 | Dopaminergic synapse | 1.01E-03 | 7 | P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23 | AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1 | More | | Omeprazole | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.62E-07 | 13 | P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
---|
P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | Q13547 | HDAC1 | Histone deacetylase 1 | P24723 | PRKCH | Protein kinase C eta type | 0.875 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | Q13547 | HDAC1 | Histone deacetylase 1 | P24723 | PRKCH | Protein kinase C eta type | 0.875 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 |
| Omeprazole | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | Omeprazole | hsa04911 | Insulin secretion | 4.09E-05 | 5 | Q08828, P51828, Q99941, P18848, Q13557 | ADCY1, ADCY7, CREBL1, ATF4, CAMK2D | More | | Omeprazole | hsa04912 | GnRH signaling pathway | 5.19E-06 | 11 | Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P45985 | ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, MAP2K4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.804 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9Y6R4 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P0DP24 | CALM2 | Calmodulin-2 | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.804 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.718 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.763 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9Y6R4 | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | -0.785 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.838 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P0DP24 | CALM2 | Calmodulin-2 | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0DP24 | CALM2 | Calmodulin-2 | 0.798 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | P08575 | PTPRC | Receptor-type tyrosine-protein phosphatase C | P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | 0.759 |
| Omeprazole | hsa04914 | Progesterone-mediated oocyte maturation | 3.92E-02 | 3 | P42338, Q13370, P08238 | PIK3CB, PDE3B, HSP90AB1 | More | | Omeprazole | hsa04915 | Estrogen signaling pathway | 1.80E-07 | 10 | Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788 | CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.86 | O14976 | GAK | Cyclin-G-associated kinase | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.711 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.753 | O14976 | GAK | Cyclin-G-associated kinase | P0DMV8 | HSPA1A | Heat shock 70 kDa protein 1A | 0.702 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.86 | O14976 | GAK | Cyclin-G-associated kinase | Q15788 | NCOA1 | Nuclear receptor coactivator 1 | 0.711 |
| Omeprazole | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | Omeprazole | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | Omeprazole | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | Omeprazole | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | Omeprazole | hsa04923 | Regulation of lipolysis in adipocytes | 9.48E-06 | 6 | Q08828, P51828, P07550, P42338, Q9Y4H2, P31751 | ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2 | More | | Omeprazole | hsa04924 | Renin secretion | 3.77E-02 | 2 | Q13370, P0DP23 | PDE3B, CALM1 | More | | Omeprazole | hsa04925 | Aldosterone synthesis and secretion | 7.87E-07 | 8 | Q99941, P18848, Q08828, P51828, P0DP23, Q16566, Q13557, P23634 | CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK4, CAMK2D, ATP2B4 | More | | Omeprazole | hsa04926 | Relaxin signaling pathway | 2.12E-03 | 5 | P31751, Q99941, P18848, Q08828, P51828 | AKT2, CREBL1, ATF4, ADCY1, ADCY7 | More | | Omeprazole | hsa04927 | Cortisol synthesis and secretion | 2.61E-05 | 4 | Q99941, P18848, Q08828, P51828 | CREBL1, ATF4, ADCY1, ADCY7 | More | | Omeprazole | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.17E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | Omeprazole | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | Omeprazole | hsa04932 | Non-alcoholic fatty liver disease | 8.76E-08 | 9 | P31751, O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298 | AKT2, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.708 | O14976 | GAK | Cyclin-G-associated kinase | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.745 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.708 | O14976 | GAK | Cyclin-G-associated kinase | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.745 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.742 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 |
| Omeprazole | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | Omeprazole | hsa04934 | Cushing syndrome | 2.20E-04 | 5 | Q99941, P18848, Q08828, P51828, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, CAMK2D | More | | Omeprazole | hsa04935 | Growth hormone synthesis, secretion and action | 1.32E-03 | 5 | Q08828, P51828, Q99941, P18848, P31751 | ADCY1, ADCY7, CREBL1, ATF4, AKT2 | More | | Omeprazole | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.40E-02 | 1 | O00141 | SGK | More | | Omeprazole | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | Omeprazole | hsa04966 | Collecting duct acid secretion | 4.48E-02 | 1 | P00918 | CA2 | More | | Omeprazole | hsa04970 | Salivary secretion | 4.65E-06 | 8 | Q08828, P51828, P22694, Q14643, P17252, P0DP24, P0DP23, P49913 | ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM2, CALM1, CAMP | More | | Omeprazole | hsa04971 | Gastric acid secretion | 6.63E-05 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | Omeprazole | hsa04972 | Pancreatic secretion | 3.65E-02 | 2 | P63092, P61586 | GNAS, RHOA | More | | Omeprazole | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | Omeprazole | hsa04976 | Bile secretion | 1.47E-06 | 6 | O43315, Q08828, P51828, P22694, P08183, Q14032 | AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | Omeprazole | hsa05010 | Alzheimer disease | 3.40E-05 | 12 | O95298, P13073, P12074, Q00535, O75460, P0DP23, P01584, P18848, P67870, P31751, P05141, P28070 | NDUFC2, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, CSNK2B, AKT2, SLC25A5, PSMB4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| Omeprazole | hsa05012 | Parkinson disease | 3.61E-02 | 8 | O95298, P13073, P12074, P05141, O75460, P18848, P28070, P0DP23 | NDUFC2, COX4I1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, CALM1 | More | | Omeprazole | hsa05016 | Huntington disease | 1.12E-04 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.85 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | -0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.83 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.722 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.761 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.784 | O14976 | GAK | Cyclin-G-associated kinase | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.718 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P24928 | POLR2A | DNA-directed RNA polymerase II subunit RPB1 | 0.709 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.795 | O14976 | GAK | Cyclin-G-associated kinase | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.713 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P30876 | POLR2B | DNA-directed RNA polymerase II subunit RPB2 | 0.703 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.855 | O14976 | GAK | Cyclin-G-associated kinase | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.776 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62487 | POLR2G | DNA-directed RNA polymerase II subunit RPB7 | 0.758 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.79 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.85 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | -0.703 |
| Omeprazole | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | Omeprazole | hsa05020 | Prion disease | 1.57E-02 | 9 | P01584, P0DMV8, O95298, P13073, P12074, P18848, P05141, P28070, P67870 | IL1B, HSPA1A, NDUFC2, COX4I1, COX6A1, ATF4, SLC25A5, PSMB4, CSNK2B | More | | Omeprazole | hsa05022 | Pathways of neurodegeneration - multiple diseases | 5.46E-04 | 12 | P67870, O95298, P13073, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070 | CSNK2B, NDUFC2, COX4I1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.866 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | O14976 | GAK | Cyclin-G-associated kinase | P67870 | CSNK2B | Casein kinase II subunit beta | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.73 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | O14976 | GAK | Cyclin-G-associated kinase | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.759 | O14976 | GAK | Cyclin-G-associated kinase | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.723 | O14976 | GAK | Cyclin-G-associated kinase | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.866 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8TEV9 | SMCR8 | Guanine nucleotide exchange protein SMCR8 | 0.807 | O14976 | GAK | Cyclin-G-associated kinase | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.781 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | O14976 | GAK | Cyclin-G-associated kinase | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | O14976 | GAK | Cyclin-G-associated kinase | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.835 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | O14976 | GAK | Cyclin-G-associated kinase | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.773 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| Omeprazole | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | Omeprazole | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | Omeprazole | hsa05032 | Morphine addiction | 2.47E-03 | 3 | P62873, P48169, P63092 | GNB1, GABRA4, GNAS | More | | Omeprazole | hsa05034 | Alcoholism | 1.53E-06 | 11 | O15399, Q16566, Q13547, P0DP23, P63218, Q93077, P58876, P62807, Q16778, O60814, P68431 | GRIN2D, CAMK4, HDAC1, CALM1, GNG5, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | Omeprazole | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.39E-05 | 6 | Q16539, P09341, P19875, P19174, P25024, P25025 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | Omeprazole | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | Omeprazole | hsa05132 | Salmonella infection | 2.98E-02 | 11 | P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509 | IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3 | More | | Omeprazole | hsa05133 | Pertussis | 1.94E-04 | 5 | P11215, P0DP23, P23528, P09871, P0C0L4 | ITGAM, CALM1, CFL1, C1S, C4A | More | | Omeprazole | hsa05134 | Legionellosis | 9.73E-06 | 8 | P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | Omeprazole | hsa05140 | Leishmaniasis | 1.18E-05 | 13 | P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | P08246 | ELA2 | Neutrophil elastase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.729 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | P08246 | ELA2 | Neutrophil elastase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.729 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 |
| Omeprazole | hsa05144 | Malaria | 7.40E-06 | 6 | P60033, O60603, P01375, P35443, P01584, P26718 | CD81, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | Omeprazole | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | Omeprazole | hsa05146 | Amoebiasis | 1.19E-07 | 13 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05089 | ARG1 | Arginase-1 | 0.819 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05089 | ARG1 | Arginase-1 | 0.848 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.708 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05089 | ARG1 | Arginase-1 | 0.819 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05089 | ARG1 | Arginase-1 | 0.848 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.708 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 |
| Omeprazole | hsa05150 | Staphylococcus aureus infection | 7.53E-06 | 10 | P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913 | C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | Omeprazole | hsa05152 | Tuberculosis | 2.07E-02 | 9 | Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617 | TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1 | More | | Omeprazole | hsa05161 | Hepatitis B | 2.41E-03 | 11 | P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765 | PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4 | More | | Omeprazole | hsa05162 | Measles | 5.20E-04 | 6 | P23458, P31751, P0DMV8, P01584, P67870, Q9NP90 | JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9B | More | | Omeprazole | hsa05163 | Human cytomegalovirus infection | 5.47E-09 | 21 | P31751, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769 | AKT2, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2M | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.736 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.795 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61769 | B2M | Beta-2-microglobulin | -0.711 | O14976 | GAK | Cyclin-G-associated kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.703 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.736 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | O14976 | GAK | Cyclin-G-associated kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.811 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | O14976 | GAK | Cyclin-G-associated kinase | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.787 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | O14976 | GAK | Cyclin-G-associated kinase | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.753 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | O14976 | GAK | Cyclin-G-associated kinase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.845 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | P01584 | IL1B | Interleukin-1 beta | 0.742 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | O14976 | GAK | Cyclin-G-associated kinase | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.795 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | O14976 | GAK | Cyclin-G-associated kinase | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.716 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61769 | B2M | Beta-2-microglobulin | -0.711 |
| Omeprazole | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | Omeprazole | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | Omeprazole | hsa05168 | Herpes simplex virus 1 infection | 1.95E-03 | 14 | P25963, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.825 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.703 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q9Y2A4 | ZNF443 | Zinc finger protein 443 | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P51522 | ZNF83 | Zinc finger protein 83 | 0.851 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P17038 | ZNF43 | Zinc finger protein 43 | 0.718 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P52738 | ZNF140 | Zinc finger protein 140 | 0.71 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | O75820 | ZNF189 | Zinc finger protein 189 | 0.768 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.825 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.703 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.781 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q9Y2A4 | ZNF443 | Zinc finger protein 443 | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P51522 | ZNF83 | Zinc finger protein 83 | 0.851 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P17038 | ZNF43 | Zinc finger protein 43 | 0.718 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P52738 | ZNF140 | Zinc finger protein 140 | 0.71 | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | O75820 | ZNF189 | Zinc finger protein 189 | 0.768 | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 |
| Omeprazole | hsa05169 | Epstein-Barr virus infection | 4.41E-02 | 8 | P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963 | HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247 | More | | Omeprazole | hsa05170 | Human immunodeficiency virus 1 infection | 1.06E-03 | 13 | P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5 | TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2 | More | | Omeprazole | hsa05171 | Coronavirus disease - COVID-19 | 3.18E-03 | 7 | P01584, P62753, P36578, P62888, P61927, P61513, P62829 | IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23 | More | | Omeprazole | hsa05200 | Pathways in cancer | 1.31E-03 | 21 | Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| Omeprazole | hsa05202 | Transcriptional misregulation in cancer | 2.47E-06 | 21 | Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P12980 | LYL1 | Protein lyl-1 | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P12980 | LYL1 | Protein lyl-1 | 0.806 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 |
| Omeprazole | hsa05203 | Viral carcinogenesis | 9.17E-05 | 10 | Q99941, P18848, P27348, Q13547, Q15283, P61978, P58876, P62807, Q16778, O60814 | CREBL1, ATF4, YWHAQ, HDAC1, RASA2, HNRPK, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12 | More | | Omeprazole | hsa05204 | Chemical carcinogenesis | 1.75E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Omeprazole | hsa05212 | Pancreatic cancer | 1.45E-04 | 8 | P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293 | PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B | More | | Omeprazole | hsa05214 | Glioma | 1.72E-02 | 3 | P0DP23, P42338, O75293 | CALM1, PIK3CB, GADD45B | More | | Omeprazole | hsa05217 | Basal cell carcinoma | 3.50E-02 | 4 | Q13635, P49841, Q9UJU2, P24522 | PTCH1, GSK3B, LEF1, GADD45A | More | | Omeprazole | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | Omeprazole | hsa05220 | Chronic myeloid leukemia | 2.16E-02 | 5 | Q13547, Q13485, P84022, P42338, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B | More | | Omeprazole | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | Omeprazole | hsa05224 | Breast cancer | 4.75E-02 | 4 | P49841, Q92837, P04637, P24522 | GSK3B, FRAT1, TP53, GADD45A | More | | Omeprazole | hsa05231 | Choline metabolism in cancer | 3.38E-02 | 3 | P31751, Q16760, O14986 | AKT2, DGKD, PIP5K1B | More | | Omeprazole | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2.89E-05 | 12 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 |
| Omeprazole | hsa05310 | Asthma | 3.88E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | Omeprazole | hsa05321 | Inflammatory bowel disease | 4.27E-04 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B | More | | Omeprazole | hsa05322 | Systemic lupus erythematosus | 1.52E-05 | 14 | P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | Omeprazole | hsa05332 | Graft-versus-host disease | 9.30E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | Omeprazole | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | Omeprazole | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | Omeprazole | hsa05418 | Fluid shear stress and atherosclerosis | 3.33E-06 | 12 | Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q14145 | KEAP1 | Kelch-like ECH-associated protein 1 | -0.733 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.792 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P10599 | TXN | Thioredoxin | 0.777 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P10599 | TXN | Thioredoxin | 0.749 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P10599 | TXN | Thioredoxin | 0.836 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.848 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q14145 | KEAP1 | Kelch-like ECH-associated protein 1 | -0.733 | P29375 | JARID1A | Lysine-specific demethylase 5A | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.792 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P10599 | TXN | Thioredoxin | 0.777 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P10599 | TXN | Thioredoxin | 0.749 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P10599 | TXN | Thioredoxin | 0.836 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.901 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.848 | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 |
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