PharmaCoNets

PharmaCoNets of Olopatadine (S_PCN: 77.07 )

Olopatadine regulated-network (S_DN: 17.20)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Olopatadine

hsa00030

Pentose phosphate pathway

5.91E-06

P60891, P51854, P04075, P37837

PRPS1, TKTL1, ALDOA, TALDO1

Olopatadine

hsa00071

Fatty acid degradation

1.72E-02

P11310, O75521, P11766, P33121

ACADM, ECI2, ADH5, ACSL1

Olopatadine

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Olopatadine

hsa00220

Arginine biosynthesis

4.33E-02

P05089, P49448

ARG1, GLUD2

Olopatadine

hsa00430

Taurine and hypotaurine metabolism

4.49E-02

Q14032

BAAT

Olopatadine

hsa00500

Starch and sucrose metabolism

4.66E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Olopatadine

hsa00512

Mucin type O-glycan biosynthesis

1.59E-03

O95395, Q8N4A0

GCNT3, GALNT4

Olopatadine

hsa00514

Other types of O-glycan biosynthesis

3.37E-02

P15907, Q8N4A0

ST6GAL1, GALNT4

Olopatadine

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Olopatadine

hsa00564

Glycerophospholipid metabolism

3.93E-02

P49619, O14494, Q3LIE5

DGKG, PLPP1, ADPRM

Olopatadine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.29E-03

P40925, P15104

MDH1, GLUL

Olopatadine

hsa00730

Thiamine metabolism

1.15E-03

Q9Y6K8, P24666

AK5, ACP1

Olopatadine

hsa00740

Riboflavin metabolism

4.03E-02

P24666

ACP1

Olopatadine

hsa00760

Nicotinate and nicotinamide metabolism

2.11E-02

P43490, Q13423

PBEF1, NNT

Olopatadine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Olopatadine

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Olopatadine

hsa00910

Nitrogen metabolism

4.33E-02

P22748, P49448

CA4, GLUD2

Olopatadine

hsa00970

Aminoacyl-tRNA biosynthesis

8.60E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Olopatadine

hsa01200

Carbon metabolism

4.76E-03

P51854, P04406, P37837, O14521, Q9P2R7, P60891, Q02252

TKTL1, GAPDH, TALDO1, SDHD, SUCLA2, PRPS1, ALDH6A1

Olopatadine

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Olopatadine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Olopatadine

hsa02010

ABC transporters

1.24E-03

P45844, P08183

ABCG1, ABCB1

Olopatadine

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Olopatadine

hsa03010

Ribosome

5.87E-03

P62753, P39019, P42677, P62906, P62917, Q07020, P61513, Q02878, P63173, P36578, P05386, P23396

RPS6, RPS19, RPS27, RPL10A, RPL8, RPL18, RPL37A, RPL6, RPL38, RPL4, RPLP1, RPS3

Olopatadine

hsa03013

RNA transport

1.54E-07

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, P23588, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, EIF4B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
P31949	S100A11	Protein S100-A11	O14980	XPO1	Exportin-1	-0.898
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P31949	S100A11	Protein S100-A11	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.837
P31949	S100A11	Protein S100-A11	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.822
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P31949	S100A11	Protein S100-A11	O14893	GEMIN2	Gem-associated protein 2	-0.812
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P31949	S100A11	Protein S100-A11	P61326	MAGOH	Protein mago nashi homolog	-0.866
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P31949	S100A11	Protein S100-A11	Q7Z3B4	NUP54	Nucleoporin p54	-0.889
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P31949	S100A11	Protein S100-A11	P35658	NUP214	Nuclear pore complex protein Nup214	0.916
P31949	S100A11	Protein S100-A11	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	-0.724
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P31949	S100A11	Protein S100-A11	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.959
P31949	S100A11	Protein S100-A11	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.959
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
P31949	S100A11	Protein S100-A11	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.876
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P31949	S100A11	Protein S100-A11	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.861
P31949	S100A11	Protein S100-A11	Q06787	FMR1	Synaptic functional regulator FMR1	-0.765
P31949	S100A11	Protein S100-A11	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.771

Olopatadine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Olopatadine

hsa03040

Spliceosome

7.18E-08

Q14562, O43143, O60508, O14776, P08579, P26368, O75940, P09651, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O43395, O75643

DHX8, DHX15, CDC40, TCERG1, SNRPB2, U2AF2, SMNDC1, HNRNPA1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, PRPF3, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P06702	S100A9	Protein S100-A9	O14776	TCERG1	Transcription elongation regulator 1	-0.791
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P06702	S100A9	Protein S100-A9	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	-0.945
P06702	S100A9	Protein S100-A9	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	-0.762
P06702	S100A9	Protein S100-A9	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	-0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P06702	S100A9	Protein S100-A9	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.783
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P06702	S100A9	Protein S100-A9	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	-0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P06702	S100A9	Protein S100-A9	O43395	PRPF3	U4/U6 small nuclear ribonucleoprotein Prp3	-0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Olopatadine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Olopatadine

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Olopatadine

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Olopatadine

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Olopatadine

hsa04060

Cytokine-cytokine receptor interaction

4.07E-03

P32927, P27930, P01584, P61073, P25024, P25025, Q9UBD3, P47992, P20333, P01375, P09341, Q99731, P18510, Q93038

CSF2RB, IL1R2, IL1B, CXCR4, CXCR1, CXCR2, XCL2, XCL1, TNFRSF1B, TNF, CXCL1, CCL19, IL1RN, TNFRSF25

Olopatadine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

5.42E-04

Q99731, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, P14784, P20333, P01375

CCL19, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL2RB, TNFRSF1B, TNF

Olopatadine

hsa04062

Chemokine signaling pathway

7.92E-05

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P80511	S100A12	Protein S100-A12	P25024	CXCR1	C-X-C chemokine receptor type 1	0.868
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P80511	S100A12	Protein S100-A12	P25025	CXCR2	C-X-C chemokine receptor type 2	0.779
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P80511	S100A12	Protein S100-A12	P07948	LYN	Tyrosine-protein kinase Lyn	0.799
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P80511	S100A12	Protein S100-A12	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.777
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P80511	S100A12	Protein S100-A12	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.789
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P80511	S100A12	Protein S100-A12	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Olopatadine

hsa04064

NF-kappa B signaling pathway

1.09E-03

O00463, P14778, P01584, P01375, P19174, Q04759, Q16548, P06239, P63279, P24522, P09341, P19875, Q99731, Q06643

TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, BCL2A1, LCK, UBE2I, GADD45A, CXCL1, CXCL2, CCL19, LTB

Olopatadine

hsa04070

Phosphatidylinositol signaling system

4.86E-02

P0DP23, P42338, P27987

CALM1, PIK3CB, ITPKB

Olopatadine

hsa04071

Sphingolipid signaling pathway

2.37E-03

P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2

Olopatadine

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Olopatadine

hsa04080

Neuroactive ligand-receptor interaction

8.52E-04

P28472, P21453, Q9H228, P43657, Q01726, P21730, P14416, P07550, P35318

GABRB3, S1PR1, EDG8, P2RY5, MC1R, C5AR1, DRD2, ADRB2, ADM

Olopatadine

hsa04114

Oocyte meiosis

2.67E-02

Q9UJX2, Q14643, P22694, Q16539, Q14683, Q13362, Q16537

CDC23, ITPR1, PRKACB, MAPK14, SMC1A, PPP2R5C, PPP2R5E

Olopatadine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Olopatadine

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Olopatadine

hsa04145

Phagosome

3.11E-02

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa04146

Peroxisome

7.06E-03

Q14032, P00441

BAAT, SOD1

Olopatadine

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Olopatadine

hsa04213

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Olopatadine

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Olopatadine

hsa04218

Cellular senescence

1.60E-02

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Olopatadine

hsa04360

Axon guidance

2.47E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1

Olopatadine

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Olopatadine

hsa04390

Hippo signaling pathway

1.52E-02

P63261, Q13485, O15105, O43623

ACTG1, SMAD4, SMAD7, SNAI2

Olopatadine

hsa04514

Cell adhesion molecules

2.20E-02

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa04520

Adherens junction

3.44E-02

Q13485, O43623, P63261

SMAD4, SNAI2, ACTG1

Olopatadine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Olopatadine

hsa04612

Antigen processing and presentation

1.07E-06

P04233, Q14953, P26715, P26717, Q13241, P01732, P01889, P10321, Q06323, P01375

CD74, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, HLA-B, HLA-C, PSME1, TNF

Olopatadine

hsa04613

Neutrophil extracellular trap formation

3.76E-04

P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539

ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Olopatadine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Olopatadine

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Olopatadine

hsa04650

Natural killer cell mediated cytotoxicity

1.05E-08

P19174, P01375, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25815	S100P	Protein S100-P	P01375	TNF	Tumor necrosis factor	0.896
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25815	S100P	Protein S100-P	P06239	LCK	Tyrosine-protein kinase Lck	-0.729
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25815	S100P	Protein S100-P	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25815	S100P	Protein S100-P	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P60903	S100A10	Protein S100-A10	Q29983	MICA	MHC class I polypeptide-related sequence A	0.757
P60903	S100A10	Protein S100-A10	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.757
P60903	S100A10	Protein S100-A10	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.757
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25815	S100P	Protein S100-P	Q13241	KLRD1	Natural killer cells antigen CD94	-0.876
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25815	S100P	Protein S100-P	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.887
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25815	S100P	Protein S100-P	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.801
P25815	S100P	Protein S100-P	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P25815	S100P	Protein S100-P	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Olopatadine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Olopatadine

hsa04658

Th1 and Th2 cell differentiation

7.59E-06

Q04759, P07766, P20963, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P46531, Q9UM47, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, NOTCH1, NOTCH3, RUNX3

Olopatadine

hsa04659

Th17 cell differentiation

1.32E-05

Q04759, P19174, P06239, P42224, P14784, P14778, P40189, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Olopatadine

hsa04660

T cell receptor signaling pathway

2.44E-04

P01375, Q04759, P42338, O95267, Q08881, P19174, Q9NQU5, P07766, P20963, P01732, Q13191, P06239

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK6, CD3E, CD247, CD8A, CBLB, LCK

Olopatadine

hsa04662

B cell receptor signaling pathway

1.33E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Olopatadine

hsa04664

Fc epsilon RI signaling pathway

2.66E-03

Q16539, P42338, P07948, P19174, P09917

MAPK14, PIK3CB, LYN, PLCG1, ALOX5

Olopatadine

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Olopatadine

hsa04668

TNF signaling pathway

3.38E-03

P01375, O00463, P18848, P09341, P19875, P01584, P20749, P14780, P20333

TNF, TRAF5, ATF4, CXCL1, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B

Olopatadine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Olopatadine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Olopatadine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Olopatadine

hsa04724

Glutamatergic synapse

1.11E-02

P43003, P63218, P50151, P15104

SLC1A3, GNG5, GNG10, GLUL

Olopatadine

hsa04728

Dopaminergic synapse

2.96E-02

P14416, P63218, P50151, P49841, Q16539

DRD2, GNG5, GNG10, GSK3B, MAPK14

Olopatadine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Olopatadine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Olopatadine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Olopatadine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Olopatadine

hsa04914

Progesterone-mediated oocyte maturation

3.92E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Olopatadine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Olopatadine

hsa04924

Renin secretion

2.98E-03

P22694, P07550, Q13370, P0DP23

PRKACB, ADRB2, PDE3B, CALM1

Olopatadine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Olopatadine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Olopatadine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Olopatadine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Olopatadine

hsa04940

Type I diabetes mellitus

5.99E-04

P48023, P01889, P10321, P01375

FASLG, HLA-B, HLA-C, TNF

Olopatadine

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Olopatadine

hsa04964

Proximal tubule bicarbonate reclamation

4.33E-02

P22748, P49448

CA4, GLUD2

Olopatadine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Olopatadine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Olopatadine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Olopatadine

hsa05014

Amyotrophic lateral sclerosis

3.44E-02

P01375, P10415, Q16539, Q16718, O14521, Q9NZJ5, Q13561, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, BCL2, MAPK14, NDUFA5, SDHD, EIF2AK3, DCTN2, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Olopatadine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Olopatadine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Olopatadine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Olopatadine

hsa05034

Alcoholism

2.10E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Olopatadine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

6.67E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Olopatadine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Olopatadine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Olopatadine

hsa05140

Leishmaniasis

1.56E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Olopatadine

hsa05143

African trypanosomiasis

1.78E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Olopatadine

hsa05144

Malaria

1.50E-03

P60033, P01375, P35443, P01584, P26718

CD81, TNF, THBS4, IL1B, KLRK1

Olopatadine

hsa05146

Amoebiasis

5.09E-06

P01584, P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Olopatadine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Olopatadine

hsa05163

Human cytomegalovirus infection

1.60E-02

P63218, P50151, Q14344, P49841, P14778, P25025, Q16539

GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14

Olopatadine

hsa05165

Human papillomavirus infection

5.90E-03

P01889, P10321, O14745

HLA-B, HLA-C, SLC9A3R1

Olopatadine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.22E-03

P01889, P10321, Q29983

HLA-B, HLA-C, MICA

Olopatadine

hsa05168

Herpes simplex virus 1 infection

6.29E-06

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, P04233, Q13489, P01889, P10321, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, CD74, BIRC3, HLA-B, HLA-C, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P60903	S100A10	Protein S100-A10	P04233	CD74	HLA class II histocompatibility antigen gamma chain	0.812
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P60903	S100A10	Protein S100-A10	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.757
P60903	S100A10	Protein S100-A10	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.757
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776

Olopatadine

hsa05169

Epstein-Barr virus infection

2.87E-02

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa05170

Human immunodeficiency virus 1 infection

2.87E-02

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa05171

Coronavirus disease - COVID-19

2.56E-02

P01375, P01584, P23396, P62753, P39019, P42677, P62906, P36578, Q02878, P62917, Q07020, P61513, P63173, P05386, P21730

TNF, IL1B, RPS3, RPS6, RPS19, RPS27, RPL10A, RPL4, RPL6, RPL8, RPL18, RPL37A, RPL38, RPLP1, C5AR1

Olopatadine

hsa05200

Pathways in cancer

1.31E-03

Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Olopatadine

hsa05202

Transcriptional misregulation in cancer

4.61E-03

P01106, P27930, P11215, P35226, O60583, P04141, P59665, P59666, P42773, Q13547, P12980, O75293

MYC, IL1R2, ITGAM, BMI1, CCNT2, CSF2, DEFA1; DEFA1B, DEFA3, CDKN2C, HDAC1, LYL1, GADD45B

Olopatadine

hsa05203

Viral carcinogenesis

2.65E-04

Q13547, P01889, P10321, P58876, Q16778, O60814

HDAC1, HLA-B, HLA-C, H2BC5, HIST2H2BE, H2BC12

Olopatadine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Olopatadine

hsa05206

MicroRNAs in cancer

3.11E-02

P01106, P26358, Q9UM47, P35226, Q96EB6, P19174

MYC, DNMT1, NOTCH3, BMI1, SIRT1, PLCG1

Olopatadine

hsa05212

Pancreatic cancer

2.14E-03

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Olopatadine

hsa05214

Glioma

1.72E-02

P0DP23, P42338, O75293

CALM1, PIK3CB, GADD45B

Olopatadine

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Olopatadine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.27E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Olopatadine

hsa05320

Autoimmune thyroid disease

3.49E-03

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa05321

Inflammatory bowel disease

2.06E-03

P01375, Q14765, Q9UL17, P23771, P01584

TNF, STAT4, TBX21, GATA3, IL1B

Olopatadine

hsa05322

Systemic lupus erythematosus

1.18E-02

P58876, Q16778, O60814

H2BC5, HIST2H2BE, H2BC12

Olopatadine

hsa05330

Allograft rejection

5.99E-04

P01889, P10321, P48023, P01375

HLA-B, HLA-C, FASLG, TNF

Olopatadine

hsa05332

Graft-versus-host disease

3.48E-05

P48023, P01889, P10321, P01375, P26715, Q13241

FASLG, HLA-B, HLA-C, TNF, KLRC1, KLRD1

Olopatadine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.29E-02

P23229, P16144, P60709, P35609

ITGA6, ITGB4, ACTB, ACTN2

Olopatadine

hsa05415

Diabetic cardiomyopathy

4.54E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Olopatadine

hsa05416

Viral myocarditis

5.53E-03

P01889, P10321

HLA-B, HLA-C

Olopatadine

hsa05418

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Community members of Olopatadine (S_DC: 4.48)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

S100A12

Protein S100NoneA12

Reported

0.4767

0.0309

0.3002

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q13822

ENPP2

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Predicted

0.113

0.305

0.0063

0.6729

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P25815

S100P

Protein S100NoneP

Predicted

0.4845

0.0294

0.301

P60903

S100A10

Protein S100NoneA10

Predicted

0.2501

0.0212

0.2333

0.4008

P33764

S100A3

Protein S100NoneA3

Predicted

0.1225

0.0202

0.1016

P31949

S100A11

Protein S100NoneA11

Predicted

0.0873

0.0186

0.0808

P06702

S100A9

Protein S100NoneA9

Predicted

0.0439

0.0256

0.1247

0.1978

P05109

S100A8

Protein S100NoneA8

Predicted

0.2672

0.0233

0.1247

0.305

PharmaCoNets of Olopatadine (SPCN: 77.07 )

Olopatadine regulated-network (SDN: 17.20)

Community members of Olopatadine (SDC: 4.48)

PharmaCoNets of Olopatadine (S_PCN: 77.07 )

Olopatadine regulated-network (S_DN: 17.20)

Community members of Olopatadine (S_DC: 4.48)