PharmaCoNets

PharmaCoNets of Olmesartan (S_PCN: 123.44 )

Olmesartan regulated-network (S_DN: 22.08)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Olmesartan

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Olmesartan

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Olmesartan

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Olmesartan

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Olmesartan

hsa00190

Oxidative phosphorylation

4.36E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Olmesartan

hsa00220

Arginine biosynthesis

6.33E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Olmesartan

hsa00500

Starch and sucrose metabolism

1.27E-08

O43451, P46976, P06737

MGAM, GYG1, PYGL

Olmesartan

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Olmesartan

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Olmesartan

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Olmesartan

hsa00591

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Olmesartan

hsa00730

Thiamine metabolism

5.65E-05

P05186, P24666

ALPL, ACP1

Olmesartan

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Olmesartan

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Olmesartan

hsa00970

Aminoacyl-tRNA biosynthesis

1.69E-07

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Olmesartan

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Olmesartan

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Olmesartan

hsa00983

Drug metabolism - other enzymes

2.22E-03

P04183, P32320, P05164

TK1, CDA, MPO

Olmesartan

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Olmesartan

hsa01230

Biosynthesis of amino acids

3.91E-02

P51854, Q99707, P50213

TKTL1, MTR, IDH3A

Olmesartan

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Olmesartan

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Olmesartan

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Olmesartan

hsa03008

Ribosome biogenesis in eukaryotes

2.60E-03

Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, RPP38, GNL3, NVL, NXF2; NXF2B

Olmesartan

hsa03010

Ribosome

5.85E-04

P62753, P25398, P32969, P46776, P62899, P18077, P61927, P36578

RPS6, RPS12, RPL9, RPL27A, RPL31, RPL35A, RPL37, RPL4

Olmesartan

hsa03013

RNA transport

2.78E-05

O14980, P52298, Q09161, O14893, P61326, Q15287, Q7Z3B4, P35658, P68104, Q14152, O15371, O75822, P78345, P11940, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NUP54, NUP214, EEF1A1, EIF3A, EIF3D, EIF3J, RPP38, PABPC1, EIF4A2, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.729
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P68104	EEF1A1	Elongation factor 1-alpha 1	0.848
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.782
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P11940	PABPC1	Polyadenylate-binding protein 1	0.767
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Olmesartan

hsa03020

RNA polymerase

2.86E-05

P24928, P62487, Q9GZM3, P52435

POLR2A, POLR2G, POLR2J2, POLR2J

Olmesartan

hsa03040

Spliceosome

3.10E-07

Q14562, O43143, O60508, Q99633, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, PRPF18, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P46091	GPR1	Chemerin-like receptor 2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.819
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P46091	GPR1	Chemerin-like receptor 2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P46091	GPR1	Chemerin-like receptor 2	O60508	CDC40	Pre-mRNA-processing factor 17	-0.778
P46091	GPR1	Chemerin-like receptor 2	Q99633	PRPF18	Pre-mRNA-splicing factor 18	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P46091	GPR1	Chemerin-like receptor 2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.753
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P46091	GPR1	Chemerin-like receptor 2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P46091	GPR1	Chemerin-like receptor 2	Q9UMS4	PRPF19	Pre-mRNA-processing factor 19	0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Olmesartan

hsa03050

Proteasome

3.05E-02

P55036

PSMD4

Olmesartan

hsa03060

Protein export

3.28E-02

Q15070, O76094

OXA1L, SRP72

Olmesartan

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Olmesartan

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Olmesartan

hsa04015

Rap1 signaling pathway

9.35E-04

P20827, P49767, P63261, Q96FS4, P11215, P25116, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174

EFNA1, VEGFC, ACTG1, SIPA1, ITGAM, F2R, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1

Olmesartan

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Olmesartan

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Olmesartan

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Olmesartan

hsa04060

Cytokine-cytokine receptor interaction

1.77E-05

P27930, P14778, P08476, P26842, Q9UHF4, Q13651, P16871, Q9HBE5, P25024, Q9UBD3, P47992, P02775, P01375, P09341, P32248, P51684, P18510, P09603, P01730, Q93038

IL1R2, IL1R1, INHBA, CD27, IL20RA, IL10RA, IL7R, IL21R, CXCR1, XCL2, XCL1, PPBP, TNF, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P08311	CTSG	Cathepsin G	P08476	INHBA	Inhibin beta A chain	0.848
P43657	P2RY5	Lysophosphatidic acid receptor 6	P26842	CD27	CD27 antigen	0.706
P32248	CCR7	C-C chemokine receptor type 7	Q9UHF4	IL20RA	Interleukin-20 receptor subunit alpha	0.756
P08311	CTSG	Cathepsin G	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.736
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P32248	CCR7	C-C chemokine receptor type 7	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.743
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P43657	P2RY5	Lysophosphatidic acid receptor 6	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.794
P08311	CTSG	Cathepsin G	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.823
P32248	CCR7	C-C chemokine receptor type 7	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.741
P08311	CTSG	Cathepsin G	P47992	XCL1	Lymphotactin	-0.823
P32248	CCR7	C-C chemokine receptor type 7	P47992	XCL1	Lymphotactin	0.741
P32248	CCR7	C-C chemokine receptor type 7	P02775	PPBP	Platelet basic protein	0.77
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
P32248	CCR7	C-C chemokine receptor type 7	P32248	CCR7	C-C chemokine receptor type 7	1
P32248	CCR7	C-C chemokine receptor type 7	P51684	CCR6	C-C chemokine receptor type 6	0.834
P08311	CTSG	Cathepsin G	P18510	IL1RN	Interleukin-1 receptor antagonist protein	0.73
P43657	P2RY5	Lysophosphatidic acid receptor 6	P18510	IL1RN	Interleukin-1 receptor antagonist protein	-0.787
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P08311	CTSG	Cathepsin G	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	-0.782

Olmesartan

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.45E-06

P51684, P32248, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, Q9UHF4, P01375

CCR6, CCR7, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, IL20RA, TNF

Olmesartan

hsa04062

Chemokine signaling pathway

9.51E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Olmesartan

hsa04064

NF-kappa B signaling pathway

6.15E-06

P10415, P51617, O00463, Q13546, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Olmesartan

hsa04066

HIF-1 signaling pathway

3.40E-02

Q09472, P07195, P10415

EP300, LDHB, BCL2

Olmesartan

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Olmesartan

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Olmesartan

hsa04071

Sphingolipid signaling pathway

1.82E-04

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2

Olmesartan

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Olmesartan

hsa04080

Neuroactive ligand-receptor interaction

1.20E-02

P08311, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318

CTSG, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADM

Olmesartan

hsa04110

Cell cycle

2.06E-02

Q9UJX4, O60566, Q09472, P24522, P04637, P49918

ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1C

Olmesartan

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Olmesartan

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Olmesartan

hsa04141

Protein processing in endoplasmic reticulum

8.43E-03

P18848, Q12933, Q15436, Q99941, P07900

ATF4, TRAF2, SEC23A, CREBL1, HSP90AA1

Olmesartan

hsa04145

Phagosome

1.86E-02

P63261, Q15080, Q13509, P68371, P27824

ACTG1, NCF4, TUBB3, TUBB2C, CANX

Olmesartan

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Olmesartan

hsa04151

PI3K-Akt signaling pathway

3.53E-05

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P62753	RPS6	40S ribosomal protein S6	0.716
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P27348	YWHAQ	14-3-3 protein theta	0.742
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.786
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q16363	LAMA4	Laminin subunit alpha-4	0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P22105	TNXB	Tenascin-X	0.72
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.72
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.773
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Olmesartan

hsa04210

Apoptosis

3.78E-05

P04637, P10415, O76075, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

TP53, BCL2, DFFB, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Olmesartan

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Olmesartan

hsa04217

Necroptosis

2.04E-05

P01375, Q12933, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557, Q9H444

TNF, TRAF2, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D, CHMP4B

Olmesartan

hsa04261

Adrenergic signaling in cardiomyocytes

3.44E-02

Q16537, P0DP23, P17252, P10415, P20020

PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Olmesartan

hsa04270

Vascular smooth muscle contraction

2.89E-02

P35579, P35318

MYH9, ADM

Olmesartan

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Olmesartan

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Olmesartan

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Olmesartan

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Olmesartan

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Olmesartan

hsa04390

Hippo signaling pathway

1.47E-02

P63261, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, LEF1, SNAI2, BIRC3

Olmesartan

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Olmesartan

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Olmesartan

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Olmesartan

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Olmesartan

hsa04540

Gap junction

4.76E-02

P17252, Q13509, P68371

PRKCA, TUBB3, TUBB2C

Olmesartan

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Olmesartan

hsa04612

Antigen processing and presentation

2.05E-05

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P48382	RFX5	DNA-binding protein RFX5	-0.747
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.704
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Olmesartan

hsa04613

Neutrophil extracellular trap formation

8.63E-06

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05164	MPO	Myeloperoxidase	0.717
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.736
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13547	HDAC1	Histone deacetylase 1	-0.759
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43315	AQP9	Aquaporin-9	0.918
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839

Olmesartan

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Olmesartan

hsa04621

NOD-like receptor signaling pathway

3.15E-02

Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838

MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4

Olmesartan

hsa04640

Hematopoietic cell lineage

5.47E-05

P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603

ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1

Olmesartan

hsa04650

Natural killer cell mediated cytotoxicity

9.07E-13

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O75475	PSIP1	PC4 and SFRS1-interacting protein	P78314	SH3BP2	SH3 domain-binding protein 2	-0.731
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.786
O75475	PSIP1	PC4 and SFRS1-interacting protein	O60880	SH2D1A	SH2 domain-containing protein 1A	0.734
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.707
O75475	PSIP1	PC4 and SFRS1-interacting protein	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.734
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.719
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q13241	KLRD1	Natural killer cells antigen CD94	0.772
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.773
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26718	KLRK1	NKG2-D type II integral membrane protein	0.83
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
O75475	PSIP1	PC4 and SFRS1-interacting protein	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.879
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26717	KLRC2	NKG2-C type II integral membrane protein	0.783
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.783
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Olmesartan

hsa04657

IL-17 signaling pathway

2.28E-06

P07900, O00463, Q12933, Q16539, P49841, P09341, P14780, P80188, P01375

HSP90AA1, TRAF5, TRAF2, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Olmesartan

hsa04658

Th1 and Th2 cell differentiation

2.31E-08

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13761	RUNX3	Runt-related transcription factor 3	0.712

Olmesartan

hsa04659

Th17 cell differentiation

6.58E-08

Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758

Olmesartan

hsa04660

T cell receptor signaling pathway

2.06E-07

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Olmesartan

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Olmesartan

hsa04664

Fc epsilon RI signaling pathway

1.48E-03

P42338, Q9UQC2, P07948, P19174, P09917, P20292

PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Olmesartan

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Olmesartan

hsa04668

TNF signaling pathway

1.32E-03

Q12933, Q99941, P18848, P01584, P20333

TRAF2, CREBL1, ATF4, IL1B, TNFRSF1B

Olmesartan

hsa04720

Long-term potentiation

2.27E-05

P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1

Olmesartan

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Olmesartan

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Olmesartan

hsa04724

Glutamatergic synapse

2.72E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Olmesartan

hsa04727

GABAergic synapse

3.89E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Olmesartan

hsa04728

Dopaminergic synapse

3.73E-03

P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407

DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1

Olmesartan

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Olmesartan

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Olmesartan

hsa04911

Insulin secretion

5.41E-03

Q99941, P18848, Q13557

CREBL1, ATF4, CAMK2D

Olmesartan

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Olmesartan

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Olmesartan

hsa04916

Melanogenesis

3.55E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Olmesartan

hsa04918

Thyroid hormone synthesis

1.44E-02

Q99941, P18848, P02768

CREBL1, ATF4, ALB

Olmesartan

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Olmesartan

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Olmesartan

hsa04922

Glucagon signaling pathway

4.18E-02

P14618, P06737

PKM2, PYGL

Olmesartan

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Olmesartan

hsa04925

Aldosterone synthesis and secretion

1.83E-05

Q14643, Q99941, P18848, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ATF4, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Olmesartan

hsa04927

Cortisol synthesis and secretion

4.36E-02

Q99941, P18848

CREBL1, ATF4

Olmesartan

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Olmesartan

hsa04932

Non-alcoholic fatty liver disease

1.38E-04

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1

Olmesartan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.93E-03

P84022, Q13485, P10415, P42338, P49767, P17252, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1

Olmesartan

hsa04934

Cushing syndrome

8.89E-04

Q99941, P18848, O15169, Q13557

CREBL1, ATF4, AXIN1, CAMK2D

Olmesartan

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Olmesartan

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Olmesartan

hsa04964

Proximal tubule bicarbonate reclamation

2.74E-03

P22748, P00918, P49448

CA4, CA2, GLUD2

Olmesartan

hsa04966

Collecting duct acid secretion

2.32E-03

P02730, P00918, Q9Y666

SLC4A1, CA2, SLC12A7

Olmesartan

hsa04970

Salivary secretion

8.71E-04

Q14643, P20020, P23634, P17252, P0DP23

ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1

Olmesartan

hsa04971

Gastric acid secretion

4.76E-02

P17252, P63261, P0DP23

PRKCA, ACTG1, CALM1

Olmesartan

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Olmesartan

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Olmesartan

hsa04976

Bile secretion

2.79E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Olmesartan

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Olmesartan

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Olmesartan

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Olmesartan

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Olmesartan

hsa05016

Huntington disease

1.46E-03

P13073, Q9GZM3, P24928, P62487, P52435, P05141, O75460, P55036

COX4I1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, ERN1, PSMD4

Olmesartan

hsa05022

Pathways of neurodegeneration - multiple diseases

1.98E-02

P13073, O75460, P18848, P05141, P20333, P01584, P0DP24

COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2

Olmesartan

hsa05030

Cocaine addiction

4.36E-02

Q99941, P18848

CREBL1, ATF4

Olmesartan

hsa05031

Amphetamine addiction

2.40E-04

O15399, P0DP23, Q16566, Q13557, Q99941, P18848, P17252

GRIN2D, CALM1, CAMK4, CAMK2D, CREBL1, ATF4, PRKCA

Olmesartan

hsa05034

Alcoholism

3.11E-05

Q96RR4, Q93077, P62807, O60814, P84243, P68431

CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Olmesartan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.22E-06

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Olmesartan

hsa05132

Salmonella infection

2.12E-04

P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Olmesartan

hsa05133

Pertussis

3.10E-03

P0DP23, P23528, P09871, P0C0L4

CALM1, CFL1, C1S, C4A

Olmesartan

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Olmesartan

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Olmesartan

hsa05140

Leishmaniasis

3.53E-06

O75015, P14598, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Olmesartan

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Olmesartan

hsa05144

Malaria

1.65E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Olmesartan

hsa05146

Amoebiasis

1.61E-10

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13751	LAMB3	Laminin subunit beta-3	-0.763
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P09341	CXCL1	Growth-regulated alpha protein	0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.953
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05089	ARG1	Arginase-1	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P43657	P2RY5	Lysophosphatidic acid receptor 6	P05089	ARG1	Arginase-1	-0.793
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.708
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P43657	P2RY5	Lysophosphatidic acid receptor 6	P12814	ACTN1	Alpha-actinin-1	-0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1

Olmesartan

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Olmesartan

hsa05161

Hepatitis B

2.86E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Olmesartan

hsa05163

Human cytomegalovirus infection

2.76E-04

P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
O75475	PSIP1	PC4 and SFRS1-interacting protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
O75475	PSIP1	PC4 and SFRS1-interacting protein	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O75475	PSIP1	PC4 and SFRS1-interacting protein	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.742
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
O75475	PSIP1	PC4 and SFRS1-interacting protein	P14778	IL1R1	Interleukin-1 receptor type 1	-0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
O75475	PSIP1	PC4 and SFRS1-interacting protein	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.903
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
O75475	PSIP1	PC4 and SFRS1-interacting protein	O00463	TRAF5	TNF receptor-associated factor 5	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788

Olmesartan

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Olmesartan

hsa05168

Herpes simplex virus 1 infection

1.94E-02

Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415

PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2

Olmesartan

hsa05169

Epstein-Barr virus infection

2.15E-03

P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693

HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3G

Olmesartan

hsa05170

Human immunodeficiency virus 1 infection

1.24E-04

Q02750, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5, P20333

MAP2K1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2, TNFRSF1B

Olmesartan

hsa05171

Coronavirus disease - COVID-19

1.51E-03

P62753, P25398, P36578, P32969, P46776, P62899, P18077, P61927

RPS6, RPS12, RPL4, RPL9, RPL27A, RPL31, RPL35A, RPL37

Olmesartan

hsa05200

Pathways in cancer

9.22E-05

Q13751, P42338, P08238, P19174, P04637, Q9UJU2, P17252, Q09472, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, Q13077, P49767, P43657, P25116, P63218, P50151, Q14344, O95267, Q7LDG7, P78417, P24522, O75293, P0DP23, P01568, P14784, P16871

LAMB3, PIK3CB, HSP90AB1, PLCG1, TP53, LEF1, PRKCA, EP300, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, TRAF1, VEGFC, P2RY5, F2R, GNG5, GNG10, GNA13, RASGRP1, RASGRP2, GSTO1, GADD45A, GADD45B, CALM1, IFNA21, IL2RB, IL7R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P32248	CCR7	C-C chemokine receptor type 7	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.813
P46091	GPR1	Chemerin-like receptor 2	P17252	PRKCA	Protein kinase C alpha type	0.741
P32248	CCR7	C-C chemokine receptor type 7	Q09472	EP300	Histone acetyltransferase p300	-0.791
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P46091	GPR1	Chemerin-like receptor 2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P46091	GPR1	Chemerin-like receptor 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P46091	GPR1	Chemerin-like receptor 2	P14923	JUP	Junction plakoglobin	0.883
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P46091	GPR1	Chemerin-like receptor 2	P49767	VEGFC	Vascular endothelial growth factor C	0.718
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P46091	GPR1	Chemerin-like receptor 2	P25116	F2R	Proteinase-activated receptor 1	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P32248	CCR7	C-C chemokine receptor type 7	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
P46091	GPR1	Chemerin-like receptor 2	P01568	IFNA21	Interferon alpha-21	0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P32248	CCR7	C-C chemokine receptor type 7	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.743

Olmesartan

hsa05202

Transcriptional misregulation in cancer

4.22E-04

Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P04637, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, TP53, MPO, DEFA4, ELA2, BCL11B, GADD45A

Olmesartan

hsa05203

Viral carcinogenesis

1.62E-04

Q12933, Q99941, P18848, P27348, Q15283, P62807, O60814

TRAF2, CREBL1, ATF4, YWHAQ, RASA2, HIST1H2BC, H2BC12

Olmesartan

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Olmesartan

hsa05210

Colorectal cancer

2.41E-02

P10415, P04637, Q9UJU2, P24522

BCL2, TP53, LEF1, GADD45A

Olmesartan

hsa05212

Pancreatic cancer

9.39E-03

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Olmesartan

hsa05213

Endometrial cancer

1.53E-03

O15169, Q9UJU2, Q02750, P04637, P24522

AXIN1, LEF1, MAP2K1, TP53, GADD45A

Olmesartan

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P04637, P24522

CALM1, CAMK4, PRKCA, TP53, GADD45A

Olmesartan

hsa05215

Prostate cancer

1.94E-02

P10415, Q9UJU2, Q09472, P04637

BCL2, LEF1, EP300, TP53

Olmesartan

hsa05216

Thyroid cancer

2.42E-04

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Olmesartan

hsa05217

Basal cell carcinoma

1.56E-03

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Olmesartan

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Olmesartan

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Olmesartan

hsa05222

Small cell lung cancer

1.94E-02

P10415, Q13077, P04637, P24522

BCL2, TRAF1, TP53, GADD45A

Olmesartan

hsa05224

Breast cancer

5.34E-03

Q9UJU2, P49841, Q92837, P04637, P24522

LEF1, GSK3B, FRAT1, TP53, GADD45A

Olmesartan

hsa05226

Gastric cancer

7.13E-04

Q02750, Q9UJU2, O15169, P04637, P24522, P14923, P10415

MAP2K1, LEF1, AXIN1, TP53, GADD45A, JUP, BCL2

Olmesartan

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Olmesartan

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.56E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Olmesartan

hsa05310

Asthma

3.20E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Olmesartan

hsa05321

Inflammatory bowel disease

1.25E-03

P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Olmesartan

hsa05322

Systemic lupus erythematosus

1.20E-05

P08246, P08311, P09871, P01375, P13765, Q93077, P62807, Q16778, O60814, P68431, P12814

ELA2, CTSG, C1S, TNF, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Olmesartan

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Olmesartan

hsa05332

Graft-versus-host disease

2.41E-03

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Olmesartan

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Olmesartan

hsa05418

Fluid shear stress and atherosclerosis

3.35E-05

Q16539, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P10599	TXN	Thioredoxin	0.777
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14780	MMP9	Matrix metalloproteinase-9	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P01375	TNF	Tumor necrosis factor	0.761
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.953
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
P46091	GPR1	Chemerin-like receptor 2	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.815