PharmaCoNets of Olanzapine (SPCN: 57.35 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Olanzapinehsa00030Pentose phosphate pathway1.13E-044P60891, P51854, P11413, P37837PRPS1, TKTL1, G6PD, TALDO1More
Olanzapinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Olanzapinehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Olanzapinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Olanzapinehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Olanzapinehsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Olanzapinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Olanzapinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Olanzapinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Olanzapinehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Olanzapinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Olanzapinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Olanzapinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Olanzapinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Olanzapinehsa01200Carbon metabolism2.23E-024P51854, P11413, P37837, P60891TKTL1, G6PD, TALDO1, PRPS1More
Olanzapinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Olanzapinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Olanzapinehsa03020RNA polymerase1.81E-021P24928POLR2AMore
Olanzapinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Olanzapinehsa03050Proteasome1.40E-021P55036PSMD4More
Olanzapinehsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Olanzapinehsa04024cAMP signaling pathway4.80E-021Q13153PAK1More
Olanzapinehsa04061Viral protein interaction with cytokine and cytokine receptor2.43E-024P09341, P02775, P47992, Q9UBD3CXCL1, PPBP, XCL1, XCL2More
Olanzapinehsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Olanzapinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Olanzapinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Olanzapinehsa04114Oocyte meiosis1.35E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Olanzapinehsa04120Ubiquitin mediated proteolysis7.08E-046Q14145, Q13042, Q13191, P62837, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, UBE2D2, HERC1, HUWE1More
Olanzapinehsa04145Phagosome2.94E-024P05164, P78380, P35443, P13765MPO, OLR1, THBS4, HLA-DOBMore
Olanzapinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Olanzapinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Olanzapinehsa04370VEGF signaling pathway9.69E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Olanzapinehsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Olanzapinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Olanzapinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Olanzapinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Olanzapinehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Olanzapinehsa04625C-type lectin receptor signaling pathway3.31E-021Q13153PAK1More
Olanzapinehsa04650Natural killer cell mediated cytotoxicity3.97E-058P01375, P20963, Q13153, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, PAK1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Olanzapinehsa04657IL-17 signaling pathway3.33E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Olanzapinehsa04658Th1 and Th2 cell differentiation1.99E-024Q04759, P06239, P23771, P13765PRKCQ, LCK, GATA3, HLA-DOBMore
Olanzapinehsa04659Th17 cell differentiation4.12E-024Q04759, P06239, P13765, P23771PRKCQ, LCK, HLA-DOB, GATA3More
Olanzapinehsa04660T cell receptor signaling pathway3.61E-021Q13153PAK1More
Olanzapinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Olanzapinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Olanzapinehsa04720Long-term potentiation4.54E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Olanzapinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Olanzapinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Olanzapinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Olanzapinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Olanzapinehsa04914Progesterone-mediated oocyte maturation1.88E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Olanzapinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Olanzapinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Olanzapinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Olanzapinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Olanzapinehsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Olanzapinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Olanzapinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Olanzapinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Olanzapinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Olanzapinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Olanzapinehsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
Olanzapinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Olanzapinehsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Olanzapinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.10E-035Q16539, Q13153, P09341, P25024, P25025MAPK14, PAK1, CXCL1, CXCR1, CXCR2More
Olanzapinehsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Olanzapinehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Olanzapinehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Olanzapinehsa05143African trypanosomiasis1.51E-032P01375, P48023TNF, FASLGMore
Olanzapinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Olanzapinehsa05146Amoebiasis3.33E-039P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACBMore
Olanzapinehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Olanzapinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Olanzapinehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Olanzapinehsa05170Human immunodeficiency virus 1 infection3.80E-025Q02750, P62879, P16298, Q05397, Q13315MAP2K1, GNB2, PPP3CB, PTK2, ATMMore
Olanzapinehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Olanzapinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Olanzapinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Olanzapinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Olanzapinehsa05211Renal cell carcinoma2.42E-021Q13153PAK1More
Olanzapinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Olanzapinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Olanzapinehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Olanzapinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Olanzapinehsa05310Asthma2.27E-022P13765, P12724HLA-DOB, RNASE3More
Olanzapinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Olanzapinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Olanzapinehsa05330Allograft rejection1.51E-032P48023, P01375FASLG, TNFMore
Olanzapinehsa05332Graft-versus-host disease6.49E-054P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Olanzapinehsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore
Olanzapinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Olanzapine (SDC: 5.10)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC5010
DRD2P14416Ki2.1
DRD2P14416Ki4
DRD2P14416Ki6.1