PharmaCoNets of Novobiocin (SPCN: 21.83 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Novobiocinhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Novobiocinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Novobiocinhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Novobiocinhsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Novobiocinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Novobiocinhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Novobiocinhsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Novobiocinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Novobiocinhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Novobiocinhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Novobiocinhsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Novobiocinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Novobiocinhsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Novobiocinhsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Novobiocinhsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Novobiocinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Novobiocinhsa04114Oocyte meiosis1.35E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Novobiocinhsa04141Protein processing in endoplasmic reticulum2.17E-039P18848, P30101, O60337, P60604, P11142, P07900, P08238, Q9H173, Q9UNL2ATF4, PDIA3, MARH6, UBE2G2, HSPA8, HSP90AA1, HSP90AB1, SIL1, SSR3More
Novobiocinhsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Novobiocinhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Novobiocinhsa04370VEGF signaling pathway9.69E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Novobiocinhsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Novobiocinhsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Novobiocinhsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Novobiocinhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Novobiocinhsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Novobiocinhsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Novobiocinhsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Novobiocinhsa04720Long-term potentiation4.54E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Novobiocinhsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Novobiocinhsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Novobiocinhsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Novobiocinhsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Novobiocinhsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Novobiocinhsa04914Progesterone-mediated oocyte maturation1.88E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Novobiocinhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Novobiocinhsa05012Parkinson disease2.58E-0311O15239, P13073, P05141, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371NDUFA1, COX4I1, SLC25A5, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Novobiocinhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Novobiocinhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Novobiocinhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Novobiocinhsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Novobiocinhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Novobiocinhsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Novobiocinhsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Novobiocinhsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Novobiocinhsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Novobiocinhsa05134Legionellosis2.12E-035P01584, P25963, P11215, P68104, P11142IL1B, NFKBIA, ITGAM, EEF1A1, HSPA8More
Novobiocinhsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Novobiocinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Novobiocinhsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Novobiocinhsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Novobiocinhsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Novobiocinhsa05170Human immunodeficiency virus 1 infection1.24E-0313Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, Q13315, P19174MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, ATM, PLCG1More
Novobiocinhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Novobiocinhsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Novobiocinhsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Novobiocinhsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Novobiocinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Novobiocinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Novobiocin (SDC: 2.61)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)