PharmaCoNets of Noscapine (SPCN: 32.93 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Noscapinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Noscapinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Noscapinehsa00480Glutathione metabolism3.02E-021P48506GCLCMore
Noscapinehsa00564Glycerophospholipid metabolism2.52E-023P48651, Q9Y6K0, Q86XP1PTDSS1, CEPT1, DGKHMore
Noscapinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Noscapinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Noscapinehsa00600Sphingolipid metabolism4.56E-023Q9BX95, Q06136, P06280SGPP1, FVT1, GLAMore
Noscapinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Noscapinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Noscapinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Noscapinehsa00983Drug metabolism - other enzymes3.10E-022P20839, Q16772IMPDH1, GSTA3More
Noscapinehsa01100Metabolic pathways2.79E-0214Q9Y234, Q16772, Q02153, P20839, O94777, Q9Y6K0, Q86XP1, Q9UHK6, Q86VZ5, P48651, Q969G6, P14927, Q06055, Q9NVH6LIPT1, GSTA3, GUCY1B3, IMPDH1, DPM2, CEPT1, DGKH, AMACR, SGMS1, PTDSS1, RFK, UQCRB, ATP5G2, TMLHEMore
Noscapinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Noscapinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Noscapinehsa02010ABC transporters2.43E-033P45844, P08183, Q99758ABCG1, ABCB1, ABCA3More
Noscapinehsa03013RNA transport1.91E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Noscapinehsa03018RNA degradation3.02E-021Q13901C1DMore
Noscapinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Noscapinehsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Noscapinehsa04064NF-kappa B signaling pathway2.83E-028P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45AMore
Noscapinehsa04071Sphingolipid signaling pathway2.76E-059P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2, GAB2More
Noscapinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Noscapinehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Noscapinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Noscapinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Noscapinehsa04216Ferroptosis4.50E-021P48506GCLCMore
Noscapinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Noscapinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Noscapinehsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Noscapinehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Noscapinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Noscapinehsa04520Adherens junction4.91E-022P07947, P19784YES1, CSNK2A2More
Noscapinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Noscapinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Noscapinehsa04613Neutrophil extracellular trap formation8.84E-0517O60603, P05164, P08246, Q9UM07, Q92769, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Noscapinehsa04622RIG-I-like receptor signaling pathway1.63E-022Q12933, P10145TRAF2, IL8More
Noscapinehsa04650Natural killer cell mediated cytotoxicity3.52E-0510P16298, P50591, P01375, P20963, Q02750, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Noscapinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Noscapinehsa04668TNF signaling pathway5.53E-039P01375, O00463, Q13546, Q13489, Q16539, P18848, P19875, Q13077, P14780TNF, TRAF5, RIPK1, BIRC3, MAPK14, ATF4, CXCL2, TRAF1, MMP9More
Noscapinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Noscapinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Noscapinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Noscapinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Noscapinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Noscapinehsa04924Renin secretion3.43E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Noscapinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Noscapinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Noscapinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Noscapinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Noscapinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Noscapinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Noscapinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Noscapinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Noscapinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Noscapinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Noscapinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Noscapinehsa05144Malaria1.25E-047P68871, O60603, P01375, P05107, P35443, P10145, P26718HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Noscapinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Noscapinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Noscapinehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Noscapinehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Noscapinehsa05202Transcriptional misregulation in cancer1.61E-0313Q15532, P41732, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q92769, P24522SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC2, GADD45AMore
Noscapinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Noscapinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Noscapinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Noscapinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Noscapinehsa05217Basal cell carcinoma2.01E-024Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore
Noscapinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Noscapinehsa05321Inflammatory bowel disease3.02E-034O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Noscapinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Noscapinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Noscapinehsa05332Graft-versus-host disease5.46E-055P48023, P10747, P01375, P26715, Q13241FASLG, CD28, TNF, KLRC1, KLRD1More
Noscapinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Noscapine (SDC: 3.69)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2Predicted10.06950.040200.1151
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P26012ITGB8Integrin betaNone8Predicted00.12270.02490.5130.6241
P09958FURINFurinPredicted10.15690.07500.2286
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)