PharmaCoNets of Norgestimate (SPCN: 10.28 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Norgestimatehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Norgestimatehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Norgestimatehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Norgestimatehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Norgestimatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Norgestimatehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Norgestimatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Norgestimatehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Norgestimatehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Norgestimatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Norgestimatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Norgestimatehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Norgestimatehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Norgestimatehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Norgestimatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Norgestimatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Norgestimatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Norgestimatehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Norgestimatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Norgestimatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Norgestimatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Norgestimatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Norgestimatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Norgestimatehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Norgestimatehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Norgestimatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Norgestimatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Norgestimatehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore

Community members of Norgestimate (SDC: 3.26)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)