PharmaCoNets of Norelgestromin (SPCN: 36.50 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Norelgestrominhsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Norelgestrominhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Norelgestrominhsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Norelgestrominhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Norelgestrominhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Norelgestrominhsa01200Carbon metabolism2.91E-021P11413G6PDMore
Norelgestrominhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Norelgestrominhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Norelgestrominhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Norelgestrominhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Norelgestrominhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Norelgestrominhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Norelgestrominhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Norelgestrominhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Norelgestrominhsa04141Protein processing in endoplasmic reticulum3.07E-037P18848, P07384, O95487, O60337, P11142, P07900, O95816ATF4, CAPN1, SEC24B, MARH6, HSPA8, HSP90AA1, BAG2More
Norelgestrominhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Norelgestrominhsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Norelgestrominhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Norelgestrominhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Norelgestrominhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Norelgestrominhsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Norelgestrominhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Norelgestrominhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Norelgestrominhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Norelgestrominhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Norelgestrominhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Norelgestrominhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Norelgestrominhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Norelgestrominhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Norelgestrominhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Norelgestrominhsa04932Non-alcoholic fatty liver disease6.43E-047P01375, P49841, P18848, P48023, P01584, P13073, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1More
Norelgestrominhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Norelgestrominhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Norelgestrominhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Norelgestrominhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Norelgestrominhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Norelgestrominhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Norelgestrominhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Norelgestrominhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Norelgestrominhsa05133Pertussis4.20E-021P0C0L4C4AMore
Norelgestrominhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Norelgestrominhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Norelgestrominhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Norelgestrominhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Norelgestrominhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Norelgestrominhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Norelgestrominhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Norelgestrominhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Norelgestrominhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Norelgestrominhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Norelgestrominhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Norelgestrominhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Norelgestrominhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Norelgestrominhsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Norelgestrominhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Norelgestrominhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Norelgestrominhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Norelgestrominhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Norelgestrominhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Norelgestrominhsa05415Diabetic cardiomyopathy7.11E-035P05141, O15239, P13073, Q13557, P11413SLC25A5, NDUFA1, COX4I1, CAMK2D, G6PDMore

Community members of Norelgestromin (SDC: 4.73)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02768ALBAlbuminReported10.28480.91110.08572.0502
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)