PharmaCoNets

PharmaCoNets of Nomifensine (S_PCN: 129.16 )

Nomifensine regulated-network (S_DN: 18.32)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nomifensine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Nomifensine

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Nomifensine

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Nomifensine

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Nomifensine

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Nomifensine

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Nomifensine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Nomifensine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Nomifensine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Nomifensine

hsa00630

Glyoxylate and dicarboxylate metabolism

9.21E-03

P40925, P15104

MDH1, GLUL

Nomifensine

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Nomifensine

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Nomifensine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Nomifensine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Nomifensine

hsa00830

Retinol metabolism

2.17E-03

P00325, P00352, Q9BPW9, O75911

ADH1B, ALDH1A1, DHRS9, DHRS3

Nomifensine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Nomifensine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Nomifensine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Nomifensine

hsa00983

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Nomifensine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Nomifensine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Nomifensine

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Nomifensine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Nomifensine

hsa03010

Ribosome

2.25E-04

P40429, Q07020, P27635, P05386, P62249

RPL13A, RPL18, RPL10, RPLP1, RPS16

Nomifensine

hsa03020

RNA polymerase

1.66E-04

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Nomifensine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Nomifensine

hsa03040

Spliceosome

1.08E-02

Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8

Nomifensine

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Nomifensine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Nomifensine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Nomifensine

hsa04014

Ras signaling pathway

8.66E-03

Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Nomifensine

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Nomifensine

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Nomifensine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Nomifensine

hsa04062

Chemokine signaling pathway

4.01E-05

P25024, P09341, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCL1, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Nomifensine

hsa04064

NF-kappa B signaling pathway

3.33E-06

P10415, O00463, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Nomifensine

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Nomifensine

hsa04071

Sphingolipid signaling pathway

2.28E-04

P17252, P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2

Nomifensine

hsa04080

Neuroactive ligand-receptor interaction

3.22E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1

Nomifensine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Nomifensine

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Nomifensine

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Nomifensine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Nomifensine

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Nomifensine

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Nomifensine

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Nomifensine

hsa04145

Phagosome

4.10E-04

O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Nomifensine

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Nomifensine

hsa04151

PI3K-Akt signaling pathway

7.39E-03

P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8

RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1

Nomifensine

hsa04210

Apoptosis

2.40E-03

Q13315, P10415, O76075, O75460, P24522, Q16548, O43521, P43234, P18848, Q14643

ATM, BCL2, DFFB, ERN1, GADD45A, BCL2A1, BCL2L11, CTSO, ATF4, ITPR1

Nomifensine

hsa04213

Longevity regulating pathway - multiple species

3.14E-03

Q9Y4H2, Q08828, P51828, P0DMV8, Q13547

IRS2, ADCY1, ADCY7, HSPA1A, HDAC1

Nomifensine

hsa04217

Necroptosis

4.76E-06

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPID

Nomifensine

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Nomifensine

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Nomifensine

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Nomifensine

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Nomifensine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Nomifensine

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Nomifensine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Nomifensine

hsa04612

Antigen processing and presentation

9.19E-05

P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.738
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.741
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Nomifensine

hsa04613

Neutrophil extracellular trap formation

5.52E-07

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.825
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43315	AQP9	Aquaporin-9	0.915
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833

Nomifensine

hsa04623

Cytosolic DNA-sensing pathway

3.84E-05

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Nomifensine

hsa04625

C-type lectin receptor signaling pathway

4.80E-02

Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539

CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14

Nomifensine

hsa04640

Hematopoietic cell lineage

5.25E-06

P13612, P21926, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, CD9, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P15144	ANPEP	Aminopeptidase N	0.879
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P11836	MS4A1	B-lymphocyte antigen CD20	-0.705
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Nomifensine

hsa04650

Natural killer cell mediated cytotoxicity

1.29E-05

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P78314	SH3BP2	SH3 domain-binding protein 2	0.809
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.879
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838

Nomifensine

hsa04657

IL-17 signaling pathway

3.57E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Nomifensine

hsa04658

Th1 and Th2 cell differentiation

4.22E-08

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.768
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Nomifensine

hsa04659

Th17 cell differentiation

1.43E-07

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77

Nomifensine

hsa04660

T cell receptor signaling pathway

3.33E-05

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Nomifensine

hsa04664

Fc epsilon RI signaling pathway

6.97E-03

P04141, P07948, P19174, P09917

CSF2, LYN, PLCG1, ALOX5

Nomifensine

hsa04668

TNF signaling pathway

2.91E-02

P18848, P01584, P20333

ATF4, IL1B, TNFRSF1B

Nomifensine

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Nomifensine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Nomifensine

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Nomifensine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Nomifensine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Nomifensine

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Nomifensine

hsa04724

Glutamatergic synapse

1.57E-02

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Nomifensine

hsa04725

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Nomifensine

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Nomifensine

hsa04727

GABAergic synapse

4.18E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Nomifensine

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Nomifensine

hsa04744

Phototransduction

9.21E-03

P62873, P0DP23

GNB1, CALM1

Nomifensine

hsa04750

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Nomifensine

hsa04912

GnRH signaling pathway

4.49E-04

P17252, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB

Nomifensine

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Nomifensine

hsa04915

Estrogen signaling pathway

2.77E-03

P14780, P22694, P18848, Q08828, P51828, P0DMV8, Q14643, P0DP23, Q15788, P10415

MMP9, PRKACB, ATF4, ADCY1, ADCY7, HSPA1A, ITPR1, CALM1, NCOA1, BCL2

Nomifensine

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Nomifensine

hsa04920

Adipocytokine signaling pathway

4.72E-02

P33121, Q04759, Q9Y4H2, P01375

ACSL1, PRKCQ, IRS2, TNF

Nomifensine

hsa04927

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Nomifensine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.11E-03

Q14643, P22694, P23771, P17252, P18848, P10415

ITPR1, PRKACB, GATA3, PRKCA, ATF4, BCL2

Nomifensine

hsa04932

Non-alcoholic fatty liver disease

6.81E-07

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Nomifensine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Nomifensine

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Nomifensine

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Nomifensine

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Nomifensine

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Nomifensine

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Nomifensine

hsa05012

Parkinson disease

3.44E-03

P13073, P05141, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371

COX4I1, SLC25A5, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2C

Nomifensine

hsa05016

Huntington disease

3.74E-03

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Nomifensine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Nomifensine

hsa05022

Pathways of neurodegeneration - multiple diseases

6.94E-04

P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24

GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2

Nomifensine

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Nomifensine

hsa05034

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Nomifensine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

6.88E-04

Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN

Nomifensine

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Nomifensine

hsa05132

Salmonella infection

2.75E-02

P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41

Nomifensine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Nomifensine

hsa05134

Legionellosis

2.84E-03

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8

Nomifensine

hsa05140

Leishmaniasis

8.06E-06

P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764

Nomifensine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Nomifensine

hsa05144

Malaria

1.54E-02

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Nomifensine

hsa05146

Amoebiasis

3.53E-05

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Nomifensine

hsa05150

Staphylococcus aureus infection

1.91E-02

Q14532, P59665, P59666, P49913

KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Nomifensine

hsa05152

Tuberculosis

1.26E-02

Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14

Nomifensine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Nomifensine

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Nomifensine

hsa05163

Human cytomegalovirus infection

4.22E-05

P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568

NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Nomifensine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.88E-06

P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBB

Nomifensine

hsa05168

Herpes simplex virus 1 infection

8.37E-05

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Nomifensine

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Nomifensine

hsa05170

Human immunodeficiency virus 1 infection

2.41E-04

Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P20333

MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, TNFRSF1B

Nomifensine

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Nomifensine

hsa05200

Pathways in cancer

1.99E-03

P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Nomifensine

hsa05202

Transcriptional misregulation in cancer

2.35E-07

Q12778, Q15532, Q13315, P41732, P14780, P27930, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41732	TSPAN7	Tetraspanin-7	0.703
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.913
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.712
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12838	DEFA4	Neutrophil defensin 4	0.767
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.765
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41182	BCL6	B-cell lymphoma 6 protein	0.9
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12980	LYL1	Protein lyl-1	0.782
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.801

Nomifensine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Nomifensine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Nomifensine

hsa05212

Pancreatic cancer

4.75E-02

P42224, P84022, O75293

STAT1, SMAD3, GADD45B

Nomifensine

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Nomifensine

hsa05214

Glioma

4.75E-02

P0DP23, P19174, O75293

CALM1, PLCG1, GADD45B

Nomifensine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Nomifensine

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Nomifensine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Nomifensine

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Nomifensine

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Nomifensine

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Nomifensine

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Nomifensine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.17E-05

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4

Nomifensine

hsa05321

Inflammatory bowel disease

1.56E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Nomifensine

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Nomifensine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Nomifensine

hsa05332

Graft-versus-host disease

2.78E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Nomifensine

hsa05340

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Nomifensine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Nomifensine

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Nomifensine

hsa05415

Diabetic cardiomyopathy

4.54E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Nomifensine

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Nomifensine (S_DC: 7.05)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

MPO

Myeloperoxidase

Reported

0.2035

0.5368

0.5502

1.7255

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Reported

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P21730

C5AR1

C5a anaphylatoxin chemotactic receptor 1

Predicted

0.0258

0.2167

0.5396

0.986

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

PharmaCoNets of Nomifensine (SPCN: 129.16 )

Nomifensine regulated-network (SDN: 18.32)

Community members of Nomifensine (SDC: 7.05)

PharmaCoNets of Nomifensine (S_PCN: 129.16 )

Nomifensine regulated-network (S_DN: 18.32)

Community members of Nomifensine (S_DC: 7.05)