PharmaCoNets of Nisoldipine (SPCN: 16.02 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nisoldipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Nisoldipinehsa00500Starch and sucrose metabolism2.55E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nisoldipinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Nisoldipinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Nisoldipinehsa00730Thiamine metabolism8.06E-042P05186, P24666ALPL, ACP1More
Nisoldipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Nisoldipinehsa04064NF-kappa B signaling pathway1.86E-0313P10415, Q13489, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Nisoldipinehsa04071Sphingolipid signaling pathway1.63E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Nisoldipinehsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Nisoldipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Nisoldipinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Nisoldipinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Nisoldipinehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Nisoldipinehsa04340Hedgehog signaling pathway1.76E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Nisoldipinehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Nisoldipinehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Nisoldipinehsa04613Neutrophil extracellular trap formation1.37E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Nisoldipinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Nisoldipinehsa04621NOD-like receptor signaling pathway7.00E-0313Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, DEFA4More
Nisoldipinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Nisoldipinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Nisoldipinehsa04657IL-17 signaling pathway2.01E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Nisoldipinehsa04658Th1 and Th2 cell differentiation3.21E-039Q04759, P20963, P09693, Q16539, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Nisoldipinehsa04659Th17 cell differentiation5.05E-0311P25963, Q04759, Q16539, P42226, P13765, Q9UL17, P23771, P84022, Q13485, P09693, P20963NFKBIA, PRKCQ, MAPK14, STAT6, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247More
Nisoldipinehsa04660T cell receptor signaling pathway1.07E-029P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Nisoldipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Nisoldipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Nisoldipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nisoldipinehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nisoldipinehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Nisoldipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Nisoldipinehsa05132Salmonella infection5.76E-047P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2CMore
Nisoldipinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Nisoldipinehsa05150Staphylococcus aureus infection8.05E-038P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P12838C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, DEFA4More
Nisoldipinehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Nisoldipinehsa05169Epstein-Barr virus infection4.32E-0211P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Nisoldipinehsa05202Transcriptional misregulation in cancer8.07E-0414Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Nisoldipinehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nisoldipinehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Nisoldipinehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Nisoldipinehsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Nisoldipinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Nisoldipinehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Nisoldipinehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Nisoldipinehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nisoldipinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Nisoldipinehsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More

Community members of Nisoldipine (SDC: 2.87)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Predicted00.10260.15390.32910.6881
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)