PharmaCoNets of Niraparib (SPCN: 278.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Niraparibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Niraparibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Niraparibhsa00030Pentose phosphate pathway7.01E-114P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Niraparibhsa00040Pentose and glucuronate interconversions1.95E-032P15121, O60701AKR1B1, UGDHMore
Niraparibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Niraparibhsa00052Galactose metabolism7.45E-086P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Niraparibhsa00071Fatty acid degradation2.23E-035P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Niraparibhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Niraparibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Niraparibhsa00190Oxidative phosphorylation2.57E-074Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Niraparibhsa00220Arginine biosynthesis1.55E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Niraparibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Niraparibhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Niraparibhsa00270Cysteine and methionine metabolism7.38E-042Q96RQ9, P40926IL4I1, MDH2More
Niraparibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Niraparibhsa00310Lysine degradation1.59E-077Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Niraparibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Niraparibhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Niraparibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Niraparibhsa00380Tryptophan metabolism1.07E-033Q16613, P46952, P51648AANAT, HAAO, ALDH3A2More
Niraparibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Niraparibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Niraparibhsa00500Starch and sucrose metabolism3.96E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Niraparibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Niraparibhsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Niraparibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Niraparibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Niraparibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Niraparibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Niraparibhsa00562Inositol phosphate metabolism1.79E-068Q9NRR6, P27987, Q13572, Q96PE3, O14732, P19174, P42338, Q02252INPP5E, ITPKB, ITPK1, INPP4A, IMPA2, PLCG1, PIK3CB, ALDH6A1More
Niraparibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Niraparibhsa00564Glycerophospholipid metabolism3.90E-068P48651, Q9Y6K0, P35790, Q9Y259, P23743, P49619, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, CHKB, DGKA, DGKG, PLPP1, ADPRMMore
Niraparibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Niraparibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Niraparibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Niraparibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Niraparibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Niraparibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Niraparibhsa00630Glyoxylate and dicarboxylate metabolism6.56E-124P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Niraparibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Niraparibhsa00670One carbon pool by folate1.09E-063O95954, P04818, Q99707FTCD, TYMS, MTRMore
Niraparibhsa00730Thiamine metabolism7.00E-072P05186, P24666ALPL, ACP1More
Niraparibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Niraparibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Niraparibhsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Niraparibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Niraparibhsa00790Folate biosynthesis4.23E-044Q92820, P05186, P15121, P42330GGH, ALPL, AKR1B1, AKR1C3More
Niraparibhsa00830Retinol metabolism1.35E-066P00325, P11766, P00352, Q9BPW9, O75911, P11712ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3, CYP2C9More
Niraparibhsa00860Porphyrin and chlorophyll metabolism5.06E-063P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Niraparibhsa00900Terpenoid backbone biosynthesis9.84E-043Q01581, P49354, Q9UHG3HMGCS1, FNTA, PCYOX1More
Niraparibhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Niraparibhsa00970Aminoacyl-tRNA biosynthesis1.54E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Niraparibhsa00980Metabolism of xenobiotics by cytochrome P4506.26E-054P78417, P28332, P09211, P11712GSTO1, ADH6, GSTP1, CYP2C9More
Niraparibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Niraparibhsa00983Drug metabolism - other enzymes8.96E-105P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Niraparibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Niraparibhsa01100Metabolic pathways8.37E-0876Q9NR34, Q9Y234, P35790, Q9Y259, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q13956, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, P49619, Q86XP1, O95861, Q96RQ9, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UBX8, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, CHKB, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, PDE6H, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKG, DGKH, BPNT1, IL4I1, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, B4GALT6, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Niraparibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Niraparibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Niraparibhsa01230Biosynthesis of amino acids1.96E-056P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Niraparibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Niraparibhsa01521EGFR tyrosine kinase inhibitor resistance3.45E-044P49841, P04049, P08069, Q9NRA1GSK3B, RAF1, IGF1R, PDGFCMore
Niraparibhsa01522Endocrine resistance2.71E-069P22694, P04049, Q9UM47, P04637, P42773, P46527, P08069, P10415, Q13323PRKACB, RAF1, NOTCH3, TP53, CDKN2C, CDKN1B, IGF1R, BCL2, BIKMore
Niraparibhsa01523Antifolate resistance2.16E-054P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Niraparibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Niraparibhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Niraparibhsa03008Ribosome biogenesis in eukaryotes6.93E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Niraparibhsa03010Ribosome5.14E-1924P26373, P62753, P42677, P25398, P32969, P40429, P62906, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P62249, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL13A, RPL10A, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS16, RPS3More
Niraparibhsa03013RNA transport3.63E-2932P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9GZY0, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114, Q53GS7RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NXF2; NXF2B, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1, GLE1More
Niraparibhsa03015mRNA surveillance pathway1.75E-038Q9BZI7, O43148, Q16537, O94913, P61326, Q9GZY0, P52298, Q53GS7UPF3B, RNMT, PPP2R5E, PCF11, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Niraparibhsa03020RNA polymerase6.43E-126P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Niraparibhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Niraparibhsa03040Spliceosome1.18E-1418Q14562, O43143, O60508, P17844, P08579, P26368, O75940, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, SMNDC1, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Niraparibhsa03050Proteasome1.53E-031P55036PSMD4More
Niraparibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Niraparibhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Niraparibhsa03410Base excision repair7.59E-031P27695APEX1More
Niraparibhsa03430Mismatch repair4.38E-021P20585MSH3More
Niraparibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Niraparibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Niraparibhsa04010MAPK signaling pathway4.32E-048P04049, Q15283, P21860, P08069, Q9H2K8, Q12933, P01584, O14944RAF1, RASA2, ERBB3, IGF1R, TAOK3, TRAF2, IL1B, EREGMore
Niraparibhsa04012ErbB signaling pathway3.62E-068Q13153, P16333, Q13191, P17252, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PRKCA, PLCG1, PIK3CB, MYC, RAF1More
Niraparibhsa04014Ras signaling pathway1.48E-0716P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Niraparibhsa04015Rap1 signaling pathway1.22E-0615P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Niraparibhsa04020Calcium signaling pathway6.89E-1018P27987, Q96DU7, Q08828, P21796, P45880, Q16566, Q13557, P17252, P21860, P30679, O15399, P19174, P0DP23, P0DP24, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Niraparibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Niraparibhsa04024cAMP signaling pathway4.19E-0511Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, O15399, P25963, Q13009, Q13153ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, GRIN2D, NFKBIA, TIAM1, PAK1More
Niraparibhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Niraparibhsa04061Viral protein interaction with cytokine and cytokine receptor1.92E-0510Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Niraparibhsa04062Chemokine signaling pathway6.19E-1123P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5More
Niraparibhsa04064NF-kappa B signaling pathway4.17E-1925P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Niraparibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Niraparibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Niraparibhsa04070Phosphatidylinositol signaling system1.02E-0813P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Niraparibhsa04071Sphingolipid signaling pathway1.66E-0915P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2, TRAF2, PRKCEMore
Niraparibhsa04072Phospholipase D signaling pathway1.18E-0513P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Niraparibhsa04080Neuroactive ligand-receptor interaction1.36E-0715P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, Q01726, P41968, P21462, P21730, Q16581, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1, HTR1F, ADRB2, ADMMore
Niraparibhsa04110Cell cycle1.44E-0913Q9UBD5, P30260, P06493, O60566, Q14683, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Niraparibhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Niraparibhsa04115p53 signaling pathway3.63E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Niraparibhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Niraparibhsa04136Autophagy - other4.46E-052O94817, Q9H1Y0ATG12, ATG5More
Niraparibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Niraparibhsa04140Autophagy - animal5.46E-0615P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Niraparibhsa04141Protein processing in endoplasmic reticulum1.91E-0815P18848, Q12933, P30101, Q15437, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3More
Niraparibhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Niraparibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Niraparibhsa04145Phagosome2.28E-1014O75015, P11215, P63261, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, ITGAM, ACTG1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Niraparibhsa04146Peroxisome1.95E-036O00623, O96011, P56589, Q9UKG9, O75521, P33121PEX12, PEX11B, PEX3, CROT, ECI2, ACSL1More
Niraparibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Niraparibhsa04151PI3K-Akt signaling pathway1.92E-1139P62753, P42338, P21860, P43657, P25116, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, P14625, Q8WYR1, P62873, P63218, P50151, P61952, P16144, O15335, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P30281, P56279RPS6, PIK3CB, ERBB3, P2RY5, F2R, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, HSP90B1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGB4, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, CCND3, TCL1AMore
Niraparibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Niraparibhsa04210Apoptosis6.69E-0514Q13315, P10415, O76075, Q14790, P01375, P48023, Q9NR28, P24522, Q16548, P43234, P18848, Q14643, P42575, P04049ATM, BCL2, DFFB, CASP8, TNF, FASLG, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, CASP2, RAF1More
Niraparibhsa04211Longevity regulating pathway2.10E-057P31751, P08069, Q08828, P51828, Q99941, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2More
Niraparibhsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Niraparibhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Niraparibhsa04217Necroptosis2.80E-1425P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Niraparibhsa04218Cellular senescence3.45E-0511P01106, P31751, P04049, P30281, O75293, P30304, P06493, P0DP23, P01889, P10321, P12236MYC, AKT2, RAF1, CCND3, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-C, SLC25A6More
Niraparibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Niraparibhsa04261Adrenergic signaling in cardiomyocytes3.91E-1015P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Niraparibhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Niraparibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Niraparibhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Niraparibhsa04340Hedgehog signaling pathway9.25E-075P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Niraparibhsa04360Axon guidance2.10E-0614P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P07332, P23528, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, FES, CFL1, RAF1, PLCG1, ABLIM1, MYL9More
Niraparibhsa04370VEGF signaling pathway3.88E-148P19174, P16298, P31751, P42338, P17252, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1More
Niraparibhsa04371Apelin signaling pathway3.11E-0918P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P62753, Q16566, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CAMK4, CALM1, CALM2More
Niraparibhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Niraparibhsa04390Hippo signaling pathway2.24E-067O95835, P84022, Q13485, P04628, Q9UJU2, O43623, Q13489LATS1, SMAD3, SMAD4, WNT1, LEF1, SNAI2, BIRC3More
Niraparibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Niraparibhsa04510Focal adhesion1.16E-0413P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, P51636, Q13489, P30281, P04049, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, CAV2, BIRC3, CCND3, RAF1, IGF1R, VEGFCMore
Niraparibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Niraparibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Niraparibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Niraparibhsa04540Gap junction3.26E-088P17252, P22694, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Niraparibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Niraparibhsa04610Complement and coagulation cascades1.45E-084P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Niraparibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Niraparibhsa04612Antigen processing and presentation1.58E-1012P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Niraparibhsa04613Neutrophil extracellular trap formation1.83E-1033P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q99878, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P63261, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, ACTG1, GP1BA, AQP9, MAPK14More
Niraparibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Niraparibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Niraparibhsa04621NOD-like receptor signaling pathway2.09E-0621P01584, P07900, Q16539, Q14643, P23458, P45880, P25963, P10599, Q9H1Y0, P43490, O00463, Q14790, P10415, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, VDAC2, NFKBIA, TXN, ATG5, PBEF1, TRAF5, CASP8, BCL2, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Niraparibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Niraparibhsa04623Cytosolic DNA-sensing pathway3.41E-126P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Niraparibhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Niraparibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Niraparibhsa04640Hematopoietic cell lineage2.74E-1220P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Niraparibhsa04650Natural killer cell mediated cytotoxicity2.32E-2019P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Niraparibhsa04657IL-17 signaling pathway7.03E-1014P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9, IL1BMore
Niraparibhsa04658Th1 and Th2 cell differentiation1.56E-3318P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Niraparibhsa04659Th17 cell differentiation5.52E-2822P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Niraparibhsa04660T cell receptor signaling pathway3.59E-2419P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Niraparibhsa04662B cell receptor signaling pathway4.10E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Niraparibhsa04664Fc epsilon RI signaling pathway4.19E-1011P01375, P31751, P04141, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5More
Niraparibhsa04666Fc gamma R-mediated phagocytosis7.21E-0510P08637, O75015, P42338, P19174, P04049, P23528, P49006, P06396, P14598, P17252FCGR3A, FCGR3B, PIK3CB, PLCG1, RAF1, CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Niraparibhsa04668TNF signaling pathway1.83E-0611P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Niraparibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Niraparibhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Niraparibhsa04713Circadian entrainment8.24E-1113O15399, P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828, P51828GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1, ADCY7More
Niraparibhsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Niraparibhsa04720Long-term potentiation9.48E-1112P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Niraparibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Niraparibhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Niraparibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Niraparibhsa04724Glutamatergic synapse3.85E-099O15399, Q08828, P17252, P62873, P63218, P50151, P61952, P15104, Q9NSB8GRIN2D, ADCY1, PRKCA, GNB1, GNG5, GNG10, GNG11, GLUL, HOMER2More
Niraparibhsa04725Cholinergic synapse9.93E-1114Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Niraparibhsa04726Serotonergic synapse4.22E-047P17252, P62873, P63218, P50151, P33260, P09917, P04049PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5, RAF1More
Niraparibhsa04727GABAergic synapse7.47E-1110Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1, PRKCAMore
Niraparibhsa04728Dopaminergic synapse2.02E-1018Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Niraparibhsa04730Long-term depression4.07E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Niraparibhsa04740Olfactory transduction5.99E-065P62873, Q9H255, Q13557, P0DP23, P0DP24GNB1, OR51E2, CAMK2D, CALM1, CALM2More
Niraparibhsa04742Taste transduction2.43E-052P30939, P17612HTR1F, PRKACAMore
Niraparibhsa04744Phototransduction4.87E-123P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Niraparibhsa04750Inflammatory mediator regulation of TRP channels2.04E-1214P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Niraparibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Niraparibhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Niraparibhsa04911Insulin secretion1.77E-105Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Niraparibhsa04912GnRH signaling pathway5.74E-0813P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Niraparibhsa04913Ovarian steroidogenesis6.44E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Niraparibhsa04914Progesterone-mediated oocyte maturation2.08E-0911P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Niraparibhsa04915Estrogen signaling pathway5.83E-1216P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, P0DP24, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, CALM2, NCOA1, BCL2More
Niraparibhsa04916Melanogenesis4.08E-056P0DP23, Q08828, P51828, P49841, Q01726, P04049CALM1, ADCY1, ADCY7, GSK3B, MC1R, RAF1More
Niraparibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Niraparibhsa04918Thyroid hormone synthesis1.53E-079P22694, Q08828, P51828, Q99941, P18848, Q14643, P14625, P02768, P05543PRKACB, ADCY1, ADCY7, CREBL1, ATF4, ITPR1, HSP90B1, ALB, SERPINA7More
Niraparibhsa04919Thyroid hormone signaling pathway3.02E-0611P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, Q9UM47, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, NOTCH3, MYCMore
Niraparibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Niraparibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Niraparibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Niraparibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Niraparibhsa04924Renin secretion9.46E-095P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Niraparibhsa04925Aldosterone synthesis and secretion1.65E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Niraparibhsa04926Relaxin signaling pathway1.30E-0916P31751, P25963, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P17252, P30679, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, PRKCA, GNA15, ARRB1More
Niraparibhsa04927Cortisol synthesis and secretion1.41E-096Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Niraparibhsa04928Parathyroid hormone synthesis, secretion and action2.24E-058Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2More
Niraparibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Niraparibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Niraparibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Niraparibhsa04932Non-alcoholic fatty liver disease3.99E-1517P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, Q12933, P01584, P13073, P12074, O15239, Q16718, O95298, P19404, O14521AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHDMore
Niraparibhsa04933AGE-RAGE signaling pathway in diabetic complications9.13E-069P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Niraparibhsa04934Cushing syndrome1.00E-119Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Niraparibhsa04935Growth hormone synthesis, secretion and action4.62E-057Q08828, P51828, P04049, Q99941, P18848, P31751, P45985ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2, MAP2K4More
Niraparibhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Niraparibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Niraparibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Niraparibhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Niraparibhsa04970Salivary secretion1.41E-1010P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Niraparibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Niraparibhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Niraparibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Niraparibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Niraparibhsa04975Fat digestion and absorption1.68E-031O14494PLPP1More
Niraparibhsa04976Bile secretion8.33E-076O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Niraparibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Niraparibhsa05010Alzheimer disease7.59E-1126P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Niraparibhsa05012Parkinson disease4.67E-0723P62987, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371UBA52, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Niraparibhsa05014Amyotrophic lateral sclerosis7.08E-0420P01375, O15239, Q16718, P19404, O14521, P12074, P36542, P05496, O75460, Q12933, P28070, P43686, Q8TEV9, P09651, P37198, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA1, NDUFA5, NDUFV2, SDHD, COX6A1, ATP5C1, ATP5G1, ERN1, TRAF2, PSMB4, PSMC4, SMCR8, HNRNPA1, NUP62, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Niraparibhsa05016Huntington disease4.22E-0815O95298, P19404, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P45880, O75460, P28070, P55036, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC2, ERN1, PSMB4, PSMD4, PSMD12More
Niraparibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Niraparibhsa05020Prion disease3.41E-1027P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q92736, Q14643, P18848, P05141, P12236, P28070, P43686, O60282, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, KIF5C, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4, MAPK14More
Niraparibhsa05022Pathways of neurodegeneration - multiple diseases9.75E-1337Q14643, Q13509, P68371, P49841, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q16539, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, MAPK14, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Niraparibhsa05030Cocaine addiction7.19E-043Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Niraparibhsa05031Amphetamine addiction8.44E-075P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Niraparibhsa05032Morphine addiction5.66E-058P62873, P63218, P50151, Q13370, P78334, P17252, P32298, P43250GNB1, GNG5, GNG10, PDE3B, GABRE, PRKCA, GRK4, GRK6More
Niraparibhsa05033Nicotine addiction2.83E-033P28472, P78334, O15399GABRB3, GABRE, GRIN2DMore
Niraparibhsa05034Alcoholism6.84E-0613Q99941, P18848, Q13547, P0DP24, P62873, P61952, P04049, P0C0S5, Q93077, P62807, Q16778, O60814, P68431CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Niraparibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Niraparibhsa05110Vibrio cholerae infection5.33E-045Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Niraparibhsa05120Epithelial cell signaling in Helicobacter pylori infection7.19E-1513Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Niraparibhsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Niraparibhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Niraparibhsa05132Salmonella infection6.21E-1324P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, P63261, O00471, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, ACTG1, EXOC5, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Niraparibhsa05133Pertussis1.43E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Niraparibhsa05134Legionellosis1.46E-109P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Niraparibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Niraparibhsa05140Leishmaniasis4.19E-1215P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Niraparibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Niraparibhsa05143African trypanosomiasis1.54E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Niraparibhsa05144Malaria1.02E-0510P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Niraparibhsa05145Toxoplasmosis1.41E-0410P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LGMore
Niraparibhsa05146Amoebiasis2.25E-1813P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Niraparibhsa05150Staphylococcus aureus infection1.90E-1115P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Niraparibhsa05152Tuberculosis2.08E-0612P04049, Q13488, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P01568, Q9UDY8, P51617RAF1, TCIRG1, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Niraparibhsa05160Hepatitis C1.31E-047Q13546, P01568, P60033, P04049, P49841, P01375, P48023RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLGMore
Niraparibhsa05161Hepatitis B1.14E-058P04049, Q99941, P18848, P25963, Q13485, P10415, P27348, P84022RAF1, CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Niraparibhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Niraparibhsa05163Human cytomegalovirus infection1.93E-1331P31751, P42338, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Niraparibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Niraparibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Niraparibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Niraparibhsa05167Kaposi sarcoma-associated herpesvirus infection1.15E-0917P01568, P31751, P42224, P25963, P42338, P40189, P62873, P63218, P50151, P19174, Q14643, P04049, P07948, P01106, P04141, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNG5, GNG10, PLCG1, ITPR1, RAF1, LYN, MYC, CSF2, CALM1, LEF1More
Niraparibhsa05168Herpes simplex virus 1 infection1.64E-0524O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Niraparibhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Niraparibhsa05170Human immunodeficiency virus 1 infection6.61E-1123P31751, P42338, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2More
Niraparibhsa05171Coronavirus disease - COVID-194.42E-1431P01584, P25963, P42224, P01568, P23396, P62753, P25398, P62249, P42677, P40429, P62906, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829, P40189, P42338, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL10A, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23, IL6ST, PIK3CB, PLCG1, PRKCAMore
Niraparibhsa05200Pathways in cancer4.15E-1341Q13751, P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, Q13547, P10826, P14923, P30279, P30281, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, RARB, JUP, CCND2, CCND3, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Niraparibhsa05202Transcriptional misregulation in cancer1.21E-1331Q12778, Q15532, P01106, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P46527, P04637, P35226, O60583, P05164, P59665, P59666, P12838, P08246, P42773, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, MYC, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, TP53, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, CDKN2C, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Niraparibhsa05203Viral carcinogenesis4.71E-0716Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P61978, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Niraparibhsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Niraparibhsa05205Proteoglycans in cancer1.28E-0517Q13009, Q12955, Q14643, O75369, P60709, P63261, P04049, P04637, P14780, P17252, O60603, P01106, P08069, P19174, Q13635, P29350, P08962TIAM1, ANK3, ITPR1, FLNB, ACTB, ACTG1, RAF1, TP53, MMP9, PRKCA, TLR2, MYC, IGF1R, PLCG1, PTCH1, PTPN6, CD63More
Niraparibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Niraparibhsa05210Colorectal cancer8.05E-0611Q9UKG1, P84022, Q13485, P43246, P04049, P01106, P10415, P52701, P20585, P37173, O75293APPL1, SMAD3, SMAD4, MSH2, RAF1, MYC, BCL2, MSH6, MSH3, TGFBR2, GADD45BMore
Niraparibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Niraparibhsa05212Pancreatic cancer2.34E-069P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Niraparibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Niraparibhsa05214Glioma2.60E-088P08069, P0DP23, P17252, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Niraparibhsa05215Prostate cancer2.89E-057P10415, Q12778, P08069, P18848, Q9NRA1, P14625, P04049BCL2, FOXO1, IGF1R, ATF4, PDGFC, HSP90B1, RAF1More
Niraparibhsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Niraparibhsa05217Basal cell carcinoma3.03E-046Q13635, P04628, P49841, Q9UJU2, P04637, P24522PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45AMore
Niraparibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Niraparibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Niraparibhsa05220Chronic myeloid leukemia3.08E-0610Q13547, P01106, Q13485, P25963, P46527, P84022, P31751, P42338, P04049, O75293HDAC1, MYC, SMAD4, NFKBIA, CDKN1B, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Niraparibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Niraparibhsa05222Small cell lung cancer7.32E-058P10826, P31751, P42338, Q13751, Q13489, P10415, P25963, O75293RARB, AKT2, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, GADD45BMore
Niraparibhsa05223Non-small cell lung cancer7.34E-078P17252, P31751, P42338, P19174, P10826, P04049, Q9HC35, O75293PRKCA, AKT2, PIK3CB, PLCG1, RARB, RAF1, EML4, GADD45BMore
Niraparibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Niraparibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Niraparibhsa05226Gastric cancer8.56E-055P04049, P31751, P84022, Q13485, P10415RAF1, AKT2, SMAD3, SMAD4, BCL2More
Niraparibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Niraparibhsa05231Choline metabolism in cancer4.26E-0911P04049, P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Niraparibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.76E-1718P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Niraparibhsa05310Asthma5.01E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Niraparibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Niraparibhsa05321Inflammatory bowel disease1.36E-178O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Niraparibhsa05322Systemic lupus erythematosus2.37E-0917P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Niraparibhsa05323Rheumatoid arthritis8.15E-078P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Niraparibhsa05330Allograft rejection7.88E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Niraparibhsa05332Graft-versus-host disease1.56E-146P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Niraparibhsa05340Primary immunodeficiency2.12E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Niraparibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Niraparibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Niraparibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Niraparibhsa05415Diabetic cardiomyopathy2.31E-0510P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, TGFBR2More
Niraparibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Niraparibhsa05418Fluid shear stress and atherosclerosis2.88E-0614Q16539, P31751, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974MAPK14, AKT2, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Niraparib (SDC: 13.07)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Reported10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Reported00.04350.26350.24610.7947
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P53609PGGT1BGeranylgeranyl transferase typeNone1 subunit betaPredicted00.04990.02700.0789
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
P24666ACP1Low molecular weight phosphotyrosine protein phosphatasePredicted00.07040.10480.23610.481
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PARP1P09874IC502
PARP1P09874IC503.2
PARP1P09874IC508.1
PARP2Q9UGN5IC502.1
PARP2Q9UGN5IC5015