PharmaCoNets of Nimodipine (SPCN: 12.80 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nimodipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Nimodipinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Nimodipinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Nimodipinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Nimodipinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Nimodipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Nimodipinehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Nimodipinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Nimodipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Nimodipinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Nimodipinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Nimodipinehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Nimodipinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Nimodipinehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Nimodipinehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Nimodipinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Nimodipinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Nimodipinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Nimodipinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Nimodipinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Nimodipinehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Nimodipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Nimodipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Nimodipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nimodipinehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nimodipinehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Nimodipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Nimodipinehsa05132Salmonella infection5.76E-047P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2CMore
Nimodipinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Nimodipinehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Nimodipinehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Nimodipinehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nimodipinehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Nimodipinehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Nimodipinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Nimodipinehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Nimodipinehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Nimodipinehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Nimodipinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More

Community members of Nimodipine (SDC: 3.16)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P08235NR3C2Mineralocorticoid receptorReported10.185510.01372.1064
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)