PharmaCoNets of Nimesulide (SPCN: 86.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nimesulidehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Nimesulidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nimesulidehsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Nimesulidehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nimesulidehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Nimesulidehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Nimesulidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nimesulidehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Nimesulidehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Nimesulidehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Nimesulidehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Nimesulidehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Nimesulidehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Nimesulidehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Nimesulidehsa01522Endocrine resistance3.67E-025P14780, P22694, Q9UM47, P46527, P10415MMP9, PRKACB, NOTCH3, CDKN1B, BCL2More
Nimesulidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Nimesulidehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Nimesulidehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Nimesulidehsa03013RNA transport3.43E-0514O14980, P52298, Q09161, O14893, P61326, P37198, Q7Z3B4, P35658, Q14152, O75822, Q14240, P23588, Q9Y6A5, Q06787XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP62, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, EIF4B, TACC3, FMR1More
Nimesulidehsa03015mRNA surveillance pathway3.71E-026O43148, Q13362, O94913, Q12996, Q09161, P52298RNMT, PPP2R5C, PCF11, CSTF3, NCBP1, NCBP2More
Nimesulidehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Nimesulidehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Nimesulidehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Nimesulidehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Nimesulidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Nimesulidehsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Nimesulidehsa04064NF-kappa B signaling pathway1.04E-0313P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Nimesulidehsa04071Sphingolipid signaling pathway3.76E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Nimesulidehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Nimesulidehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Nimesulidehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Nimesulidehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Nimesulidehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Nimesulidehsa04137Mitophagy - animal3.24E-024Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Nimesulidehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Nimesulidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Nimesulidehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Nimesulidehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Nimesulidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Nimesulidehsa04217Necroptosis7.72E-0614P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Nimesulidehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Nimesulidehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Nimesulidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Nimesulidehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Nimesulidehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Nimesulidehsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Nimesulidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Nimesulidehsa04612Antigen processing and presentation2.26E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Nimesulidehsa04613Neutrophil extracellular trap formation2.32E-0315O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Nimesulidehsa04621NOD-like receptor signaling pathway6.10E-0415Q16539, Q14643, P25963, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, NFKBIA, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Nimesulidehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Nimesulidehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Nimesulidehsa04650Natural killer cell mediated cytotoxicity2.54E-0513P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3BMore
Nimesulidehsa04657IL-17 signaling pathway1.28E-0411P25963, P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9, IL1BMore
Nimesulidehsa04658Th1 and Th2 cell differentiation5.38E-0713Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Nimesulidehsa04659Th17 cell differentiation2.35E-0614Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Nimesulidehsa04660T cell receptor signaling pathway5.05E-0515P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Nimesulidehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Nimesulidehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Nimesulidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Nimesulidehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Nimesulidehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Nimesulidehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Nimesulidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Nimesulidehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Nimesulidehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Nimesulidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Nimesulidehsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Nimesulidehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Nimesulidehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Nimesulidehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Nimesulidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Nimesulidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Nimesulidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Nimesulidehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Nimesulidehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Nimesulidehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Nimesulidehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Nimesulidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Nimesulidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Nimesulidehsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Nimesulidehsa05140Leishmaniasis8.87E-0511P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4More
Nimesulidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Nimesulidehsa05144Malaria1.44E-036P60033, P69905, P68871, O60603, P35443, P26718CD81, HBA2, HBB, TLR2, THBS4, KLRK1More
Nimesulidehsa05146Amoebiasis7.41E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Nimesulidehsa05150Staphylococcus aureus infection3.71E-026P21462, O75015, P59665, P59666, P12838, P49913FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Nimesulidehsa05152Tuberculosis3.04E-029Q13488, O75015, P48382, P25208, O60603, P01375, P10415, P49913, Q9UDY8TCIRG1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, CAMP, MALT1More
Nimesulidehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Nimesulidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Nimesulidehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Nimesulidehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Nimesulidehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Nimesulidehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Nimesulidehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Nimesulidehsa05202Transcriptional misregulation in cancer3.97E-0520Q15532, Q13315, P14780, P27930, Q15744, Q16548, Q13077, O15550, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246, Q9C0K0, P41182, P12980, P24522SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Nimesulidehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Nimesulidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Nimesulidehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Nimesulidehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Nimesulidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.00E-039P42338, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Nimesulidehsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Nimesulidehsa05321Inflammatory bowel disease2.00E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Nimesulidehsa05332Graft-versus-host disease7.10E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Nimesulidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Nimesulidehsa05415Diabetic cardiomyopathy1.49E-0310P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDHMore

Community members of Nimesulide (SDC: 5.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02788LTFLactotransferrinReported10.48660.052100.3474
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)