PharmaCoNets of Nilotinib (SPCN: 276.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nilotinibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Nilotinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Nilotinibhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Nilotinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Nilotinibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Nilotinibhsa00052Galactose metabolism1.02E-066P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Nilotinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nilotinibhsa00071Fatty acid degradation2.23E-035P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Nilotinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Nilotinibhsa00190Oxidative phosphorylation1.22E-073Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Nilotinibhsa00220Arginine biosynthesis1.55E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Nilotinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Nilotinibhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Nilotinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Nilotinibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Nilotinibhsa00310Lysine degradation1.30E-067Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Nilotinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Nilotinibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Nilotinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Nilotinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Nilotinibhsa00500Starch and sucrose metabolism1.65E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Nilotinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Nilotinibhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Nilotinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Nilotinibhsa00520Amino sugar and nucleotide sugar metabolism1.75E-063Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Nilotinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Nilotinibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Nilotinibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Nilotinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Nilotinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Nilotinibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nilotinibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Nilotinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Nilotinibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Nilotinibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Nilotinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Nilotinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Nilotinibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Nilotinibhsa00630Glyoxylate and dicarboxylate metabolism1.44E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Nilotinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Nilotinibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Nilotinibhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Nilotinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Nilotinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Nilotinibhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Nilotinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Nilotinibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Nilotinibhsa00830Retinol metabolism2.70E-065P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Nilotinibhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Nilotinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Nilotinibhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Nilotinibhsa00970Aminoacyl-tRNA biosynthesis3.83E-022P54136, P14868RARS1, DARSMore
Nilotinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Nilotinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Nilotinibhsa00983Drug metabolism - other enzymes5.42E-095P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Nilotinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Nilotinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Nilotinibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Nilotinibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Nilotinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Nilotinibhsa01230Biosynthesis of amino acids1.89E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Nilotinibhsa01240Biosynthesis of cofactors3.32E-057Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Nilotinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Nilotinibhsa01522Endocrine resistance2.90E-058P22694, P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323PRKACB, RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Nilotinibhsa01523Antifolate resistance2.16E-054P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Nilotinibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Nilotinibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Nilotinibhsa03010Ribosome8.92E-1421P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Nilotinibhsa03013RNA transport1.20E-2131P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Nilotinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Nilotinibhsa03020RNA polymerase3.33E-124P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Nilotinibhsa03022Basal transcription factors2.72E-033O00268, Q12962, Q15544TAF4, TAF10, TAF11More
Nilotinibhsa03040Spliceosome1.74E-1121Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, O75940, P51991, P38159, P61978, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, SMNDC1, HNRPA3, RBMX, HNRPK, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Nilotinibhsa03060Protein export1.99E-114Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Nilotinibhsa03320PPAR signaling pathway6.48E-033Q6PCB7, Q13418, Q9UNU6SLC27A1, ILK, CYP8B1More
Nilotinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Nilotinibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Nilotinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Nilotinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Nilotinibhsa04012ErbB signaling pathway3.89E-0710P21860, Q13153, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, PAK1, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Nilotinibhsa04014Ras signaling pathway1.42E-0513P04049, P31751, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, CALM1, GNB1, GNG5, GNG10, PLCG1More
Nilotinibhsa04015Rap1 signaling pathway9.37E-0615P04049, P09603, P20827, Q9NRA1, P49767, Q9GZP0, P08069, P06213, P11215, O00522, P31751, P0DP23, Q86WV1, P17252, P19174RAF1, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, IGF1R, INSR, ITGAM, KRIT1, AKT2, CALM1, SKAP1, PRKCA, PLCG1More
Nilotinibhsa04020Calcium signaling pathway9.86E-1017Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, P19174, P0DP23, P0DP24, P05141, P51828, P20020, P23634, Q9NRA1, P49767ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Nilotinibhsa04022cGMP-PKG signaling pathway1.80E-0913Q02153, P04049, Q99941, P18848, P23634, Q8WYR1, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Nilotinibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Nilotinibhsa04060Cytokine-cytokine receptor interaction8.92E-0621P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P19875, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, CXCL2, CCL8, IL1RN, CD4, TNFRSF25More
Nilotinibhsa04061Viral protein interaction with cytokine and cytokine receptor3.46E-0710Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Nilotinibhsa04062Chemokine signaling pathway2.55E-0820P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Nilotinibhsa04064NF-kappa B signaling pathway1.49E-2126P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Nilotinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Nilotinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Nilotinibhsa04070Phosphatidylinositol signaling system1.22E-0712P19174, P0DP23, Q14643, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Nilotinibhsa04071Sphingolipid signaling pathway5.05E-0913P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCEMore
Nilotinibhsa04072Phospholipase D signaling pathway1.18E-0513P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Nilotinibhsa04080Neuroactive ligand-receptor interaction2.38E-0812P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Nilotinibhsa04110Cell cycle1.19E-0813Q9UBD5, P30260, P06493, O60566, Q14683, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Nilotinibhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Nilotinibhsa04115p53 signaling pathway4.19E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Nilotinibhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Nilotinibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Nilotinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Nilotinibhsa04140Autophagy - animal5.46E-0615P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Nilotinibhsa04141Protein processing in endoplasmic reticulum2.05E-0916P18848, Q12933, P30101, Q15437, Q15436, O60337, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23B, SEC23A, MARH6, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Nilotinibhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Nilotinibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Nilotinibhsa04145Phagosome1.81E-0913O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Nilotinibhsa04146Peroxisome1.01E-036O43933, O00623, P56589, Q9UKG9, O75521, P33121PEX1, PEX12, PEX3, CROT, ECI2, ACSL1More
Nilotinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Nilotinibhsa04151PI3K-Akt signaling pathway1.17E-1137P62753, P21860, P43657, P25116, P01106, O43521, P04637, P27348, P09603, P49767, Q9GZP0, Q13362, P07900, Q8WYR1, P62873, P63218, P50151, P61952, P13612, P16144, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, P2RY5, F2R, MYC, BCL2L11, TP53, YWHAQ, CSF1, VEGFC, PDGFD, PPP2R5C, HSP90AA1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGA4, ITGB4, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Nilotinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Nilotinibhsa04210Apoptosis8.14E-0618Q13315, P10415, Q13489, O76075, P25963, Q14790, P01375, P48023, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643, P42575, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, CASP8, TNF, FASLG, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1, CASP2, RAF1More
Nilotinibhsa04211Longevity regulating pathway2.10E-057P31751, P08069, Q08828, P51828, Q99941, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2More
Nilotinibhsa04213Longevity regulating pathway - multiple species2.09E-099P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Nilotinibhsa04217Necroptosis2.65E-1923Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P07900, P08238, P15104, P05141, P01584, P07384, P0C0S5, Q6FI13, Q93077, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, CAPN1, H2AFZ, H2AC18; H2AC19, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Nilotinibhsa04218Cellular senescence3.45E-0511P01106, P31751, P04049, P30281, O75293, P30304, P06493, P0DP23, P01889, P10321, P12236MYC, AKT2, RAF1, CCND3, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-C, SLC25A6More
Nilotinibhsa04260Cardiac muscle contraction3.93E-035P09493, P67936, P13073, P12074, P14927TPM1, TPM4, COX4I1, COX6A1, UQCRBMore
Nilotinibhsa04261Adrenergic signaling in cardiomyocytes5.61E-1115P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Nilotinibhsa04270Vascular smooth muscle contraction3.81E-0811P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Nilotinibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Nilotinibhsa04330Notch signaling pathway3.00E-064Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Nilotinibhsa04340Hedgehog signaling pathway6.28E-065P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Nilotinibhsa04360Axon guidance7.12E-0512P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, RAF1, PLCG1, ABLIM1, MYL9More
Nilotinibhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Nilotinibhsa04371Apelin signaling pathway6.52E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14344, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, RPS6, CALM1, CALM2More
Nilotinibhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Nilotinibhsa04390Hippo signaling pathway5.23E-079P35240, O95835, Q92796, P63261, O15105, P04628, Q9UJU2, O43623, Q13489NF2, LATS1, DLG3, ACTG1, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Nilotinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Nilotinibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Nilotinibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Nilotinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Nilotinibhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Nilotinibhsa04540Gap junction1.19E-088P17252, P22694, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Nilotinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Nilotinibhsa04610Complement and coagulation cascades6.48E-145P09871, P00734, P0C0L4, P20023, P05107C1S, F2, C4A, CR2, ITGB2More
Nilotinibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Nilotinibhsa04612Antigen processing and presentation1.30E-0911P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Nilotinibhsa04613Neutrophil extracellular trap formation1.02E-1333P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q99878, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Nilotinibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Nilotinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Nilotinibhsa04621NOD-like receptor signaling pathway2.37E-0618P01584, P07900, Q14643, P23458, P45880, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Nilotinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Nilotinibhsa04623Cytosolic DNA-sensing pathway2.59E-146P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Nilotinibhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Nilotinibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Nilotinibhsa04640Hematopoietic cell lineage1.31E-1421P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Nilotinibhsa04650Natural killer cell mediated cytotoxicity5.15E-2219P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Nilotinibhsa04657IL-17 signaling pathway9.46E-1216P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9, IL1BMore
Nilotinibhsa04658Th1 and Th2 cell differentiation4.32E-3818P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Nilotinibhsa04659Th17 cell differentiation2.25E-2721P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Nilotinibhsa04660T cell receptor signaling pathway1.98E-2623P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049, Q16539, P49841TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1, MAPK14, GSK3BMore
Nilotinibhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Nilotinibhsa04664Fc epsilon RI signaling pathway1.84E-1011P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Nilotinibhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Nilotinibhsa04668TNF signaling pathway7.18E-0814P01375, Q12933, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Nilotinibhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Nilotinibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Nilotinibhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Nilotinibhsa04713Circadian entrainment1.61E-0913P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828, P51828, O15055CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1, ADCY7, PER2More
Nilotinibhsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Nilotinibhsa04720Long-term potentiation9.48E-1112P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Nilotinibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Nilotinibhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Nilotinibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Nilotinibhsa04724Glutamatergic synapse1.34E-067O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Nilotinibhsa04725Cholinergic synapse2.93E-0914Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Nilotinibhsa04726Serotonergic synapse5.74E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Nilotinibhsa04727GABAergic synapse1.20E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Nilotinibhsa04728Dopaminergic synapse2.02E-1018Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Nilotinibhsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Nilotinibhsa04740Olfactory transduction5.99E-065P62873, Q9H255, Q13557, P0DP23, P0DP24GNB1, OR51E2, CAMK2D, CALM1, CALM2More
Nilotinibhsa04742Taste transduction2.43E-052P30939, P17612HTR1F, PRKACAMore
Nilotinibhsa04744Phototransduction3.05E-123P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Nilotinibhsa04750Inflammatory mediator regulation of TRP channels1.95E-1214P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Nilotinibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Nilotinibhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Nilotinibhsa04911Insulin secretion1.14E-105Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Nilotinibhsa04912GnRH signaling pathway5.74E-0813P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Nilotinibhsa04913Ovarian steroidogenesis6.44E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Nilotinibhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Nilotinibhsa04915Estrogen signaling pathway2.16E-1212P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Nilotinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Nilotinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Nilotinibhsa04918Thyroid hormone synthesis2.03E-066Q08828, P51828, Q99941, P18848, P02768, P05543ADCY1, ADCY7, CREBL1, ATF4, ALB, SERPINA7More
Nilotinibhsa04919Thyroid hormone signaling pathway3.02E-0611P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, Q9UM47, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, NOTCH3, MYCMore
Nilotinibhsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Nilotinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Nilotinibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Nilotinibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Nilotinibhsa04924Renin secretion9.46E-095P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Nilotinibhsa04925Aldosterone synthesis and secretion3.02E-128Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Nilotinibhsa04926Relaxin signaling pathway1.66E-0814P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Nilotinibhsa04927Cortisol synthesis and secretion2.64E-086Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Nilotinibhsa04928Parathyroid hormone synthesis, secretion and action1.61E-048Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2More
Nilotinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Nilotinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Nilotinibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nilotinibhsa04932Non-alcoholic fatty liver disease1.66E-1615P31751, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, P19404, O14521AKT2, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHDMore
Nilotinibhsa04933AGE-RAGE signaling pathway in diabetic complications6.00E-046P42224, P10415, Q12778, P49767, P17252, P19174STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1More
Nilotinibhsa04934Cushing syndrome6.33E-129Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Nilotinibhsa04935Growth hormone synthesis, secretion and action4.62E-057Q08828, P51828, P04049, Q99941, P18848, P31751, P45985ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2, MAP2K4More
Nilotinibhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Nilotinibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Nilotinibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Nilotinibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Nilotinibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Nilotinibhsa04970Salivary secretion2.81E-1111P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Nilotinibhsa04971Gastric acid secretion1.49E-086Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Nilotinibhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Nilotinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Nilotinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Nilotinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Nilotinibhsa04976Bile secretion8.33E-076O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Nilotinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Nilotinibhsa05010Alzheimer disease1.41E-1128P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P45880, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PPID, PSMB4, PSMC4More
Nilotinibhsa05012Parkinson disease1.34E-0822O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Nilotinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Nilotinibhsa05016Huntington disease3.16E-0813O15239, O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Nilotinibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Nilotinibhsa05020Prion disease1.27E-1027P13591, P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P45880, P28070, P43686, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080, Q16539NCAM1, IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4, MAPK14More
Nilotinibhsa05022Pathways of neurodegeneration - multiple diseases8.24E-1439Q14643, Q13509, P68371, P49841, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P19174, P05141, P45880, P17252, P20333, Q16539, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, PLCG1, SLC25A5, VDAC2, PRKCA, TNFRSF1B, MAPK14, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Nilotinibhsa05030Cocaine addiction7.19E-043Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Nilotinibhsa05031Amphetamine addiction8.44E-075P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Nilotinibhsa05032Morphine addiction4.54E-058P62873, P63218, P50151, Q13370, Q07343, P78334, P32298, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GABRE, GRK4, GRK6More
Nilotinibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Nilotinibhsa05034Alcoholism1.22E-0816Q99941, P18848, Q13547, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P58876, P62807, Q16778, O60814, P84243, P68431CREBL1, ATF4, HDAC1, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nilotinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Nilotinibhsa05110Vibrio cholerae infection2.61E-045Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Nilotinibhsa05120Epithelial cell signaling in Helicobacter pylori infection6.93E-1413Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Nilotinibhsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Nilotinibhsa05131Shigellosis9.80E-0724P01375, P25963, Q12933, O00463, Q13546, P68431, Q05655, Q02156, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32, P07737TNF, NFKBIA, TRAF2, TRAF5, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF, PFN1More
Nilotinibhsa05132Salmonella infection5.71E-1223P51617, P25963, P01375, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Nilotinibhsa05133Pertussis1.42E-074P05107, P0DP23, P10145, P0C0L4ITGB2, CALM1, IL8, C4AMore
Nilotinibhsa05134Legionellosis9.22E-129P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Nilotinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Nilotinibhsa05140Leishmaniasis1.06E-1216P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Nilotinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Nilotinibhsa05143African trypanosomiasis9.08E-062P69905, P68871HBA2, HBBMore
Nilotinibhsa05144Malaria8.71E-0810P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Nilotinibhsa05145Toxoplasmosis1.19E-039P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Nilotinibhsa05146Amoebiasis1.48E-1913P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Nilotinibhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Nilotinibhsa05152Tuberculosis6.47E-0714P04049, Q13488, P0DP23, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, CALM1, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1More
Nilotinibhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Nilotinibhsa05161Hepatitis B4.72E-0512P17252, P04049, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Nilotinibhsa05162Measles6.91E-057P23458, P31751, P0DMV8, P11142, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, HSPA8, IL1B, CSNK2B, RAB9BMore
Nilotinibhsa05163Human cytomegalovirus infection2.00E-1229P31751, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Nilotinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Nilotinibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Nilotinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Nilotinibhsa05167Kaposi sarcoma-associated herpesvirus infection1.28E-0916P01568, P31751, P42224, P25963, P40189, P62873, P63218, P50151, P19174, Q14643, P04049, P07948, P01106, P04141, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, IL6ST, GNB1, GNG5, GNG10, PLCG1, ITPR1, RAF1, LYN, MYC, CSF2, CALM1, LEF1More
Nilotinibhsa05168Herpes simplex virus 1 infection1.18E-0523O00463, O60603, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q16629, P30101, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PDIA3, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Nilotinibhsa05169Epstein-Barr virus infection6.88E-0817P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Nilotinibhsa05170Human immunodeficiency virus 1 infection1.30E-1126P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2More
Nilotinibhsa05171Coronavirus disease - COVID-195.57E-1228P01584, P25963, P42224, P01568, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829, P40189, P04141, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23, IL6ST, CSF2, PLCG1, PRKCAMore
Nilotinibhsa05200Pathways in cancer7.91E-1034P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Nilotinibhsa05202Transcriptional misregulation in cancer5.56E-1525Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Nilotinibhsa05203Viral carcinogenesis2.40E-0817Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P61978, P06493, P58876, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Nilotinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Nilotinibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Nilotinibhsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Nilotinibhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Nilotinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Nilotinibhsa05212Pancreatic cancer1.31E-047P31751, P04049, Q15311, P23458, P42224, P84022, O75293AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Nilotinibhsa05213Endometrial cancer5.61E-053Q13418, P31751, P04049ILK, AKT2, RAF1More
Nilotinibhsa05214Glioma8.96E-087P08069, P0DP23, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Nilotinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Nilotinibhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Nilotinibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Nilotinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Nilotinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Nilotinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Nilotinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Nilotinibhsa05222Small cell lung cancer5.10E-037P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Nilotinibhsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Nilotinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Nilotinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Nilotinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Nilotinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Nilotinibhsa05231Choline metabolism in cancer2.31E-0811P04049, P31751, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Nilotinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.37E-1918P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Nilotinibhsa05310Asthma4.09E-103P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Nilotinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Nilotinibhsa05321Inflammatory bowel disease9.10E-188O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Nilotinibhsa05322Systemic lupus erythematosus6.14E-1119P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14678, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1, SSBMore
Nilotinibhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Nilotinibhsa05330Allograft rejection9.93E-044P13765, P29965, P10747, P01375HLA-DOB, CD40LG, CD28, TNFMore
Nilotinibhsa05332Graft-versus-host disease4.13E-145P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Nilotinibhsa05340Primary immunodeficiency2.12E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Nilotinibhsa05410Hypertrophic cardiomyopathy1.24E-032P26012, P09493ITGB8, TPM1More
Nilotinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.97E-053P54284, P15924, P26012CACNB3, DSP, ITGB8More
Nilotinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Nilotinibhsa05415Diabetic cardiomyopathy1.38E-0715P17252, P30405, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P14780, P37173, P04406PRKCA, PPIF, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, MMP9, TGFBR2, GAPDHMore
Nilotinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Nilotinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Nilotinib (SDC: 12.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P04628WNT1ProtoNoneoncogene WntNone1Predicted00.02820.02250.45140.5105
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P42226STAT6Signal transducer and activator of transcription 6Predicted00.31610.03530.5090.7378
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
Q13418ILKIntegrinNonelinked protein kinasePredicted00.58850.03880.3940.7658
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
O60880SH2D1ASH2 domainNonecontaining protein 1APredicted00.03520.01650.18070.2313
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)