PharmaCoNets

PharmaCoNets of Nifedipine (S_PCN: 42.24 )

Nifedipine regulated-network (S_DN: 17.97)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nifedipine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Nifedipine

hsa00061

Fatty acid biosynthesis

4.83E-02

P33121

ACSL1

Nifedipine

hsa00190

Oxidative phosphorylation

3.50E-02

Q16718, Q13488

NDUFA5, TCIRG1

Nifedipine

hsa00230

Purine metabolism

4.60E-02

Q13370, P36959, Q13956, P27707

PDE3B, GMPR, PDE6H, DCK

Nifedipine

hsa00240

Pyrimidine metabolism

4.50E-02

P32320, P27707

CDA, DCK

Nifedipine

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Nifedipine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Nifedipine

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

4.77E-02

Q7LGA3

HS2ST1

Nifedipine

hsa00600

Sphingolipid metabolism

3.01E-02

Q9BX95, P06280

SGPP1, GLA

Nifedipine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

1.34E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Nifedipine

hsa00620

Pyruvate metabolism

4.20E-02

P40926, P14550

MDH2, AKR1A1

Nifedipine

hsa00670

One carbon pool by folate

3.99E-02

O95954, Q99707

FTCD, MTR

Nifedipine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Nifedipine

hsa00920

Sulfur metabolism

3.01E-02

O95571

ETHE1

Nifedipine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Nifedipine

hsa01100

Metabolic pathways

6.77E-03

Q9Y234, P15144, Q99707, P29218, P11310, P27707, P32320, Q13370, P36959, Q13956, P06280, P30043, P24666, Q02252, O60701, O14772, O95954, P33121, Q02318, P42330, P04406, Q13093, Q9NY28, O15466, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809

LIPT1, ANPEP, MTR, IMPA1, ACADM, DCK, CDA, PDE3B, GMPR, PDE6H, GLA, BLVRB, ACP1, ALDH6A1, UGDH, FPGT, FTCD, ACSL1, CYP27A1, AKR1C3, GAPDH, PLA2G7, GALNT8, ST8SIA5, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15182	CETN3	Centrin-3	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.727
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P15144	ANPEP	Aminopeptidase N	0.763
O15182	CETN3	Centrin-3	Q99707	MTR	Methionine synthase	0.924
O15182	CETN3	Centrin-3	P29218	IMPA1	Inositol monophosphatase 1	0.739
O15182	CETN3	Centrin-3	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.881
O15182	CETN3	Centrin-3	P27707	DCK	Deoxycytidine kinase	0.937
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P32320	CDA	Cytidine deaminase	0.706
O15182	CETN3	Centrin-3	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.707
O15182	CETN3	Centrin-3	P36959	GMPR	GMP reductase 1	-0.724
O15182	CETN3	Centrin-3	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.857
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P06280	GLA	Alpha-galactosidase A	0.764
O15182	CETN3	Centrin-3	P30043	BLVRB	Flavin reductase	-0.859
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.709
O15182	CETN3	Centrin-3	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.801
O15182	CETN3	Centrin-3	O60701	UGDH	UDP-glucose 6-dehydrogenase	0.717
O15182	CETN3	Centrin-3	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.862
O15182	CETN3	Centrin-3	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.706
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.734
O15182	CETN3	Centrin-3	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.805
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P42330	AKR1C3	Aldo-keto reductase family 1 member C3	-0.708
O15182	CETN3	Centrin-3	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.765
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	-0.7
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q9NY28	GALNT8	Probable polypeptide N-acetylgalactosaminyltransferase 8	-0.795
O15182	CETN3	Centrin-3	O15466	ST8SIA5	Alpha-2,8-sialyltransferase 8E	-0.748
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.713
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P09960	LTA4H	Leukotriene A-4 hydrolase	0.772
O15182	CETN3	Centrin-3	P09960	LTA4H	Leukotriene A-4 hydrolase	-0.728
O15182	CETN3	Centrin-3	Q9P2R7	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0.84
O15182	CETN3	Centrin-3	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.707
O15182	CETN3	Centrin-3	P35573	AGL	Glycogen debranching enzyme	0.749
O15182	CETN3	Centrin-3	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.767
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.837
O15182	CETN3	Centrin-3	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.785
O15182	CETN3	Centrin-3	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	-0.849

Nifedipine

hsa01524

Platinum drug resistance

4.45E-02

P10415, Q13489, P78417, P43246

BCL2, BIRC3, GSTO1, MSH2

Nifedipine

hsa02010

ABC transporters

4.89E-02

Q99758

ABCA3

Nifedipine

hsa03010

Ribosome

3.56E-06

P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396

RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3

Nifedipine

hsa03013

RNA transport

4.79E-02

P62826, P63279

RAN, UBE2I

Nifedipine

hsa03015

mRNA surveillance pathway

3.62E-02

O43148, P61326, P52298

RNMT, MAGOH, NCBP2

Nifedipine

hsa03020

RNA polymerase

9.86E-07

Q9GZM3, P52435

POLR2J2, POLR2J

Nifedipine

hsa03040

Spliceosome

1.11E-07

Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326

DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP25	CALM3	Calmodulin-3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP24	CALM2	Calmodulin-2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP23	CALM1	Calmodulin-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP25	CALM3	Calmodulin-3	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP24	CALM2	Calmodulin-2	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP23	CALM1	Calmodulin-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP25	CALM3	Calmodulin-3	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.734
O15182	CETN3	Centrin-3	O14776	TCERG1	Transcription elongation regulator 1	0.758
P0DP23	CALM1	Calmodulin-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP25	CALM3	Calmodulin-3	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP24	CALM2	Calmodulin-2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
O15182	CETN3	Centrin-3	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.859
O15182	CETN3	Centrin-3	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.701
O15182	CETN3	Centrin-3	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.757
P0DP24	CALM2	Calmodulin-2	Q15365	PCBP1	Poly(rC)-binding protein 1	0.75
O15182	CETN3	Centrin-3	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.85
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
O15182	CETN3	Centrin-3	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.723
P0DP23	CALM1	Calmodulin-1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP25	CALM3	Calmodulin-3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP24	CALM2	Calmodulin-2	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
O15182	CETN3	Centrin-3	P61326	MAGOH	Protein mago nashi homolog	0.811

Nifedipine

hsa03050

Proteasome

5.53E-03

P43686, P28070

PSMC4, PSMB4

Nifedipine

hsa03320

PPAR signaling pathway

2.18E-02

O00767, Q02318

SCD, CYP27A1

Nifedipine

hsa03460

Fanconi anemia pathway

3.70E-03

Q9NPI8, O60673, Q9UNA4

FANCF, REV3L, POLI

Nifedipine

hsa04014

Ras signaling pathway

2.65E-03

P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174

AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1

Nifedipine

hsa04015

Rap1 signaling pathway

5.41E-03

P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174

EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1

Nifedipine

hsa04020

Calcium signaling pathway

1.04E-06

P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767

ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP25	CALM3	Calmodulin-3	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84

Nifedipine

hsa04024

cAMP signaling pathway

2.79E-04

P49019, Q08828, P51828, P22694, P31751, P0DP23, P20020, P23634, Q13557, Q13370, P48058, O15399, Q13009

HCAR3, ADCY1, ADCY7, PRKACB, AKT2, CALM1, ATP2B1, ATP2B4, CAMK2D, PDE3B, GRIA4, GRIN2D, TIAM1

Nifedipine

hsa04062

Chemokine signaling pathway

2.04E-02

P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751

CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2

Nifedipine

hsa04064

NF-kappa B signaling pathway

1.74E-05

P10415, Q13489, P51617, Q13546, P01584, P29965, P19174, Q9UDY8, O75293, Q8NHW4, Q9UNE0, Q9NQC7

BCL2, BIRC3, IRAK1, RIPK1, IL1B, CD40LG, PLCG1, MALT1, GADD45B, CCL4L2, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	P29965	CD40LG	CD40 ligand	-0.721
P0DP25	CALM3	Calmodulin-3	P29965	CD40LG	CD40 ligand	-0.721
P0DP24	CALM2	Calmodulin-2	P29965	CD40LG	CD40 ligand	-0.721
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778

Nifedipine

hsa04070

Phosphatidylinositol signaling system

5.66E-04

P19174, P0DP23, P23743, P48426, P27987, P17252

PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCA

Nifedipine

hsa04071

Sphingolipid signaling pathway

2.78E-03

P17252, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042

PRKCA, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1

Nifedipine

hsa04072

Phospholipase D signaling pathway

2.03E-02

P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734

AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2

Nifedipine

hsa04140

Autophagy - animal

2.58E-02

P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9

AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8

Nifedipine

hsa04144

Endocytosis

8.99E-03

P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Nifedipine

hsa04145

Phagosome

4.88E-04

P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, O60603

ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2

Nifedipine

hsa04151

PI3K-Akt signaling pathway

4.68E-03

O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8

BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1

Nifedipine

hsa04210

Apoptosis

7.52E-04

O76075, P07384, P01375, Q9NR28, Q16548, P60709, P63261

DFFB, CAPN1, TNF, DIABLO, BCL2A1, ACTB, ACTG1

Nifedipine

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Nifedipine

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Nifedipine

hsa04217

Necroptosis

2.51E-10

P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P08238, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752

IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P01568	IFNA21	Interferon alpha-21	0.838
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.785
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.799
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P0C0S5	H2AFZ	Histone H2A.Z	0.749
P0DP23	CALM1	Calmodulin-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP25	CALM3	Calmodulin-3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP24	CALM2	Calmodulin-2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.73
P0DP24	CALM2	Calmodulin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.713
P0DP23	CALM1	Calmodulin-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.702
P0DP25	CALM3	Calmodulin-3	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP23	CALM1	Calmodulin-1	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.713
P0DP24	CALM2	Calmodulin-2	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.763
P0DP23	CALM1	Calmodulin-1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.784
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.817

Nifedipine

hsa04261

Adrenergic signaling in cardiomyocytes

4.43E-06

P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Nifedipine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Nifedipine

hsa04360

Axon guidance

8.44E-04

P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174

CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1

Nifedipine

hsa04371

Apelin signaling pathway

3.08E-02

P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23

GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1

Nifedipine

hsa04380

Osteoclast differentiation

4.18E-02

Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598

CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1

Nifedipine

hsa04390

Hippo signaling pathway

1.38E-03

P60709, P63261, P84022, Q13485, Q13489

ACTB, ACTG1, SMAD3, SMAD4, BIRC3

Nifedipine

hsa04510

Focal adhesion

3.76E-02

P16144, O75369, Q15942, P17252, Q13489, P10415, P49767

ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFC

Nifedipine

hsa04520

Adherens junction

1.58E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa04530

Tight junction

3.88E-03

P60709, P63261, P60660

ACTB, ACTG1, MYL6

Nifedipine

hsa04540

Gap junction

4.08E-02

P17252, Q13509, P68371, Q08828, P51828

PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7

Nifedipine

hsa04610

Complement and coagulation cascades

4.69E-03

P0C0L4

C4A

Nifedipine

hsa04611

Platelet activation

2.61E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa04620

Toll-like receptor signaling pathway

2.13E-03

P51617, Q13546, P01568, P31751, P42224, Q8NHW4

IRAK1, RIPK1, IFNA21, AKT2, STAT1, CCL4L2

Nifedipine

hsa04621

NOD-like receptor signaling pathway

7.87E-03

P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415, Q13546

IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2, RIPK1

Nifedipine

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Nifedipine

hsa04623

Cytosolic DNA-sensing pathway

7.83E-04

P01568, Q13546, Q8NHW4

IFNA21, RIPK1, CCL4L2

Nifedipine

hsa04630

JAK-STAT signaling pathway

1.16E-02

P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568

AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21

Nifedipine

hsa04640

Hematopoietic cell lineage

2.82E-03

P08514, P21926, P07766, P09564

ITGA2B, CD9, CD3E, CD7

Nifedipine

hsa04650

Natural killer cell mediated cytotoxicity

2.11E-02

P17252, O60880, P26717, P26715

PRKCA, SH2D1A, KLRC2, KLRC1

Nifedipine

hsa04657

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Nifedipine

hsa04659

Th17 cell differentiation

3.17E-02

P25963, P84022, Q13485

NFKBIA, SMAD3, SMAD4

Nifedipine

hsa04662

B cell receptor signaling pathway

3.68E-02

P25963, P20023

NFKBIA, CR2

Nifedipine

hsa04666

Fc gamma R-mediated phagocytosis

2.78E-02

P08575, P19174, P23528, Q9UQC2, P14598, P17252

PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCA

Nifedipine

hsa04670

Leukocyte transendothelial migration

4.07E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Nifedipine

hsa04713

Circadian entrainment

4.27E-06

O15399, P0DP23, Q13557, P17252, P62873, P48058, Q08828, P51828, P22694

GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GRIA4, ADCY1, ADCY7, PRKACB

Nifedipine

hsa04714

Thermogenesis

2.20E-04

P22694, P15336, P60709, P63261, P33121, Q16718, P36542

PRKACB, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, ATP5C1

Nifedipine

hsa04720

Long-term potentiation

3.26E-03

P17252, Q13557, P0DP23, P18848, O15399, Q08828

PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1

Nifedipine

hsa04721

Synaptic vesicle cycle

1.14E-02

Q13488, P31645

TCIRG1, SLC6A4

Nifedipine

hsa04723

Retrograde endocannabinoid signaling

1.20E-03

P17252, P48058, P22694, Q16718

PRKCA, GRIA4, PRKACB, NDUFA5

Nifedipine

hsa04724

Glutamatergic synapse

3.16E-04

P48058, O15399, Q08828, P51828, P22694, P17252, P62873, P15104

GRIA4, GRIN2D, ADCY1, ADCY7, PRKACB, PRKCA, GNB1, GLUL

Nifedipine

hsa04725

Cholinergic synapse

4.42E-04

Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415

ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2

Nifedipine

hsa04726

Serotonergic synapse

2.62E-02

P22694, P17252, P31645

PRKACB, PRKCA, SLC6A4

Nifedipine

hsa04727

GABAergic synapse

4.08E-02

Q08828, P51828, P62873, P46459, P17252

ADCY1, ADCY7, GNB1, NSF, PRKCA

Nifedipine

hsa04740

Olfactory transduction

2.61E-02

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Nifedipine

hsa04744

Phototransduction

1.30E-05

P62873, P0DP23

GNB1, CALM1

Nifedipine

hsa04750

Inflammatory mediator regulation of TRP channels

4.32E-05

P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042

IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1

Nifedipine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Nifedipine

hsa04911

Insulin secretion

3.01E-03

Q08828, P22694, P17252, P18848, Q13557

ADCY1, PRKACB, PRKCA, ATF4, CAMK2D

Nifedipine

hsa04912

GnRH signaling pathway

2.85E-02

P17252, Q08828, P18848, Q13557, P0DP23

PRKCA, ADCY1, ATF4, CAMK2D, CALM1

Nifedipine

hsa04913

Ovarian steroidogenesis

1.28E-02

P42330, P22694

AKR1C3, PRKACB

Nifedipine

hsa04914

Progesterone-mediated oocyte maturation

3.26E-02

Q08828, P51828, P31751, Q13370, Q9UJX4, P08238

ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1

Nifedipine

hsa04915

Estrogen signaling pathway

3.28E-03

P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415

ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2

Nifedipine

hsa04918

Thyroid hormone synthesis

3.01E-02

P22694, P17252

PRKACB, PRKCA

Nifedipine

hsa04919

Thyroid hormone signaling pathway

5.60E-04

P49841, P22694, P60709, P63261, O60244, Q9NVC6

GSK3B, PRKACB, ACTB, ACTG1, MED14, MED17

Nifedipine

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Nifedipine

hsa04921

Oxytocin signaling pathway

1.77E-03

P60660, P60709, P63261

MYL6, ACTB, ACTG1

Nifedipine

hsa04923

Regulation of lipolysis in adipocytes

2.12E-02

Q08828, P51828, Q13370, P31751

ADCY1, ADCY7, PDE3B, AKT2

Nifedipine

hsa04925

Aldosterone synthesis and secretion

3.12E-05

P18848, Q08828, P51828, P0DP23, P17252, Q13557, P22694, P20020, P23634

ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, PRKACB, ATP2B1, ATP2B4

Nifedipine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Nifedipine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.51E-07

P84022, Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174

SMAD3, SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Nifedipine

hsa04935

Growth hormone synthesis, secretion and action

3.93E-02

P19174, Q08828, P51828, P17252, P31751, P42224

PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1

Nifedipine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

9.85E-05

P20020, P17252, P22694

ATP2B1, PRKCA, PRKACB

Nifedipine

hsa04962

Vasopressin-regulated water reabsorption

6.61E-03

P22694, Q13561

PRKACB, DCTN2

Nifedipine

hsa04970

Salivary secretion

5.78E-05

Q08828, P51828, P22694, P20020, P23634, P17252, P0DP23

ADCY1, ADCY7, PRKACB, ATP2B1, ATP2B4, PRKCA, CALM1

Nifedipine

hsa04971

Gastric acid secretion

1.02E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa04972

Pancreatic secretion

1.26E-05

P20020, P23634, P17252, Q08828, P51828, P62491

ATP2B1, ATP2B4, PRKCA, ADCY1, ADCY7, RAB11A

Nifedipine

hsa04975

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Nifedipine

hsa04976

Bile secretion

1.51E-03

P22694, P08183

PRKACB, ABCB1

Nifedipine

hsa05010

Alzheimer disease

7.11E-03

O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686

NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4

Nifedipine

hsa05012

Parkinson disease

2.14E-02

O15239, P13073, P05141, P12236, P18848, P28070, P43686

NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4

Nifedipine

hsa05014

Amyotrophic lateral sclerosis

2.98E-02

P36542, P60709, P63261

ATP5C1, ACTB, ACTG1

Nifedipine

hsa05016

Huntington disease

2.46E-05

Q9GZM3, P52435, Q9NYC9

POLR2J2, POLR2J, DNAH9

Nifedipine

hsa05017

Spinocerebellar ataxia

4.93E-04

P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232, P05141, P12236

PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12, SLC25A5, SLC25A6

Nifedipine

hsa05020

Prion disease

1.55E-03

P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636

NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2

Nifedipine

hsa05022

Pathways of neurodegeneration - multiple diseases

5.20E-04

P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686

CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4

Nifedipine

hsa05031

Amphetamine addiction

2.07E-03

O15399, P48058, P0DP23, Q13557, P22694, P18848, P17252

GRIN2D, GRIA4, CALM1, CAMK2D, PRKACB, ATF4, PRKCA

Nifedipine

hsa05032

Morphine addiction

4.08E-02

Q08828, P51828, P62873, Q13370, P17252

ADCY1, ADCY7, GNB1, PDE3B, PRKCA

Nifedipine

hsa05100

Bacterial invasion of epithelial cells

8.79E-04

P60709, P63261, Q92529

ACTB, ACTG1, SHC3

Nifedipine

hsa05110

Vibrio cholerae infection

4.61E-04

P17252, P22694, P60709, P63261

PRKCA, PRKACB, ACTB, ACTG1

Nifedipine

hsa05131

Shigellosis

1.91E-02

P60709, P63261, P07384

ACTB, ACTG1, CAPN1

Nifedipine

hsa05132

Salmonella infection

1.85E-06

P51617, P01584, P25963, P08238, Q96RF0, Q13546, Q13489, P10415, P08575, O75369, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754, Q9NP90

IRAK1, IL1B, NFKBIA, HSP90AB1, SNAG1, RIPK1, BIRC3, BCL2, PTPRC, FLNB, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	Q96RF0	SNAG1	Sorting nexin-18	0.703
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	0.716
P0DP25	CALM3	Calmodulin-3	O75369	FLNB	Filamin-B	0.874
P0DP24	CALM2	Calmodulin-2	O75369	FLNB	Filamin-B	0.874
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P0DP25	CALM3	Calmodulin-3	Q13561	DCTN2	Dynactin subunit 2	0.739
P0DP24	CALM2	Calmodulin-2	Q13561	DCTN2	Dynactin subunit 2	0.739
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P0DP25	CALM3	Calmodulin-3	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP24	CALM2	Calmodulin-2	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P0DP25	CALM3	Calmodulin-3	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP24	CALM2	Calmodulin-2	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP25	CALM3	Calmodulin-3	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791

Nifedipine

hsa05133

Pertussis

3.94E-04

P0DP23, P01584, P23528, P09871, P51617

CALM1, IL1B, CFL1, C1S, IRAK1

Nifedipine

hsa05135

Yersinia infection

3.88E-03

P60709, P63261, Q16513

ACTB, ACTG1, PKN2

Nifedipine

hsa05140

Leishmaniasis

2.58E-02

P14598, O60603, P25963, P29350, Q15080

NCF1, TLR2, NFKBIA, PTPN6, NCF4

Nifedipine

hsa05143

African trypanosomiasis

3.87E-02

P01584, P17252, P01042

IL1B, PRKCA, KNG1

Nifedipine

hsa05145

Toxoplasmosis

7.31E-06

P51617, P25963, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651

IRAK1, NFKBIA, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP23	CALM1	Calmodulin-1	P29965	CD40LG	CD40 ligand	-0.721
P0DP25	CALM3	Calmodulin-3	P29965	CD40LG	CD40 ligand	-0.721
P0DP24	CALM2	Calmodulin-2	P29965	CD40LG	CD40 ligand	-0.721
P0DP23	CALM1	Calmodulin-1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.701

Nifedipine

hsa05150

Staphylococcus aureus infection

4.36E-02

P0C0L4, P13646

C4A, KRT13

Nifedipine

hsa05161

Hepatitis B

1.11E-05

P17252, P18848, P23458, P25963, Q13485, P31751, P10415, P27348, P84022, P01568, P42224, P51617

PRKCA, ATF4, JAK1, NFKBIA, SMAD4, AKT2, BCL2, YWHAQ, SMAD3, IFNA21, STAT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P27348	YWHAQ	14-3-3 protein theta	0.777
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703

Nifedipine

hsa05162

Measles

1.74E-04

P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415

IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2

Nifedipine

hsa05163

Human cytomegalovirus infection

2.59E-03

P31751, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568

AKT2, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21

Nifedipine

hsa05164

Influenza A

7.10E-03

P48551, P60709, P63261

IFNAR2, ACTB, ACTG1

Nifedipine

hsa05168

Herpes simplex virus 1 infection

2.45E-05

P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232

IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.743
P0DP24	CALM2	Calmodulin-2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.772
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP25	CALM3	Calmodulin-3	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP24	CALM2	Calmodulin-2	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP23	CALM1	Calmodulin-1	Q6P280	ZNF529	Zinc finger protein 529	0.767
P0DP23	CALM1	Calmodulin-1	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP25	CALM3	Calmodulin-3	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP24	CALM2	Calmodulin-2	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP23	CALM1	Calmodulin-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP25	CALM3	Calmodulin-3	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP24	CALM2	Calmodulin-2	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.797

Nifedipine

hsa05170

Human immunodeficiency virus 1 infection

4.12E-05

P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5

AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P23528	CFL1	Cofilin-1	-0.832
P0DP25	CALM3	Calmodulin-3	P23528	CFL1	Cofilin-1	-0.832
P0DP24	CALM2	Calmodulin-2	P23528	CFL1	Cofilin-1	-0.832
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP25	CALM3	Calmodulin-3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP24	CALM2	Calmodulin-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742

Nifedipine

hsa05171

Coronavirus disease - COVID-19

1.08E-04

P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386

RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1

Nifedipine

hsa05200

Pathways in cancer

4.30E-09

P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042

JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP25	CALM3	Calmodulin-3	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP24	CALM2	Calmodulin-2	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP23	CALM1	Calmodulin-1	P14923	JUP	Junction plakoglobin	-0.852
P0DP25	CALM3	Calmodulin-3	P14923	JUP	Junction plakoglobin	-0.852
P0DP24	CALM2	Calmodulin-2	P14923	JUP	Junction plakoglobin	-0.852
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP25	CALM3	Calmodulin-3	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP24	CALM2	Calmodulin-2	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.731
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP23	CALM1	Calmodulin-1	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.718
P0DP23	CALM1	Calmodulin-1	P00734	F2	Prothrombin	-0.738
P0DP23	CALM1	Calmodulin-1	P01042	KNG1	Kininogen-1	-0.71
P0DP25	CALM3	Calmodulin-3	P01042	KNG1	Kininogen-1	-0.71
P0DP24	CALM2	Calmodulin-2	P01042	KNG1	Kininogen-1	-0.71

Nifedipine

hsa05204

Chemical carcinogenesis

3.70E-03

P00325, P78417, P33260

ADH1B, GSTO1, CYP2C18

Nifedipine

hsa05206

MicroRNAs in cancer

4.07E-02

P15311, P63279

VIL2, UBE2I

Nifedipine

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Nifedipine

hsa05212

Pancreatic cancer

5.79E-04

P31751, Q15311, P23458, P42224, P84022, Q13485, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B

Nifedipine

hsa05214

Glioma

2.38E-06

P09619, P0DP23, Q13557, P17252, Q02750, P31751, P19174, O75293

PDGFRB, CALM1, CAMK2D, PRKCA, MAP2K1, AKT2, PLCG1, GADD45B

Nifedipine

hsa05218

Melanoma

1.34E-02

P09619, Q02750

PDGFRB, MAP2K1

Nifedipine

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Nifedipine

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Nifedipine

hsa05224

Breast cancer

3.88E-02

P46531, Q9UM47, O15169

NOTCH1, NOTCH3, AXIN1

Nifedipine

hsa05225

Hepatocellular carcinoma

4.07E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Nifedipine

hsa05230

Central carbon metabolism in cancer

4.10E-02

P09619, Q02750

PDGFRB, MAP2K1

Nifedipine

hsa05340

Primary immunodeficiency

2.68E-02

P11912, P07766

CD79A, CD3E

Nifedipine

hsa05410

Hypertrophic cardiomyopathy

1.02E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

8.96E-03

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa05414

Dilated cardiomyopathy

1.73E-02

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa05415

Diabetic cardiomyopathy

2.75E-02

P17252, P14598, Q15080, Q16718

PRKCA, NCF1, NCF4, NDUFA5

Nifedipine

hsa05416

Viral myocarditis

8.96E-03

P60709, P63261

ACTB, ACTG1

Nifedipine

hsa05418

Fluid shear stress and atherosclerosis

3.64E-03

P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974

NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2

Community members of Nifedipine (S_DC: 2.35)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P0DP23

CALM1

CalmodulinNone1

Reported

0.4552

0.1479

1.5235

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P54284

CACNB3

VoltageNonedependent LNonetype calcium channel subunit betaNone3

Predicted

0.1026

0.1539

0.3291

0.6881

P0DP25

CALM3

CalmodulinNone3

Predicted

0.5661

0.1479

0.5789

P0DP24

CALM2

CalmodulinNone2

Predicted

0.4376

0.1479

0.5147

P16389

KCNA2

Potassium voltageNonegated channel subfamily A member 2

Predicted

0.0131

0.0835

0.1736

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P17658

KCNA6

Potassium voltageNonegated channel subfamily A member 6

Predicted

0.2827

0.0785

0.2984

Q9ULS6

KCNS2

Potassium voltageNonegated channel subfamily S member 2

Predicted

0.1955

0.0412

0.1801

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

P60660

MYL6

Myosin light polypeptide 6

Predicted

0.5595

0.0687

0.2175

0.6346

P24844

MYL9

Myosin regulatory light polypeptide 9

Predicted

0.0064

0.063

0.6026

0.7318

P14649

MYL6B

Myosin light chain 6B

Predicted

0.0477

0.0653

0.2175

0.3719

P05976

MYL1

Myosin light chain 1/3, skeletal muscle isoform

Predicted

0.2581

0.0619

0.2528

O15182

CETN3

CentrinNone3

Predicted

0.1872

0.0594

0.2123

Q96A32

MYLPF

Myosin regulatory light chain 2, skeletal muscle isoform

Predicted

0.0135

0.0473

0.5412

0.6425

PharmaCoNets of Nifedipine (SPCN: 42.24 )

Nifedipine regulated-network (SDN: 17.97)

Community members of Nifedipine (SDC: 2.35)

PharmaCoNets of Nifedipine (S_PCN: 42.24 )

Nifedipine regulated-network (S_DN: 17.97)

Community members of Nifedipine (S_DC: 2.35)