PharmaCoNets of Nicotinamide (SPCN: 13.78 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nicotinamidehsa00030Pentose phosphate pathway2.27E-022P60891, P37837PRPS1, TALDO1More
Nicotinamidehsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Nicotinamidehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Nicotinamidehsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Nicotinamidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Nicotinamidehsa00980Metabolism of xenobiotics by cytochrome P4504.50E-021P28332ADH6More
Nicotinamidehsa00982Drug metabolism - cytochrome P4504.50E-021P28332ADH6More
Nicotinamidehsa012102-Oxocarboxylic acid metabolism3.56E-021P50213IDH3AMore
Nicotinamidehsa03008Ribosome biogenesis in eukaryotes2.99E-022P78345, Q9BVP2RPP38, GNL3More
Nicotinamidehsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Nicotinamidehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Nicotinamidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Nicotinamidehsa04130SNARE interactions in vesicular transport1.27E-021O15155BET1More
Nicotinamidehsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Nicotinamidehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Nicotinamidehsa04360Axon guidance1.66E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Nicotinamidehsa04390Hippo signaling pathway2.30E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Nicotinamidehsa04550Signaling pathways regulating pluripotency of stem cells1.96E-023P04628, P40189, P14653WNT1, IL6ST, HOXB1More
Nicotinamidehsa04612Antigen processing and presentation2.21E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Nicotinamidehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Nicotinamidehsa04630JAK-STAT signaling pathway4.43E-023P48551, P40189, Q06124IFNAR2, IL6ST, PTPN11More
Nicotinamidehsa04640Hematopoietic cell lineage1.58E-026P13612, P20023, P11836, P09693, P01732, P13765ITGA4, CR2, MS4A1, CD3G, CD8A, HLA-DOBMore
Nicotinamidehsa04650Natural killer cell mediated cytotoxicity1.28E-026P20963, Q13241, P26718, O14931, P26717, P26715CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Nicotinamidehsa04658Th1 and Th2 cell differentiation1.36E-025P20963, P09693, P23771, Q9UL17, P13765CD247, CD3G, GATA3, TBX21, HLA-DOBMore
Nicotinamidehsa04659Th17 cell differentiation3.36E-025P13765, Q9UL17, P23771, P09693, P20963HLA-DOB, TBX21, GATA3, CD3G, CD247More
Nicotinamidehsa04660T cell receptor signaling pathway1.58E-026O95267, Q08881, P20963, P09693, P01732, Q13191RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Nicotinamidehsa04672Intestinal immune network for IgA production4.27E-022P13765, P13612HLA-DOB, ITGA4More
Nicotinamidehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Nicotinamidehsa05020Prion disease3.28E-022Q92736, O60282RYR2, KIF5CMore
Nicotinamidehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Nicotinamidehsa05132Salmonella infection4.83E-022O00471, O60282EXOC5, KIF5CMore
Nicotinamidehsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Nicotinamidehsa05169Epstein-Barr virus infection3.10E-027P20023, P13765, Q92769, O00463, P24522, P09693, P20963CR2, HLA-DOB, HDAC2, TRAF5, GADD45A, CD3G, CD247More
Nicotinamidehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Nicotinamidehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Nicotinamidehsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Nicotinamidehsa05321Inflammatory bowel disease3.98E-023P13765, Q9UL17, P23771HLA-DOB, TBX21, GATA3More
Nicotinamidehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Nicotinamidehsa05332Graft-versus-host disease1.89E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Nicotinamidehsa05416Viral myocarditis2.30E-022P10747, P63261CD28, ACTG1More

Community members of Nicotinamide (SDC: 2.87)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Reported10.553610.44822.725
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q86W56PARGPoly(ADPNoneribose) glycohydrolasePredicted00.03580.044100.106
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PARP1P09874IC5050119
PARP1P09874IC50210000