PharmaCoNets of Nicergoline (SPCN: 58.90 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nicergolinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Nicergolinehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Nicergolinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Nicergolinehsa00240Pyrimidine metabolism2.20E-023P21589, P32320, P04183NT5E, CDA, TK1More
Nicergolinehsa00500Starch and sucrose metabolism9.19E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nicergolinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Nicergolinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Nicergolinehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Nicergolinehsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Nicergolinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Nicergolinehsa00790Folate biosynthesis4.74E-022P07101, P42330TH, AKR1C3More
Nicergolinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Nicergolinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Nicergolinehsa00983Drug metabolism - other enzymes7.78E-043P04183, P32320, P05164TK1, CDA, MPOMore
Nicergolinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Nicergolinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Nicergolinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Nicergolinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Nicergolinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Nicergolinehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Nicergolinehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Nicergolinehsa04060Cytokine-cytokine receptor interaction3.33E-028P48551, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P01730IFNAR2, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, CD4More
Nicergolinehsa04061Viral protein interaction with cytokine and cytokine receptor4.51E-036P51684, P32248, P09341, P02775, P47992, Q9UBD3CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2More
Nicergolinehsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Nicergolinehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Nicergolinehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Nicergolinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Nicergolinehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Nicergolinehsa04140Autophagy - animal2.09E-024Q9NQL2, Q14643, P10415, Q04759RRAGD, ITPR1, BCL2, PRKCQMore
Nicergolinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Nicergolinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Nicergolinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Nicergolinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Nicergolinehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Nicergolinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Nicergolinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Nicergolinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Nicergolinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Nicergolinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Nicergolinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Nicergolinehsa04657IL-17 signaling pathway1.69E-058O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Nicergolinehsa04658Th1 and Th2 cell differentiation1.71E-025Q04759, P09693, P01730, P23771, P13765PRKCQ, CD3G, CD4, GATA3, HLA-DOBMore
Nicergolinehsa04659Th17 cell differentiation4.92E-039Q04759, P01730, P42224, P14784, P13765, P40189, P23771, P08238, P09693PRKCQ, CD4, STAT1, IL2RB, HLA-DOB, IL6ST, GATA3, HSP90AB1, CD3GMore
Nicergolinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Nicergolinehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Nicergolinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Nicergolinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Nicergolinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Nicergolinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Nicergolinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Nicergolinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Nicergolinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Nicergolinehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Nicergolinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Nicergolinehsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Nicergolinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Nicergolinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Nicergolinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nicergolinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Nicergolinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Nicergolinehsa04966Collecting duct acid secretion2.52E-022P02730, Q9Y666SLC4A1, SLC12A7More
Nicergolinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Nicergolinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Nicergolinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Nicergolinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Nicergolinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Nicergolinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nicergolinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Nicergolinehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Nicergolinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Nicergolinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Nicergolinehsa05146Amoebiasis3.33E-039P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACBMore
Nicergolinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Nicergolinehsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Nicergolinehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Nicergolinehsa05169Epstein-Barr virus infection4.06E-027P13765, P04637, P10415, P24522, P48551, P29728, P09693HLA-DOB, TP53, BCL2, GADD45A, IFNAR2, OAS2, CD3GMore
Nicergolinehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Nicergolinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Nicergolinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Nicergolinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Nicergolinehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Nicergolinehsa05213Endometrial cancer4.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Nicergolinehsa05214Glioma2.03E-036P0DP23, Q16566, P42338, P04637, P24522, O75293CALM1, CAMK4, PIK3CB, TP53, GADD45A, GADD45BMore
Nicergolinehsa05216Thyroid cancer1.35E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Nicergolinehsa05217Basal cell carcinoma3.97E-034Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Nicergolinehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Nicergolinehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Nicergolinehsa05226Gastric cancer3.41E-025Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Nicergolinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Nicergolinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Nicergolinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nicergolinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Nicergolinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Nicergolinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Nicergolinehsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Nicergoline (SDC: 4.97)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)