PharmaCoNets of Netupitant (SPCN: 51.30 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Netupitanthsa00052Galactose metabolism2.33E-032P06280, O43451GLA, MGAMMore
Netupitanthsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Netupitanthsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Netupitanthsa00500Starch and sucrose metabolism8.52E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Netupitanthsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Netupitanthsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Netupitanthsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Netupitanthsa00730Thiamine metabolism5.68E-042P05186, P24666ALPL, ACP1More
Netupitanthsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Netupitanthsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Netupitanthsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Netupitanthsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Netupitanthsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Netupitanthsa03040Spliceosome2.92E-0614Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Netupitanthsa03050Proteasome4.83E-021P55036PSMD4More
Netupitanthsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Netupitanthsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Netupitanthsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Netupitanthsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Netupitanthsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Netupitanthsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Netupitanthsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Netupitanthsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Netupitanthsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Netupitanthsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Netupitanthsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Netupitanthsa04370VEGF signaling pathway3.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Netupitanthsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Netupitanthsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Netupitanthsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Netupitanthsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Netupitanthsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Netupitanthsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Netupitanthsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Netupitanthsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Netupitanthsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Netupitanthsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Netupitanthsa04662B cell receptor signaling pathway1.17E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Netupitanthsa04664Fc epsilon RI signaling pathway1.62E-047P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Netupitanthsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Netupitanthsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Netupitanthsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Netupitanthsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Netupitanthsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Netupitanthsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Netupitanthsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Netupitanthsa04742Taste transduction3.91E-021P17612PRKACAMore
Netupitanthsa04914Progesterone-mediated oocyte maturation1.00E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Netupitanthsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Netupitanthsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Netupitanthsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Netupitanthsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Netupitanthsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Netupitanthsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Netupitanthsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Netupitanthsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Netupitanthsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Netupitanthsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Netupitanthsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Netupitanthsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Netupitanthsa05120Epithelial cell signaling in Helicobacter pylori infection3.14E-023Q16539, P25024, P25025MAPK14, CXCR1, CXCR2More
Netupitanthsa05133Pertussis4.20E-021P0C0L4C4AMore
Netupitanthsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Netupitanthsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Netupitanthsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Netupitanthsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Netupitanthsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Netupitanthsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Netupitanthsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Netupitanthsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Netupitanthsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Netupitanthsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Netupitanthsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Netupitanthsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Netupitanthsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Netupitanthsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Netupitant (SDC: 6.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P24666ACP1Low molecular weight phosphotyrosine protein phosphatasePredicted00.07040.10480.23610.481
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)