PharmaCoNets of Netarsudil (SPCN: 257.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Netarsudilhsa00030Pentose phosphate pathway1.28E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Netarsudilhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Netarsudilhsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Netarsudilhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Netarsudilhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Netarsudilhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Netarsudilhsa00190Oxidative phosphorylation1.36E-036P13073, Q16718, O15239, P12074, P05496, O14521COX4I1, NDUFA5, NDUFA1, COX6A1, ATP5G1, SDHDMore
Netarsudilhsa00220Arginine biosynthesis4.87E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Netarsudilhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Netarsudilhsa00250Alanine, aspartate and glutamate metabolism4.40E-032P49448, P15104GLUD2, GLULMore
Netarsudilhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Netarsudilhsa00310Lysine degradation2.86E-022Q96KQ7, Q02809EHMT2, PLOD1More
Netarsudilhsa00471D-Glutamine and D-glutamate metabolism3.94E-021P49448GLUD2More
Netarsudilhsa00480Glutathione metabolism3.02E-021P48506GCLCMore
Netarsudilhsa00500Starch and sucrose metabolism1.33E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Netarsudilhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Netarsudilhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Netarsudilhsa00513Various types of N-glycan biosynthesis2.36E-031Q9NR34MAN1C1More
Netarsudilhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Netarsudilhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Netarsudilhsa00562Inositol phosphate metabolism4.55E-022P27987, P42338ITPKB, PIK3CBMore
Netarsudilhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Netarsudilhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Netarsudilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Netarsudilhsa00591Linoleic acid metabolism1.95E-031P11712CYP2C9More
Netarsudilhsa00600Sphingolipid metabolism2.46E-033P07602, Q13510, P15289PSAP, ASAH1, ARSAMore
Netarsudilhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Netarsudilhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Netarsudilhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Netarsudilhsa00730Thiamine metabolism2.43E-032P05186, P24666ALPL, ACP1More
Netarsudilhsa00740Riboflavin metabolism3.03E-021P30043BLVRBMore
Netarsudilhsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Netarsudilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Netarsudilhsa00830Retinol metabolism3.75E-056P00325, P11766, P00352, Q9BPW9, O75911, P11712ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3, CYP2C9More
Netarsudilhsa00860Porphyrin and chlorophyll metabolism1.73E-032P36551, P30043CPOX, BLVRBMore
Netarsudilhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Netarsudilhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Netarsudilhsa00920Sulfur metabolism5.99E-041Q16762TSTMore
Netarsudilhsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Netarsudilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Netarsudilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Netarsudilhsa00983Drug metabolism - other enzymes2.83E-023P20839, P32320, P05164IMPDH1, CDA, MPOMore
Netarsudilhsa01100Metabolic pathways3.02E-0330Q9NR34, P05089, P21953, P15104, P42338, P27987, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, Q9HCC0, P33121, P09917, P57054, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, MCCC2, ACSL1, ALOX5, PIGP, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Netarsudilhsa012102-Oxocarboxylic acid metabolism7.29E-041P50213IDH3AMore
Netarsudilhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Netarsudilhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Netarsudilhsa01521EGFR tyrosine kinase inhibitor resistance3.45E-044P49841, P04049, P08069, Q9NRA1GSK3B, RAF1, IGF1R, PDGFCMore
Netarsudilhsa01522Endocrine resistance2.21E-037P14780, P22694, P04049, Q9UM47, P08069, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, IGF1R, BCL2, BIKMore
Netarsudilhsa01523Antifolate resistance6.83E-053Q92820, P04818, P18054GGH, TYMS, ALOX12More
Netarsudilhsa01524Platinum drug resistance4.42E-023P10415, Q13489, P23025BCL2, BIRC3, XPAMore
Netarsudilhsa02010ABC transporters3.36E-054P45844, P08183, Q8IZY2, Q99758ABCG1, ABCB1, ABCA7, ABCA3More
Netarsudilhsa03008Ribosome biogenesis in eukaryotes1.37E-034O14980, O60832, P78345, Q9BVP2XPO1, DKC1, RPP38, GNL3More
Netarsudilhsa03010Ribosome6.10E-0412P62753, P39019, P42677, P62917, Q9H0U6, Q07020, P61513, Q02878, P63173, P27635, P05386, P23396RPS6, RPS19, RPS27, RPL8, MRPL18, RPL18, RPL37A, RPL6, RPL38, RPL10, RPLP1, RPS3More
Netarsudilhsa03013RNA transport9.32E-0920O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3, FXR1More
Netarsudilhsa03018RNA degradation3.02E-021Q13901C1DMore
Netarsudilhsa03020RNA polymerase2.45E-112Q9GZM3, P52435POLR2J2, POLR2JMore
Netarsudilhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Netarsudilhsa03040Spliceosome4.98E-0718Q14562, O43143, O60508, P08579, Q15427, P26368, P52298, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, NCBP2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Netarsudilhsa03050Proteasome4.83E-021P55036PSMD4More
Netarsudilhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Netarsudilhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Netarsudilhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Netarsudilhsa03430Mismatch repair4.38E-021P20585MSH3More
Netarsudilhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Netarsudilhsa04010MAPK signaling pathway4.73E-037P04049, Q15283, P21860, P08069, Q12933, P01584, O14944RAF1, RASA2, ERBB3, IGF1R, TRAF2, IL1B, EREGMore
Netarsudilhsa04012ErbB signaling pathway8.14E-034P21860, Q13557, O14944, P04049ERBB3, CAMK2D, EREG, RAF1More
Netarsudilhsa04014Ras signaling pathway4.60E-0310P04049, P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174RAF1, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Netarsudilhsa04015Rap1 signaling pathway2.15E-0716P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1More
Netarsudilhsa04020Calcium signaling pathway5.35E-068Q96DU7, Q08828, P45880, Q13557, P21860, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, SLC25A5, ADCY7, ATP2B4More
Netarsudilhsa04022cGMP-PKG signaling pathway4.95E-048P24844, P04049, Q99941, P23634, Q8WYR1, P51828, P45880, Q15746MYL9, RAF1, CREBL1, ATP2B4, PIK3R5, ADCY7, VDAC2, MYLKMore
Netarsudilhsa04024cAMP signaling pathway1.66E-034P04049, P48058, P25116, P24844RAF1, GRIA4, F2R, MYL9More
Netarsudilhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Netarsudilhsa04061Viral protein interaction with cytokine and cytokine receptor2.01E-049P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Netarsudilhsa04062Chemokine signaling pathway8.22E-0719P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P04049, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, RAF1, PIK3R5More
Netarsudilhsa04064NF-kappa B signaling pathway7.21E-1622P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Netarsudilhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Netarsudilhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Netarsudilhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Netarsudilhsa04071Sphingolipid signaling pathway6.75E-1312P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, P01042RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, KNG1More
Netarsudilhsa04072Phospholipase D signaling pathway3.15E-039P04049, P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, Q08828RAF1, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, ADCY1More
Netarsudilhsa04080Neuroactive ligand-receptor interaction8.38E-1114P08311, Q15722, P21453, Q9H228, O00398, P25116, Q01726, P41968, P21462, P21730, Q16581, P07550, P01042, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, F2R, MC1R, MC3R, FPR1, C5AR1, C3AR1, ADRB2, KNG1, ADMMore
Netarsudilhsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Netarsudilhsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Netarsudilhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Netarsudilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Netarsudilhsa04122Sulfur relay system5.99E-041Q16762TSTMore
Netarsudilhsa04136Autophagy - other2.44E-052O94817, Q9H1Y0ATG12, ATG5More
Netarsudilhsa04140Autophagy - animal2.32E-047P08069, P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Netarsudilhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Netarsudilhsa04144Endocytosis4.51E-022P40818, P49407USP8, ARRB1More
Netarsudilhsa04145Phagosome5.04E-0811O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Netarsudilhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Netarsudilhsa04151PI3K-Akt signaling pathway5.02E-0316P42338, P43657, O43521, P20827, P49767, Q13362, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P23458, Q6ZUJ8, P30281PIK3CB, P2RY5, BCL2L11, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, JAK1, PIK3AP1, CCND3More
Netarsudilhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Netarsudilhsa04210Apoptosis2.38E-0412Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, RAF1More
Netarsudilhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Netarsudilhsa04213Longevity regulating pathway - multiple species3.72E-047P42338, P08069, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1More
Netarsudilhsa04215Apoptosis - multiple species3.01E-022Q13489, P10415BIRC3, BCL2More
Netarsudilhsa04216Ferroptosis4.50E-021P48506GCLCMore
Netarsudilhsa04217Necroptosis2.64E-0310P01375, P01568, P48023, Q13489, Q13546, Q14765, Q6FI13, Q99878, P10415, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2AMore
Netarsudilhsa04218Cellular senescence8.08E-035P01106, P04049, O75293, P30304, P06493MYC, RAF1, GADD45B, CDC25A, CDK1More
Netarsudilhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Netarsudilhsa04270Vascular smooth muscle contraction5.32E-046Q15746, P24844, P04049, Q08828, P35579, P35318MYLK, MYL9, RAF1, ADCY1, MYH9, ADMMore
Netarsudilhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Netarsudilhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Netarsudilhsa04340Hedgehog signaling pathway2.53E-075P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Netarsudilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Netarsudilhsa04360Axon guidance7.76E-0511P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174, Q06124, O14639, P24844NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1, PTPN11, ABLIM1, MYL9More
Netarsudilhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Netarsudilhsa04371Apelin signaling pathway4.16E-038P63218, P50151, Q8WYR1, P04049, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, RAF1, MEF2D, GNA13, SMAD4, SMAD3More
Netarsudilhsa04380Osteoclast differentiation2.42E-0412Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Netarsudilhsa04390Hippo signaling pathway2.41E-034P63261, O15105, P04628, O43623ACTG1, SMAD7, WNT1, SNAI2More
Netarsudilhsa04510Focal adhesion2.26E-049P16144, P08514, Q15746, P24844, Q15942, Q13489, P10415, P04049, P08069ITGB4, ITGA2B, MYLK, MYL9, ZYX, BIRC3, BCL2, RAF1, IGF1RMore
Netarsudilhsa04512ECM-receptor interaction2.02E-032P07359, P08514GP1BA, ITGA2BMore
Netarsudilhsa04514Cell adhesion molecules5.78E-053P16109, P56750, O00501SELP, CLDN17, CLDN5More
Netarsudilhsa04520Adherens junction8.29E-031P08069IGF1RMore
Netarsudilhsa04530Tight junction1.31E-108Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Netarsudilhsa04540Gap junction2.13E-046P17252, P22694, Q13509, P68371, P04049, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, RAF1, ITPR1More
Netarsudilhsa04550Signaling pathways regulating pluripotency of stem cells2.80E-045P04628, P40189, P04049, P08069, P14653WNT1, IL6ST, RAF1, IGF1R, HOXB1More
Netarsudilhsa04610Complement and coagulation cascades3.90E-117P25116, P01042, P09871, P00734, P0C0L4, P10909, Q16581F2R, KNG1, C1S, F2, C4A, CLU, C3AR1More
Netarsudilhsa04611Platelet activation5.68E-128P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P17612, P07359F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, PRKACA, GP1BAMore
Netarsudilhsa04612Antigen processing and presentation3.64E-089P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Netarsudilhsa04613Neutrophil extracellular trap formation3.09E-1528P17252, P04049, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, RAF1, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Netarsudilhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Netarsudilhsa04621NOD-like receptor signaling pathway2.29E-0616Q16539, Q14643, P23458, P25963, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, JAK1, NFKBIA, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Netarsudilhsa04623Cytosolic DNA-sensing pathway2.86E-022P01568, Q13546IFNA21, RIPK1More
Netarsudilhsa04625C-type lectin receptor signaling pathway2.72E-0410Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Netarsudilhsa04630JAK-STAT signaling pathway3.67E-034P48551, P40189, Q06124, P04049IFNAR2, IL6ST, PTPN11, RAF1More
Netarsudilhsa04640Hematopoietic cell lineage4.88E-0917P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Netarsudilhsa04650Natural killer cell mediated cytotoxicity5.95E-1214P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Netarsudilhsa04657IL-17 signaling pathway1.34E-0811P25963, O00463, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Netarsudilhsa04658Th1 and Th2 cell differentiation7.48E-2016Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Netarsudilhsa04659Th17 cell differentiation2.00E-1320Q04759, Q16539, P19174, P01730, P06239, P42226, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Netarsudilhsa04660T cell receptor signaling pathway5.54E-1819P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Netarsudilhsa04662B cell receptor signaling pathway1.07E-046P42338, P60033, P07948, P21854, Q8N149, P04049PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Netarsudilhsa04664Fc epsilon RI signaling pathway1.31E-057P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Netarsudilhsa04666Fc gamma R-mediated phagocytosis2.24E-037O75015, P04049, P23528, P06396, O14494, P14598, P17252FCGR3B, RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Netarsudilhsa04668TNF signaling pathway1.73E-0411P01375, Q12933, O00463, Q13489, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429TNF, TRAF2, TRAF5, BIRC3, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4More
Netarsudilhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Netarsudilhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Netarsudilhsa04713Circadian entrainment2.75E-037P0DP23, Q13557, Q02153, P17252, P62873, Q14643, Q08828CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, ITPR1, ADCY1More
Netarsudilhsa04714Thermogenesis2.22E-0410Q16539, Q08828, P62753, P33121, P13073, P12074, O15239, Q16718, O14521, P05496MAPK14, ADCY1, RPS6, ACSL1, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHD, ATP5G1More
Netarsudilhsa04720Long-term potentiation2.79E-035P17252, Q16566, P0DP23, P04049, Q14643PRKCA, CAMK4, CALM1, RAF1, ITPR1More
Netarsudilhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Netarsudilhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Netarsudilhsa04725Cholinergic synapse2.86E-046P22694, Q14643, P17252, P62873, Q16566, P10415PRKACB, ITPR1, PRKCA, GNB1, CAMK4, BCL2More
Netarsudilhsa04726Serotonergic synapse7.13E-035Q14643, P17252, P62873, P33260, P04049ITPR1, PRKCA, GNB1, CYP2C18, RAF1More
Netarsudilhsa04727GABAergic synapse3.63E-022P50151, P15104GNG10, GLULMore
Netarsudilhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Netarsudilhsa04742Taste transduction3.91E-021P17612PRKACAMore
Netarsudilhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Netarsudilhsa04750Inflammatory mediator regulation of TRP channels5.39E-0613P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Netarsudilhsa04810Regulation of actin cytoskeleton4.34E-055P24844, Q15746, P04049, P08514, P25116MYL9, MYLK, RAF1, ITGA2B, F2RMore
Netarsudilhsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Netarsudilhsa04911Insulin secretion6.45E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Netarsudilhsa04912GnRH signaling pathway6.10E-0513P17252, Q08828, P51828, P18848, Q13557, Q16539, Q99759, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K3, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1More
Netarsudilhsa04913Ovarian steroidogenesis6.44E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Netarsudilhsa04914Progesterone-mediated oocyte maturation4.47E-042P08069, P04049IGF1R, RAF1More
Netarsudilhsa04915Estrogen signaling pathway3.98E-048P04049, Q99941, Q08828, P51828, P07900, P0DMV8, P11142, Q15788RAF1, CREBL1, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, NCOA1More
Netarsudilhsa04916Melanogenesis2.03E-033P49841, Q01726, P04049GSK3B, MC1R, RAF1More
Netarsudilhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Netarsudilhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Netarsudilhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Netarsudilhsa04920Adipocytokine signaling pathway3.60E-047P25963, P33121, Q04759, Q15831, P20333, Q9Y4H2, P01375NFKBIA, ACSL1, PRKCQ, STK11, TNFRSF1B, IRS2, TNFMore
Netarsudilhsa04921Oxytocin signaling pathway1.14E-046Q15746, Q08828, P04049, P24844, Q96RR4, Q8WYR1MYLK, ADCY1, RAF1, MYL9, CAMKK2, PIK3R5More
Netarsudilhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Netarsudilhsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Netarsudilhsa04924Renin secretion2.80E-063P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Netarsudilhsa04925Aldosterone synthesis and secretion2.18E-048Q14643, Q99941, P51828, P0DP23, P17252, Q16566, Q13557, P23634ITPR1, CREBL1, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B4More
Netarsudilhsa04926Relaxin signaling pathway3.12E-045P42338, P50151, P02452, P04049, P49407PIK3CB, GNG10, COL1A1, RAF1, ARRB1More
Netarsudilhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Netarsudilhsa04928Parathyroid hormone synthesis, secretion and action5.30E-045Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Netarsudilhsa04929GnRH secretion5.75E-043P42338, P49407, P04049PIK3CB, ARRB1, RAF1More
Netarsudilhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Netarsudilhsa04932Non-alcoholic fatty liver disease1.07E-0511P01375, P49841, P18848, P48023, Q12933, P01584, P13073, P12074, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Netarsudilhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Netarsudilhsa04934Cushing syndrome9.24E-068Q14643, Q99941, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Netarsudilhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Netarsudilhsa04940Type I diabetes mellitus9.23E-054P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Netarsudilhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Netarsudilhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Netarsudilhsa04966Collecting duct acid secretion5.21E-064Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Netarsudilhsa04970Salivary secretion1.47E-045P07550, P22694, Q14643, P17252, P49913ADRB2, PRKACB, ITPR1, PRKCA, CAMPMore
Netarsudilhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Netarsudilhsa04972Pancreatic secretion4.73E-022Q08828, P62491ADCY1, RAB11AMore
Netarsudilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Netarsudilhsa04974Protein digestion and absorption3.03E-021P02452COL1A1More
Netarsudilhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Netarsudilhsa05010Alzheimer disease2.87E-0514Q92542, O15239, P05496, P13073, P12074, O75460, P01584, Q12933, P18848, O15169, P05141, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, ERN1, IL1B, TRAF2, ATF4, AXIN1, SLC25A5, VDAC2, PSMB4, PSMC4More
Netarsudilhsa05012Parkinson disease2.56E-0410P62987, O15239, P13073, P12074, P05496, P05141, P18848, P28070, P43686, Q13557UBA52, NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ATF4, PSMB4, PSMC4, CAMK2DMore
Netarsudilhsa05014Amyotrophic lateral sclerosis2.94E-0412P20333, O15239, P13073, P12074, P05496, P18848, Q12933, P28070, P43686, P37198, P35658, Q9UBU9TNFRSF1B, NDUFA1, COX4I1, COX6A1, ATP5G1, ATF4, TRAF2, PSMB4, PSMC4, NUP62, NUP214, NXF1More
Netarsudilhsa05016Huntington disease9.49E-0812O15239, P13073, P12074, P05496, Q9GZM3, P24928, P62487, P52435, P05141, Q9NYC9, P28070, P43686NDUFA1, COX4I1, COX6A1, ATP5G1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, DNAH9, PSMB4, PSMC4More
Netarsudilhsa05020Prion disease7.47E-0823P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, P49841, P51636, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, GSK3B, CAV2, CREBL1, NCF1, NCF4, MAPK14More
Netarsudilhsa05022Pathways of neurodegeneration - multiple diseases7.53E-0726Q14643, Q13509, P68371, P49841, P10415, O15239, Q16718, O14521, P13073, P12074, P05496, P18848, Q12933, Q13561, P05141, P17252, P20333, Q16539, O15169, P01584, Q08752, P0DP23, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, ATF4, TRAF2, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, AXIN1, IL1B, PPID, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Netarsudilhsa05034Alcoholism2.78E-045P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Netarsudilhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Netarsudilhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Netarsudilhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Netarsudilhsa05130Pathogenic Escherichia coli infection4.91E-044Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Netarsudilhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Netarsudilhsa05132Salmonella infection9.82E-0414P51617, P25963, P01375, P04049, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, RAF1, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Netarsudilhsa05133Pertussis3.32E-075P0DP23, P23528, P09871, P0C0L4, Q02556CALM1, CFL1, C1S, C4A, IRF8More
Netarsudilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Netarsudilhsa05140Leishmaniasis2.66E-1115P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Netarsudilhsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Netarsudilhsa05144Malaria6.98E-068P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Netarsudilhsa05145Toxoplasmosis8.39E-0511P51617, P25963, Q16539, P01375, P10415, Q13489, P23458, P13765, Q8WYR1, P0DMV8, O60603IRAK1, NFKBIA, MAPK14, TNF, BCL2, BIRC3, JAK1, HLA-DOB, PIK3R5, HSPA1A, TLR2More
Netarsudilhsa05146Amoebiasis4.92E-1113P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Netarsudilhsa05150Staphylococcus aureus infection3.43E-0712P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Netarsudilhsa05152Tuberculosis1.76E-0718P04049, Q13488, Q99437, P13473, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617RAF1, TCIRG1, ATP6V0B, LAMP2, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Netarsudilhsa05160Hepatitis C1.98E-048P60033, O00501, P29728, P04049, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, RAF1, GSK3B, TNF, FASLG, MYCMore
Netarsudilhsa05161Hepatitis B4.82E-039P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Netarsudilhsa05162Measles2.68E-022P23458, P0DMV8JAK1, HSPA1AMore
Netarsudilhsa05163Human cytomegalovirus infection6.53E-0313P04049, P62873, Q14643, P0DP23, P49841, P14778, P17252, P25025, Q16539, P04637, Q13546, O00463, P01568RAF1, GNB1, ITPR1, CALM1, GSK3B, IL1R1, PRKCA, CXCR2, MAPK14, TP53, RIPK1, TRAF5, IFNA21More
Netarsudilhsa05164Influenza A3.65E-021P04049RAF1More
Netarsudilhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Netarsudilhsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Netarsudilhsa05169Epstein-Barr virus infection1.02E-0316P13765, P01106, Q13547, O00463, P16070, P10415, Q16539, P07948, Q13761, P24522, Q8WV28, P01375, O60603, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, CD44, BCL2, MAPK14, LYN, RUNX3, GADD45A, BLNK, TNF, TLR2, CD3E, CD3G, CD247More
Netarsudilhsa05170Human immunodeficiency virus 1 infection1.13E-0721P04049, P62873, P0DP23, P01375, P17252, Q13546, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P23528, Q9NQU5, P10415, Q13619, Q93034, Q9Y6Q5, P20333RAF1, GNB1, CALM1, TNF, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CFL1, PAK6, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Netarsudilhsa05171Coronavirus disease - COVID-192.46E-0417P01375, P01584, P51617, P25963, P42224, P23396, P62753, P39019, P42677, Q02878, P62917, P27635, Q07020, P61513, P63173, P05386, P04141TNF, IL1B, IRAK1, NFKBIA, STAT1, RPS3, RPS6, RPS19, RPS27, RPL6, RPL8, RPL10, RPL18, RPL37A, RPL38, RPLP1, CSF2More
Netarsudilhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Netarsudilhsa05202Transcriptional misregulation in cancer5.14E-1826Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P68431, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, HDAC1, HDAC2, LYL1, GADD45AMore
Netarsudilhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Netarsudilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Netarsudilhsa05205Proteoglycans in cancer2.57E-036Q12955, P04049, Q14247, P17252, P08069, P08962ANK3, RAF1, CTTN, PRKCA, IGF1R, CD63More
Netarsudilhsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Netarsudilhsa05210Colorectal cancer1.66E-021P04049RAF1More
Netarsudilhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Netarsudilhsa05212Pancreatic cancer1.85E-036P42338, P04049, P37173, P84022, Q13485, O75293PIK3CB, RAF1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Netarsudilhsa05213Endometrial cancer9.95E-031P04049RAF1More
Netarsudilhsa05214Glioma9.08E-052P08069, P04049IGF1R, RAF1More
Netarsudilhsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Netarsudilhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Netarsudilhsa05217Basal cell carcinoma1.30E-034Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Netarsudilhsa05218Melanoma7.23E-055P08069, P09619, Q9GZP0, Q02750, P04049IGF1R, PDGFRB, PDGFD, MAP2K1, RAF1More
Netarsudilhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Netarsudilhsa05220Chronic myeloid leukemia3.00E-036Q13547, Q13485, P84022, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, PIK3CB, RAF1, GADD45BMore
Netarsudilhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Netarsudilhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Netarsudilhsa05223Non-small cell lung cancer6.95E-044P10826, P04049, Q9HC35, O75293RARB, RAF1, EML4, GADD45BMore
Netarsudilhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Netarsudilhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Netarsudilhsa05226Gastric cancer8.29E-031P04049RAF1More
Netarsudilhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Netarsudilhsa05231Choline metabolism in cancer1.49E-035Q02750, P04049, P09619, Q9GZP0, O15245MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1More
Netarsudilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.17E-0815P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Netarsudilhsa05310Asthma7.17E-094P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Netarsudilhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Netarsudilhsa05321Inflammatory bowel disease4.34E-199O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B, IL21RMore
Netarsudilhsa05322Systemic lupus erythematosus3.97E-0613O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Netarsudilhsa05323Rheumatoid arthritis1.05E-035P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Netarsudilhsa05330Allograft rejection1.60E-045P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Netarsudilhsa05332Graft-versus-host disease2.64E-136P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Netarsudilhsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Netarsudilhsa05412Arrhythmogenic right ventricular cardiomyopathy3.75E-056Q8IZS8, P54284, P14923, P08514, P13612, Q9UJU2CACNA2D3, CACNB3, JUP, ITGA2B, ITGA4, LEF1More
Netarsudilhsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Netarsudilhsa05415Diabetic cardiomyopathy3.67E-0512P05141, O15239, Q16718, O14521, P05496, P13073, P12074, Q92736, Q16539, P49841, Q13557, P02452SLC25A5, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, MAPK14, GSK3B, CAMK2D, COL1A1More
Netarsudilhsa05416Viral myocarditis2.18E-034P13765, P29965, P10747, P63261HLA-DOB, CD40LG, CD28, ACTG1More
Netarsudilhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Netarsudil (SDC: 9.26)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P46531NOTCH1Neurogenic locus notch homolog protein 1Predicted00.44070.02220.50470.7694
Q9UM47NOTCH3Neurogenic locus notch homolog protein 3Predicted00.35290.02220.48680.7077
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2Predicted10.06950.040200.1151
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
Q16581C3AR1C3a anaphylatoxin chemotactic receptorPredicted00.13880.03850.34280.4892
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P40818USP8Ubiquitin carboxylNoneterminal hydrolase 8Predicted00.22780.02220.20360.362
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13489BIRC3Baculoviral IAP repeatNonecontaining protein 3Predicted00.33620.04930.84721.114
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)