PharmaCoNets of Nelfinavir (SPCN: 41.16 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nelfinavirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Nelfinavirhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nelfinavirhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Nelfinavirhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Nelfinavirhsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nelfinavirhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nelfinavirhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Nelfinavirhsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Nelfinavirhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Nelfinavirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Nelfinavirhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Nelfinavirhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Nelfinavirhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Nelfinavirhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Nelfinavirhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Nelfinavirhsa04071Sphingolipid signaling pathway4.61E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Nelfinavirhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Nelfinavirhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Nelfinavirhsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Nelfinavirhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Nelfinavirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Nelfinavirhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Nelfinavirhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Nelfinavirhsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Nelfinavirhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Nelfinavirhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Nelfinavirhsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Nelfinavirhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Nelfinavirhsa04657IL-17 signaling pathway7.74E-047O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Nelfinavirhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Nelfinavirhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Nelfinavirhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Nelfinavirhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Nelfinavirhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Nelfinavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Nelfinavirhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Nelfinavirhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Nelfinavirhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Nelfinavirhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Nelfinavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Nelfinavirhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Nelfinavirhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Nelfinavirhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Nelfinavirhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Nelfinavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nelfinavirhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Nelfinavirhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Nelfinavirhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Nelfinavirhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Nelfinavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Nelfinavirhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Nelfinavirhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Nelfinavirhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Nelfinavirhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Nelfinavirhsa05133Pertussis4.20E-021P0C0L4C4AMore
Nelfinavirhsa05140Leishmaniasis1.46E-038P13612, O75015, P13765, O60603, P01375, P49006, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4More
Nelfinavirhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Nelfinavirhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Nelfinavirhsa05145Toxoplasmosis3.96E-022P28068, Q16787HLA-DMB, LAMA3More
Nelfinavirhsa05146Amoebiasis5.02E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Nelfinavirhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Nelfinavirhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Nelfinavirhsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Nelfinavirhsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Nelfinavirhsa05166Human T-cell leukemia virus 1 infection2.91E-023Q02930, P28068, Q13315CREB5, HLA-DMB, ATMMore
Nelfinavirhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Nelfinavirhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Nelfinavirhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Nelfinavirhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Nelfinavirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Nelfinavirhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Nelfinavirhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Nelfinavirhsa05332Graft-versus-host disease3.46E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Nelfinavirhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Nelfinavirhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Nelfinavir (SDC: 4.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)