PharmaCoNets of Nelarabine (SPCN: 162.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nelarabinehsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Nelarabinehsa00030Pentose phosphate pathway9.98E-044P51854, P08237, P52209, P37837TKTL1, PFKM, PGD, TALDO1More
Nelarabinehsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Nelarabinehsa00052Galactose metabolism6.10E-033P06280, O43451, P35557GLA, MGAM, GCKMore
Nelarabinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nelarabinehsa00100Steroid biosynthesis4.70E-021P35610SOAT1More
Nelarabinehsa00220Arginine biosynthesis3.73E-032P05089, P49448ARG1, GLUD2More
Nelarabinehsa00230Purine metabolism2.11E-023Q7LG56, P31350, P21589RRM2B, RRM2, NT5EMore
Nelarabinehsa00240Pyrimidine metabolism6.02E-096Q7LG56, P31350, P21589, P32320, P04183, P04818RRM2B, RRM2, NT5E, CDA, TK1, TYMSMore
Nelarabinehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Nelarabinehsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Nelarabinehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Nelarabinehsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Nelarabinehsa00471D-Glutamine and D-glutamate metabolism6.90E-042Q7Z3D6, P49448C14orf159, GLUD2More
Nelarabinehsa00480Glutathione metabolism3.36E-056Q9UJ14, Q16772, P09211, Q7LG56, P31350, P30041GGTL3, GSTA3, GSTP1, RRM2B, RRM2, PRDX6More
Nelarabinehsa00500Starch and sucrose metabolism6.00E-064O43451, P46976, P35557, P06737MGAM, GYG1, GCK, PYGLMore
Nelarabinehsa00512Mucin type O-glycan biosynthesis1.31E-032O95395, Q8N4A0GCNT3, GALNT4More
Nelarabinehsa00524Neomycin, kanamycin and gentamicin biosynthesis8.73E-041P35557GCKMore
Nelarabinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Nelarabinehsa00564Glycerophospholipid metabolism3.84E-045P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Nelarabinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nelarabinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Nelarabinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Nelarabinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Nelarabinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Nelarabinehsa00630Glyoxylate and dicarboxylate metabolism2.86E-072P40925, P15104MDH1, GLULMore
Nelarabinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Nelarabinehsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Nelarabinehsa00900Terpenoid backbone biosynthesis3.05E-021Q01581HMGCS1More
Nelarabinehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Nelarabinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Nelarabinehsa00980Metabolism of xenobiotics by cytochrome P4508.69E-065Q16772, P78417, P11766, P09211, P11712GSTA3, GSTO1, ADH5, GSTP1, CYP2C9More
Nelarabinehsa00982Drug metabolism - cytochrome P4501.66E-055P11712, Q16772, P09211, P78417, P11766CYP2C9, GSTA3, GSTP1, GSTO1, ADH5More
Nelarabinehsa00983Drug metabolism - other enzymes3.59E-097P04183, P32320, Q7LG56, P31350, P05164, Q16772, P09211TK1, CDA, RRM2B, RRM2, MPO, GSTA3, GSTP1More
Nelarabinehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Nelarabinehsa01100Metabolic pathways6.27E-0541Q9Y234, P35790, Q9Y259, Q16772, P09211, Q9UJ14, P15144, P30041, O14732, Q13956, Q02153, Q16774, P20839, P00918, P40926, P10768, P55809, P06280, Q7KZN9, Q9Y6K0, P15121, P08237, P49619, P21399, O95954, Q02318, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, Q9UBX8, O96024, P37837, P50213, P43490, P35573, Q9BQB6, Q969G6, Q13029, Q9NVH6LIPT1, CHKA, CHKB, GSTA3, GSTP1, GGTL3, ANPEP, PRDX6, IMPA2, PDE6H, GUCY1B3, GUK1, IMPDH1, CA2, MDH2, ESD, OXCT1, GLA, COX15, CEPT1, AKR1B1, PFKM, DGKG, ACO1, FTCD, CYP27A1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B4GALT6, B3GALT4, TALDO1, IDH3A, PBEF1, AGL, VKORC1, RFK, PRDM2, TMLHEMore
Nelarabinehsa01200Carbon metabolism3.30E-0413P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P10768, Q02252ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1More
Nelarabinehsa012102-Oxocarboxylic acid metabolism6.75E-042P21399, P50213ACO1, IDH3AMore
Nelarabinehsa01230Biosynthesis of amino acids2.08E-0410P60174, P04406, P06733, P04075, P08237, P51854, Q99707, P21399, P50213, P37837TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, MTR, ACO1, IDH3A, TALDO1More
Nelarabinehsa01521EGFR tyrosine kinase inhibitor resistance2.82E-022P49841, P42338GSK3B, PIK3CBMore
Nelarabinehsa01522Endocrine resistance2.84E-023P22694, Q9UM47, P46527PRKACB, NOTCH3, CDKN1BMore
Nelarabinehsa01524Platinum drug resistance6.95E-034Q16772, P09211, P78417, P52701GSTA3, GSTP1, GSTO1, MSH6More
Nelarabinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Nelarabinehsa03008Ribosome biogenesis in eukaryotes8.16E-033Q9NYH9, P78345, Q9GZY0UTP6, RPP38, NXF2; NXF2BMore
Nelarabinehsa03010Ribosome1.22E-022P46777, P50914RPL5, RPL14More
Nelarabinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Nelarabinehsa03015mRNA surveillance pathway3.37E-023O43148, Q9GZY0, P52298RNMT, NXF2; NXF2B, NCBP2More
Nelarabinehsa03020RNA polymerase8.48E-065P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Nelarabinehsa03040Spliceosome2.22E-1214Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Nelarabinehsa03060Protein export2.65E-033Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Nelarabinehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Nelarabinehsa03430Mismatch repair4.38E-021P20585MSH3More
Nelarabinehsa04012ErbB signaling pathway2.82E-022P49841, P42338GSK3B, PIK3CBMore
Nelarabinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Nelarabinehsa04015Rap1 signaling pathway2.64E-0310P20827, P49767, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174EFNA1, VEGFC, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1More
Nelarabinehsa04020Calcium signaling pathway5.11E-049P27987, P21796, P45880, Q13557, P30679, P19174, P0DP23, P05141, P23634ITPKB, VDAC1, VDAC2, CAMK2D, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4More
Nelarabinehsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Nelarabinehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Nelarabinehsa04060Cytokine-cytokine receptor interaction3.16E-024P27930, P14778, P25024, O75509IL1R2, IL1R1, CXCR1, TNFRSF21More
Nelarabinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Nelarabinehsa04062Chemokine signaling pathway4.14E-0516P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, GSK3B, PIK3R5More
Nelarabinehsa04064NF-kappa B signaling pathway5.13E-0821P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Nelarabinehsa04070Phosphatidylinositol signaling system1.67E-036P19174, P0DP23, P42338, O14986, P23743, P27987PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, ITPKBMore
Nelarabinehsa04071Sphingolipid signaling pathway1.54E-047Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Nelarabinehsa04072Phospholipase D signaling pathway3.22E-036P42338, Q9UQC2, P43657, P25024, P25025, P19174PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1More
Nelarabinehsa04080Neuroactive ligand-receptor interaction8.70E-035P00734, Q96G91, Q01726, P41968, P14416F2, P2RY11, MC1R, MC3R, DRD2More
Nelarabinehsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Nelarabinehsa04115p53 signaling pathway1.37E-058P24522, Q13315, Q7LG56, P31350, Q9HA38, P04637, O95067, P10415GADD45A, ATM, RRM2B, RRM2, ZMAT3, TP53, CCNB2, BCL2More
Nelarabinehsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Nelarabinehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Nelarabinehsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Nelarabinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Nelarabinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Nelarabinehsa04150mTOR signaling pathway3.46E-022P42338, P49841PIK3CB, GSK3BMore
Nelarabinehsa04151PI3K-Akt signaling pathway1.64E-0321P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, P30279, P30281RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, CCND2, CCND3More
Nelarabinehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Nelarabinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Nelarabinehsa04213Longevity regulating pathway - multiple species2.70E-037P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Nelarabinehsa04217Necroptosis1.06E-0311P01568, Q13489, Q13546, P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880IFNA21, BIRC3, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2More
Nelarabinehsa04261Adrenergic signaling in cardiomyocytes1.71E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Nelarabinehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Nelarabinehsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Nelarabinehsa04330Notch signaling pathway3.28E-034Q92542, P49768, Q92830, P78504NCSTN, PSEN1, KAT2A, JAG1More
Nelarabinehsa04340Hedgehog signaling pathway1.37E-035P49841, P22694, Q13635, P49407, P10415GSK3B, PRKACB, PTCH1, ARRB1, BCL2More
Nelarabinehsa04360Axon guidance2.47E-037P16333, P20827, O95631, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1More
Nelarabinehsa04371Apelin signaling pathway1.23E-037P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Nelarabinehsa04380Osteoclast differentiation1.79E-047Q9UQC2, Q16539, P42338, P14778, O75015, P01375, Q8N149GAB2, MAPK14, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2More
Nelarabinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Nelarabinehsa04510Focal adhesion4.60E-023Q15942, P51636, P30281ZYX, CAV2, CCND3More
Nelarabinehsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Nelarabinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Nelarabinehsa04610Complement and coagulation cascades4.31E-074P00734, P0C0L4, P05107, P21730F2, C4A, ITGB2, C5AR1More
Nelarabinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Nelarabinehsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Nelarabinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Nelarabinehsa04621NOD-like receptor signaling pathway3.39E-038P01568, P25963, Q13489, Q13546, Q05823, P01375, P49913, P12838IFNA21, NFKBIA, BIRC3, RIPK1, RNASEL, TNF, CAMP, DEFA4More
Nelarabinehsa04622RIG-I-like receptor signaling pathway1.53E-034P01568, Q13546, Q12933, P10145IFNA21, RIPK1, TRAF2, IL8More
Nelarabinehsa04623Cytosolic DNA-sensing pathway9.06E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Nelarabinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Nelarabinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Nelarabinehsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Nelarabinehsa04657IL-17 signaling pathway2.40E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Nelarabinehsa04658Th1 and Th2 cell differentiation4.79E-0710Q04759, P07766, P20963, Q16539, P19174, P01730, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, MAPK14, PLCG1, CD4, LCK, TBX21, IL2RB, RUNX3More
Nelarabinehsa04659Th17 cell differentiation5.82E-1016Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P14778, P40189, Q9UL17, P84022, Q13485, P07900, P08238, P07766, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, SMAD3, SMAD4, HSP90AA1, HSP90AB1, CD3E, CD247More
Nelarabinehsa04660T cell receptor signaling pathway8.88E-0511Q04759, P42338, P19174, P07766, P20963, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Nelarabinehsa04662B cell receptor signaling pathway5.80E-076P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Nelarabinehsa04664Fc epsilon RI signaling pathway1.75E-057P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Nelarabinehsa04666Fc gamma R-mediated phagocytosis3.17E-034P42338, P23528, Q9UQC2, P14598PIK3CB, CFL1, GAB2, NCF1More
Nelarabinehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Nelarabinehsa04713Circadian entrainment4.76E-024P0DP23, Q13557, P62873, P63218CALM1, CAMK2D, GNB1, GNG5More
Nelarabinehsa04721Synaptic vesicle cycle3.77E-021P43003SLC1A3More
Nelarabinehsa04724Glutamatergic synapse3.88E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Nelarabinehsa04725Cholinergic synapse5.23E-036P62873, P63218, P50151, P18848, Q13557, P42338GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CBMore
Nelarabinehsa04727GABAergic synapse3.09E-045P62873, P63218, P50151, P15104, P46459GNB1, GNG5, GNG10, GLUL, NSFMore
Nelarabinehsa04728Dopaminergic synapse1.82E-0412P14416, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP23, P48058DRD2, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM1, GRIA4More
Nelarabinehsa04730Long-term depression3.20E-022Q14344, P07948GNA13, LYNMore
Nelarabinehsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Nelarabinehsa04744Phototransduction1.42E-022P62873, P0DP23GNB1, CALM1More
Nelarabinehsa04750Inflammatory mediator regulation of TRP channels7.24E-0611P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1, KNG1More
Nelarabinehsa04911Insulin secretion4.31E-022P22694, P18848PRKACB, ATF4More
Nelarabinehsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Nelarabinehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Nelarabinehsa04915Estrogen signaling pathway1.27E-0310Q99941, P18848, Q08828, P51828, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Nelarabinehsa04916Melanogenesis2.82E-022P49841, Q01726GSK3B, MC1RMore
Nelarabinehsa04917Prolactin signaling pathway2.82E-022P42338, P49841PIK3CB, GSK3BMore
Nelarabinehsa04918Thyroid hormone synthesis4.31E-022P22694, P18848PRKACB, ATF4More
Nelarabinehsa04923Regulation of lipolysis in adipocytes4.17E-045P22694, P07550, P06213, P42338, Q9Y4H2PRKACB, ADRB2, INSR, PIK3CB, IRS2More
Nelarabinehsa04924Renin secretion2.54E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Nelarabinehsa04925Aldosterone synthesis and secretion3.35E-024Q99941, P18848, P0DP23, Q13557CREBL1, ATF4, CALM1, CAMK2DMore
Nelarabinehsa04926Relaxin signaling pathway8.02E-046P42338, P63218, P50151, P49767, P30679, P49407PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1More
Nelarabinehsa04927Cortisol synthesis and secretion1.86E-022P18848, P22694ATF4, PRKACBMore
Nelarabinehsa04929GnRH secretion1.13E-032P42338, P49407PIK3CB, ARRB1More
Nelarabinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Nelarabinehsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Nelarabinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Nelarabinehsa04934Cushing syndrome2.84E-023P18848, P22694, P46527ATF4, PRKACB, CDKN1BMore
Nelarabinehsa04940Type I diabetes mellitus2.99E-022P10747, P01375CD28, TNFMore
Nelarabinehsa04950Maturity onset diabetes of the young8.73E-041P35557GCKMore
Nelarabinehsa04960Aldosterone-regulated sodium reabsorption6.19E-043P06213, P42338, P48048INSR, PIK3CB, KCNJ1More
Nelarabinehsa04964Proximal tubule bicarbonate reclamation4.53E-032P00918, P49448CA2, GLUD2More
Nelarabinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Nelarabinehsa04970Salivary secretion1.77E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Nelarabinehsa04971Gastric acid secretion3.46E-022P48048, P78508KCNJ1, KCNJ10More
Nelarabinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Nelarabinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Nelarabinehsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Nelarabinehsa05010Alzheimer disease4.56E-029P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Nelarabinehsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Nelarabinehsa05016Huntington disease5.53E-0619O95298, P19404, P13073, P12074, Q13547, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P21796, P45880, Q9NYC9, O75460, Q71U36, Q13509, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, HDAC1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC1, VDAC2, DNAH9, ERN1, TUBA1A, TUBB3, PSMB4, PSMD12More
Nelarabinehsa05017Spinocerebellar ataxia1.93E-035Q92915, Q8TB72, O15399, P42338, P21796FGF14, PUM2, GRIN2D, PIK3CB, VDAC1More
Nelarabinehsa05020Prion disease9.64E-0310P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1More
Nelarabinehsa05022Pathways of neurodegeneration - multiple diseases1.36E-0212Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2DMore
Nelarabinehsa05030Cocaine addiction4.31E-022P22694, P18848PRKACB, ATF4More
Nelarabinehsa05031Amphetamine addiction6.57E-035P0DP23, Q13557, Q99941, P18848, Q13547CALM1, CAMK2D, CREBL1, ATF4, HDAC1More
Nelarabinehsa05032Morphine addiction1.01E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Nelarabinehsa05034Alcoholism2.40E-0410Q99941, P18848, Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nelarabinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Nelarabinehsa05120Epithelial cell signaling in Helicobacter pylori infection5.53E-068Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSKMore
Nelarabinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Nelarabinehsa05133Pertussis8.35E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Nelarabinehsa05134Legionellosis1.03E-048P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Nelarabinehsa05143African trypanosomiasis7.35E-042P69905, P68871HBA2, HBBMore
Nelarabinehsa05144Malaria4.24E-068P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Nelarabinehsa05146Amoebiasis2.52E-079P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Nelarabinehsa05150Staphylococcus aureus infection5.16E-035P0C0L4, P21730, P21462, P13646, P05107C4A, C5AR1, FPR1, KRT13, ITGB2More
Nelarabinehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Nelarabinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Nelarabinehsa05163Human cytomegalovirus infection1.74E-0515P42338, P01375, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463PIK3CB, TNF, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5More
Nelarabinehsa05165Human papillomavirus infection9.48E-048P46527, P35443, P01375, Q08999, Q9UM47, P22694, Q13362, Q13315CDKN1B, THBS4, TNF, RBL2, NOTCH3, PRKACB, PPP2R5C, ATMMore
Nelarabinehsa05166Human T-cell leukemia virus 1 infection4.93E-026P22694, P18848, P25963, P25208, Q13315, P01375PRKACB, ATF4, NFKBIA, NFYB, ATM, TNFMore
Nelarabinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-027P42224, P62873, P63218, P19875, P19174, P07948, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Nelarabinehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Nelarabinehsa05169Epstein-Barr virus infection4.48E-039Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3EMore
Nelarabinehsa05200Pathways in cancer1.45E-0630Q16363, Q13751, P42338, P07900, P08238, P42224, P19174, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, Q13557, P14784, P40189, P01042LAMA4, LAMB3, PIK3CB, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, IL6ST, KNG1More
Nelarabinehsa05202Transcriptional misregulation in cancer6.60E-0618Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P46527, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, CDKN1B, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Nelarabinehsa05203Viral carcinogenesis2.25E-0619Q08999, Q12933, Q99941, P18848, P42229, P06746, P07948, P30279, P27348, P29083, Q7KZF4, P46527, Q13547, Q15283, P06396, P25963, P22694, P62807, O60814RBL2, TRAF2, CREBL1, ATF4, STAT5A, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, CDKN1B, HDAC1, RASA2, GSN, NFKBIA, PRKACB, HIST1H2BC, H2BC12More
Nelarabinehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Nelarabinehsa05206MicroRNAs in cancer1.67E-024P46527, Q9UM47, P35226, Q13315CDKN1B, NOTCH3, BMI1, ATMMore
Nelarabinehsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Nelarabinehsa05212Pancreatic cancer2.14E-035P42338, P42224, P84022, Q13485, O75293PIK3CB, STAT1, SMAD3, SMAD4, GADD45BMore
Nelarabinehsa05213Endometrial cancer2.82E-022P49841, P42338GSK3B, PIK3CBMore
Nelarabinehsa05214Glioma8.31E-045P0DP23, Q13557, P42338, P19174, O75293CALM1, CAMK2D, PIK3CB, PLCG1, GADD45BMore
Nelarabinehsa05215Prostate cancer1.08E-023P49841, P42338, P27930GSK3B, PIK3CB, IL1R2More
Nelarabinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Nelarabinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Nelarabinehsa05224Breast cancer4.88E-022P42338, P49841PIK3CB, GSK3BMore
Nelarabinehsa05225Hepatocellular carcinoma3.69E-023P42338, P49841, P51531PIK3CB, GSK3B, SMARCA2More
Nelarabinehsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Nelarabinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.26E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q16539, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, MAPK14, CD4More
Nelarabinehsa05310Asthma3.01E-022P13765, P12724HLA-DOB, RNASE3More
Nelarabinehsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Nelarabinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nelarabinehsa05330Allograft rejection4.31E-022P10747, P01375CD28, TNFMore
Nelarabinehsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Nelarabinehsa05410Hypertrophic cardiomyopathy2.60E-022P26012, P09493ITGB8, TPM1More
Nelarabinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Nelarabinehsa05418Fluid shear stress and atherosclerosis1.02E-0511Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Nelarabine (SDC: 6.74)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11142HSPA8Heat shock cognate 71 kDa proteinPredicted00.96820.07730.67291.3115
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P21589NT5E5'NonenucleotidasePredicted10.29240.08550.15390.4711
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P43003SLC1A3Excitatory amino acid transporter 1Predicted00.09730.07740.16580.3692
P43005SLC1A1Excitatory amino acid transporter 3Predicted00.08270.06630.0190.193
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q53EL6PDCD4Programmed cell death protein 4Predicted00.38990.06530.32020.6457
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P51531SMARCA2Probable global transcription activator SNF2L2Predicted00.22310.0450.13750.3391
P35557GCKHexokinaseNone4Predicted00.00490.05580.32420.4382
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P49913CAMPCathelicidin antimicrobial peptidePredicted10.33560.04070.52750.7766
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)