PharmaCoNets

PharmaCoNets of Nefazodone (S_PCN: 148.16 )

Nefazodone regulated-network (S_DN: 16.82)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nefazodone

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Nefazodone

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Nefazodone

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Nefazodone

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Nefazodone

hsa00220

Arginine biosynthesis

3.02E-05

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Nefazodone

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Nefazodone

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Nefazodone

hsa00500

Starch and sucrose metabolism

6.79E-08

O43451, P46976, P06737

MGAM, GYG1, PYGL

Nefazodone

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Nefazodone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Nefazodone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Nefazodone

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Nefazodone

hsa00630

Glyoxylate and dicarboxylate metabolism

6.37E-05

P40925, P15104

MDH1, GLUL

Nefazodone

hsa00730

Thiamine metabolism

2.21E-07

P05186, P24666

ALPL, ACP1

Nefazodone

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Nefazodone

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Nefazodone

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Nefazodone

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Nefazodone

hsa00970

Aminoacyl-tRNA biosynthesis

1.92E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Nefazodone

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Nefazodone

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Nefazodone

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Nefazodone

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Nefazodone

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Nefazodone

hsa01230

Biosynthesis of amino acids

1.42E-04

P51854, P60891, Q99707, P15104, P37837

TKTL1, PRPS1, MTR, GLUL, TALDO1

Nefazodone

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Nefazodone

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Nefazodone

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Nefazodone

hsa03013

RNA transport

3.08E-05

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3

Nefazodone

hsa03020

RNA polymerase

5.06E-03

P24928, P62487

POLR2A, POLR2G

Nefazodone

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Nefazodone

hsa03040

Spliceosome

4.08E-05

Q14562, O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Nefazodone

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Nefazodone

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Nefazodone

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Nefazodone

hsa04012

ErbB signaling pathway

3.31E-02

Q13153

PAK1

Nefazodone

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Nefazodone

hsa04024

cAMP signaling pathway

4.80E-02

Q13153

PAK1

Nefazodone

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Nefazodone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Nefazodone

hsa04062

Chemokine signaling pathway

6.08E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Nefazodone

hsa04064

NF-kappa B signaling pathway

7.87E-09

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Nefazodone

hsa04071

Sphingolipid signaling pathway

2.41E-06

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Nefazodone

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Nefazodone

hsa04080

Neuroactive ligand-receptor interaction

1.08E-04

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM

Nefazodone

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Nefazodone

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Nefazodone

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Nefazodone

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Nefazodone

hsa04144

Endocytosis

1.24E-02

Q13191, P11142, O75351, P62491, P25024, P43250, Q14161, P14784, Q9Y5X3

CBLB, HSPA8, VPS4B, RAB11A, CXCR1, GRK6, GIT2, IL2RB, SNX5

Nefazodone

hsa04145

Phagosome

7.50E-03

Q15080, P14598, Q13509, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774

NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSS

Nefazodone

hsa04151

PI3K-Akt signaling pathway

7.39E-03

P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8

RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1

Nefazodone

hsa04210

Apoptosis

2.95E-04

Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1

Nefazodone

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Nefazodone

hsa04217

Necroptosis

3.89E-04

P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444

TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4B

Nefazodone

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Nefazodone

hsa04340

Hedgehog signaling pathway

1.76E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Nefazodone

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Nefazodone

hsa04392

Hippo signaling pathway - multiple species

1.51E-02

Q13153

PAK1

Nefazodone

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Nefazodone

hsa04610

Complement and coagulation cascades

1.15E-08

P0C0L4

C4A

Nefazodone

hsa04612

Antigen processing and presentation

2.51E-06

P13765, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375

HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF

Nefazodone

hsa04613

Neutrophil extracellular trap formation

2.56E-06

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863

Nefazodone

hsa04621

NOD-like receptor signaling pathway

3.34E-04

Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838

MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Nefazodone

hsa04625

C-type lectin receptor signaling pathway

8.18E-03

Q9ULY5, Q13153, P20749, P01375, Q16539

CLEC4E, PAK1, BCL3, TNF, MAPK14

Nefazodone

hsa04640

Hematopoietic cell lineage

1.03E-05

P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Nefazodone

hsa04650

Natural killer cell mediated cytotoxicity

2.01E-14

P19174, P01375, P06239, O60880, P20963, P42338, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Nefazodone

hsa04657

IL-17 signaling pathway

1.15E-06

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769

Nefazodone

hsa04658

Th1 and Th2 cell differentiation

1.83E-15

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73

Nefazodone

hsa04659

Th17 cell differentiation

4.18E-12

Q04759, Q16539, P19174, P01730, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Nefazodone

hsa04660

T cell receptor signaling pathway

1.11E-11

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Nefazodone

hsa04662

B cell receptor signaling pathway

2.54E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Nefazodone

hsa04664

Fc epsilon RI signaling pathway

2.20E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5

Nefazodone

hsa04668

TNF signaling pathway

1.99E-05

P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P01584, P20749, Q13077, P14780, P20333

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B

Nefazodone

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Nefazodone

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Nefazodone

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Nefazodone

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Nefazodone

hsa04725

Cholinergic synapse

4.10E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Nefazodone

hsa04727

GABAergic synapse

1.82E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Nefazodone

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Nefazodone

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Nefazodone

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Nefazodone

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Nefazodone

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Nefazodone

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Nefazodone

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Nefazodone

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Nefazodone

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Nefazodone

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Nefazodone

hsa04926

Relaxin signaling pathway

3.93E-04

P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407

PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1

Nefazodone

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Nefazodone

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Nefazodone

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Nefazodone

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Nefazodone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Nefazodone

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Nefazodone

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Nefazodone

hsa04966

Collecting duct acid secretion

9.41E-05

P02730, P00918

SLC4A1, CA2

Nefazodone

hsa04970

Salivary secretion

2.82E-03

P07550, P22694, Q14643, P17252, P49913

ADRB2, PRKACB, ITPR1, PRKCA, CAMP

Nefazodone

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Nefazodone

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Nefazodone

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Nefazodone

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Nefazodone

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Nefazodone

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Nefazodone

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Nefazodone

hsa05022

Pathways of neurodegeneration - multiple diseases

6.94E-04

P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24

GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2

Nefazodone

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Nefazodone

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Nefazodone

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Nefazodone

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.35E-06

Q16539, Q13153, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Nefazodone

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Nefazodone

hsa05132

Salmonella infection

2.98E-02

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Nefazodone

hsa05133

Pertussis

3.47E-04

P0C0L4

C4A

Nefazodone

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Nefazodone

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Nefazodone

hsa05140

Leishmaniasis

9.33E-04

O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Nefazodone

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Nefazodone

hsa05144

Malaria

1.12E-04

P60033, P69905, P68871, P01375, P35443, P26718

CD81, HBA2, HBB, TNF, THBS4, KLRK1

Nefazodone

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Nefazodone

hsa05146

Amoebiasis

1.52E-08

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09341	CXCL1	Growth-regulated alpha protein	-0.796
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P05089	ARG1	Arginase-1	-0.703
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P12814	ACTN1	Alpha-actinin-1	-0.8
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P08311	CTSG	Cathepsin G	-0.733

Nefazodone

hsa05150

Staphylococcus aureus infection

5.34E-03

P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P12838

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, DEFA4

Nefazodone

hsa05152

Tuberculosis

9.13E-03

Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617

TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1

Nefazodone

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Nefazodone

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Nefazodone

hsa05163

Human cytomegalovirus infection

1.78E-04

P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788

Nefazodone

hsa05169

Epstein-Barr virus infection

1.44E-04

P13765, P01106, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Nefazodone

hsa05170

Human immunodeficiency virus 1 infection

1.06E-03

P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5

TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2

Nefazodone

hsa05202

Transcriptional misregulation in cancer

5.55E-07

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q16548, Q13489, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7

Nefazodone

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Nefazodone

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Nefazodone

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Nefazodone

hsa05211

Renal cell carcinoma

2.42E-02

Q13153

PAK1

Nefazodone

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Nefazodone

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Nefazodone

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Nefazodone

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Nefazodone

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Nefazodone

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Nefazodone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.10E-07

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746

Nefazodone

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Nefazodone

hsa05321

Inflammatory bowel disease

1.94E-06

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3

Nefazodone

hsa05322

Systemic lupus erythematosus

1.11E-05

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Nefazodone

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Nefazodone

hsa05332

Graft-versus-host disease

2.84E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Nefazodone

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Nefazodone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

6.71E-04

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Nefazodone

hsa05414

Dilated cardiomyopathy

2.58E-03

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Nefazodone

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Nefazodone

hsa05418

Fluid shear stress and atherosclerosis

1.79E-05

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Nefazodone (S_DC: 8.81)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

SLC6A4

SodiumNonedependent serotonin transporter

Reported

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P00352

ALDH1A1

Aldehyde dehydrogenase 1A1

Predicted

0.3208

0.2925

0.1543

0.8998

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

P06737

PYGL

Glycogen phosphorylase, liver form

Predicted

0.3733

0.2211

0.3169

0.9457

O14786

NRP1

NeuropilinNone1

Predicted

0.3834

0.2026

0.5153

1.1123

Q13153

PAK1

Serine/threonineNoneprotein kinase PAK 1

Predicted

0.4647

0.3471

0.7819

1.7084

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Nefazodone (SPCN: 148.16 )

Nefazodone regulated-network (SDN: 16.82)

Community members of Nefazodone (SDC: 8.81)

PharmaCoNets of Nefazodone (S_PCN: 148.16 )

Nefazodone regulated-network (S_DN: 16.82)

Community members of Nefazodone (S_DC: 8.81)