PharmaCoNets

PharmaCoNets of Nedocromil (S_PCN: 57.74 )

Nedocromil regulated-network (S_DN: 19.18)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nedocromil

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Nedocromil

hsa00190

Oxidative phosphorylation

1.60E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Nedocromil

hsa00220

Arginine biosynthesis

6.33E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Nedocromil

hsa00240

Pyrimidine metabolism

2.20E-02

P21589, P32320, P04183

NT5E, CDA, TK1

Nedocromil

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Nedocromil

hsa00500

Starch and sucrose metabolism

9.22E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Nedocromil

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Nedocromil

hsa00591

Linoleic acid metabolism

3.18E-02

P11712

CYP2C9

Nedocromil

hsa00600

Sphingolipid metabolism

4.50E-02

P15289

ARSA

Nedocromil

hsa00630

Glyoxylate and dicarboxylate metabolism

6.56E-05

P40925, P40926, P15104

MDH1, MDH2, GLUL

Nedocromil

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Nedocromil

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Nedocromil

hsa00790

Folate biosynthesis

4.74E-02

P07101, P42330

TH, AKR1C3

Nedocromil

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Nedocromil

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Nedocromil

hsa00983

Drug metabolism - other enzymes

8.03E-05

P04183, P32320, P05164

TK1, CDA, MPO

Nedocromil

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Nedocromil

hsa02010

ABC transporters

4.48E-02

Q8IZY2

ABCA7

Nedocromil

hsa03008

Ribosome biogenesis in eukaryotes

2.60E-03

Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, RPP38, GNL3, NVL, NXF2; NXF2B

Nedocromil

hsa03010

Ribosome

1.53E-05

P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396

RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3

Nedocromil

hsa03013

RNA transport

4.19E-05

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Nedocromil

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Nedocromil

hsa03040

Spliceosome

4.11E-07

Q14562, O43143, O60508, Q99633, P17844, P51991, P61978, Q13595, Q07955, Q01130, Q13243, Q9UMS4, P11142

DHX8, DHX15, CDC40, PRPF18, DDX5, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS5, PRPF19, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P46091	GPR1	Chemerin-like receptor 2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P46091	GPR1	Chemerin-like receptor 2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P46091	GPR1	Chemerin-like receptor 2	O60508	CDC40	Pre-mRNA-processing factor 17	-0.778
P46091	GPR1	Chemerin-like receptor 2	Q99633	PRPF18	Pre-mRNA-splicing factor 18	-0.711
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P46091	GPR1	Chemerin-like receptor 2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.753
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P46091	GPR1	Chemerin-like receptor 2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P46091	GPR1	Chemerin-like receptor 2	Q9UMS4	PRPF19	Pre-mRNA-processing factor 19	0.703
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709

Nedocromil

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Nedocromil

hsa04014

Ras signaling pathway

8.66E-03

Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Nedocromil

hsa04015

Rap1 signaling pathway

1.58E-02

P20827, P49767, P63261, P25116, P0DP23, P17252

EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCA

Nedocromil

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Nedocromil

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Nedocromil

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Nedocromil

hsa04060

Cytokine-cytokine receptor interaction

2.13E-06

P27930, P14778, P08476, P26842, Q9UHF4, Q13651, P48551, P16871, Q9HBE5, P25024, Q9UBD3, P47992, P02775, P01375, P09341, P32248, P51684, P18510, P09603, P01730, Q93038

IL1R2, IL1R1, INHBA, CD27, IL20RA, IL10RA, IFNAR2, IL7R, IL21R, CXCR1, XCL2, XCL1, PPBP, TNF, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P08311	CTSG	Cathepsin G	P08476	INHBA	Inhibin beta A chain	0.848
P43657	P2RY5	Lysophosphatidic acid receptor 6	P26842	CD27	CD27 antigen	0.706
P32248	CCR7	C-C chemokine receptor type 7	Q9UHF4	IL20RA	Interleukin-20 receptor subunit alpha	0.756
P08311	CTSG	Cathepsin G	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.736
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P32249	GPR183	G-protein coupled receptor 183	P48551	IFNAR2	Interferon alpha/beta receptor 2	0.714
P32248	CCR7	C-C chemokine receptor type 7	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.743
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P43657	P2RY5	Lysophosphatidic acid receptor 6	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.794
P08311	CTSG	Cathepsin G	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.823
P32249	GPR183	G-protein coupled receptor 183	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.83
P32248	CCR7	C-C chemokine receptor type 7	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.741
P08311	CTSG	Cathepsin G	P47992	XCL1	Lymphotactin	-0.823
P32249	GPR183	G-protein coupled receptor 183	P47992	XCL1	Lymphotactin	0.83
P32248	CCR7	C-C chemokine receptor type 7	P47992	XCL1	Lymphotactin	0.741
P32249	GPR183	G-protein coupled receptor 183	P02775	PPBP	Platelet basic protein	0.794
P32248	CCR7	C-C chemokine receptor type 7	P02775	PPBP	Platelet basic protein	0.77
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
P32249	GPR183	G-protein coupled receptor 183	P09341	CXCL1	Growth-regulated alpha protein	-0.764
P32249	GPR183	G-protein coupled receptor 183	P32248	CCR7	C-C chemokine receptor type 7	0.887
P32248	CCR7	C-C chemokine receptor type 7	P32248	CCR7	C-C chemokine receptor type 7	1
P32249	GPR183	G-protein coupled receptor 183	P51684	CCR6	C-C chemokine receptor type 6	0.778
P32248	CCR7	C-C chemokine receptor type 7	P51684	CCR6	C-C chemokine receptor type 6	0.834
P08311	CTSG	Cathepsin G	P18510	IL1RN	Interleukin-1 receptor antagonist protein	0.73
P43657	P2RY5	Lysophosphatidic acid receptor 6	P18510	IL1RN	Interleukin-1 receptor antagonist protein	-0.787
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P32249	GPR183	G-protein coupled receptor 183	P01730	CD4	T-cell surface glycoprotein CD4	0.713
P08311	CTSG	Cathepsin G	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	-0.782

Nedocromil

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.30E-06

P51684, P32248, P09341, P02775, P47992, Q9UBD3, Q13651, Q9UHF4, P01375

CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2, IL10RA, IL20RA, TNF

Nedocromil

hsa04062

Chemokine signaling pathway

2.38E-05

P25024, P25025, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P49407, Q08881, Q13009, P14598, P42224, P25963, P49841

CXCR1, CXCR2, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, ARRB1, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Nedocromil

hsa04064

NF-kappa B signaling pathway

3.48E-08

P10415, Q13489, P25963, P51617, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P24158	PRTN3	Myeloblastin	O00463	TRAF5	TNF receptor-associated factor 5	-0.8
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P24158	PRTN3	Myeloblastin	Q04759	PRKCQ	Protein kinase C theta type	-0.845
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877

Nedocromil

hsa04066

HIF-1 signaling pathway

3.40E-02

Q09472, P07195, P10415

EP300, LDHB, BCL2

Nedocromil

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Nedocromil

hsa04070

Phosphatidylinositol signaling system

3.02E-03

P19174, P0DP23, Q14643, P23743, O14732, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, IMPA2, ITPKB, PRKCA

Nedocromil

hsa04071

Sphingolipid signaling pathway

5.09E-06

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P24158	PRTN3	Myeloblastin	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.82
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P24158	PRTN3	Myeloblastin	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.904
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P24158	PRTN3	Myeloblastin	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.756
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P51684	CCR6	C-C chemokine receptor type 6	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.819
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P51684	CCR6	C-C chemokine receptor type 6	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.876
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84

Nedocromil

hsa04080

Neuroactive ligand-receptor interaction

1.83E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Nedocromil

hsa04110

Cell cycle

2.06E-02

Q9UJX4, O60566, Q09472, P24522, P04637, P49918

ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1C

Nedocromil

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Nedocromil

hsa04140

Autophagy - animal

2.09E-02

Q9NQL2, Q14643, P10415, Q04759

RRAGD, ITPR1, BCL2, PRKCQ

Nedocromil

hsa04141

Protein processing in endoplasmic reticulum

2.83E-07

P18848, P30101, Q15437, Q15436, P60604, Q99941, P11142, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P14625	HSP90B1	Endoplasmin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.739
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q15437	SEC23B	Protein transport protein Sec23B	0.768
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q15437	SEC23B	Protein transport protein Sec23B	0.768
P14625	HSP90B1	Endoplasmin	Q15436	SEC23A	Protein transport protein Sec23A	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.7
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.7
P14625	HSP90B1	Endoplasmin	P14625	HSP90B1	Endoplasmin	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9H173	SIL1	Nucleotide exchange factor SIL1	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	-0.706

Nedocromil

hsa04145

Phagosome

1.75E-08

P11215, P63261, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P27824, P13765

ITGAM, ACTG1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
O00398	P2RY10	Putative P2Y purinoceptor 10	Q15080	NCF4	Neutrophil cytosol factor 4	-0.871
P46091	GPR1	Chemerin-like receptor 2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.702
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
O00398	P2RY10	Putative P2Y purinoceptor 10	P14598	NCF1	Neutrophil cytosol factor 1	-0.851
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13509	TUBB3	Tubulin beta-3 chain	-0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P46091	GPR1	Chemerin-like receptor 2	Q13509	TUBB3	Tubulin beta-3 chain	-0.748
O00398	P2RY10	Putative P2Y purinoceptor 10	P68371	TUBB2C	Tubulin beta-4B chain	-0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P46091	GPR1	Chemerin-like receptor 2	P68371	TUBB2C	Tubulin beta-4B chain	-0.751
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
O00398	P2RY10	Putative P2Y purinoceptor 10	P05164	MPO	Myeloperoxidase	-0.709
P24158	PRTN3	Myeloblastin	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	0.736
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P24158	PRTN3	Myeloblastin	P35443	THBS4	Thrombospondin-4	0.935
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P46091	GPR1	Chemerin-like receptor 2	P27824	CANX	Calnexin	-0.779
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
O00398	P2RY10	Putative P2Y purinoceptor 10	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.705

Nedocromil

hsa04151

PI3K-Akt signaling pathway

1.64E-07

P62753, O43521, P27348, P07900, P14625, Q8WYR1, Q16363, P22105, Q99941, P18848, O00141, Q6ZUJ8

RPS6, BCL2L11, YWHAQ, HSP90AA1, HSP90B1, PIK3R5, LAMA4, TNXB, CREBL1, ATF4, SGK, PIK3AP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P14625	HSP90B1	Endoplasmin	P62753	RPS6	40S ribosomal protein S6	0.738
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P62753	RPS6	40S ribosomal protein S6	0.722
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P27348	YWHAQ	14-3-3 protein theta	0.833
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P14625	HSP90B1	Endoplasmin	P14625	HSP90B1	Endoplasmin	1
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P14625	HSP90B1	Endoplasmin	Q16363	LAMA4	Laminin subunit alpha-4	0.818
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P22105	TNXB	Tenascin-X	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P14625	HSP90B1	Endoplasmin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.739
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728

Nedocromil

hsa04210

Apoptosis

1.82E-06

Q13315, P04637, P10415, Q13489, O76075, P25963, P01375, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

ATM, TP53, BCL2, BIRC3, DFFB, NFKBIA, TNF, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P24158	PRTN3	Myeloblastin	O76075	DFFB	DNA fragmentation factor subunit beta	-0.747
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P24158	PRTN3	Myeloblastin	P43234	CTSO	Cathepsin O	-0.722
P32248	CCR7	C-C chemokine receptor type 7	P43234	CTSO	Cathepsin O	0.783
P32248	CCR7	C-C chemokine receptor type 7	Q9UBR2	CTSZ	Cathepsin Z	0.92
P24158	PRTN3	Myeloblastin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.743
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P24158	PRTN3	Myeloblastin	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.766
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P32248	CCR7	C-C chemokine receptor type 7	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823

Nedocromil

hsa04211

Longevity regulating pathway

1.79E-03

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Nedocromil

hsa04217

Necroptosis

5.66E-03

P15104, P05141, P01584, P0C0S5, Q9H444

GLUL, SLC25A5, IL1B, H2AFZ, CHMP4B

Nedocromil

hsa04260

Cardiac muscle contraction

3.76E-02

P07951

TPM2

Nedocromil

hsa04261

Adrenergic signaling in cardiomyocytes

1.24E-04

P51828, Q99941, P18848, Q16537, P0DP23, Q13557, P17252, P10415, P20020

ADCY7, CREBL1, ATF4, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1

Nedocromil

hsa04340

Hedgehog signaling pathway

4.63E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Nedocromil

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Nedocromil

hsa04390

Hippo signaling pathway

1.47E-02

P63261, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, LEF1, SNAI2, BIRC3

Nedocromil

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Nedocromil

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Nedocromil

hsa04540

Gap junction

1.01E-04

P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643

PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1

Nedocromil

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Nedocromil

hsa04612

Antigen processing and presentation

8.57E-07

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.738
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.741
P24158	PRTN3	Myeloblastin	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.767
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Nedocromil

hsa04613

Neutrophil extracellular trap formation

9.39E-08

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, P62807, P33778, O60814, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, HIST1H2BC, H2BC3, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P24158	PRTN3	Myeloblastin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.873
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.825
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P24158	PRTN3	Myeloblastin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.713
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764
P24158	PRTN3	Myeloblastin	P20160	AZU1	Azurocidin	0.942
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P24158	PRTN3	Myeloblastin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.738
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	1
P24158	PRTN3	Myeloblastin	P21462	FPR1	fMet-Leu-Phe receptor	0.73
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.842
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43315	AQP9	Aquaporin-9	0.915
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833

Nedocromil

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Nedocromil

hsa04623

Cytosolic DNA-sensing pathway

1.85E-03

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Nedocromil

hsa04625

C-type lectin receptor signaling pathway

4.80E-02

Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539

CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14

Nedocromil

hsa04640

Hematopoietic cell lineage

1.08E-04

P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43657	P2RY5	Lysophosphatidic acid receptor 6	P13612	ITGA4	Integrin alpha-4	0.764
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P15144	ANPEP	Aminopeptidase N	0.879
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P11836	MS4A1	B-lymphocyte antigen CD20	-0.705
P08311	CTSG	Cathepsin G	P25063	CD24	Signal transducer CD24	0.902
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09564	CD7	T-cell antigen CD7	0.735
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715

Nedocromil

hsa04650

Natural killer cell mediated cytotoxicity

3.86E-09

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P78314	SH3BP2	SH3 domain-binding protein 2	0.809
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.879
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838

Nedocromil

hsa04657

IL-17 signaling pathway

1.36E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Nedocromil

hsa04658

Th1 and Th2 cell differentiation

5.13E-08

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P32249	GPR183	G-protein coupled receptor 183	Q04759	PRKCQ	Protein kinase C theta type	0.71
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P32249	GPR183	G-protein coupled receptor 183	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P32249	GPR183	G-protein coupled receptor 183	P01730	CD4	T-cell surface glycoprotein CD4	0.713
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P32249	GPR183	G-protein coupled receptor 183	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.927
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P32249	GPR183	G-protein coupled receptor 183	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.845
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13761	RUNX3	Runt-related transcription factor 3	0.712

Nedocromil

hsa04659

Th17 cell differentiation

1.54E-07

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P32249	GPR183	G-protein coupled receptor 183	Q04759	PRKCQ	Protein kinase C theta type	0.71
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P32249	GPR183	G-protein coupled receptor 183	P01730	CD4	T-cell surface glycoprotein CD4	0.713
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P32249	GPR183	G-protein coupled receptor 183	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.845
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P32249	GPR183	G-protein coupled receptor 183	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.927
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P32249	GPR183	G-protein coupled receptor 183	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77

Nedocromil

hsa04660

T cell receptor signaling pathway

6.64E-08

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.806
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.812
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.816
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.781

Nedocromil

hsa04664

Fc epsilon RI signaling pathway

6.97E-03

P04141, P07948, P19174, P09917

CSF2, LYN, PLCG1, ALOX5

Nedocromil

hsa04666

Fc gamma R-mediated phagocytosis

4.13E-04

P23528, P49006, P06396, O14494, P14598, P17252

CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Nedocromil

hsa04668

TNF signaling pathway

2.43E-03

P01375, O00463, Q13489, P25963, P18848, P01584, P20749, Q13077, P14780, P20333

TNF, TRAF5, BIRC3, NFKBIA, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B

Nedocromil

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Nedocromil

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Nedocromil

hsa04714

Thermogenesis

2.88E-03

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Nedocromil

hsa04720

Long-term potentiation

1.12E-05

P17252, Q16566, P0DP23, O15399, Q14643

PRKCA, CAMK4, CALM1, GRIN2D, ITPR1

Nedocromil

hsa04723

Retrograde endocannabinoid signaling

3.86E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Nedocromil

hsa04724

Glutamatergic synapse

1.18E-04

P48058, P43003, P62873, P63218, P50151, P15104

GRIA4, SLC1A3, GNB1, GNG5, GNG10, GLUL

Nedocromil

hsa04725

Cholinergic synapse

7.91E-06

P51828, P22694, Q14643, P17252, P62873, P18848, Q16566, Q13557, P10415

ADCY7, PRKACB, ITPR1, PRKCA, GNB1, ATF4, CAMK4, CAMK2D, BCL2

Nedocromil

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Nedocromil

hsa04727

GABAergic synapse

4.36E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Nedocromil

hsa04728

Dopaminergic synapse

5.98E-04

P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407

DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1

Nedocromil

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Nedocromil

hsa04744

Phototransduction

1.48E-04

P62873, P0DP23

GNB1, CALM1

Nedocromil

hsa04911

Insulin secretion

3.90E-07

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Nedocromil

hsa04912

GnRH signaling pathway

1.29E-04

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB

Nedocromil

hsa04915

Estrogen signaling pathway

1.08E-05

P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, P10415

MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, BCL2

Nedocromil

hsa04916

Melanogenesis

1.54E-03

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Nedocromil

hsa04918

Thyroid hormone synthesis

8.47E-07

P22694, P51828, Q99941, P18848, Q14643, P14625, P02768

PRKACB, ADCY7, CREBL1, ATF4, ITPR1, HSP90B1, ALB

Nedocromil

hsa04920

Adipocytokine signaling pathway

5.72E-03

P25963, P33121, Q04759, Q9Y4H2, P01375

NFKBIA, ACSL1, PRKCQ, IRS2, TNF

Nedocromil

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Nedocromil

hsa04925

Aldosterone synthesis and secretion

3.48E-09

Q14643, Q99941, P18848, P51828, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ATF4, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00398	P2RY10	Putative P2Y purinoceptor 10	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.793
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	P51828	ADCY7	Adenylate cyclase type 7	0.726
O00398	P2RY10	Putative P2Y purinoceptor 10	P0DP23	CALM1	Calmodulin-1	-0.815
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
O00398	P2RY10	Putative P2Y purinoceptor 10	P17252	PRKCA	Protein kinase C alpha type	0.887
P46091	GPR1	Chemerin-like receptor 2	P17252	PRKCA	Protein kinase C alpha type	0.741
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
O00398	P2RY10	Putative P2Y purinoceptor 10	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.721
P46091	GPR1	Chemerin-like receptor 2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.865
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.763
Q14568	HSP90AA2	Heat shock protein HSP 90-alpha A2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.763
P51684	CCR6	C-C chemokine receptor type 6	P20020	ATP2B1	Plasma membrane calcium-transporting ATPase 1	0.727
P46091	GPR1	Chemerin-like receptor 2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	-0.766

Nedocromil

hsa04926

Relaxin signaling pathway

2.69E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Nedocromil

hsa04927

Cortisol synthesis and secretion

2.91E-06

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Nedocromil

hsa04928

Parathyroid hormone synthesis, secretion and action

8.75E-05

Q14643, P51828, P22694, P23771, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2

Nedocromil

hsa04932

Non-alcoholic fatty liver disease

2.05E-03

O43521, P18848, O75460, P01584, P13073

BCL2L11, ATF4, ERN1, IL1B, COX4I1

Nedocromil

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.36E-02

Q13485, P10415, P49767, P17252

SMAD4, BCL2, VEGFC, PRKCA

Nedocromil

hsa04934

Cushing syndrome

3.21E-06

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Nedocromil

hsa04935

Growth hormone synthesis, secretion and action

1.79E-03

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Nedocromil

hsa04964

Proximal tubule bicarbonate reclamation

2.61E-03

P22748, P00918, P49448

CA4, CA2, GLUD2

Nedocromil

hsa04966

Collecting duct acid secretion

8.03E-06

Q13488, P02730, P00918, Q9Y666

TCIRG1, SLC4A1, CA2, SLC12A7

Nedocromil

hsa04970

Salivary secretion

1.38E-04

P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913

PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMP

Nedocromil

hsa04971

Gastric acid secretion

4.76E-02

P17252, P63261, P0DP23

PRKCA, ACTG1, CALM1

Nedocromil

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Nedocromil

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Nedocromil

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Nedocromil

hsa05012

Parkinson disease

3.44E-03

P13073, P05141, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371

COX4I1, SLC25A5, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2C

Nedocromil

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Nedocromil

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Nedocromil

hsa05020

Prion disease

3.49E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Nedocromil

hsa05022

Pathways of neurodegeneration - multiple diseases

3.11E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, P04628, P01584, P0DP23, P0DP24

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, WNT1, IL1B, CALM1, CALM2

Nedocromil

hsa05030

Cocaine addiction

4.88E-03

Q99941, P18848

CREBL1, ATF4

Nedocromil

hsa05031

Amphetamine addiction

5.04E-06

O15399, P0DP23, Q16566, Q13557, Q99941, P18848, P17252

GRIN2D, CALM1, CAMK4, CAMK2D, CREBL1, ATF4, PRKCA

Nedocromil

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Nedocromil

hsa05034

Alcoholism

4.54E-02

P62807, O60814

HIST1H2BC, H2BC12

Nedocromil

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

9.05E-04

Q16539, P25963, Q13488, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, PLCG1, CXCR1, CXCR2, LYN

Nedocromil

hsa05130

Pathogenic Escherichia coli infection

4.43E-03

Q71U36, P16333, Q13509, P68371, Q14344, P25963, Q06124, O95487

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA, PTPN11, SEC24B

Nedocromil

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Nedocromil

hsa05132

Salmonella infection

1.94E-07

P51617, P25963, P01375, P08238, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, P51808, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DYNLT3, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.877
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P51684	CCR6	C-C chemokine receptor type 6	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.835
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.819
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.981
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P51684	CCR6	C-C chemokine receptor type 6	O75369	FLNB	Filamin-B	-0.717
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.774
P51684	CCR6	C-C chemokine receptor type 6	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.721
P51684	CCR6	C-C chemokine receptor type 6	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.731
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13561	DCTN2	Dynactin subunit 2	-0.876
P51684	CCR6	C-C chemokine receptor type 6	Q13561	DCTN2	Dynactin subunit 2	-0.781
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13509	TUBB3	Tubulin beta-3 chain	-0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P46091	GPR1	Chemerin-like receptor 2	Q13509	TUBB3	Tubulin beta-3 chain	-0.748
P51684	CCR6	C-C chemokine receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	-0.835
O00398	P2RY10	Putative P2Y purinoceptor 10	P68371	TUBB2C	Tubulin beta-4B chain	-0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P46091	GPR1	Chemerin-like receptor 2	P68371	TUBB2C	Tubulin beta-4B chain	-0.751
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Nedocromil

hsa05133

Pertussis

2.81E-03

P0DP23, P23528, P09871, P0C0L4

CALM1, CFL1, C1S, C4A

Nedocromil

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Nedocromil

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Nedocromil

hsa05140

Leishmaniasis

4.32E-06

P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P51684	CCR6	C-C chemokine receptor type 6	P49006	MARCKSL1	MARCKS-related protein	0.727
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764

Nedocromil

hsa05144

Malaria

3.76E-06

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Nedocromil

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Nedocromil

hsa05146

Amoebiasis

5.64E-08

Q13751, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

LAMB3, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13751	LAMB3	Laminin subunit beta-3	-0.763
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09341	CXCL1	Growth-regulated alpha protein	0.781
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P24158	PRTN3	Myeloblastin	P05089	ARG1	Arginase-1	0.834
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P43657	P2RY5	Lysophosphatidic acid receptor 6	P05089	ARG1	Arginase-1	-0.793
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05089	ARG1	Arginase-1	0.811
P24158	PRTN3	Myeloblastin	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.792
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.779
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P43657	P2RY5	Lysophosphatidic acid receptor 6	P12814	ACTN1	Alpha-actinin-1	-0.814
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709

Nedocromil

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Nedocromil

hsa05152

Tuberculosis

5.68E-05

Q13488, P0DP23, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.769
O00398	P2RY10	Putative P2Y purinoceptor 10	P0DP23	CALM1	Calmodulin-1	-0.815
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
O00398	P2RY10	Putative P2Y purinoceptor 10	P48382	RFX5	DNA-binding protein RFX5	0.74
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
O00398	P2RY10	Putative P2Y purinoceptor 10	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.705
O00398	P2RY10	Putative P2Y purinoceptor 10	P01568	IFNA21	Interferon alpha-21	0.876
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.88
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Nedocromil

hsa05161

Hepatitis B

2.50E-04

P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765

PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4

Nedocromil

hsa05163

Human cytomegalovirus infection

1.72E-04

P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568

TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Nedocromil

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.62E-05

P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Nedocromil

hsa05168

Herpes simplex virus 1 infection

2.35E-03

Q9UKJ0, P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q03923, O75820, Q9UDV6, P10415

PILRB, NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF85, ZNF189, ZNF212, BCL2

Nedocromil

hsa05169

Epstein-Barr virus infection

2.91E-04

P13765, Q92769, P04637, Q13546, P10415, P24522, P48551, O60603, P29728, P51617, P09693

HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, IFNAR2, TLR2, OAS2, IRAK1, CD3G

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P32249	GPR183	G-protein coupled receptor 183	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.845
P32248	CCR7	C-C chemokine receptor type 7	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.808
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P32249	GPR183	G-protein coupled receptor 183	P04637	TP53	Cellular tumor antigen p53	0.711
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P32249	GPR183	G-protein coupled receptor 183	P10415	BCL2	Apoptosis regulator Bcl-2	0.719
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P32249	GPR183	G-protein coupled receptor 183	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.925
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P32249	GPR183	G-protein coupled receptor 183	P48551	IFNAR2	Interferon alpha/beta receptor 2	0.714
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P32249	GPR183	G-protein coupled receptor 183	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.705
P32248	CCR7	C-C chemokine receptor type 7	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.738
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P32249	GPR183	G-protein coupled receptor 183	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P32248	CCR7	C-C chemokine receptor type 7	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753

Nedocromil

hsa05170

Human immunodeficiency virus 1 infection

2.73E-08

P62873, P63218, P50151, P0DP23, P01375, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P09693, P10415, Q13619, Q93034, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3G, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00398	P2RY10	Putative P2Y purinoceptor 10	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.805
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O00398	P2RY10	Putative P2Y purinoceptor 10	P0DP23	CALM1	Calmodulin-1	-0.815
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
O00398	P2RY10	Putative P2Y purinoceptor 10	P17252	PRKCA	Protein kinase C alpha type	0.887
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.819
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
O00398	P2RY10	Putative P2Y purinoceptor 10	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.793
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
O00398	P2RY10	Putative P2Y purinoceptor 10	P01568	IFNA21	Interferon alpha-21	0.876
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
O00398	P2RY10	Putative P2Y purinoceptor 10	P23528	CFL1	Cofilin-1	0.8
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.838
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.86

Nedocromil

hsa05171

Coronavirus disease - COVID-19

4.36E-05

P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513

RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37A

Nedocromil

hsa05200

Pathways in cancer

2.23E-05

P08238, P42224, P25963, P19174, P04637, Q9UJU2, P17252, Q09472, P43246, P84022, Q13485, P20585, P14923, P10415, Q13489, Q13077, P49767, P25116, P62873, P63218, P50151, Q14344, O95267, P78417, P24522, O75293, P0DP23, P01568, P14784, P16871

HSP90AB1, STAT1, NFKBIA, PLCG1, TP53, LEF1, PRKCA, EP300, MSH2, SMAD3, SMAD4, MSH3, JUP, BCL2, BIRC3, TRAF1, VEGFC, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP1, GSTO1, GADD45A, GADD45B, CALM1, IFNA21, IL2RB, IL7R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P32248	CCR7	C-C chemokine receptor type 7	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.813
P46091	GPR1	Chemerin-like receptor 2	P17252	PRKCA	Protein kinase C alpha type	0.741
P32248	CCR7	C-C chemokine receptor type 7	Q09472	EP300	Histone acetyltransferase p300	-0.791
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P46091	GPR1	Chemerin-like receptor 2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P46091	GPR1	Chemerin-like receptor 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.809
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P46091	GPR1	Chemerin-like receptor 2	P14923	JUP	Junction plakoglobin	0.883
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P46091	GPR1	Chemerin-like receptor 2	P49767	VEGFC	Vascular endothelial growth factor C	0.718
P46091	GPR1	Chemerin-like receptor 2	P25116	F2R	Proteinase-activated receptor 1	0.76
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P32248	CCR7	C-C chemokine receptor type 7	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.792
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P46091	GPR1	Chemerin-like receptor 2	P01568	IFNA21	Interferon alpha-21	0.724
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P32248	CCR7	C-C chemokine receptor type 7	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.743

Nedocromil

hsa05202

Transcriptional misregulation in cancer

3.15E-10

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P32248	CCR7	C-C chemokine receptor type 7	Q15532	SS18	Protein SSXT	0.804
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41732	TSPAN7	Tetraspanin-7	0.703
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.913
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.712
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
P32248	CCR7	C-C chemokine receptor type 7	O15550	UTX	Lysine-specific demethylase 6A	-0.715
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12838	DEFA4	Neutrophil defensin 4	0.767
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P32248	CCR7	C-C chemokine receptor type 7	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.72
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.765
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41182	BCL6	B-cell lymphoma 6 protein	0.9
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12980	LYL1	Protein lyl-1	0.782
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.801

Nedocromil

hsa05203

Viral carcinogenesis

6.66E-05

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Nedocromil

hsa05210

Colorectal cancer

2.41E-02

P10415, P04637, Q9UJU2, P24522

BCL2, TP53, LEF1, GADD45A

Nedocromil

hsa05211

Renal cell carcinoma

3.76E-02

Q06124

PTPN11

Nedocromil

hsa05212

Pancreatic cancer

4.75E-02

P42224, P84022, O75293

STAT1, SMAD3, GADD45B

Nedocromil

hsa05213

Endometrial cancer

2.20E-03

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Nedocromil

hsa05214

Glioma

1.41E-05

P0DP23, Q16566, P17252, P04637, P19174, P24522, O75293

CALM1, CAMK4, PRKCA, TP53, PLCG1, GADD45A, GADD45B

Nedocromil

hsa05215

Prostate cancer

1.97E-03

P10415, Q9UJU2, Q09472, P04637, P18848, P14625

BCL2, LEF1, EP300, TP53, ATF4, HSP90B1

Nedocromil

hsa05216

Thyroid cancer

7.94E-06

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Nedocromil

hsa05217

Basal cell carcinoma

1.84E-05

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Nedocromil

hsa05222

Small cell lung cancer

1.93E-03

Q13489, P10415, P25963, Q13077, O00463, P04637, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, TP53, GADD45A

Nedocromil

hsa05224

Breast cancer

4.32E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Nedocromil

hsa05226

Gastric cancer

9.75E-04

Q9UJU2, P04637, P24522, P14923, P10415

LEF1, TP53, GADD45A, JUP, BCL2

Nedocromil

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Nedocromil

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.34E-02

O95267, P20963, P09693, P06239, Q04759

RASGRP1, CD247, CD3G, LCK, PRKCQ

Nedocromil

hsa05310

Asthma

1.00E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Nedocromil

hsa05320

Autoimmune thyroid disease

2.91E-02

P13765, P01568, P10747

HLA-DOB, IFNA21, CD28

Nedocromil

hsa05321

Inflammatory bowel disease

6.92E-09

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P24158	PRTN3	Myeloblastin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.753
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.768
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P24158	PRTN3	Myeloblastin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.81
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763

Nedocromil

hsa05322

Systemic lupus erythematosus

1.16E-04

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, P62807, Q16778, O60814, P12814, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H2BC12, ACTN1, SSB

Nedocromil

hsa05323

Rheumatoid arthritis

1.79E-03

P01375, P13765, Q13488, P10747, P09341, O60603

TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2

Nedocromil

hsa05332

Graft-versus-host disease

2.43E-06

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Nedocromil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Nedocromil

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Nedocromil

hsa05418

Fluid shear stress and atherosclerosis

2.49E-03

Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Community members of Nedocromil (S_DC: 3.01)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

FPR1

fMetNoneLeuNonePhe receptor

Reported

0.1205

0.3492

0.4378

1.1964

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Reported

0.4727

0.6064

0.741

2.1901

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

P24158

PRTN3

Myeloblastin

Predicted

0.0516

0.0511

0.1281

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

Q14568

HSP90AA2

Heat shock protein HSP 90Nonealpha A2

Predicted

0.3626

0.0128

0.2069

P14625

HSP90B1

Endoplasmin

Predicted

0.2336

0.1497

0.5384

0.9546

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P21730

C5AR1

C5a anaphylatoxin chemotactic receptor 1

Predicted

0.0258

0.2167

0.5396

0.986

P46091

GPR1

ChemerinNonelike receptor 2

Predicted

0.2476

0.1372

0.3982

P43657

P2RY5

Lysophosphatidic acid receptor 6

Predicted

0.7539

0.0448

0.3708

0.8373

P32249

GPR183

GNoneprotein coupled receptor 183

Predicted

0.071

0.0485

0.1324

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

O00398

P2RY10

Putative P2Y purinoceptor 10

Predicted

0.0701

0.0152

0.0654

P32302

CXCR5

CNoneXNoneC chemokine receptor type 5

Predicted

0.2455

0.0459

0.3304

0.545

Q15743

GPR68

Ovarian cancer GNoneprotein coupled receptor 1

Predicted

0.0658

0.0137

0.0602

P32248

CCR7

CNoneC chemokine receptor type 7

Predicted

0.1391

0.0461

0.3304

0.4922

Q99527

GPER1

GNoneprotein coupled estrogen receptor 1

Predicted

0.0249

0.1294

0.2138

0.485

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

PharmaCoNets of Nedocromil (SPCN: 57.74 )

Nedocromil regulated-network (SDN: 19.18)

Community members of Nedocromil (SDC: 3.01)

PharmaCoNets of Nedocromil (S_PCN: 57.74 )

Nedocromil regulated-network (S_DN: 19.18)

Community members of Nedocromil (S_DC: 3.01)