PharmaCoNets of Nateglinide (SPCN: 134.12 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nateglinidehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Nateglinidehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Nateglinidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nateglinidehsa00190Oxidative phosphorylation1.00E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Nateglinidehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Nateglinidehsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Nateglinidehsa00480Glutathione metabolism6.94E-065Q9UJ14, P48506, Q16772, P09211, P30041GGTL3, GCLC, GSTA3, GSTP1, PRDX6More
Nateglinidehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Nateglinidehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Nateglinidehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Nateglinidehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Nateglinidehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Nateglinidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nateglinidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Nateglinidehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Nateglinidehsa00630Glyoxylate and dicarboxylate metabolism6.74E-052P40925, P15104MDH1, GLULMore
Nateglinidehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Nateglinidehsa00920Sulfur metabolism5.99E-041Q16762TSTMore
Nateglinidehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Nateglinidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Nateglinidehsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Nateglinidehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Nateglinidehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Nateglinidehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Nateglinidehsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Nateglinidehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Nateglinidehsa02010ABC transporters7.05E-032Q8IZY2, Q99758ABCA7, ABCA3More
Nateglinidehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Nateglinidehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Nateglinidehsa03013RNA transport3.08E-0513O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Nateglinidehsa03018RNA degradation3.02E-021Q13901C1DMore
Nateglinidehsa03020RNA polymerase7.74E-102Q9GZM3, P52435POLR2J2, POLR2JMore
Nateglinidehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Nateglinidehsa03040Spliceosome6.14E-1214Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Nateglinidehsa03050Proteasome9.60E-032P55036, P28074PSMD4, PSMB5More
Nateglinidehsa03060Protein export1.90E-022Q15070, O76094OXA1L, SRP72More
Nateglinidehsa04012ErbB signaling pathway1.34E-024P16333, P19174, P42338, P01106NCK1, PLCG1, PIK3CB, MYCMore
Nateglinidehsa04014Ras signaling pathway5.21E-0711P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Nateglinidehsa04015Rap1 signaling pathway5.94E-0714P20827, Q9NRA1, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1More
Nateglinidehsa04020Calcium signaling pathway3.06E-0817P27987, Q96DU7, P21796, Q16566, Q13557, P21860, P30679, O15399, P19174, P0DP23, P05141, P12236, P26678, P63092, P23634, Q9NRA1, P49767ITPKB, ITPKC, VDAC1, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, ATP2B4, PDGFC, VEGFCMore
Nateglinidehsa04022cGMP-PKG signaling pathway2.71E-049P24844, P61586, P26678, Q99941, P18848, Q8WYR1, P05141, P12236, Q15746MYL9, RHOA, PLN, CREBL1, ATF4, PIK3R5, SLC25A5, SLC25A6, MYLKMore
Nateglinidehsa04024cAMP signaling pathway7.60E-048P42338, P0DP23, P23634, Q16566, P48058, O15399, P25116, P24844PIK3CB, CALM1, ATP2B4, CAMK4, GRIA4, GRIN2D, F2R, MYL9More
Nateglinidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Nateglinidehsa04062Chemokine signaling pathway1.30E-0618P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5More
Nateglinidehsa04064NF-kappa B signaling pathway5.98E-0718P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Nateglinidehsa04070Phosphatidylinositol signaling system6.04E-057P19174, P0DP23, P42338, P23743, Q96PE3, Q13572, P27987PLCG1, CALM1, PIK3CB, DGKA, INPP4A, ITPK1, ITPKBMore
Nateglinidehsa04071Sphingolipid signaling pathway2.65E-089P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Nateglinidehsa04072Phospholipase D signaling pathway5.49E-038P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFCMore
Nateglinidehsa04080Neuroactive ligand-receptor interaction1.11E-038P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Nateglinidehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Nateglinidehsa04122Sulfur relay system5.99E-041Q16762TSTMore
Nateglinidehsa04136Autophagy - other4.02E-042O94817, Q9H1Y0ATG12, ATG5More
Nateglinidehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Nateglinidehsa04142Lysosome3.65E-021Q99523SORT1More
Nateglinidehsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Nateglinidehsa04145Phagosome5.70E-059O75015, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Nateglinidehsa04151PI3K-Akt signaling pathway2.63E-0625P42338, P21860, P43657, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P30281, O95988PIK3CB, ERBB3, P2RY5, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, CCND3, TCL1BMore
Nateglinidehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Nateglinidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Nateglinidehsa04216Ferroptosis4.50E-021P48506GCLCMore
Nateglinidehsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Nateglinidehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Nateglinidehsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Nateglinidehsa04340Hedgehog signaling pathway1.40E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Nateglinidehsa04360Axon guidance3.83E-036P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Nateglinidehsa04371Apelin signaling pathway2.51E-0611P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Nateglinidehsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Nateglinidehsa04512ECM-receptor interaction2.02E-032P07359, P08514GP1BA, ITGA2BMore
Nateglinidehsa04514Cell adhesion molecules5.78E-053P16109, P56750, O00501SELP, CLDN17, CLDN5More
Nateglinidehsa04530Tight junction7.89E-096Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Nateglinidehsa04610Complement and coagulation cascades8.94E-054P25116, P09871, P0C0L4, P10909F2R, C1S, C4A, CLUMore
Nateglinidehsa04611Platelet activation1.66E-095P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Nateglinidehsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Nateglinidehsa04613Neutrophil extracellular trap formation4.02E-1029P42338, P19174, P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PIK3CB, PLCG1, PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Nateglinidehsa04620Toll-like receptor signaling pathway4.00E-024P01568, P42224, P25963, P42338IFNA21, STAT1, NFKBIA, PIK3CBMore
Nateglinidehsa04621NOD-like receptor signaling pathway2.68E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Nateglinidehsa04623Cytosolic DNA-sensing pathway1.85E-032P01568, P25963IFNA21, NFKBIAMore
Nateglinidehsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Nateglinidehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Nateglinidehsa04650Natural killer cell mediated cytotoxicity2.83E-0410P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Nateglinidehsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Nateglinidehsa04658Th1 and Th2 cell differentiation8.33E-0915P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Nateglinidehsa04659Th17 cell differentiation8.16E-0613P25963, Q04759, P19174, P06239, P42224, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Nateglinidehsa04660T cell receptor signaling pathway2.96E-0717P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Nateglinidehsa04662B cell receptor signaling pathway3.13E-066P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Nateglinidehsa04664Fc epsilon RI signaling pathway3.34E-064P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Nateglinidehsa04666Fc gamma R-mediated phagocytosis2.94E-049O75015, P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252FCGR3B, LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Nateglinidehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Nateglinidehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Nateglinidehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Nateglinidehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Nateglinidehsa04713Circadian entrainment1.06E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Nateglinidehsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Nateglinidehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Nateglinidehsa04722Neurotrophin signaling pathway2.32E-021Q99523SORT1More
Nateglinidehsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Nateglinidehsa04724Glutamatergic synapse3.14E-058P48058, O15399, P43003, P62873, P63218, P50151, P15104, Q9NSB8GRIA4, GRIN2D, SLC1A3, GNB1, GNG5, GNG10, GLUL, HOMER2More
Nateglinidehsa04725Cholinergic synapse5.42E-045P62873, P63218, P50151, Q16566, P42338GNB1, GNG5, GNG10, CAMK4, PIK3CBMore
Nateglinidehsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Nateglinidehsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Nateglinidehsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Nateglinidehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Nateglinidehsa04750Inflammatory mediator regulation of TRP channels8.12E-046P14778, P19174, P42338, P24723, Q04759, P0DP23IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Nateglinidehsa04810Regulation of actin cytoskeleton3.78E-0510P12814, P24844, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116ACTN1, MYL9, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2RMore
Nateglinidehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Nateglinidehsa04912GnRH signaling pathway3.14E-035P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Nateglinidehsa04914Progesterone-mediated oocyte maturation4.00E-024P42338, Q13370, P30304, P08238PIK3CB, PDE3B, CDC25A, HSP90AB1More
Nateglinidehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Nateglinidehsa04920Adipocytokine signaling pathway5.84E-036P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Nateglinidehsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Nateglinidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Nateglinidehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Nateglinidehsa04925Aldosterone synthesis and secretion1.15E-037Q99941, P18848, P0DP23, P63092, Q16566, Q13557, P23634CREBL1, ATF4, CALM1, GNAS, CAMK4, CAMK2D, ATP2B4More
Nateglinidehsa04926Relaxin signaling pathway1.60E-047P25963, P42338, P62873, P63218, P50151, P49767, P30679NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC, GNA15More
Nateglinidehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Nateglinidehsa04928Parathyroid hormone synthesis, secretion and action2.66E-039Q14643, P63092, P22694, P23771, P17252, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, PRKCA, RHOA, CREBL1, ATF4, BCL2More
Nateglinidehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Nateglinidehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Nateglinidehsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Nateglinidehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Nateglinidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Nateglinidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Nateglinidehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Nateglinidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Nateglinidehsa04979Cholesterol metabolism8.29E-031Q99523SORT1More
Nateglinidehsa05010Alzheimer disease1.36E-029Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5More
Nateglinidehsa05012Parkinson disease5.04E-0415O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Nateglinidehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Nateglinidehsa05016Huntington disease8.43E-064Q9GZM3, P52435, Q9NYC9, P55036POLR2J2, POLR2J, DNAH9, PSMD4More
Nateglinidehsa05017Spinocerebellar ataxia3.86E-035Q8TB72, O15399, P42338, P28074, P21796PUM2, GRIN2D, PIK3CB, PSMB5, VDAC1More
Nateglinidehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Nateglinidehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Nateglinidehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Nateglinidehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Nateglinidehsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Nateglinidehsa05034Alcoholism1.30E-0512O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nateglinidehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Nateglinidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Nateglinidehsa05130Pathogenic Escherichia coli infection4.91E-044Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Nateglinidehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Nateglinidehsa05132Salmonella infection2.51E-0317P51617, P25963, P01375, P08238, Q9UJU2, P01106, P42338, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P49754IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, MYC, PIK3CB, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, VPS41More
Nateglinidehsa05133Pertussis1.86E-033P09871, P0C0L4, Q02556C1S, C4A, IRF8More
Nateglinidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Nateglinidehsa05140Leishmaniasis1.43E-0612P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4More
Nateglinidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Nateglinidehsa05144Malaria6.79E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Nateglinidehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Nateglinidehsa05146Amoebiasis7.41E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Nateglinidehsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Nateglinidehsa05152Tuberculosis4.18E-0511Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1More
Nateglinidehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Nateglinidehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Nateglinidehsa05163Human cytomegalovirus infection7.31E-0510P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21More
Nateglinidehsa05167Kaposi sarcoma-associated herpesvirus infection1.68E-0511P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1More
Nateglinidehsa05168Herpes simplex virus 1 infection6.47E-0415P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Nateglinidehsa05169Epstein-Barr virus infection1.08E-0311P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3EMore
Nateglinidehsa05170Human immunodeficiency virus 1 infection1.62E-0623P42338, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P10415, Q13619, Q93034, Q9Y6Q5PIK3CB, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, BCL2, CUL4A, CUL5, AP1M2More
Nateglinidehsa05200Pathways in cancer7.17E-0523Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RBMore
Nateglinidehsa05202Transcriptional misregulation in cancer2.00E-0820Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Nateglinidehsa05203Viral carcinogenesis2.57E-0618Q12933, Q99941, P18848, P42229, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079, O60814TRAF2, CREBL1, ATF4, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12More
Nateglinidehsa05204Chemical carcinogenesis2.55E-055Q16772, P09211, P78417, P11712, P33260GSTA3, GSTP1, GSTO1, CYP2C9, CYP2C18More
Nateglinidehsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Nateglinidehsa05206MicroRNAs in cancer1.34E-0313P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1More
Nateglinidehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Nateglinidehsa05214Glioma7.71E-045P0DP23, Q16566, P42338, P19174, O75293CALM1, CAMK4, PIK3CB, PLCG1, GADD45BMore
Nateglinidehsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Nateglinidehsa05220Chronic myeloid leukemia1.15E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Nateglinidehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Nateglinidehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Nateglinidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.10E-048P25963, P42338, P19174, P07766, P20963, P06239, P42224, Q04759NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, PRKCQMore
Nateglinidehsa05310Asthma7.97E-064P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Nateglinidehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Nateglinidehsa05321Inflammatory bowel disease8.23E-086O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Nateglinidehsa05322Systemic lupus erythematosus2.54E-0513O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Nateglinidehsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Nateglinidehsa05332Graft-versus-host disease1.46E-075P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Nateglinidehsa05412Arrhythmogenic right ventricular cardiomyopathy2.77E-034P54284, P14923, P08514, Q9UJU2CACNB3, JUP, ITGA2B, LEF1More
Nateglinidehsa05415Diabetic cardiomyopathy6.60E-0412P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P26678PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, PLNMore
Nateglinidehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Nateglinide (SDC: 6.30)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DPredicted00.10350.15650.64481.0095
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2Predicted10.06950.040200.1151
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
Q99523SORT1SortilinPredicted00.2830.02810.25760.4554
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)