Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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Nateglinide | hsa00030 | Pentose phosphate pathway | 1.69E-02 | 2 | P60891, P37837 | PRPS1, TALDO1 | More | | Nateglinide | hsa00040 | Pentose and glucuronate interconversions | 9.59E-03 | 2 | P15121, P14550 | AKR1B1, AKR1A1 | More | | Nateglinide | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | Nateglinide | hsa00190 | Oxidative phosphorylation | 1.00E-02 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | Nateglinide | hsa00240 | Pyrimidine metabolism | 4.29E-02 | 2 | P21589, P04183 | NT5E, TK1 | More | | Nateglinide | hsa00310 | Lysine degradation | 1.53E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | Nateglinide | hsa00480 | Glutathione metabolism | 6.94E-06 | 5 | Q9UJ14, P48506, Q16772, P09211, P30041 | GGTL3, GCLC, GSTA3, GSTP1, PRDX6 | More | | Nateglinide | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | Nateglinide | hsa00513 | Various types of N-glycan biosynthesis | 4.96E-02 | 1 | Q9NR34 | MAN1C1 | More | | Nateglinide | hsa00561 | Glycerolipid metabolism | 7.94E-03 | 3 | P15121, P14550, Q86XP1 | AKR1B1, AKR1A1, DGKH | More | | Nateglinide | hsa00562 | Inositol phosphate metabolism | 2.54E-03 | 4 | P27987, Q13572, Q96PE3, P42338 | ITPKB, ITPK1, INPP4A, PIK3CB | More | | Nateglinide | hsa00564 | Glycerophospholipid metabolism | 4.29E-02 | 2 | Q6P1A2, P23743 | MBOAT5, DGKA | More | | Nateglinide | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | Nateglinide | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | Nateglinide | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | Nateglinide | hsa00630 | Glyoxylate and dicarboxylate metabolism | 6.74E-05 | 2 | P40925, P15104 | MDH1, GLUL | More | | Nateglinide | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | Nateglinide | hsa00920 | Sulfur metabolism | 5.99E-04 | 1 | Q16762 | TST | More | | Nateglinide | hsa00970 | Aminoacyl-tRNA biosynthesis | 3.78E-02 | 2 | O95363, Q15046 | FARS2, KARS | More | | Nateglinide | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-05 | 4 | Q16772, P78417, P09211, P11712 | GSTA3, GSTO1, GSTP1, CYP2C9 | More | | Nateglinide | hsa00982 | Drug metabolism - cytochrome P450 | 1.77E-04 | 4 | P11712, Q16772, P09211, P78417 | CYP2C9, GSTA3, GSTP1, GSTO1 | More | | Nateglinide | hsa00983 | Drug metabolism - other enzymes | 1.72E-02 | 2 | Q16772, P09211 | GSTA3, GSTP1 | More | | Nateglinide | hsa01100 | Metabolic pathways | 8.43E-03 | 11 | P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6 | CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1 | More | | Nateglinide | hsa01230 | Biosynthesis of amino acids | 3.59E-02 | 3 | P60891, Q99707, P37837 | PRPS1, MTR, TALDO1 | More | | Nateglinide | hsa01522 | Endocrine resistance | 4.55E-02 | 5 | P14780, P22694, Q9UM47, P10415, Q13323 | MMP9, PRKACB, NOTCH3, BCL2, BIK | More | | Nateglinide | hsa01524 | Platinum drug resistance | 4.44E-02 | 2 | Q16772, P09211 | GSTA3, GSTP1 | More | | Nateglinide | hsa02010 | ABC transporters | 7.05E-03 | 2 | Q8IZY2, Q99758 | ABCA7, ABCA3 | More | | Nateglinide | hsa03008 | Ribosome biogenesis in eukaryotes | 1.88E-02 | 3 | O14980, O60832, Q9BVP2 | XPO1, DKC1, GNL3 | More | | Nateglinide | hsa03010 | Ribosome | 1.60E-02 | 9 | P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396 | RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3 | More | | Nateglinide | hsa03013 | RNA transport | 3.08E-05 | 13 | O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3 | More | | Nateglinide | hsa03018 | RNA degradation | 3.02E-02 | 1 | Q13901 | C1D | More | | Nateglinide | hsa03020 | RNA polymerase | 7.74E-10 | 2 | Q9GZM3, P52435 | POLR2J2, POLR2J | More | | Nateglinide | hsa03030 | DNA replication | 1.48E-02 | 3 | P49005, P33993, P15927 | POLD2, MCM7, RPA2 | More | | Nateglinide | hsa03040 | Spliceosome | 6.14E-12 | 14 | Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.803 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.745 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.869 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.734 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.827 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.859 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.778 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.714 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.747 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.866 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.835 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.908 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.928 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | 0.786 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.793 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | 0.78 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| Nateglinide | hsa03050 | Proteasome | 9.60E-03 | 2 | P55036, P28074 | PSMD4, PSMB5 | More | | Nateglinide | hsa03060 | Protein export | 1.90E-02 | 2 | Q15070, O76094 | OXA1L, SRP72 | More | | Nateglinide | hsa04012 | ErbB signaling pathway | 1.34E-02 | 4 | P16333, P19174, P42338, P01106 | NCK1, PLCG1, PIK3CB, MYC | More | | Nateglinide | hsa04014 | Ras signaling pathway | 5.21E-07 | 11 | P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.757 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P49767 | VEGFC | Vascular endothelial growth factor C | 0.842 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P0DP23 | CALM1 | Calmodulin-1 | -0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.814 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.718 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| Nateglinide | hsa04015 | Rap1 signaling pathway | 5.94E-07 | 14 | P20827, Q9NRA1, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174 | EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q96FS4 | SIPA1 | Signal-induced proliferation-associated protein 1 | 0.728 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11215 | ITGAM | Integrin alpha-M | -0.877 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11215 | ITGAM | Integrin alpha-M | 0.817 | P08514 | ITGA2B | Integrin alpha-IIb | P25116 | F2R | Proteinase-activated receptor 1 | 0.813 | P25116 | F2R | Proteinase-activated receptor 1 | P25116 | F2R | Proteinase-activated receptor 1 | 1 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | P25116 | F2R | Proteinase-activated receptor 1 | 0.783 | P08514 | ITGA2B | Integrin alpha-IIb | Q8TEU7 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 | -0.786 | P25116 | F2R | Proteinase-activated receptor 1 | Q8TEU7 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 | -0.811 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | Q8TEU7 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 | -0.727 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | P08514 | ITGA2B | Integrin alpha-IIb | P08514 | ITGA2B | Integrin alpha-IIb | 1 | P25116 | F2R | Proteinase-activated receptor 1 | P08514 | ITGA2B | Integrin alpha-IIb | 0.813 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | P08514 | ITGA2B | Integrin alpha-IIb | 0.941 | P25116 | F2R | Proteinase-activated receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.857 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| Nateglinide | hsa04020 | Calcium signaling pathway | 3.06E-08 | 17 | P27987, Q96DU7, P21796, Q16566, Q13557, P21860, P30679, O15399, P19174, P0DP23, P05141, P12236, P26678, P63092, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, VDAC1, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, ATP2B4, PDGFC, VEGFC | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | 0.891 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | -0.717 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q96DU7 | ITPKC | Inositol-trisphosphate 3-kinase C | -0.766 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.72 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | -0.765 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.773 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.749 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.731 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P30679 | GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | 0.739 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | 1 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P0DP23 | CALM1 | Calmodulin-1 | -0.764 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.725 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P12236 | SLC25A6 | ADP/ATP translocase 3 | 0.722 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P26678 | PLN | Cardiac phospholamban | -0.71 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | 0.736 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | -0.762 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P49767 | VEGFC | Vascular endothelial growth factor C | 0.842 |
| Nateglinide | hsa04022 | cGMP-PKG signaling pathway | 2.71E-04 | 9 | P24844, P61586, P26678, Q99941, P18848, Q8WYR1, P05141, P12236, Q15746 | MYL9, RHOA, PLN, CREBL1, ATF4, PIK3R5, SLC25A5, SLC25A6, MYLK | More | | Nateglinide | hsa04024 | cAMP signaling pathway | 7.60E-04 | 8 | P42338, P0DP23, P23634, Q16566, P48058, O15399, P25116, P24844 | PIK3CB, CALM1, ATP2B4, CAMK4, GRIA4, GRIN2D, F2R, MYL9 | More | | Nateglinide | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | Nateglinide | hsa04062 | Chemokine signaling pathway | 1.30E-06 | 18 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.775 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| Nateglinide | hsa04064 | NF-kappa B signaling pathway | 5.98E-07 | 18 | P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB | More | | Nateglinide | hsa04070 | Phosphatidylinositol signaling system | 6.04E-05 | 7 | P19174, P0DP23, P42338, P23743, Q96PE3, Q13572, P27987 | PLCG1, CALM1, PIK3CB, DGKA, INPP4A, ITPK1, ITPKB | More | | Nateglinide | hsa04071 | Sphingolipid signaling pathway | 2.65E-08 | 9 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | Nateglinide | hsa04072 | Phospholipase D signaling pathway | 5.49E-03 | 8 | P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC | More | | Nateglinide | hsa04080 | Neuroactive ligand-receptor interaction | 1.11E-03 | 8 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1 | More | | Nateglinide | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | Nateglinide | hsa04122 | Sulfur relay system | 5.99E-04 | 1 | Q16762 | TST | More | | Nateglinide | hsa04136 | Autophagy - other | 4.02E-04 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | Nateglinide | hsa04140 | Autophagy - animal | 4.55E-02 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | Nateglinide | hsa04142 | Lysosome | 3.65E-02 | 1 | Q99523 | SORT1 | More | | Nateglinide | hsa04144 | Endocytosis | 4.10E-02 | 3 | O75351, P62491, Q14161 | VPS4B, RAB11A, GIT2 | More | | Nateglinide | hsa04145 | Phagosome | 5.70E-05 | 9 | O75015, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Nateglinide | hsa04151 | PI3K-Akt signaling pathway | 2.63E-06 | 25 | P42338, P21860, P43657, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P30281, O95988 | PIK3CB, ERBB3, P2RY5, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, CCND3, TCL1B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.731 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P27348 | YWHAQ | 14-3-3 protein theta | 0.711 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O14944 | EREG | Proepiregulin [Cleaved into: Epiregulin | -0.778 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.718 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q15831 | STK11 | Serine/threonine-protein kinase STK11 | 0.731 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O15335 | CHAD | Chondroadherin | -0.704 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P22105 | TNXB | Tenascin-X | 0.802 | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.802 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.781 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O95988 | TCL1B | T-cell leukemia/lymphoma protein 1B | 0.719 |
| Nateglinide | hsa04210 | Apoptosis | 1.52E-02 | 9 | Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643 | ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1 | More | | Nateglinide | hsa04213 | Longevity regulating pathway - multiple species | 3.85E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | Nateglinide | hsa04216 | Ferroptosis | 4.50E-02 | 1 | P48506 | GCLC | More | | Nateglinide | hsa04217 | Necroptosis | 2.87E-03 | 8 | P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752 | IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPID | More | | Nateglinide | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.12E-02 | 5 | P63092, Q99941, P18848, P26678, Q13557 | GNAS, CREBL1, ATF4, PLN, CAMK2D | More | | Nateglinide | hsa04270 | Vascular smooth muscle contraction | 4.65E-02 | 2 | Q15746, P24844 | MYLK, MYL9 | More | | Nateglinide | hsa04340 | Hedgehog signaling pathway | 1.40E-03 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | Nateglinide | hsa04360 | Axon guidance | 3.83E-03 | 6 | P16333, P20827, O95631, P42338, P07332, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1 | More | | Nateglinide | hsa04371 | Apelin signaling pathway | 2.51E-06 | 11 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | | Nateglinide | hsa04510 | Focal adhesion | 3.36E-02 | 3 | P08514, Q15746, P24844 | ITGA2B, MYLK, MYL9 | More | | Nateglinide | hsa04512 | ECM-receptor interaction | 2.02E-03 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | Nateglinide | hsa04514 | Cell adhesion molecules | 5.78E-05 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | | Nateglinide | hsa04530 | Tight junction | 7.89E-09 | 6 | Q8TEU7, P16989, P56750, O00501, Q14247, P24844 | RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9 | More | | Nateglinide | hsa04610 | Complement and coagulation cascades | 8.94E-05 | 4 | P25116, P09871, P0C0L4, P10909 | F2R, C1S, C4A, CLU | More | | Nateglinide | hsa04611 | Platelet activation | 1.66E-09 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | Nateglinide | hsa04612 | Antigen processing and presentation | 2.40E-02 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | Nateglinide | hsa04613 | Neutrophil extracellular trap formation | 4.02E-10 | 29 | P42338, P19174, P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539 | PIK3CB, PLCG1, PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | P16109 | SELP | P-selectin | 0.819 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11215 | ITGAM | Integrin alpha-M | -0.877 | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.942 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.799 | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.833 | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q93079 | H2BC9 | Histone H2B type 1-H | 0.756 | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | O60814 | H2BC12 | Histone H2B type 1-K | 0.783 | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.72 | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.918 | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.737 | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.875 | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | P08514 | ITGA2B | Integrin alpha-IIb | 0.941 | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.888 | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | P18054 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | P07359 | GP1BA | Platelet glycoprotein Ib alpha chain | 0.876 | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O43315 | AQP9 | Aquaporin-9 | 0.79 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 |
| Nateglinide | hsa04620 | Toll-like receptor signaling pathway | 4.00E-02 | 4 | P01568, P42224, P25963, P42338 | IFNA21, STAT1, NFKBIA, PIK3CB | More | | Nateglinide | hsa04621 | NOD-like receptor signaling pathway | 2.68E-04 | 14 | Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838 | MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4 | More | | Nateglinide | hsa04623 | Cytosolic DNA-sensing pathway | 1.85E-03 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | Nateglinide | hsa04625 | C-type lectin receptor signaling pathway | 2.17E-02 | 5 | Q9ULY5, P42224, P25963, P42338, P0DP23 | CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1 | More | | Nateglinide | hsa04640 | Hematopoietic cell lineage | 1.37E-02 | 7 | P14778, P27930, P11215, P25063, P07766, P01732, P09564 | IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7 | More | | Nateglinide | hsa04650 | Natural killer cell mediated cytotoxicity | 2.83E-04 | 10 | P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715 | PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | Nateglinide | hsa04657 | IL-17 signaling pathway | 3.91E-02 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | Nateglinide | hsa04658 | Th1 and Th2 cell differentiation | 8.33E-09 | 15 | P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | P13612 | ITGA4 | Integrin alpha-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.764 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | P13612 | ITGA4 | Integrin alpha-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.822 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.804 | P13612 | ITGA4 | Integrin alpha-4 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.78 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| Nateglinide | hsa04659 | Th17 cell differentiation | 8.16E-06 | 13 | P25963, Q04759, P19174, P06239, P42224, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247 | More | | Nateglinide | hsa04660 | T cell receptor signaling pathway | 2.96E-07 | 17 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Nateglinide | hsa04662 | B cell receptor signaling pathway | 3.13E-06 | 6 | P25963, P42338, P60033, P07948, P21854, Q8N149 | NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | Nateglinide | hsa04664 | Fc epsilon RI signaling pathway | 3.34E-06 | 4 | P42338, P07948, P19174, P09917 | PIK3CB, LYN, PLCG1, ALOX5 | More | | Nateglinide | hsa04666 | Fc gamma R-mediated phagocytosis | 2.94E-04 | 9 | O75015, P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252 | FCGR3B, LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | Nateglinide | hsa04668 | TNF signaling pathway | 2.59E-02 | 7 | P01375, O00463, Q13489, P25963, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9 | More | | Nateglinide | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | Nateglinide | hsa04672 | Intestinal immune network for IgA production | 1.35E-02 | 2 | P29965, P13765 | CD40LG, HLA-DOB | More | | Nateglinide | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | Nateglinide | hsa04713 | Circadian entrainment | 1.06E-03 | 5 | O15399, P0DP23, P62873, P63218, P50151 | GRIN2D, CALM1, GNB1, GNG5, GNG10 | More | | Nateglinide | hsa04720 | Long-term potentiation | 1.63E-02 | 3 | Q16566, P0DP23, O15399 | CAMK4, CALM1, GRIN2D | More | | Nateglinide | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | Nateglinide | hsa04722 | Neurotrophin signaling pathway | 2.32E-02 | 1 | Q99523 | SORT1 | More | | Nateglinide | hsa04723 | Retrograde endocannabinoid signaling | 1.75E-02 | 5 | Q14643, P17252, P22694, Q16539, Q16718 | ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5 | More | | Nateglinide | hsa04724 | Glutamatergic synapse | 3.14E-05 | 8 | P48058, O15399, P43003, P62873, P63218, P50151, P15104, Q9NSB8 | GRIA4, GRIN2D, SLC1A3, GNB1, GNG5, GNG10, GLUL, HOMER2 | More | | Nateglinide | hsa04725 | Cholinergic synapse | 5.42E-04 | 5 | P62873, P63218, P50151, Q16566, P42338 | GNB1, GNG5, GNG10, CAMK4, PIK3CB | More | | Nateglinide | hsa04726 | Serotonergic synapse | 1.52E-02 | 4 | P63218, P50151, P33260, P09917 | GNG5, GNG10, CYP2C18, ALOX5 | More | | Nateglinide | hsa04727 | GABAergic synapse | 8.14E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | Nateglinide | hsa04728 | Dopaminergic synapse | 4.47E-02 | 4 | P63218, P50151, P0DP23, O00327 | GNG5, GNG10, CALM1, ARNTL | More | | Nateglinide | hsa04744 | Phototransduction | 1.32E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | Nateglinide | hsa04750 | Inflammatory mediator regulation of TRP channels | 8.12E-04 | 6 | P14778, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | Nateglinide | hsa04810 | Regulation of actin cytoskeleton | 3.78E-05 | 10 | P12814, P24844, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116 | ACTN1, MYL9, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2R | More | | Nateglinide | hsa04911 | Insulin secretion | 4.47E-03 | 4 | P63092, Q99941, P18848, Q13557 | GNAS, CREBL1, ATF4, CAMK2D | More | | Nateglinide | hsa04912 | GnRH signaling pathway | 3.14E-03 | 5 | P17252, Q16539, Q9Y6R4, Q14643, P22694 | PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB | More | | Nateglinide | hsa04914 | Progesterone-mediated oocyte maturation | 4.00E-02 | 4 | P42338, Q13370, P30304, P08238 | PIK3CB, PDE3B, CDC25A, HSP90AB1 | More | | Nateglinide | hsa04918 | Thyroid hormone synthesis | 3.16E-02 | 2 | P17252, P27824 | PRKCA, CANX | More | | Nateglinide | hsa04920 | Adipocytokine signaling pathway | 5.84E-03 | 6 | P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375 | NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNF | More | | Nateglinide | hsa04921 | Oxytocin signaling pathway | 6.37E-03 | 3 | Q15746, P24844, Q8WYR1 | MYLK, MYL9, PIK3R5 | More | | Nateglinide | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | Nateglinide | hsa04924 | Renin secretion | 3.64E-02 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | Nateglinide | hsa04925 | Aldosterone synthesis and secretion | 1.15E-03 | 7 | Q99941, P18848, P0DP23, P63092, Q16566, Q13557, P23634 | CREBL1, ATF4, CALM1, GNAS, CAMK4, CAMK2D, ATP2B4 | More | | Nateglinide | hsa04926 | Relaxin signaling pathway | 1.60E-04 | 7 | P25963, P42338, P62873, P63218, P50151, P49767, P30679 | NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC, GNA15 | More | | Nateglinide | hsa04927 | Cortisol synthesis and secretion | 2.40E-02 | 3 | Q99941, P18848, P63092 | CREBL1, ATF4, GNAS | More | | Nateglinide | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.66E-03 | 9 | Q14643, P63092, P22694, P23771, P17252, P61586, Q99941, P18848, P10415 | ITPR1, GNAS, PRKACB, GATA3, PRKCA, RHOA, CREBL1, ATF4, BCL2 | More | | Nateglinide | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | Nateglinide | hsa04934 | Cushing syndrome | 1.37E-03 | 5 | Q99941, P18848, P63092, O15169, Q13557 | CREBL1, ATF4, GNAS, AXIN1, CAMK2D | More | | Nateglinide | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | Nateglinide | hsa04962 | Vasopressin-regulated water reabsorption | 1.80E-02 | 2 | P62491, P46459 | RAB11A, NSF | More | | Nateglinide | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | Nateglinide | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | Nateglinide | hsa04970 | Salivary secretion | 4.49E-02 | 4 | P22694, Q14643, P17252, P49913 | PRKACB, ITPR1, PRKCA, CAMP | More | | Nateglinide | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | Nateglinide | hsa04979 | Cholesterol metabolism | 8.29E-03 | 1 | Q99523 | SORT1 | More | | Nateglinide | hsa05010 | Alzheimer disease | 1.36E-02 | 9 | Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195 | NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5 | More | | Nateglinide | hsa05012 | Parkinson disease | 5.04E-04 | 15 | O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509 | NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3 | More | | Nateglinide | hsa05014 | Amyotrophic lateral sclerosis | 3.92E-02 | 8 | P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658 | TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214 | More | | Nateglinide | hsa05016 | Huntington disease | 8.43E-06 | 4 | Q9GZM3, P52435, Q9NYC9, P55036 | POLR2J2, POLR2J, DNAH9, PSMD4 | More | | Nateglinide | hsa05017 | Spinocerebellar ataxia | 3.86E-03 | 5 | Q8TB72, O15399, P42338, P28074, P21796 | PUM2, GRIN2D, PIK3CB, PSMB5, VDAC1 | More | | Nateglinide | hsa05020 | Prion disease | 1.15E-02 | 9 | P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941 | NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1 | More | | Nateglinide | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.57E-02 | 10 | O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195 | NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5 | More | | Nateglinide | hsa05030 | Cocaine addiction | 2.40E-02 | 3 | P63092, Q99941, P18848 | GNAS, CREBL1, ATF4 | More | | Nateglinide | hsa05031 | Amphetamine addiction | 4.47E-03 | 4 | Q13557, P63092, Q99941, P18848 | CAMK2D, GNAS, CREBL1, ATF4 | More | | Nateglinide | hsa05032 | Morphine addiction | 7.60E-03 | 5 | P62873, P63218, P50151, Q13370, P43250 | GNB1, GNG5, GNG10, PDE3B, GRK6 | More | | Nateglinide | hsa05034 | Alcoholism | 1.30E-05 | 12 | O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431 | GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | Nateglinide | hsa05100 | Bacterial invasion of epithelial cells | 4.50E-02 | 1 | Q92529 | SHC3 | More | | Nateglinide | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | Nateglinide | hsa05130 | Pathogenic Escherichia coli infection | 4.91E-04 | 4 | Q14247, P56750, O00501, P25116 | CTTN, CLDN17, CLDN5, F2R | More | | Nateglinide | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | Nateglinide | hsa05132 | Salmonella infection | 2.51E-03 | 17 | P51617, P25963, P01375, P08238, Q9UJU2, P01106, P42338, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P49754 | IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, MYC, PIK3CB, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, VPS41 | More | | Nateglinide | hsa05133 | Pertussis | 1.86E-03 | 3 | P09871, P0C0L4, Q02556 | C1S, C4A, IRF8 | More | | Nateglinide | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | Nateglinide | hsa05140 | Leishmaniasis | 1.43E-06 | 12 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4 | More | | Nateglinide | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | Nateglinide | hsa05144 | Malaria | 6.79E-03 | 6 | P69905, P68871, O60603, P01375, P35443, P26718 | HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | Nateglinide | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | Nateglinide | hsa05146 | Amoebiasis | 7.41E-05 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | Nateglinide | hsa05150 | Staphylococcus aureus infection | 1.65E-02 | 6 | P21730, P21462, O75015, P13765, Q16581, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP | More | | Nateglinide | hsa05152 | Tuberculosis | 4.18E-05 | 11 | Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617 | TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1 | More | | Nateglinide | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | Nateglinide | hsa05162 | Measles | 1.84E-02 | 7 | P01568, P25963, P42224, P14784, P07766, P42338, P11142 | IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8 | More | | Nateglinide | hsa05163 | Human cytomegalovirus infection | 7.31E-05 | 10 | P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568 | PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21 | More | | Nateglinide | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.68E-05 | 11 | P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1 | More | | Nateglinide | hsa05168 | Herpes simplex virus 1 infection | 6.47E-04 | 15 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | Nateglinide | hsa05169 | Epstein-Barr virus infection | 1.08E-03 | 11 | P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766 | MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3E | More | | Nateglinide | hsa05170 | Human immunodeficiency virus 1 infection | 1.62E-06 | 23 | P42338, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P10415, Q13619, Q93034, Q9Y6Q5 | PIK3CB, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, BCL2, CUL4A, CUL5, AP1M2 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.757 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.814 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.718 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P0DP23 | CALM1 | Calmodulin-1 | -0.764 | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.896 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P30101 | PDIA3 | Protein disulfide-isomerase A3 | -0.712 | P08246 | ELA2 | Neutrophil elastase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.816 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | P08246 | ELA2 | Neutrophil elastase | O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | 0.711 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P23528 | CFL1 | Cofilin-1 | 0.715 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | P08246 | ELA2 | Neutrophil elastase | Q13619 | CUL4A | Cullin-4A | -0.707 | P08246 | ELA2 | Neutrophil elastase | Q93034 | CUL5 | Cullin-5 | -0.744 | P08246 | ELA2 | Neutrophil elastase | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.811 |
| Nateglinide | hsa05200 | Pathways in cancer | 7.17E-05 | 23 | Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.887 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.735 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.847 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 |
| Nateglinide | hsa05202 | Transcriptional misregulation in cancer | 2.00E-08 | 20 | Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q12778 | FOXO1 | Forkhead box protein O1 | -0.769 | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15532 | SS18 | Protein SSXT | -0.803 | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P41732 | TSPAN7 | Tetraspanin-7 | 0.775 | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.861 | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.734 | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.837 | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.797 | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O15550 | UTX | Lysine-specific demethylase 6A | 0.789 | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.808 | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.764 | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 |
| Nateglinide | hsa05203 | Viral carcinogenesis | 2.57E-06 | 18 | Q12933, Q99941, P18848, P42229, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079, O60814 | TRAF2, CREBL1, ATF4, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12 | More | | Nateglinide | hsa05204 | Chemical carcinogenesis | 2.55E-05 | 5 | Q16772, P09211, P78417, P11712, P33260 | GSTA3, GSTP1, GSTO1, CYP2C9, CYP2C18 | More | | Nateglinide | hsa05205 | Proteoglycans in cancer | 4.46E-02 | 4 | Q12955, Q14247, P17252, P08962 | ANK3, CTTN, PRKCA, CD63 | More | | Nateglinide | hsa05206 | MicroRNAs in cancer | 1.34E-03 | 13 | P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174 | CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1 | More | | Nateglinide | hsa05212 | Pancreatic cancer | 3.94E-02 | 4 | P42338, P84022, Q13485, O75293 | PIK3CB, SMAD3, SMAD4, GADD45B | More | | Nateglinide | hsa05214 | Glioma | 7.71E-04 | 5 | P0DP23, Q16566, P42338, P19174, O75293 | CALM1, CAMK4, PIK3CB, PLCG1, GADD45B | More | | Nateglinide | hsa05218 | Melanoma | 2.31E-02 | 3 | Q9NRA1, P42338, O75293 | PDGFC, PIK3CB, GADD45B | More | | Nateglinide | hsa05220 | Chronic myeloid leukemia | 1.15E-03 | 7 | Q13547, P01106, Q13485, P25963, P84022, P42338, O75293 | HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B | More | | Nateglinide | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | Nateglinide | hsa05231 | Choline metabolism in cancer | 2.92E-03 | 5 | P42338, Q9NRA1, Q9Y259, P19174, P23743 | PIK3CB, PDGFC, CHKB, PLCG1, DGKA | More | | Nateglinide | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 9.10E-04 | 8 | P25963, P42338, P19174, P07766, P20963, P06239, P42224, Q04759 | NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, PRKCQ | More | | Nateglinide | hsa05310 | Asthma | 7.97E-06 | 4 | P13765, P29965, P12724, P01375 | HLA-DOB, CD40LG, RNASE3, TNF | More | | Nateglinide | hsa05320 | Autoimmune thyroid disease | 3.16E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | Nateglinide | hsa05321 | Inflammatory bowel disease | 8.23E-08 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | Nateglinide | hsa05322 | Systemic lupus erythematosus | 2.54E-05 | 13 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | Nateglinide | hsa05330 | Allograft rejection | 3.16E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | Nateglinide | hsa05332 | Graft-versus-host disease | 1.46E-07 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | Nateglinide | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 2.77E-03 | 4 | P54284, P14923, P08514, Q9UJU2 | CACNB3, JUP, ITGA2B, LEF1 | More | | Nateglinide | hsa05415 | Diabetic cardiomyopathy | 6.60E-04 | 12 | P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P26678 | PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, PLN | More | | Nateglinide | hsa05416 | Viral myocarditis | 4.29E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | |