PharmaCoNets of Naratriptan (SPCN: 180.77 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Naratriptanhsa00030Pentose phosphate pathway1.08E-044P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Naratriptanhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Naratriptanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Naratriptanhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Naratriptanhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Naratriptanhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Naratriptanhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Naratriptanhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Naratriptanhsa00561Glycerolipid metabolism3.35E-022P14550, Q86XP1AKR1A1, DGKHMore
Naratriptanhsa00565Ether lipid metabolism1.77E-042Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Naratriptanhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Naratriptanhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Naratriptanhsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Naratriptanhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Naratriptanhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Naratriptanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Naratriptanhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Naratriptanhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Naratriptanhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Naratriptanhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Naratriptanhsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Naratriptanhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Naratriptanhsa01100Metabolic pathways2.24E-0213Q9Y234, Q6ZQY3, Q02153, P20839, Q9Y6K0, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q9BVK2, P37837, Q99437, Q9NVH6LIPT1, GADL1, GUCY1B3, IMPDH1, CEPT1, DGKH, AKR1A1, AMACR, SGMS1, ALG8, TALDO1, ATP6V0B, TMLHEMore
Naratriptanhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Naratriptanhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Naratriptanhsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Naratriptanhsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Naratriptanhsa01524Platinum drug resistance1.47E-033O15392, P11388, P31751BIRC5, TOP2A, AKT2More
Naratriptanhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Naratriptanhsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Naratriptanhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Naratriptanhsa03020RNA polymerase1.37E-065P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Naratriptanhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Naratriptanhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Naratriptanhsa03060Protein export7.71E-042P37108, Q15005SRP14, SPCS2More
Naratriptanhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Naratriptanhsa03460Fanconi anemia pathway4.83E-022Q9BXW9, P07992FANCD2, ERCC1More
Naratriptanhsa04014Ras signaling pathway5.91E-038Q02750, P31751, Q15389, P17252, P21359, P0DP23, P62879, P22694MAP2K1, AKT2, ANGPT1, PRKCA, NF1, CALM1, GNB2, PRKACBMore
Naratriptanhsa04015Rap1 signaling pathway6.14E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04022cGMP-PKG signaling pathway1.41E-036P18848, Q8WYR1, P31751, P05141, P0DP24, P0DP23ATF4, PIK3R5, AKT2, SLC25A5, CALM2, CALM1More
Naratriptanhsa04024cAMP signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Naratriptanhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Naratriptanhsa04064NF-kappa B signaling pathway6.41E-0621Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Naratriptanhsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Naratriptanhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Naratriptanhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Naratriptanhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Naratriptanhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Naratriptanhsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Naratriptanhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Naratriptanhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Naratriptanhsa04142Lysosome7.47E-059P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Naratriptanhsa04144Endocytosis2.00E-049P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q8WU79, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, SMAP1L, GIT2, SNX12More
Naratriptanhsa04145Phagosome2.61E-025P63261, Q15080, P14598, Q13509, P68371ACTG1, NCF4, NCF1, TUBB3, TUBB2CMore
Naratriptanhsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Naratriptanhsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Naratriptanhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Naratriptanhsa04213Longevity regulating pathway - multiple species4.52E-047P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Naratriptanhsa04217Necroptosis7.45E-1023P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P07384, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, CAPN1, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, VPS4B, PPIDMore
Naratriptanhsa04218Cellular senescence3.65E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04261Adrenergic signaling in cardiomyocytes2.83E-036P07550, P22694, P31751, P18848, Q13362, P0DP23ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, CALM1More
Naratriptanhsa04270Vascular smooth muscle contraction2.36E-046P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Naratriptanhsa04370VEGF signaling pathway3.60E-021P31751AKT2More
Naratriptanhsa04371Apelin signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04380Osteoclast differentiation5.19E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Naratriptanhsa04510Focal adhesion4.64E-026O75369, Q15942, Q13489, P10415, P49767, P63261FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1More
Naratriptanhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Naratriptanhsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Naratriptanhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Naratriptanhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Naratriptanhsa04613Neutrophil extracellular trap formation8.84E-0419O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Naratriptanhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Naratriptanhsa04620Toll-like receptor signaling pathway4.81E-033Q13546, P01568, P31751RIPK1, IFNA21, AKT2More
Naratriptanhsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Naratriptanhsa04622RIG-I-like receptor signaling pathway1.02E-033P01568, Q9NQC7, Q13546IFNA21, CYLD, RIPK1More
Naratriptanhsa04623Cytosolic DNA-sensing pathway3.54E-075P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Naratriptanhsa04625C-type lectin receptor signaling pathway1.92E-0511Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Naratriptanhsa04640Hematopoietic cell lineage2.62E-0314P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Naratriptanhsa04650Natural killer cell mediated cytotoxicity3.46E-0614P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Naratriptanhsa04657IL-17 signaling pathway1.06E-049O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Naratriptanhsa04658Th1 and Th2 cell differentiation2.95E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Naratriptanhsa04659Th17 cell differentiation1.17E-0414Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Naratriptanhsa04660T cell receptor signaling pathway1.96E-0414P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Naratriptanhsa04662B cell receptor signaling pathway1.60E-046P31751, P42338, P60033, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, LYN, CD72, LILRA2More
Naratriptanhsa04664Fc epsilon RI signaling pathway5.75E-047P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Naratriptanhsa04668TNF signaling pathway1.71E-049P01375, O00463, Q16539, P18848, P19875, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1BMore
Naratriptanhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Naratriptanhsa04720Long-term potentiation1.09E-024P17252, P51812, P22694, Q02750PRKCA, RPS6KA3, PRKACB, MAP2K1More
Naratriptanhsa04721Synaptic vesicle cycle4.76E-034Q13488, Q99437, P43005, P31645TCIRG1, ATP6V0B, SLC1A1, SLC6A4More
Naratriptanhsa04722Neurotrophin signaling pathway1.26E-035P31751, P49841, O43524, P48023, P0DP23AKT2, GSK3B, FOXO3, FASLG, CALM1More
Naratriptanhsa04724Glutamatergic synapse1.75E-046O15399, P51828, P62873, P63218, P50151, P15104GRIN2D, ADCY7, GNB1, GNG5, GNG10, GLULMore
Naratriptanhsa04725Cholinergic synapse2.59E-037P22694, P17252, P62879, P63218, P50151, P42338, Q02750PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1More
Naratriptanhsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Naratriptanhsa04727GABAergic synapse8.55E-059P51828, P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252ADCY7, GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Naratriptanhsa04728Dopaminergic synapse3.23E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Naratriptanhsa04742Taste transduction1.01E-021P30939HTR1FMore
Naratriptanhsa04744Phototransduction1.81E-021P0DP23CALM1More
Naratriptanhsa04750Inflammatory mediator regulation of TRP channels3.66E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Naratriptanhsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Naratriptanhsa04912GnRH signaling pathway5.53E-038Q08828, P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Naratriptanhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Naratriptanhsa04915Estrogen signaling pathway6.26E-056Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Naratriptanhsa04916Melanogenesis4.78E-021P0DP23CALM1More
Naratriptanhsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Naratriptanhsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Naratriptanhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Naratriptanhsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa04923Regulation of lipolysis in adipocytes3.88E-034P07550, P42338, Q9Y4H2, P31751ADRB2, PIK3CB, IRS2, AKT2More
Naratriptanhsa04924Renin secretion6.94E-043P22694, P07550, P0DP23PRKACB, ADRB2, CALM1More
Naratriptanhsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Naratriptanhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Naratriptanhsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Naratriptanhsa04929GnRH secretion3.61E-033P42338, P31751, P49407PIK3CB, AKT2, ARRB1More
Naratriptanhsa04932Non-alcoholic fatty liver disease6.81E-0712P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Naratriptanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Naratriptanhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Naratriptanhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Naratriptanhsa04970Salivary secretion3.34E-067P07550, Q08828, P51828, P22694, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMPMore
Naratriptanhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Naratriptanhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Naratriptanhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Naratriptanhsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Naratriptanhsa05010Alzheimer disease8.89E-049P13073, Q00535, O75460, P0DP24, P0DP23, P01584, P18848, P31751, P05141COX4I1, CDK5, ERN1, CALM2, CALM1, IL1B, ATF4, AKT2, SLC25A5More
Naratriptanhsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Naratriptanhsa05016Huntington disease1.94E-0513O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12More
Naratriptanhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Naratriptanhsa05022Pathways of neurodegeneration - multiple diseases5.79E-0521O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P07384, Q00535, P04628, P01584, Q08752, P0DP23, P0DP24GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, CAPN1, CDK5, WNT1, IL1B, PPID, CALM1, CALM2More
Naratriptanhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Naratriptanhsa05031Amphetamine addiction6.98E-034P0DP23, P22694, P18848, Q13547CALM1, PRKACB, ATF4, HDAC1More
Naratriptanhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Naratriptanhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Naratriptanhsa05120Epithelial cell signaling in Helicobacter pylori infection2.44E-047Q99437, P09341, P19875, P10145, P19174, P25024, P25025ATP6V0B, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2More
Naratriptanhsa05132Salmonella infection3.09E-049P63261, Q13546, Q13489, P10415, O75369, Q13561, O60282, Q13509, P68371ACTG1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, KIF5C, TUBB3, TUBB2CMore
Naratriptanhsa05133Pertussis4.20E-021P0C0L4C4AMore
Naratriptanhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Naratriptanhsa05140Leishmaniasis1.29E-0313P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4More
Naratriptanhsa05143African trypanosomiasis3.77E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Naratriptanhsa05144Malaria1.48E-059P60033, P69905, P68871, O60603, P01375, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, IL8, KLRK1More
Naratriptanhsa05146Amoebiasis1.27E-0514P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Naratriptanhsa05152Tuberculosis9.92E-032P0DP23, P31751CALM1, AKT2More
Naratriptanhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Naratriptanhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Naratriptanhsa05163Human cytomegalovirus infection7.23E-0414P31751, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463AKT2, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5More
Naratriptanhsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Naratriptanhsa05167Kaposi sarcoma-associated herpesvirus infection5.07E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa05168Herpes simplex virus 1 infection1.40E-0418Q9UKJ0, Q06124, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q13398, Q9NR11, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415PILRB, PTPN11, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF211, ZNF302, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Naratriptanhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Naratriptanhsa05170Human immunodeficiency virus 1 infection6.71E-032P31751, P0DP23AKT2, CALM1More
Naratriptanhsa05200Pathways in cancer3.07E-022P31751, P0DP23AKT2, CALM1More
Naratriptanhsa05202Transcriptional misregulation in cancer9.77E-0523Q92570, Q12778, Q13315, O94812, P58340, P10145, P17844, P14780, P27930, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522NR4A3, FOXO1, ATM, BAIAP3, MLF1, IL8, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Naratriptanhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Naratriptanhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Naratriptanhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Naratriptanhsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Naratriptanhsa05211Renal cell carcinoma4.78E-021P31751AKT2More
Naratriptanhsa05212Pancreatic cancer4.78E-021P31751AKT2More
Naratriptanhsa05213Endometrial cancer3.60E-021P31751AKT2More
Naratriptanhsa05214Glioma5.75E-042P0DP23, P31751CALM1, AKT2More
Naratriptanhsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Naratriptanhsa05218Melanoma3.01E-021P31751AKT2More
Naratriptanhsa05220Chronic myeloid leukemia4.19E-021P31751AKT2More
Naratriptanhsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Naratriptanhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Naratriptanhsa05223Non-small cell lung cancer2.41E-021P31751AKT2More
Naratriptanhsa05226Gastric cancer3.60E-021P31751AKT2More
Naratriptanhsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Naratriptanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.58E-0311P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Naratriptanhsa05321Inflammatory bowel disease7.47E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Naratriptanhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Naratriptanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Naratriptanhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Naratriptanhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Naratriptanhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Naratriptanhsa05418Fluid shear stress and atherosclerosis6.43E-059Q16539, P31751, Q14145, P10599, P14780, P01375, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1More

Community members of Naratriptan (SDC: 7.78)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O60502MGEA5Protein ONoneGlcNAcasePredicted00.51010.04550.10570.4517
P38919EIF4A3Eukaryotic initiation factor 4ANoneIIIPredicted00.36460.03340.48860.7378
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)