PharmaCoNets

PharmaCoNets of Naphazoline (S_PCN: 100.78 )

Naphazoline regulated-network (S_DN: 15.63)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Naphazoline

hsa00030

Pentose phosphate pathway

1.65E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Naphazoline

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Naphazoline

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Naphazoline

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Naphazoline

hsa00240

Pyrimidine metabolism

2.54E-04

P31350, P21589, P04818

RRM2, NT5E, TYMS

Naphazoline

hsa00500

Starch and sucrose metabolism

3.85E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Naphazoline

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Naphazoline

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Naphazoline

hsa00730

Thiamine metabolism

2.49E-03

P05186, P24666

ALPL, ACP1

Naphazoline

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Naphazoline

hsa00830

Retinol metabolism

4.25E-02

P00325

ADH1B

Naphazoline

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Naphazoline

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Naphazoline

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Naphazoline

hsa01523

Antifolate resistance

5.80E-04

Q92820, P04818

GGH, TYMS

Naphazoline

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Naphazoline

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Naphazoline

hsa03015

mRNA surveillance pathway

1.37E-03

Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148

PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBP

Naphazoline

hsa03020

RNA polymerase

9.80E-05

Q9GZM3, P52435

POLR2J2, POLR2J

Naphazoline

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Naphazoline

hsa03050

Proteasome

1.53E-03

P55036

PSMD4

Naphazoline

hsa04020

Calcium signaling pathway

1.39E-02

P30679, O15399, P07550, P23634

GNA15, GRIN2D, ADRB2, ATP2B4

Naphazoline

hsa04064

NF-kappa B signaling pathway

1.14E-06

P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341, Q9UNE0

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819

Naphazoline

hsa04071

Sphingolipid signaling pathway

3.74E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Naphazoline

hsa04080

Neuroactive ligand-receptor interaction

1.02E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2

Naphazoline

hsa04110

Cell cycle

2.55E-04

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Naphazoline

hsa04114

Oocyte meiosis

1.25E-03

P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738

RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5D

Naphazoline

hsa04115

p53 signaling pathway

5.07E-03

P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415

GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2

Naphazoline

hsa04120

Ubiquitin mediated proteolysis

3.42E-03

Q14145, Q13042, P30260, Q13191, P62837, Q15751

KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1

Naphazoline

hsa04145

Phagosome

1.98E-02

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Naphazoline

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Naphazoline

hsa04152

AMPK signaling pathway

1.83E-02

Q96RR4, Q13362, Q14738

CAMKK2, PPP2R5C, PPP2R5D

Naphazoline

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Naphazoline

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Naphazoline

hsa04217

Necroptosis

1.85E-03

P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14

Naphazoline

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Naphazoline

hsa04261

Adrenergic signaling in cardiomyocytes

3.75E-03

P07550, P22694, P18848, Q13362, Q14738, P0DP23

ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1

Naphazoline

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Naphazoline

hsa04340

Hedgehog signaling pathway

3.91E-02

P17612

PRKACA

Naphazoline

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Naphazoline

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Naphazoline

hsa04610

Complement and coagulation cascades

3.71E-08

P00734, P0C0L4

F2, C4A

Naphazoline

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Naphazoline

hsa04612

Antigen processing and presentation

9.68E-05

P13765, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Naphazoline

hsa04613

Neutrophil extracellular trap formation

2.81E-04

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14

Naphazoline

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Naphazoline

hsa04621

NOD-like receptor signaling pathway

7.18E-04

Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838

ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4

Naphazoline

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Naphazoline

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Naphazoline

hsa04640

Hematopoietic cell lineage

1.67E-03

P13612, P21926, P20023, P11836, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, CD9, CR2, MS4A1, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Naphazoline

hsa04650

Natural killer cell mediated cytotoxicity

4.64E-07

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Naphazoline

hsa04657

IL-17 signaling pathway

3.33E-03

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Naphazoline

hsa04658

Th1 and Th2 cell differentiation

3.82E-04

P20963, P09693, Q16539, P06239, P23771, Q9UL17, P13765

CD247, CD3G, MAPK14, LCK, GATA3, TBX21, HLA-DOB

Naphazoline

hsa04659

Th17 cell differentiation

7.45E-04

Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963

MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247

Naphazoline

hsa04660

T cell receptor signaling pathway

2.38E-03

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB

Naphazoline

hsa04668

TNF signaling pathway

2.93E-03

P01375, O00463, Q13489, P25963, P18848, P19875, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9

Naphazoline

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Naphazoline

hsa04672

Intestinal immune network for IgA production

4.27E-02

P13765, P13612

HLA-DOB, ITGA4

Naphazoline

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Naphazoline

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Naphazoline

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Naphazoline

hsa04728

Dopaminergic synapse

2.66E-02

Q13362, Q14738, P0DP23

PPP2R5C, PPP2R5D, CALM1

Naphazoline

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Naphazoline

hsa04742

Taste transduction

7.70E-04

P30939, P17612

HTR1F, PRKACA

Naphazoline

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Naphazoline

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Naphazoline

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Naphazoline

hsa04921

Oxytocin signaling pathway

3.13E-02

P0DP23, Q96RR4, Q13469

CALM1, CAMKK2, NFATC2

Naphazoline

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Naphazoline

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Naphazoline

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Naphazoline

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Naphazoline

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Naphazoline

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Naphazoline

hsa04966

Collecting duct acid secretion

2.17E-03

P00918

CA2

Naphazoline

hsa04970

Salivary secretion

2.82E-03

P07550, P22694, Q14643, P17252, P49913

ADRB2, PRKACB, ITPR1, PRKCA, CAMP

Naphazoline

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Naphazoline

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Naphazoline

hsa04979

Cholesterol metabolism

1.61E-02

P38571, P61916

LIPA, NPC2

Naphazoline

hsa05016

Huntington disease

1.07E-02

Q9GZM3, P52435, P55036

POLR2J2, POLR2J, PSMD4

Naphazoline

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Naphazoline

hsa05022

Pathways of neurodegeneration - multiple diseases

4.25E-03

P49841, Q16718, O14521, Q06055, Q13561, Q16539, Q08752, O15020

GSK3B, NDUFA5, SDHD, ATP5G2, DCTN2, MAPK14, PPID, SPTBN2

Naphazoline

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Naphazoline

hsa05033

Nicotine addiction

1.22E-02

P28472, O15399

GABRB3, GRIN2D

Naphazoline

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Naphazoline

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Naphazoline

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Naphazoline

hsa05132

Salmonella infection

2.05E-03

P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Naphazoline

hsa05133

Pertussis

2.60E-04

P0DP23, P0C0L4

CALM1, C4A

Naphazoline

hsa05140

Leishmaniasis

9.33E-04

O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Naphazoline

hsa05143

African trypanosomiasis

1.11E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Naphazoline

hsa05144

Malaria

7.08E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Naphazoline

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Naphazoline

hsa05146

Amoebiasis

3.33E-03

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB

Naphazoline

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Naphazoline

hsa05152

Tuberculosis

2.07E-02

Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Naphazoline

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Naphazoline

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Naphazoline

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Naphazoline

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.39E-03

P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47

JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBB

Naphazoline

hsa05169

Epstein-Barr virus infection

4.16E-03

P20023, P13765, Q13547, Q92769, O00463, Q16539, P24522, O60603, P09693, P20963

CR2, HLA-DOB, HDAC1, HDAC2, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247

Naphazoline

hsa05170

Human immunodeficiency virus 1 infection

2.58E-05

Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Naphazoline

hsa05202

Transcriptional misregulation in cancer

1.51E-04

Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Naphazoline

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Naphazoline

hsa05212

Pancreatic cancer

4.16E-02

Q15311, P23458

RALBP1, JAK1

Naphazoline

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Naphazoline

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Naphazoline

hsa05217

Basal cell carcinoma

2.83E-02

Q13635, Q9UJU2, P24522

PTCH1, LEF1, GADD45A

Naphazoline

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Naphazoline

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Naphazoline

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Naphazoline

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Naphazoline

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Naphazoline

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.47E-04

O95267, P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4

Naphazoline

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Naphazoline

hsa05321

Inflammatory bowel disease

7.59E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Naphazoline

hsa05322

Systemic lupus erythematosus

4.20E-02

P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Naphazoline

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Naphazoline

hsa05332

Graft-versus-host disease

1.24E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Naphazoline

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Naphazoline

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Naphazoline

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Naphazoline

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Naphazoline

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Naphazoline (S_DC: 6.45)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

GNA15

Guanine nucleotideNonebinding protein subunit alphaNone15

Predicted

0.0373

0.1146

0.2891

0.5369

Q9Y2I1

NISCH

Nischarin

Predicted

0.6082

0.2251

0.7543

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P07195

LDHB

LNonelactate dehydrogenase B chain

Predicted

0.0167

0.1749

0.231

0.5892

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

Q9GZR1

SENP6

SentrinNonespecific protease 6

Predicted

0.3844

0.0784

0.349

P04818

TYMS

Thymidylate synthase

Predicted

0.4553

0.2706

0.1893

0.9582

P30530

AXL

TyrosineNoneprotein kinase receptor UFO

Predicted

0.3797

0.5365

0.1637

1.4264

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

O15164

TRIM24

Transcription intermediary factor 1Nonealpha

Predicted

0.2807

0.1055

0.3514

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Naphazoline (SPCN: 100.78 )

Naphazoline regulated-network (SDN: 15.63)

Community members of Naphazoline (SDC: 6.45)

PharmaCoNets of Naphazoline (S_PCN: 100.78 )

Naphazoline regulated-network (S_DN: 15.63)

Community members of Naphazoline (S_DC: 6.45)