PharmaCoNets

PharmaCoNets of Nandrolone-decanoate (S_PCN: 51.33 )

Nandrolone-decanoate regulated-network (S_DN: 10.27)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nandrolone-decanoate

hsa00040

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Nandrolone-decanoate

hsa00052

Galactose metabolism

2.91E-02

P06280, O43451

GLA, MGAM

Nandrolone-decanoate

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Nandrolone-decanoate

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Nandrolone-decanoate

hsa00500

Starch and sucrose metabolism

4.62E-02

O43451, P06737

MGAM, PYGL

Nandrolone-decanoate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Nandrolone-decanoate

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Nandrolone-decanoate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Nandrolone-decanoate

hsa00730

Thiamine metabolism

1.53E-02

P05186, P24666

ALPL, ACP1

Nandrolone-decanoate

hsa00830

Retinol metabolism

1.11E-03

P00352, Q9BPW9, O75911, P11712

ALDH1A1, DHRS9, DHRS3, CYP2C9

Nandrolone-decanoate

hsa01100

Metabolic pathways

2.25E-02

Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573

CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGL

Nandrolone-decanoate

hsa01210

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Nandrolone-decanoate

hsa01240

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Nandrolone-decanoate

hsa03013

RNA transport

8.18E-05

P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042

EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Nandrolone-decanoate

hsa03040

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Nandrolone-decanoate

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Nandrolone-decanoate

hsa03320

PPAR signaling pathway

1.62E-02

Q13133, Q02318

NR1H3, CYP27A1

Nandrolone-decanoate

hsa04012

ErbB signaling pathway

2.98E-03

P21860, P16333, Q13557, P19174, O14944, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC

Nandrolone-decanoate

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Nandrolone-decanoate

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Nandrolone-decanoate

hsa04060

Cytokine-cytokine receptor interaction

8.46E-04

P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730

IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4

Nandrolone-decanoate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Nandrolone-decanoate

hsa04062

Chemokine signaling pathway

6.73E-03

P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881

CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK

Nandrolone-decanoate

hsa04064

NF-kappa B signaling pathway

3.44E-06

P10415, Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643, Q9UNE0

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTB, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819

Nandrolone-decanoate

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Nandrolone-decanoate

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Nandrolone-decanoate

hsa04110

Cell cycle

1.79E-03

Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547

ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Nandrolone-decanoate

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Nandrolone-decanoate

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Nandrolone-decanoate

hsa04141

Protein processing in endoplasmic reticulum

2.01E-03

P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816

CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2

Nandrolone-decanoate

hsa04145

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Nandrolone-decanoate

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Nandrolone-decanoate

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Nandrolone-decanoate

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Nandrolone-decanoate

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Nandrolone-decanoate

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Nandrolone-decanoate

hsa04330

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Nandrolone-decanoate

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Nandrolone-decanoate

hsa04360

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Nandrolone-decanoate

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Nandrolone-decanoate

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Nandrolone-decanoate

hsa04530

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Nandrolone-decanoate

hsa04612

Antigen processing and presentation

2.20E-03

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Nandrolone-decanoate

hsa04613

Neutrophil extracellular trap formation

4.93E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1

Nandrolone-decanoate

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Nandrolone-decanoate

hsa04621

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Nandrolone-decanoate

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Nandrolone-decanoate

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Nandrolone-decanoate

hsa04640

Hematopoietic cell lineage

1.60E-04

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Nandrolone-decanoate

hsa04650

Natural killer cell mediated cytotoxicity

1.86E-05

P16298, P50591, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Nandrolone-decanoate

hsa04658

Th1 and Th2 cell differentiation

1.39E-12

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Nandrolone-decanoate

hsa04659

Th17 cell differentiation

1.55E-08

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Nandrolone-decanoate

hsa04660

T cell receptor signaling pathway

4.91E-06

Q9UDY8, Q04759, P10747, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

MALT1, PRKCQ, CD28, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Nandrolone-decanoate

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Nandrolone-decanoate

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Nandrolone-decanoate

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Nandrolone-decanoate

hsa04750

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Nandrolone-decanoate

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Nandrolone-decanoate

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Nandrolone-decanoate

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Nandrolone-decanoate

hsa04920

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Nandrolone-decanoate

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Nandrolone-decanoate

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Nandrolone-decanoate

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Nandrolone-decanoate

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Nandrolone-decanoate

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Nandrolone-decanoate

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Nandrolone-decanoate

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Nandrolone-decanoate

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Nandrolone-decanoate

hsa05020

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Nandrolone-decanoate

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.14E-02

Q16539, P25024, P25025

MAPK14, CXCR1, CXCR2

Nandrolone-decanoate

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Nandrolone-decanoate

hsa05132

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Nandrolone-decanoate

hsa05146

Amoebiasis

9.73E-03

P09341, P14778, P27930, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSG

Nandrolone-decanoate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Nandrolone-decanoate

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Nandrolone-decanoate

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Nandrolone-decanoate

hsa05202

Transcriptional misregulation in cancer

2.90E-02

Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45A

Nandrolone-decanoate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Nandrolone-decanoate

hsa05210

Colorectal cancer

3.43E-02

Q9UKG1, P37173

APPL1, TGFBR2

Nandrolone-decanoate

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Nandrolone-decanoate

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Nandrolone-decanoate

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Nandrolone-decanoate

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Nandrolone-decanoate

hsa05231

Choline metabolism in cancer

2.99E-03

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Nandrolone-decanoate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.59E-06

P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35, P01730

PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4, CD4

Nandrolone-decanoate

hsa05321

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Nandrolone-decanoate

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Nandrolone-decanoate

hsa05332

Graft-versus-host disease

3.63E-04

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Nandrolone-decanoate

hsa05340

Primary immunodeficiency

2.26E-03

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Nandrolone-decanoate

hsa05415

Diabetic cardiomyopathy

4.23E-02

P30405, P37173

PPIF, TGFBR2

UniProtAC	Gene Name	Protein Name	Reported/ Predicted	DisGeNET	S_PV	S_drugability	S_HiSBiN	S_DisG

PharmaCoNets of Nandrolone-decanoate (SPCN: 51.33 )

Nandrolone-decanoate regulated-network (SDN: 10.27)

Community members of Nandrolone-decanoate (SDC: 5.00)

PharmaCoNets of Nandrolone-decanoate (S_PCN: 51.33 )

Nandrolone-decanoate regulated-network (S_DN: 10.27)

Community members of Nandrolone-decanoate (S_DC: 5.00)