PharmaCoNets of Naloxone (SPCN: 25.18 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Naloxonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Naloxonehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Naloxonehsa00500Starch and sucrose metabolism5.45E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Naloxonehsa00730Thiamine metabolism7.19E-042P05186, P24666ALPL, ACP1More
Naloxonehsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Naloxonehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Naloxonehsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Naloxonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Naloxonehsa01522Endocrine resistance4.51E-022P04637, P42773TP53, CDKN2CMore
Naloxonehsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Naloxonehsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Naloxonehsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Naloxonehsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Naloxonehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Naloxonehsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Naloxonehsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Naloxonehsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Naloxonehsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Naloxonehsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Naloxonehsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Naloxonehsa04071Sphingolipid signaling pathway1.82E-049P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2More
Naloxonehsa04110Cell cycle1.29E-024P30260, P04637, P49918, P42773CDC27, TP53, CDKN1C, CDKN2CMore
Naloxonehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Naloxonehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Naloxonehsa04145Phagosome1.86E-025P63261, Q15080, Q13509, P68371, P27824ACTG1, NCF4, TUBB3, TUBB2C, CANXMore
Naloxonehsa04151PI3K-Akt signaling pathway4.57E-023P04637, Q96BR1, P56279TP53, SGK3, TCL1AMore
Naloxonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Naloxonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Naloxonehsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Naloxonehsa04261Adrenergic signaling in cardiomyocytes4.37E-037P17612, Q13362, Q16537, P0DP23, P17252, P10415, P20020PRKACA, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Naloxonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Naloxonehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Naloxonehsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Naloxonehsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Naloxonehsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Naloxonehsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Naloxonehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Naloxonehsa04613Neutrophil extracellular trap formation2.98E-0414P17252, P11215, O60603, P08246, Q13547, Q92769, Q6FI13, P58876, P33778, Q16778, O60814, P14598, Q15080, P21462PRKCA, ITGAM, TLR2, ELA2, HDAC1, HDAC2, H2AC18; H2AC19, H2BC5, H2BC3, HIST2H2BE, H2BC12, NCF1, NCF4, FPR1More
Naloxonehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Naloxonehsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Naloxonehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Naloxonehsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Naloxonehsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Naloxonehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Naloxonehsa04720Long-term potentiation8.84E-056P17252, Q16566, P0DP23, O15399, P17612, Q14643PRKCA, CAMK4, CALM1, GRIN2D, PRKACA, ITPR1More
Naloxonehsa04728Dopaminergic synapse2.18E-039P17612, P14416, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23PRKACA, DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1More
Naloxonehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Naloxonehsa04910Insulin signaling pathway1.91E-035P0DP23, P17612, P22694, P06737, P49841CALM1, PRKACA, PRKACB, PYGL, GSK3BMore
Naloxonehsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Naloxonehsa04916Melanogenesis2.99E-034P17612, P0DP23, Q9UJU2, P17252PRKACA, CALM1, LEF1, PRKCAMore
Naloxonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Naloxonehsa04921Oxytocin signaling pathway3.44E-036P0DP23, P17612, P17252, Q16566, P63261, Q96RR4CALM1, PRKACA, PRKCA, CAMK4, ACTG1, CAMKK2More
Naloxonehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Naloxonehsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Naloxonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Naloxonehsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Naloxonehsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Naloxonehsa04970Salivary secretion6.19E-056P17612, Q14643, P20020, P23634, P17252, P0DP23PRKACA, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Naloxonehsa04971Gastric acid secretion3.94E-034P17612, P17252, P63261, P0DP23PRKACA, PRKCA, ACTG1, CALM1More
Naloxonehsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Naloxonehsa04976Bile secretion1.19E-034P17612, P22694, P08183, Q14032PRKACA, PRKACB, ABCB1, BAATMore
Naloxonehsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Naloxonehsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Naloxonehsa05031Amphetamine addiction9.97E-045O15399, P0DP23, Q16566, P17612, P17252GRIN2D, CALM1, CAMK4, PRKACA, PRKCAMore
Naloxonehsa05034Alcoholism9.58E-057P17612, Q13547, P0DP23, Q96RR4, P58876, Q16778, O60814PRKACA, HDAC1, CALM1, CAMKK2, H2BC5, HIST2H2BE, H2BC12More
Naloxonehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Naloxonehsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Naloxonehsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Naloxonehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Naloxonehsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Naloxonehsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Naloxonehsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Naloxonehsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Naloxonehsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Naloxonehsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Naloxonehsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Naloxonehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Naloxonehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Naloxonehsa05212Pancreatic cancer2.97E-033Q15311, P23458, P37173RALBP1, JAK1, TGFBR2More
Naloxonehsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Naloxonehsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Naloxonehsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Naloxonehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Naloxonehsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Naloxone (SDC: 2.12)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)