PharmaCoNets of Naloxegol (SPCN: 4.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Naloxegolhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Naloxegolhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Naloxegolhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Naloxegolhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Naloxegolhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Naloxegolhsa03008Ribosome biogenesis in eukaryotes4.42E-023Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Naloxegolhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Naloxegolhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Naloxegolhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Naloxegolhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Naloxegolhsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Naloxegolhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Naloxegolhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Naloxegolhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Naloxegolhsa04613Neutrophil extracellular trap formation1.68E-029P17252, O60603, P08246, Q92769, Q6FI13, P33778, P14598, Q15080, P21462PRKCA, TLR2, ELA2, HDAC2, H2AC18; H2AC19, H2BC3, NCF1, NCF4, FPR1More
Naloxegolhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Naloxegolhsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Naloxegolhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Naloxegolhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Naloxegolhsa04720Long-term potentiation4.42E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Naloxegolhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Naloxegolhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Naloxegolhsa04925Aldosterone synthesis and secretion1.54E-024Q14643, P0DP23, P17252, P20020ITPR1, CALM1, PRKCA, ATP2B1More
Naloxegolhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Naloxegolhsa04970Salivary secretion1.00E-024Q14643, P20020, P17252, P0DP23ITPR1, ATP2B1, PRKCA, CALM1More
Naloxegolhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Naloxegolhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Naloxegolhsa05132Salmonella infection1.02E-0310P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3More
Naloxegolhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Naloxegolhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Naloxegolhsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Naloxegolhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Naloxegolhsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Naloxegolhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Naloxegolhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Naloxegolhsa05214Glioma1.00E-024P0DP23, P17252, P04637, P24522CALM1, PRKCA, TP53, GADD45AMore
Naloxegolhsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Naloxegolhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Naloxegolhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Naloxegol (SDC: 0.81)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)