PharmaCoNets of Nafarelin (SPCN: 4.64 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nafarelinhsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Nafarelinhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Nafarelinhsa00500Starch and sucrose metabolism2.10E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nafarelinhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Nafarelinhsa00970Aminoacyl-tRNA biosynthesis9.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Nafarelinhsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Nafarelinhsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Nafarelinhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Nafarelinhsa03013RNA transport4.73E-029P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Nafarelinhsa04080Neuroactive ligand-receptor interaction8.48E-039P08311, P48058, Q15722, Q9H228, P43657, Q01726, P41968, P21730, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, MC1R, MC3R, C5AR1, ADMMore
Nafarelinhsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Nafarelinhsa04613Neutrophil extracellular trap formation9.53E-0313P17252, O60603, P08246, Q9UM07, Q92769, Q6FI13, P14598, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF1, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Nafarelinhsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Nafarelinhsa04650Natural killer cell mediated cytotoxicity2.05E-039P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Nafarelinhsa04658Th1 and Th2 cell differentiation1.27E-049Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21More
Nafarelinhsa04659Th17 cell differentiation1.64E-0410Q04759, Q16539, P01730, P06239, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Nafarelinhsa04660T cell receptor signaling pathway6.29E-0410Q04759, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Nafarelinhsa04912GnRH signaling pathway3.39E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Nafarelinhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Nafarelinhsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Nafarelinhsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Nafarelinhsa05120Epithelial cell signaling in Helicobacter pylori infection3.76E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Nafarelinhsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Nafarelinhsa05146Amoebiasis2.10E-026P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Nafarelinhsa05222Small cell lung cancer4.26E-026P10826, Q13489, P10415, Q13077, O00463, P24522RARB, BIRC3, BCL2, TRAF1, TRAF5, GADD45AMore
Nafarelinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.79E-037P07766, P20963, P09693, P06239, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Nafarelinhsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Nafarelinhsa05415Diabetic cardiomyopathy3.19E-027P17252, P14598, Q15080, Q16718, O14521, Q16539, P14780PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9More

Community members of Nafarelin (SDC: 1.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
O60603TLR2TollNonelike receptor 2Predicted10.21260.080511.2673
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)