PharmaCoNets of Nabumetone (SPCN: 58.27 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nabumetonehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Nabumetonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Nabumetonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Nabumetonehsa00500Starch and sucrose metabolism5.73E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Nabumetonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Nabumetonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Nabumetonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Nabumetonehsa00730Thiamine metabolism5.35E-042P05186, P24666ALPL, ACP1More
Nabumetonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Nabumetonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Nabumetonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Nabumetonehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Nabumetonehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Nabumetonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Nabumetonehsa03013RNA transport3.53E-026P62826, Q15287, Q9UBU9, P63279, P20042, Q14232RAN, RNPS1, NXF1, UBE2I, EIF2S2, EIF2B1More
Nabumetonehsa03060Protein export3.20E-022P37108, Q15005SRP14, SPCS2More
Nabumetonehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Nabumetonehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Nabumetonehsa04064NF-kappa B signaling pathway2.98E-0413P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Nabumetonehsa04071Sphingolipid signaling pathway2.60E-057P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Nabumetonehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Nabumetonehsa04080Neuroactive ligand-receptor interaction6.04E-048P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Nabumetonehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Nabumetonehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Nabumetonehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Nabumetonehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Nabumetonehsa04210Apoptosis4.11E-039Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1More
Nabumetonehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Nabumetonehsa04217Necroptosis1.85E-026P23458, Q9NQC7, P01584, P0C0S5, Q9H444, O75351JAK1, CYLD, IL1B, H2AFZ, CHMP4B, VPS4BMore
Nabumetonehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Nabumetonehsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Nabumetonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Nabumetonehsa04380Osteoclast differentiation4.17E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Nabumetonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Nabumetonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Nabumetonehsa04612Antigen processing and presentation2.58E-047P13765, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Nabumetonehsa04613Neutrophil extracellular trap formation3.77E-0312O60603, P05164, P08246, Q9UM07, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1More
Nabumetonehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Nabumetonehsa04650Natural killer cell mediated cytotoxicity1.11E-0817P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Nabumetonehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Nabumetonehsa04658Th1 and Th2 cell differentiation3.29E-0813Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Nabumetonehsa04659Th17 cell differentiation2.21E-0612Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Nabumetonehsa04660T cell receptor signaling pathway1.09E-0412Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Nabumetonehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Nabumetonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Nabumetonehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Nabumetonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Nabumetonehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Nabumetonehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Nabumetonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Nabumetonehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Nabumetonehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Nabumetonehsa04924Renin secretion8.77E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Nabumetonehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Nabumetonehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Nabumetonehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Nabumetonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Nabumetonehsa04932Non-alcoholic fatty liver disease2.78E-025O43521, O75460, P01584, P12074, O95298BCL2L11, ERN1, IL1B, COX6A1, NDUFC2More
Nabumetonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Nabumetonehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Nabumetonehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Nabumetonehsa04971Gastric acid secretion4.51E-023Q08828, P15311, P0DP23ADCY1, VIL2, CALM1More
Nabumetonehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Nabumetonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Nabumetonehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Nabumetonehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nabumetonehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Nabumetonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Nabumetonehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Nabumetonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Nabumetonehsa05144Malaria7.08E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Nabumetonehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Nabumetonehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Nabumetonehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Nabumetonehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Nabumetonehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Nabumetonehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Nabumetonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Nabumetonehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Nabumetonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Nabumetonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Nabumetonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.73E-0510P42338, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14More
Nabumetonehsa05321Inflammatory bowel disease6.21E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Nabumetonehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Nabumetonehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Nabumetonehsa05332Graft-versus-host disease7.32E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Nabumetonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Nabumetone (SDC: 5.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)