PharmaCoNets of Nabilone (SPCN: 40.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Nabilonehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Nabilonehsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Nabilonehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Nabilonehsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Nabilonehsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Nabilonehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Nabilonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Nabilonehsa01522Endocrine resistance1.69E-024P22694, P08069, P10415, Q13323PRKACB, IGF1R, BCL2, BIKMore
Nabilonehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Nabilonehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Nabilonehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Nabilonehsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Nabilonehsa04014Ras signaling pathway1.13E-029P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Nabilonehsa04015Rap1 signaling pathway5.95E-039P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Nabilonehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Nabilonehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Nabilonehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Nabilonehsa04070Phosphatidylinositol signaling system2.96E-023P19174, P49619, P27987PLCG1, DGKG, ITPKBMore
Nabilonehsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Nabilonehsa04110Cell cycle1.72E-037Q9UBD5, P06493, Q14683, P30304, P33981, P01106, Q13547ORC3, CDK1, SMC1A, CDC25A, TTK, MYC, HDAC1More
Nabilonehsa04114Oocyte meiosis1.45E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Nabilonehsa04140Autophagy - animal2.81E-024P08069, P22694, Q14643, P10415IGF1R, PRKACB, ITPR1, BCL2More
Nabilonehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Nabilonehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Nabilonehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Nabilonehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Nabilonehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Nabilonehsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Nabilonehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Nabilonehsa04370VEGF signaling pathway9.46E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Nabilonehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Nabilonehsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Nabilonehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Nabilonehsa04520Adherens junction8.29E-031P08069IGF1RMore
Nabilonehsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Nabilonehsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, Q02750, P08069, Q86SE9BMPR2, MAP2K1, IGF1R, PCGF5More
Nabilonehsa04613Neutrophil extracellular trap formation1.56E-025P19174, P11215, Q13547, P62807, Q16778PLCG1, ITGAM, HDAC1, HIST1H2BC, HIST2H2BEMore
Nabilonehsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Nabilonehsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Nabilonehsa04658Th1 and Th2 cell differentiation1.48E-046P07766, P19174, P06239, P42224, P14784, Q13761CD3E, PLCG1, LCK, STAT1, IL2RB, RUNX3More
Nabilonehsa04659Th17 cell differentiation3.55E-049P19174, P06239, P42224, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, LCK, STAT1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Nabilonehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Nabilonehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Nabilonehsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Nabilonehsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Nabilonehsa04730Long-term depression1.16E-021P08069IGF1RMore
Nabilonehsa04913Ovarian steroidogenesis8.54E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Nabilonehsa04914Progesterone-mediated oocyte maturation2.23E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Nabilonehsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Nabilonehsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Nabilonehsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Nabilonehsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Nabilonehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Nabilonehsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Nabilonehsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Nabilonehsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Nabilonehsa05034Alcoholism4.79E-023Q13547, P62807, Q16778HDAC1, HIST1H2BC, HIST2H2BEMore
Nabilonehsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Nabilonehsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Nabilonehsa05169Epstein-Barr virus infection3.66E-025P01106, Q13547, Q13761, P42224, P07766MYC, HDAC1, RUNX3, STAT1, CD3EMore
Nabilonehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Nabilonehsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Nabilonehsa05203Viral carcinogenesis9.16E-035Q13547, P12814, P06493, P62807, Q16778HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BEMore
Nabilonehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Nabilonehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Nabilonehsa05214Glioma9.95E-031P08069IGF1RMore
Nabilonehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Nabilonehsa05218Melanoma6.63E-031P08069IGF1RMore
Nabilonehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Nabilonehsa05224Breast cancer1.49E-021P08069IGF1RMore
Nabilonehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Nabilonehsa05231Choline metabolism in cancer8.99E-043Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Nabilonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.46E-035P19174, P07766, P06239, P42224, Q9HC35PLCG1, CD3E, LCK, STAT1, EML4More
Nabilonehsa05322Systemic lupus erythematosus2.75E-023P62807, Q16778, P12814HIST1H2BC, HIST2H2BE, ACTN1More

Community members of Nabilone (SDC: 4.14)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)