PharmaCoNets of Moxifloxacin (SPCN: 29.73 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Moxifloxacinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Moxifloxacinhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Moxifloxacinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Moxifloxacinhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Moxifloxacinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Moxifloxacinhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Moxifloxacinhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Moxifloxacinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Moxifloxacinhsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Moxifloxacinhsa03050Proteasome4.83E-021P55036PSMD4More
Moxifloxacinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Moxifloxacinhsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Moxifloxacinhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Moxifloxacinhsa04064NF-kappa B signaling pathway1.19E-0513P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Moxifloxacinhsa04071Sphingolipid signaling pathway8.11E-059P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Moxifloxacinhsa04080Neuroactive ligand-receptor interaction9.01E-048P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Moxifloxacinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Moxifloxacinhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Moxifloxacinhsa04115p53 signaling pathway3.32E-035P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Moxifloxacinhsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Moxifloxacinhsa04210Apoptosis1.53E-0312Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1More
Moxifloxacinhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Moxifloxacinhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Moxifloxacinhsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Moxifloxacinhsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Moxifloxacinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Moxifloxacinhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Moxifloxacinhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Moxifloxacinhsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Moxifloxacinhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Moxifloxacinhsa04668TNF signaling pathway1.83E-038P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Moxifloxacinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Moxifloxacinhsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Moxifloxacinhsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Moxifloxacinhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Moxifloxacinhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Moxifloxacinhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Moxifloxacinhsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Moxifloxacinhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Moxifloxacinhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Moxifloxacinhsa04970Salivary secretion1.06E-037P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMPMore
Moxifloxacinhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Moxifloxacinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Moxifloxacinhsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Moxifloxacinhsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Moxifloxacinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Moxifloxacinhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Moxifloxacinhsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Moxifloxacinhsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Moxifloxacinhsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Moxifloxacinhsa05202Transcriptional misregulation in cancer1.07E-0516Q12778, Q15532, Q13315, P14780, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Moxifloxacinhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Moxifloxacinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Moxifloxacinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Moxifloxacinhsa05321Inflammatory bowel disease7.73E-046O60603, P01375, P13765, Q14765, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, GATA3, IL21RMore
Moxifloxacinhsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Moxifloxacinhsa05332Graft-versus-host disease2.37E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Moxifloxacinhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Moxifloxacin (SDC: 3.87)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)