PharmaCoNets

PharmaCoNets of Montelukast (S_PCN: 51.80 )

Montelukast regulated-network (S_DN: 15.10)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Montelukast

hsa00190

Oxidative phosphorylation

1.18E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Montelukast

hsa00220

Arginine biosynthesis

2.86E-02

P15104, P05089

GLUL, ARG1

Montelukast

hsa00250

Alanine, aspartate and glutamate metabolism

8.48E-03

Q96RQ9, P15104

IL4I1, GLUL

Montelukast

hsa00270

Cysteine and methionine metabolism

2.39E-02

Q96RQ9, P40926

IL4I1, MDH2

Montelukast

hsa00280

Valine, leucine and isoleucine degradation

8.48E-03

Q96RQ9, P05166

IL4I1, PCCB

Montelukast

hsa00310

Lysine degradation

4.50E-02

Q9NVH6, O15047

TMLHE, SETD1A

Montelukast

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Montelukast

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Montelukast

hsa00591

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Montelukast

hsa00600

Sphingolipid metabolism

4.50E-02

P15289

ARSA

Montelukast

hsa00630

Glyoxylate and dicarboxylate metabolism

6.65E-03

P40926, P05166, P15104

MDH2, PCCB, GLUL

Montelukast

hsa00670

One carbon pool by folate

3.15E-02

O95954, Q99707

FTCD, MTR

Montelukast

hsa00860

Porphyrin and chlorophyll metabolism

3.15E-02

P36551, P30043

CPOX, BLVRB

Montelukast

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Montelukast

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Montelukast

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Montelukast

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Montelukast

hsa01100

Metabolic pathways

1.59E-02

Q9UJ14, P15104, Q96DU7, Q08828, Q02153, P40926, Q86XP1, Q96RQ9, Q9UHK6, Q9H4F1, Q9BRR6, P05166, P12074, P05496, O15239, O15047, Q9NVH6

GGTL3, GLUL, ITPKC, ADCY1, GUCY1B3, MDH2, DGKH, IL4I1, AMACR, ST6GALNAC4, ADPGK, PCCB, COX6A1, ATP5G1, NDUFA1, SETD1A, TMLHE

Montelukast

hsa03008

Ribosome biogenesis in eukaryotes

4.42E-02

Q9NYH9, P78345, Q9BVP2

UTP6, RPP38, GNL3

Montelukast

hsa03013

RNA transport

6.53E-09

O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UBU7	DBF4	Protein DBF4 homolog A	O14980	XPO1	Exportin-1	0.943
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
Q9UBU7	DBF4	Protein DBF4 homolog A	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
Q9UBU7	DBF4	Protein DBF4 homolog A	P61326	MAGOH	Protein mago nashi homolog	0.737
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q9UBU7	DBF4	Protein DBF4 homolog A	Q9H307	PNN	Pinin	0.722
Q9UBU7	DBF4	Protein DBF4 homolog A	Q7Z3B4	NUP54	Nucleoporin p54	0.787
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
Q9UBU7	DBF4	Protein DBF4 homolog A	P35658	NUP214	Nuclear pore complex protein Nup214	-0.781
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.902
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
Q9UBU7	DBF4	Protein DBF4 homolog A	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.83
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.867
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
Q9UBU7	DBF4	Protein DBF4 homolog A	Q06787	FMR1	Synaptic functional regulator FMR1	0.772
Q9UBU7	DBF4	Protein DBF4 homolog A	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.854

Montelukast

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Montelukast

hsa03040

Spliceosome

1.81E-06

O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Montelukast

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Montelukast

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Montelukast

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Montelukast

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Montelukast

hsa04015

Rap1 signaling pathway

2.69E-03

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Montelukast

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Montelukast

hsa04022

cGMP-PKG signaling pathway

3.25E-03

Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, VDAC2, CALM2

Montelukast

hsa04060

Cytokine-cytokine receptor interaction

1.71E-02

P27930, P14778, P26842, Q13651, P25024, P09341, P18510, P09603, P01730

IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCL1, IL1RN, CSF1, CD4

Montelukast

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Montelukast

hsa04064

NF-kappa B signaling pathway

4.92E-02

P10415, P51617, Q13546, Q9UDY8, Q13077, P24522

BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45A

Montelukast

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Montelukast

hsa04071

Sphingolipid signaling pathway

1.13E-02

P17252, Q16537, Q9BX95, P04637, P10415

PRKCA, PPP2R5E, SGPP1, TP53, BCL2

Montelukast

hsa04120

Ubiquitin mediated proteolysis

1.68E-02

O00762, Q14139

UBE2C, UBE4A

Montelukast

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Montelukast

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Montelukast

hsa04145

Phagosome

6.28E-06

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Montelukast

hsa04151

PI3K-Akt signaling pathway

1.67E-03

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Montelukast

hsa04210

Apoptosis

3.63E-02

O75460, O43521, P18848

ERN1, BCL2L11, ATF4

Montelukast

hsa04217

Necroptosis

5.66E-03

P15104, P05141, P01584, P0C0S5, Q9H444

GLUL, SLC25A5, IL1B, H2AFZ, CHMP4B

Montelukast

hsa04261

Adrenergic signaling in cardiomyocytes

4.32E-03

P51828, Q99941, Q16537, P0DP23, Q13557, P17252, P10415, P20020, P23634

ADCY7, CREBL1, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4

Montelukast

hsa04270

Vascular smooth muscle contraction

2.89E-02

P35579, P35318

MYH9, ADM

Montelukast

hsa04330

Notch signaling pathway

5.96E-04

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Montelukast

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Montelukast

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Montelukast

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Montelukast

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Montelukast

hsa04530

Tight junction

2.47E-05

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Montelukast

hsa04540

Gap junction

2.72E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Montelukast

hsa04610

Complement and coagulation cascades

4.47E-02

P25116, P09871

F2R, C1S

Montelukast

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Montelukast

hsa04613

Neutrophil extracellular trap formation

1.41E-05

P17252, P16109, P11215, O60603, P08246, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P08514, P21462, P07359

PRKCA, SELP, ITGAM, TLR2, ELA2, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, ITGA2B, FPR1, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876

Montelukast

hsa04623

Cytosolic DNA-sensing pathway

4.32E-02

P01568, Q13546

IFNA21, RIPK1

Montelukast

hsa04640

Hematopoietic cell lineage

7.16E-03

P13612, P14778, P27930, P07766, P01730, P09564, P09603

ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1

Montelukast

hsa04658

Th1 and Th2 cell differentiation

4.54E-03

P07766, P20963, P01730, P06239, Q9UL17, Q13761

CD3E, CD247, CD4, LCK, TBX21, RUNX3

Montelukast

hsa04659

Th17 cell differentiation

7.46E-04

P19174, P01730, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PLCG1, CD4, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Montelukast

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Montelukast

hsa04664

Fc epsilon RI signaling pathway

1.48E-03

P42338, Q9UQC2, P07948, P19174, P09917, P20292

PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Montelukast

hsa04666

Fc gamma R-mediated phagocytosis

3.21E-05

P23528, P49006, P06396, O14494, P14598, P17252

CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Montelukast

hsa04668

TNF signaling pathway

3.36E-03

Q99941, P18848, P01584, P20333, O95429

CREBL1, ATF4, IL1B, TNFRSF1B, BAG4

Montelukast

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Montelukast

hsa04713

Circadian entrainment

9.20E-03

Q13557, Q02153, P61952, Q08828

CAMK2D, GUCY1B3, GNG11, ADCY1

Montelukast

hsa04720

Long-term potentiation

1.17E-03

P17252, Q16566, P0DP23, Q14643

PRKCA, CAMK4, CALM1, ITPR1

Montelukast

hsa04723

Retrograde endocannabinoid signaling

3.86E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Montelukast

hsa04724

Glutamatergic synapse

2.72E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Montelukast

hsa04725

Cholinergic synapse

7.09E-03

Q14643, P17252, P62873, Q16566, P10415

ITPR1, PRKCA, GNB1, CAMK4, BCL2

Montelukast

hsa04727

GABAergic synapse

1.36E-03

Q08828, P63218, P50151, P61952, P15104, Q15111

ADCY1, GNG5, GNG10, GNG11, GLUL, PLCL1

Montelukast

hsa04744

Phototransduction

4.54E-04

P62873, P0DP23

GNB1, CALM1

Montelukast

hsa04750

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Montelukast

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Montelukast

hsa04911

Insulin secretion

1.04E-03

Q08828, P51828, Q99941, Q13557

ADCY1, ADCY7, CREBL1, CAMK2D

Montelukast

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Montelukast

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Montelukast

hsa04916

Melanogenesis

2.21E-03

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Montelukast

hsa04925

Aldosterone synthesis and secretion

2.56E-05

Q14643, Q99941, P51828, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Montelukast

hsa04932

Non-alcoholic fatty liver disease

2.05E-03

O43521, P18848, O75460, P01584, P13073

BCL2L11, ATF4, ERN1, IL1B, COX4I1

Montelukast

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Montelukast

hsa04934

Cushing syndrome

8.32E-05

Q99941, Q08828, P51828, O15169, Q13557

CREBL1, ADCY1, ADCY7, AXIN1, CAMK2D

Montelukast

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Montelukast

hsa04966

Collecting duct acid secretion

2.20E-03

Q13488, P02730, Q9Y666

TCIRG1, SLC4A1, SLC12A7

Montelukast

hsa04970

Salivary secretion

1.00E-02

Q14643, P20020, P17252, P0DP23

ITPR1, ATP2B1, PRKCA, CALM1

Montelukast

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Montelukast

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Montelukast

hsa04976

Bile secretion

4.50E-02

Q9BY07

SLC4A5

Montelukast

hsa05010

Alzheimer disease

1.35E-04

P49768, Q92542, O15239, P05496, P13073, P12074, O75460, P0DP24, P01584, Q12933, P18848, O15169, P05141, P45880, P43686

PSEN1, NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, TRAF2, ATF4, AXIN1, SLC25A5, VDAC2, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P49768	PSEN1	Presenilin-1	-0.732
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q92542	NCSTN	Nicastrin	-0.729
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	-0.834
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	-0.815
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	-0.715
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q12933	TRAF2	TNF receptor-associated factor 2	-0.771
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15169	AXIN1	Axin-1	-0.74
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P43686	PSMC4	26S proteasome regulatory subunit 6B	-0.729

Montelukast

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Montelukast

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Montelukast

hsa05020

Prion disease

4.54E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q14643, P45880, Q13509, P68371, Q99941, P14598, Q15080

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, VDAC2, TUBB3, TUBB2C, CREBL1, NCF1, NCF4

Montelukast

hsa05022

Pathways of neurodegeneration - multiple diseases

8.21E-05

Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P13073, P12074, P05496, O75460, P18848, Q12933, Q13561, P05141, P17252, P20333, O15169, P04628, P01584, P49768, O15020, P0DP23, P0DP24, Q13557, P62987, P43686

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, PRKCA, TNFRSF1B, AXIN1, WNT1, IL1B, PSEN1, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00398	P2RY10	Putative P2Y purinoceptor 10	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.793
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13509	TUBB3	Tubulin beta-3 chain	-0.787
O00398	P2RY10	Putative P2Y purinoceptor 10	P68371	TUBB2C	Tubulin beta-4B chain	-0.908
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	-0.834
O00398	P2RY10	Putative P2Y purinoceptor 10	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.709
O00398	P2RY10	Putative P2Y purinoceptor 10	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.719
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	-0.715
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	-0.815
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q12933	TRAF2	TNF receptor-associated factor 2	-0.771
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13561	DCTN2	Dynactin subunit 2	-0.876
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
O00398	P2RY10	Putative P2Y purinoceptor 10	P17252	PRKCA	Protein kinase C alpha type	0.887
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15169	AXIN1	Axin-1	-0.74
O00398	P2RY10	Putative P2Y purinoceptor 10	P04628	WNT1	Proto-oncogene Wnt-1	0.732
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P49768	PSEN1	Presenilin-1	-0.732
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	-0.718
O00398	P2RY10	Putative P2Y purinoceptor 10	P0DP23	CALM1	Calmodulin-1	-0.815
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	-0.85
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P62987	UBA52	Ubiquitin-60S ribosomal protein L40	0.772
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P43686	PSMC4	26S proteasome regulatory subunit 6B	-0.729

Montelukast

hsa05034

Alcoholism

3.11E-05

Q96RR4, Q93077, P62807, O60814, P84243, P68431

CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Montelukast

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Montelukast

hsa05132

Salmonella infection

8.23E-06

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.877
P51684	CCR6	C-C chemokine receptor type 6	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.835
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.819
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.981
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
P51684	CCR6	C-C chemokine receptor type 6	O75369	FLNB	Filamin-B	-0.717
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.774
P51684	CCR6	C-C chemokine receptor type 6	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.721
P51684	CCR6	C-C chemokine receptor type 6	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.731
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13561	DCTN2	Dynactin subunit 2	-0.876
P51684	CCR6	C-C chemokine receptor type 6	Q13561	DCTN2	Dynactin subunit 2	-0.781
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13509	TUBB3	Tubulin beta-3 chain	-0.787
P51684	CCR6	C-C chemokine receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	-0.835
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
O00398	P2RY10	Putative P2Y purinoceptor 10	P68371	TUBB2C	Tubulin beta-4B chain	-0.908

Montelukast

hsa05133

Pertussis

2.41E-02

P09871, Q02556

C1S, IRF8

Montelukast

hsa05140

Leishmaniasis

1.56E-02

P14598, O60603, P49006, P51617, Q15080

NCF1, TLR2, MARCKSL1, IRAK1, NCF4

Montelukast

hsa05146

Amoebiasis

4.54E-03

Q13751, P09341, P14778, P27930, P05089, P12814

LAMB3, CXCL1, IL1R1, IL1R2, ARG1, ACTN1

Montelukast

hsa05152

Tuberculosis

6.49E-05

Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Montelukast

hsa05169

Epstein-Barr virus infection

2.54E-02

Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693

HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3G

Montelukast

hsa05170

Human immunodeficiency virus 1 infection

3.40E-06

P62873, P0DP23, P17252, Q13546, O00463, Q14643, P01568, P51617, O60603, P23528, P09693, P10415, Q93034, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, CD3G, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
O00398	P2RY10	Putative P2Y purinoceptor 10	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
O00398	P2RY10	Putative P2Y purinoceptor 10	P0DP23	CALM1	Calmodulin-1	-0.815
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
O00398	P2RY10	Putative P2Y purinoceptor 10	P17252	PRKCA	Protein kinase C alpha type	0.887
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
O00398	P2RY10	Putative P2Y purinoceptor 10	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.819
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
O00398	P2RY10	Putative P2Y purinoceptor 10	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.793
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
O00398	P2RY10	Putative P2Y purinoceptor 10	P01568	IFNA21	Interferon alpha-21	0.876
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
O00398	P2RY10	Putative P2Y purinoceptor 10	O60603	TLR2	Toll-like receptor 2	-0.788
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
O00398	P2RY10	Putative P2Y purinoceptor 10	P23528	CFL1	Cofilin-1	0.8
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
O00398	P2RY10	Putative P2Y purinoceptor 10	P10415	BCL2	Apoptosis regulator Bcl-2	0.919
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
O00398	P2RY10	Putative P2Y purinoceptor 10	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.838
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.86

Montelukast

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Montelukast

hsa05202

Transcriptional misregulation in cancer

3.51E-02

Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0

FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B

Montelukast

hsa05203

Viral carcinogenesis

2.93E-03

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Montelukast

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Montelukast

hsa05205

Proteoglycans in cancer

1.09E-02

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Montelukast

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Montelukast

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Montelukast

hsa05214

Glioma

1.00E-02

P0DP23, P17252, P04637, P24522

CALM1, PRKCA, TP53, GADD45A

Montelukast

hsa05216

Thyroid cancer

1.85E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Montelukast

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Montelukast

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Montelukast

hsa05320

Autoimmune thyroid disease

5.52E-04

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Montelukast

hsa05322

Systemic lupus erythematosus

1.44E-05

P08246, P09871, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

ELA2, C1S, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Montelukast

hsa05323

Rheumatoid arthritis

2.72E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Community members of Montelukast (S_DC: 3.43)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Reported

0.3822

0.2701

2.4612

Q9UBU7

DBF4

Protein DBF4 homolog A

Predicted

0.0075

0.1961

0.259

0.655

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P21860

ERBB3

Receptor tyrosineNoneprotein kinase erbBNone3

Predicted

0.126

0.2729

0.4788

1.0876

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

O75342

ALOX12B

Arachidonate 12Nonelipoxygenase, 12RNonetype

Predicted

0.075

0.0399

0.1589

0.2762

P43657

P2RY5

Lysophosphatidic acid receptor 6

Predicted

0.7539

0.0448

0.3708

0.8373

O00398

P2RY10

Putative P2Y purinoceptor 10

Predicted

0.0701

0.0152

0.0654

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

Q99527

GPER1

GNoneprotein coupled estrogen receptor 1

Predicted

0.0249

0.1294

0.2138

0.485

PharmaCoNets of Montelukast (SPCN: 51.80 )

Montelukast regulated-network (SDN: 15.10)

Community members of Montelukast (SDC: 3.43)

PharmaCoNets of Montelukast (S_PCN: 51.80 )

Montelukast regulated-network (S_DN: 15.10)

Community members of Montelukast (S_DC: 3.43)