PharmaCoNets of Molindone (SPCN: 32.16 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Molindonehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Molindonehsa00052Galactose metabolism5.00E-021P35557GCKMore
Molindonehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Molindonehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Molindonehsa00524Neomycin, kanamycin and gentamicin biosynthesis1.27E-021P35557GCKMore
Molindonehsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Molindonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Molindonehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Molindonehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Molindonehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Molindonehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Molindonehsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Molindonehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Molindonehsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Molindonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Molindonehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Molindonehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Molindonehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Molindonehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Molindonehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Molindonehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Molindonehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Molindonehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Molindonehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Molindonehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Molindonehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Molindonehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Molindonehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Molindonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Molindonehsa04721Synaptic vesicle cycle3.62E-033Q13488, P43003, P31645TCIRG1, SLC1A3, SLC6A4More
Molindonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Molindonehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Molindonehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Molindonehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Molindonehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Molindonehsa04742Taste transduction1.01E-021P30939HTR1FMore
Molindonehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Molindonehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Molindonehsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Molindonehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Molindonehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Molindonehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Molindonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Molindonehsa04950Maturity onset diabetes of the young1.27E-021P35557GCKMore
Molindonehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Molindonehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Molindonehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Molindonehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Molindonehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Molindonehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Molindonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Molindonehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Molindonehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Molindonehsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Molindonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Molindonehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Molindonehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Molindonehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Molindonehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Molindonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Molindonehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Molindonehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Molindone (SDC: 4.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P35557GCKHexokinaseNone4Predicted00.00490.05580.32420.4382
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki3.8
DRD2P14416Ki6
DRD2P14416Ki20