PharmaCoNets of Moexipril (SPCN: 45.71 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Moexiprilhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Moexiprilhsa00052Galactose metabolism5.59E-032P06280, O43451GLA, MGAMMore
Moexiprilhsa00500Starch and sucrose metabolism9.14E-032O43451, P06737MGAM, PYGLMore
Moexiprilhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Moexiprilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Moexiprilhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Moexiprilhsa00730Thiamine metabolism2.85E-032P05186, P24666ALPL, ACP1More
Moexiprilhsa00770Pantothenate and CoA biosynthesis1.27E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Moexiprilhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Moexiprilhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Moexiprilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Moexiprilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Moexiprilhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Moexiprilhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Moexiprilhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Moexiprilhsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Moexiprilhsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Moexiprilhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Moexiprilhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Moexiprilhsa04060Cytokine-cytokine receptor interaction3.62E-024P27930, P14778, P25024, P25025IL1R2, IL1R1, CXCR1, CXCR2More
Moexiprilhsa04061Viral protein interaction with cytokine and cytokine receptor3.57E-038Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Moexiprilhsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Moexiprilhsa04064NF-kappa B signaling pathway4.05E-0412P14778, P01584, P19174, Q04759, P67870, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7IL1R1, IL1B, PLCG1, PRKCQ, CSNK2B, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Moexiprilhsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Moexiprilhsa04072Phospholipase D signaling pathway3.40E-036P42338, Q9UQC2, P43657, P25024, P25025, P19174PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1More
Moexiprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Moexiprilhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Moexiprilhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Moexiprilhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Moexiprilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Moexiprilhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Moexiprilhsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Moexiprilhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Moexiprilhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Moexiprilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Moexiprilhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Moexiprilhsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Moexiprilhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Moexiprilhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Moexiprilhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Moexiprilhsa04659Th17 cell differentiation9.05E-0511Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Moexiprilhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Moexiprilhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Moexiprilhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Moexiprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Moexiprilhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Moexiprilhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Moexiprilhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Moexiprilhsa04932Non-alcoholic fatty liver disease6.66E-049P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Moexiprilhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Moexiprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Moexiprilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Moexiprilhsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Moexiprilhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Moexiprilhsa05120Epithelial cell signaling in Helicobacter pylori infection3.24E-045P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Moexiprilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Moexiprilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Moexiprilhsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Moexiprilhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Moexiprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Moexiprilhsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Moexiprilhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Moexiprilhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Moexiprilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Moexiprilhsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Moexiprilhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Moexiprilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Moexiprilhsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Moexiprilhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Moexiprilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Moexiprilhsa05332Graft-versus-host disease2.02E-035P48023, P10747, P01375, P26715, Q13241FASLG, CD28, TNF, KLRC1, KLRD1More

Community members of Moexipril (SDC: 4.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
Q13451FKBP5PeptidylNoneprolyl cisNonetrans isomerase FKBP5Predicted00.22890.05860.14230.374
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)