PharmaCoNets

PharmaCoNets of Modafinil (S_PCN: 31.17 )

Modafinil regulated-network (S_DN: 9.74)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Armodafinil

hsa00190

Oxidative phosphorylation

1.10E-03

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Armodafinil

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Armodafinil

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Armodafinil

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Armodafinil

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Armodafinil

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Armodafinil

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Armodafinil

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Armodafinil

hsa00983

Drug metabolism - other enzymes

3.59E-02

P04183, P32320, P05164

TK1, CDA, MPO

Armodafinil

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Armodafinil

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Armodafinil

hsa03008

Ribosome biogenesis in eukaryotes

1.46E-02

Q9NYH9, P78345, Q9BVP2, Q9GZY0

UTP6, RPP38, GNL3, NXF2; NXF2B

Armodafinil

hsa03013

RNA transport

2.88E-05

O14980, P52298, Q09161, O14893, P61326, Q9GZY0, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114, Q53GS7

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723

Armodafinil

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Armodafinil

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Armodafinil

hsa03022

Basal transcription factors

2.97E-03

P20226, O00268, Q15544

TBP, TAF4, TAF11

Armodafinil

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Armodafinil

hsa04071

Sphingolipid signaling pathway

3.08E-02

P17252, Q16537, Q9BX95, P04637, P10415

PRKCA, PPP2R5E, SGPP1, TP53, BCL2

Armodafinil

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Armodafinil

hsa04145

Phagosome

3.27E-04

P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765

ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOB

Armodafinil

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Armodafinil

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Armodafinil

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Armodafinil

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Armodafinil

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Armodafinil

hsa04613

Neutrophil extracellular trap formation

3.43E-04

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, P63261, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, ACTG1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Armodafinil

hsa04666

Fc gamma R-mediated phagocytosis

9.96E-03

P23528, P49006, P06396, P14598, P17252

CFL1, MARCKSL1, GSN, NCF1, PRKCA

Armodafinil

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Armodafinil

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Armodafinil

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Armodafinil

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Armodafinil

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Armodafinil

hsa04972

Pancreatic secretion

1.67E-03

Q14643, P20020, P17252, Q08828, P62491

ITPR1, ATP2B1, PRKCA, ADCY1, RAB11A

Armodafinil

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Armodafinil

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P01375	TNF	Tumor necrosis factor	-0.76
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.702
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P36542	ATP5C1	ATP synthase subunit gamma, mitochondrial	0.792
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P43243	MATR3	Matrin-3	0.724
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16629	SFRS7	Serine/arginine-rich splicing factor 7	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P01375	TNF	Tumor necrosis factor	-0.76
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.702
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P36542	ATP5C1	ATP synthase subunit gamma, mitochondrial	0.792
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P43243	MATR3	Matrin-3	0.724
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16629	SFRS7	Serine/arginine-rich splicing factor 7	0.801

Armodafinil

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Armodafinil

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Armodafinil

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Armodafinil

hsa05132

Salmonella infection

2.10E-02

Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Armodafinil

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Armodafinil

hsa05140

Leishmaniasis

4.13E-02

P14598, P13765, O60603, P49006, Q15080

NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4

Armodafinil

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Armodafinil

hsa05150

Staphylococcus aureus infection

4.02E-03

P21462, O75015, Q14532, P59665, P59666, P12838

FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Armodafinil

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Armodafinil

hsa05202

Transcriptional misregulation in cancer

6.80E-03

Q12778, Q15532, P41732, P14780, P14923, Q13489, O15550, P04637, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, TSPAN7, MMP9, JUP, BIRC3, UTX, TP53, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768

Armodafinil

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Armodafinil

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Armodafinil

hsa05205

Proteoglycans in cancer

2.66E-02

Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.885
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13635	PTCH1	Protein patched homolog 1	0.733
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08962	CD63	CD63 antigen	-0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.885
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13635	PTCH1	Protein patched homolog 1	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08962	CD63	CD63 antigen	-0.737

Armodafinil

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Armodafinil

hsa05217

Basal cell carcinoma

1.46E-02

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Armodafinil

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Armodafinil

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Armodafinil

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Armodafinil

hsa05323

Rheumatoid arthritis

3.53E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Armodafinil

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Armodafinil

hsa05332

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Armodafinil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Armodafinil

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Armodafinil

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Armodafinil

hsa05418

Fluid shear stress and atherosclerosis

4.26E-02

P14598, P14780, P63261, P04637, P10415, Q92974

NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2

Modafinil

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Modafinil

hsa00190

Oxidative phosphorylation

1.10E-03

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Modafinil

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Modafinil

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Modafinil

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Modafinil

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Modafinil

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Modafinil

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Modafinil

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Modafinil

hsa00983

Drug metabolism - other enzymes

3.59E-02

P04183, P32320, P05164

TK1, CDA, MPO

Modafinil

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Modafinil

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Modafinil

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Modafinil

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Modafinil

hsa03008

Ribosome biogenesis in eukaryotes

1.46E-02

Q9NYH9, P78345, Q9BVP2, Q9GZY0

UTP6, RPP38, GNL3, NXF2; NXF2B

Modafinil

hsa03013

RNA transport

2.88E-05

O14980, P52298, Q09161, O14893, P61326, Q9GZY0, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114, Q53GS7

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723

Modafinil

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Modafinil

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Modafinil

hsa03022

Basal transcription factors

2.97E-03

P20226, O00268, Q15544

TBP, TAF4, TAF11

Modafinil

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Modafinil

hsa04071

Sphingolipid signaling pathway

1.22E-03

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Modafinil

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Modafinil

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Modafinil

hsa04145

Phagosome

3.27E-04

P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765

ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOB

Modafinil

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Modafinil

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Modafinil

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Modafinil

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Modafinil

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Modafinil

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Modafinil

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Modafinil

hsa04613

Neutrophil extracellular trap formation

3.43E-04

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, P63261, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, ACTG1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Modafinil

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Modafinil

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Modafinil

hsa04666

Fc gamma R-mediated phagocytosis

9.96E-03

P23528, P49006, P06396, P14598, P17252

CFL1, MARCKSL1, GSN, NCF1, PRKCA

Modafinil

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Modafinil

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Modafinil

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Modafinil

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Modafinil

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Modafinil

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Modafinil

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Modafinil

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Modafinil

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Modafinil

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Modafinil

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Modafinil

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Modafinil

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Modafinil

hsa04972

Pancreatic secretion

1.67E-03

Q14643, P20020, P17252, Q08828, P62491

ITPR1, ATP2B1, PRKCA, ADCY1, RAB11A

Modafinil

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Modafinil

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P01375	TNF	Tumor necrosis factor	-0.76
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.702
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P36542	ATP5C1	ATP synthase subunit gamma, mitochondrial	0.792
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P43243	MATR3	Matrin-3	0.724
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16629	SFRS7	Serine/arginine-rich splicing factor 7	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P01375	TNF	Tumor necrosis factor	-0.76
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.702
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P36542	ATP5C1	ATP synthase subunit gamma, mitochondrial	0.792
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P43243	MATR3	Matrin-3	0.724
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16629	SFRS7	Serine/arginine-rich splicing factor 7	0.801

Modafinil

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Modafinil

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Modafinil

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Modafinil

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Modafinil

hsa05132

Salmonella infection

2.10E-02

Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Modafinil

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Modafinil

hsa05140

Leishmaniasis

4.13E-02

P14598, P13765, O60603, P49006, Q15080

NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4

Modafinil

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Modafinil

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Modafinil

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Modafinil

hsa05150

Staphylococcus aureus infection

4.02E-03

P21462, O75015, Q14532, P59665, P59666, P12838

FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Modafinil

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Modafinil

hsa05202

Transcriptional misregulation in cancer

6.80E-03

Q12778, Q15532, P41732, P14780, P14923, Q13489, O15550, P04637, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, TSPAN7, MMP9, JUP, BIRC3, UTX, TP53, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768

Modafinil

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Modafinil

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Modafinil

hsa05205

Proteoglycans in cancer

3.08E-03

Q14643, P63261, P04637, P14780, P17252, O60603, P01375, P23588, Q13635, P22694, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, TNF, EIF4B, PTCH1, PRKACB, CD63

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.885
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13635	PTCH1	Protein patched homolog 1	0.733
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08962	CD63	CD63 antigen	-0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.885
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13635	PTCH1	Protein patched homolog 1	0.733
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08962	CD63	CD63 antigen	-0.737

Modafinil

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Modafinil

hsa05217

Basal cell carcinoma

1.46E-02

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Modafinil

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Modafinil

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Modafinil

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Modafinil

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Modafinil

hsa05323

Rheumatoid arthritis

3.53E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Modafinil

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Modafinil

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Modafinil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Modafinil

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Modafinil

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Modafinil

hsa05418

Fluid shear stress and atherosclerosis

4.26E-02

P14598, P14780, P63261, P04637, P10415, Q92974

NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2

Community members of Modafinil (S_DC: 3.20)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

Q13093

PLA2G7

PlateletNoneactivating factor acetylhydrolase

Predicted

0.0505

0.2096

0.1558

0.6001

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Modafinil (SPCN: 31.17 )

Modafinil regulated-network (SDN: 9.74)

Community members of Modafinil (SDC: 3.20)

PharmaCoNets of Modafinil (S_PCN: 31.17 )

Modafinil regulated-network (S_DN: 9.74)

Community members of Modafinil (S_DC: 3.20)