PharmaCoNets of Moclobemide (SPCN: 14.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Moclobemidehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Moclobemidehsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Moclobemidehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Moclobemidehsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Moclobemidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Moclobemidehsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Moclobemidehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Moclobemidehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Moclobemidehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Moclobemidehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Moclobemidehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Moclobemidehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Moclobemidehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Moclobemidehsa04115p53 signaling pathway1.69E-022P31350, P06493RRM2, CDK1More
Moclobemidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Moclobemidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Moclobemidehsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Moclobemidehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Moclobemidehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Moclobemidehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Moclobemidehsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Moclobemidehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Moclobemidehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Moclobemidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Moclobemidehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Moclobemidehsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Moclobemidehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Moclobemidehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Moclobemidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Moclobemidehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Moclobemidehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Moclobemidehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Moclobemidehsa05133Pertussis4.94E-021P0C0L4C4AMore
Moclobemidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Moclobemidehsa05152Tuberculosis3.52E-022Q15075, Q13651EEA1, IL10RAMore
Moclobemidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Moclobemidehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Moclobemidehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Moclobemidehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Moclobemidehsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Moclobemidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Moclobemidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Moclobemidehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Moclobemidehsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Moclobemide (SDC: 2.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)