PharmaCoNets

PharmaCoNets of Minocycline (S_PCN: 101.21 )

Minocycline regulated-network (S_DN: 21.86)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Minocycline

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Minocycline

hsa00051

Fructose and mannose metabolism

3.92E-03

P15121, P19367, P08237

AKR1B1, HK1, PFKM

Minocycline

hsa00052

Galactose metabolism

3.77E-04

P06280, P08237, O43451, P15121, P19367

GLA, PFKM, MGAM, AKR1B1, HK1

Minocycline

hsa00190

Oxidative phosphorylation

4.36E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Minocycline

hsa00220

Arginine biosynthesis

2.33E-02

P05089, P49448

ARG1, GLUD2

Minocycline

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Minocycline

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Minocycline

hsa00564

Glycerophospholipid metabolism

3.56E-02

P48651, Q9Y6K0, P35790

PTDSS1, CEPT1, CHKA

Minocycline

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Minocycline

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Minocycline

hsa00600

Sphingolipid metabolism

4.50E-02

P15289

ARSA

Minocycline

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Minocycline

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Minocycline

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Minocycline

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Minocycline

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Minocycline

hsa01100

Metabolic pathways

2.92E-03

Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927

MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.829
P19784	CSNK2A2	Casein kinase II subunit alpha'	P35790	CHKA	Choline kinase alpha	-0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q16772	GSTA3	Glutathione S-transferase A3	-0.791
P19784	CSNK2A2	Casein kinase II subunit alpha'	P30041	PRDX6	Peroxiredoxin-6	0.893
P19784	CSNK2A2	Casein kinase II subunit alpha'	P19367	HK1	Hexokinase-1	0.777
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.745
P19784	CSNK2A2	Casein kinase II subunit alpha'	P22557	ALAS2	5-aminolevulinate synthase, erythroid-specific, mitochondrial	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P19784	CSNK2A2	Casein kinase II subunit alpha'	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.828
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P19784	CSNK2A2	Casein kinase II subunit alpha'	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	0.732
P19784	CSNK2A2	Casein kinase II subunit alpha'	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.82
P19784	CSNK2A2	Casein kinase II subunit alpha'	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	-0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.795
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48651	PTDSS1	Phosphatidylserine synthase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q969G6	RFK	Riboflavin kinase	0.797
P19784	CSNK2A2	Casein kinase II subunit alpha'	P14927	UQCRB	Cytochrome b-c1 complex subunit 7	0.721

Minocycline

hsa01230

Biosynthesis of amino acids

3.91E-02

P51854, Q99707, P50213

TKTL1, MTR, IDH3A

Minocycline

hsa01240

Biosynthesis of cofactors

4.63E-02

Q969G6, P22557, Q9Y234

RFK, ALAS2, LIPT1

Minocycline

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Minocycline

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Minocycline

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Minocycline

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Minocycline

hsa03013

RNA transport

4.49E-02

P62826, Q9UBU9, P63279, P68104, Q14232

RAN, NXF1, UBE2I, EEF1A1, EIF2B1

Minocycline

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Minocycline

hsa03020

RNA polymerase

6.08E-05

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Minocycline

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Minocycline

hsa03060

Protein export

3.56E-02

P37108, Q15005

SRP14, SPCS2

Minocycline

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Minocycline

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Minocycline

hsa04015

Rap1 signaling pathway

3.98E-04

P09603, P20827, P49767, Q9GZP0, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, Q86WV1, P19174

CSF1, EFNA1, VEGFC, PDGFD, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, SKAP1, PLCG1

Minocycline

hsa04020

Calcium signaling pathway

1.09E-03

Q08828, Q13557, P61073, P0DP24, P0DP23, P05141, P51828

ADCY1, CAMK2D, CXCR4, CALM2, CALM1, SLC25A5, ADCY7

Minocycline

hsa04022

cGMP-PKG signaling pathway

2.77E-04

Q99941, P18848, P31751, Q08828, P51828, P05141, P0DP24, P0DP23

CREBL1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM2, CALM1

Minocycline

hsa04024

cAMP signaling pathway

3.94E-02

Q08828, P51828, P31751, P0DP23

ADCY1, ADCY7, AKT2, CALM1

Minocycline

hsa04060

Cytokine-cytokine receptor interaction

8.61E-03

P14784, P27930, P14778, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, Q93038

IL2RB, IL1R2, IL1R1, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNFRSF25

Minocycline

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-04

Q8NHW4, P25024, P61073, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCR1, CXCR4, XCL1, XCL2, IL10RA, IL2RB

Minocycline

hsa04062

Chemokine signaling pathway

1.70E-04

P25024, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, Q8WYR1

CXCR1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15131	CDK10	Cyclin-dependent kinase 10	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.726
Q15131	CDK10	Cyclin-dependent kinase 10	P47992	XCL1	Lymphotactin	0.703
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q15131	CDK10	Cyclin-dependent kinase 10	P07948	LYN	Tyrosine-protein kinase Lyn	-0.713
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q15131	CDK10	Cyclin-dependent kinase 10	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q15131	CDK10	Cyclin-dependent kinase 10	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.758
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q15131	CDK10	Cyclin-dependent kinase 10	P49407	ARRB1	Beta-arrestin-1	0.807
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Minocycline

hsa04064

NF-kappa B signaling pathway

6.30E-07

P10415, Q13489, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7

BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Minocycline

hsa04070

Phosphatidylinositol signaling system

9.86E-03

P0DP23, O14986, Q16760, P48426

CALM1, PIP5K1B, DGKD, PIP4K2A

Minocycline

hsa04071

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Minocycline

hsa04072

Phospholipase D signaling pathway

2.40E-03

P31751, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Minocycline

hsa04080

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Minocycline

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Minocycline

hsa04114

Oocyte meiosis

1.78E-03

Q13557, P0DP24, P0DP23, Q08828, P51828, P27348, Q13362, Q14738

CAMK2D, CALM2, CALM1, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5D

Minocycline

hsa04120

Ubiquitin mediated proteolysis

1.68E-02

O00762, Q14139

UBE2C, UBE4A

Minocycline

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Minocycline

hsa04140

Autophagy - animal

7.25E-04

P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9

AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8

Minocycline

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Minocycline

hsa04145

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Minocycline

hsa04151

PI3K-Akt signaling pathway

1.92E-03

P42338, P43657, P01106, P09603, P20827, P49767, Q9GZP0, P08238, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, MYC, CSF1, EFNA1, VEGFC, PDGFD, HSP90AB1, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Minocycline

hsa04211

Longevity regulating pathway

2.57E-03

P31751, Q08828, P51828, Q99941, P18848

AKT2, ADCY1, ADCY7, CREBL1, ATF4

Minocycline

hsa04213

Longevity regulating pathway - multiple species

4.54E-02

P31751, Q08828, P51828

AKT2, ADCY1, ADCY7

Minocycline

hsa04217

Necroptosis

1.54E-05

P23458, Q9NQC7, P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444

JAK1, CYLD, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B

Minocycline

hsa04261

Adrenergic signaling in cardiomyocytes

3.19E-05

Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557

ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D

Minocycline

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Minocycline

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Minocycline

hsa04371

Apelin signaling pathway

1.11E-03

P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Minocycline

hsa04380

Osteoclast differentiation

9.07E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Minocycline

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Minocycline

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Minocycline

hsa04530

Tight junction

2.47E-05

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Minocycline

hsa04610

Complement and coagulation cascades

6.18E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Minocycline

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Minocycline

hsa04612

Antigen processing and presentation

1.94E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Minocycline

hsa04613

Neutrophil extracellular trap formation

3.09E-06

P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Minocycline

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Minocycline

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Minocycline

hsa04623

Cytosolic DNA-sensing pathway

7.66E-06

P01584, Q9Y535, Q8NHW4

IL1B, POLR3H, CCL4L2

Minocycline

hsa04625

C-type lectin receptor signaling pathway

1.14E-03

Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Minocycline

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Minocycline

hsa04640

Hematopoietic cell lineage

5.54E-05

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q15131	CDK10	Cyclin-dependent kinase 10	P27930	IL1R2	Interleukin-1 receptor type 2	-0.771
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
Q15131	CDK10	Cyclin-dependent kinase 10	P25063	CD24	Signal transducer CD24	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q15131	CDK10	Cyclin-dependent kinase 10	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.744
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q15131	CDK10	Cyclin-dependent kinase 10	P09564	CD7	T-cell antigen CD7	0.723
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73

Minocycline

hsa04657

IL-17 signaling pathway

2.20E-05

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Minocycline

hsa04658

Th1 and Th2 cell differentiation

6.36E-08

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UL17	TBX21	T-box transcription factor TBX21	0.79
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q15131	CDK10	Cyclin-dependent kinase 10	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q15131	CDK10	Cyclin-dependent kinase 10	Q13761	RUNX3	Runt-related transcription factor 3	0.82

Minocycline

hsa04659

Th17 cell differentiation

2.93E-05

Q04759, P19174, P06239, P14784, P14778, Q9HBE5, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, IL21R, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Minocycline

hsa04660

T cell receptor signaling pathway

7.97E-07

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q15131	CDK10	Cyclin-dependent kinase 10	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.744
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
Q15131	CDK10	Cyclin-dependent kinase 10	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.738
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Minocycline

hsa04662

B cell receptor signaling pathway

2.31E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Minocycline

hsa04664

Fc epsilon RI signaling pathway

2.06E-04

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Minocycline

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Minocycline

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Minocycline

hsa04672

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Minocycline

hsa04713

Circadian entrainment

2.10E-03

P0DP24, P0DP23, Q13557, Q08828, P51828

CALM2, CALM1, CAMK2D, ADCY1, ADCY7

Minocycline

hsa04720

Long-term potentiation

2.10E-03

Q13557, P0DP24, P0DP23, P18848, Q08828

CAMK2D, CALM2, CALM1, ATF4, ADCY1

Minocycline

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Minocycline

hsa04725

Cholinergic synapse

1.44E-03

Q08828, P51828, P18848, Q13557, P31751

ADCY1, ADCY7, ATF4, CAMK2D, AKT2

Minocycline

hsa04728

Dopaminergic synapse

6.42E-04

P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP24, P0DP23, O15516

AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK

Minocycline

hsa04750

Inflammatory mediator regulation of TRP channels

6.39E-06

P14778, P01584, Q08828, P51828, Q13557, P42338, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1

Minocycline

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Minocycline

hsa04911

Insulin secretion

5.02E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Minocycline

hsa04912

GnRH signaling pathway

2.59E-04

Q08828, P51828, P18848, Q13557, P0DP24, P0DP23

ADCY1, ADCY7, ATF4, CAMK2D, CALM2, CALM1

Minocycline

hsa04915

Estrogen signaling pathway

2.13E-02

P18848, Q08828, P51828, P31751, P0DP23

ATF4, ADCY1, ADCY7, AKT2, CALM1

Minocycline

hsa04916

Melanogenesis

4.36E-04

Q13557, P0DP24, P0DP23, Q08828, P51828

CAMK2D, CALM2, CALM1, ADCY1, ADCY7

Minocycline

hsa04918

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Minocycline

hsa04923

Regulation of lipolysis in adipocytes

5.15E-03

Q08828, P51828, P31751

ADCY1, ADCY7, AKT2

Minocycline

hsa04924

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Minocycline

hsa04925

Aldosterone synthesis and secretion

1.54E-05

Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D

Minocycline

hsa04926

Relaxin signaling pathway

2.46E-02

P31751, P18848, Q08828, P51828

AKT2, ATF4, ADCY1, ADCY7

Minocycline

hsa04927

Cortisol synthesis and secretion

1.43E-05

Q14643, Q99941, P18848, Q08828, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB

Minocycline

hsa04928

Parathyroid hormone synthesis, secretion and action

3.77E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Minocycline

hsa04932

Non-alcoholic fatty liver disease

4.14E-05

P31751, P18848, O75460, P01584, P13073, P12074, O15239, O95298

AKT2, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2

Minocycline

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Minocycline

hsa04934

Cushing syndrome

4.71E-05

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Minocycline

hsa04935

Growth hormone synthesis, secretion and action

2.57E-03

Q08828, P51828, Q99941, P18848, P31751

ADCY1, ADCY7, CREBL1, ATF4, AKT2

Minocycline

hsa04940

Type I diabetes mellitus

2.91E-03

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Minocycline

hsa04970

Salivary secretion

2.09E-04

P07550, Q08828, P51828, P22694, Q14643, P0DP24, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM2, CALM1, CAMP

Minocycline

hsa04971

Gastric acid secretion

4.55E-06

Q08828, P51828, P15311, P0DP24, P0DP23, Q13557

ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2D

Minocycline

hsa04976

Bile secretion

1.64E-03

Q08828, P51828, Q14032, Q9BY07

ADCY1, ADCY7, BAAT, SLC4A5

Minocycline

hsa05010

Alzheimer disease

6.54E-05

O15239, O95298, P12074, Q00535, O75460, P0DP24, P0DP23, P01584, P18848, O15169, P31751, P05141, P28070, P43686

NDUFA1, NDUFC2, COX6A1, CDK5, ERN1, CALM2, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, PSMB4, PSMC4

Minocycline

hsa05012

Parkinson disease

6.66E-04

O15239, P13073, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557

NDUFA1, COX4I1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2D

Minocycline

hsa05016

Huntington disease

2.83E-04

O15239, O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, P43686

NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Minocycline

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Minocycline

hsa05020

Prion disease

5.42E-04

P13591, P01584, P46531, P11142, O15239, P13073, P12074, P18848, P05141, P28070, P43686, Q99941

NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, COX4I1, COX6A1, ATF4, SLC25A5, PSMB4, PSMC4, CREBL1

Minocycline

hsa05022

Pathways of neurodegeneration - multiple diseases

1.48E-05

O15239, O95298, P13073, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, P0DP23, Q13557, P28070, P43686

NDUFA1, NDUFC2, COX4I1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CALM1, CAMK2D, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Minocycline

hsa05030

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Minocycline

hsa05031

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Minocycline

hsa05032

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Minocycline

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Minocycline

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Minocycline

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Minocycline

hsa05133

Pertussis

2.41E-02

P09871, Q02556

C1S, IRF8

Minocycline

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Minocycline

hsa05140

Leishmaniasis

1.04E-06

P13612, O75015, P14598, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Minocycline

hsa05143

African trypanosomiasis

3.19E-02

P69905, P68871

HBA2, HBB

Minocycline

hsa05144

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Minocycline

hsa05146

Amoebiasis

4.21E-06

P09341, P14778, P27930, P01375, O60603, P42338, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q15131	CDK10	Cyclin-dependent kinase 10	P27930	IL1R2	Interleukin-1 receptor type 2	-0.771
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
Q15131	CDK10	Cyclin-dependent kinase 10	P05089	ARG1	Arginase-1	-0.79
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
Q15131	CDK10	Cyclin-dependent kinase 10	P12814	ACTN1	Alpha-actinin-1	-0.819
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
Q15131	CDK10	Cyclin-dependent kinase 10	P08311	CTSG	Cathepsin G	-0.734

Minocycline

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Minocycline

hsa05152

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Minocycline

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Minocycline

hsa05163

Human cytomegalovirus infection

4.76E-09

P31751, P01375, Q14643, P0DP24, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463

AKT2, TNF, ITPR1, CALM2, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734

Minocycline

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Minocycline

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Minocycline

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Minocycline

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Minocycline

hsa05202

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Minocycline

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Minocycline

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Minocycline

hsa05212

Pancreatic cancer

2.74E-03

P42338, P31751, Q15311, P23458, P84022, Q13485, O75293

PIK3CB, AKT2, RALBP1, JAK1, SMAD3, SMAD4, GADD45B

Minocycline

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Minocycline

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Minocycline

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Minocycline

hsa05231

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Minocycline

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.97E-03

P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Minocycline

hsa05310

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Minocycline

hsa05321

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Minocycline

hsa05322

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB