PharmaCoNets

PharmaCoNets of Minaprine (S_PCN: 119.13 )

Minaprine regulated-network (S_DN: 20.65)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Minaprine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Minaprine

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Minaprine

hsa00190

Oxidative phosphorylation

4.38E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Minaprine

hsa00230

Purine metabolism

4.93E-02

P21589

NT5E

Minaprine

hsa00240

Pyrimidine metabolism

1.81E-02

P21589

NT5E

Minaprine

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Minaprine

hsa00564

Glycerophospholipid metabolism

2.49E-03

Q9Y259, P23743, P49619, Q3LIE5

CHKB, DGKA, DGKG, ADPRM

Minaprine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Minaprine

hsa00630

Glyoxylate and dicarboxylate metabolism

5.34E-03

P40925, P15104

MDH1, GLUL

Minaprine

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Minaprine

hsa00760

Nicotinate and nicotinamide metabolism

9.09E-03

P21589

NT5E

Minaprine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Minaprine

hsa00790

Folate biosynthesis

1.04E-02

Q92820, P05186, P42330

GGH, ALPL, AKR1C3

Minaprine

hsa00830

Retinol metabolism

3.49E-02

P00325

ADH1B

Minaprine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Minaprine

hsa00983

Drug metabolism - other enzymes

4.16E-02

P04183, P32320, P05164

TK1, CDA, MPO

Minaprine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Minaprine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Minaprine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Minaprine

hsa01523

Antifolate resistance

3.99E-03

P41440, Q92820, P04818, P01375

SLC19A1, GGH, TYMS, TNF

Minaprine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Minaprine

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Minaprine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Minaprine

hsa03040

Spliceosome

1.06E-04

Q14562, O43143, O60508, P08579, O75940, O75494, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Minaprine

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Minaprine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Minaprine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Minaprine

hsa03460

Fanconi anemia pathway

2.71E-02

O94782

USP1

Minaprine

hsa04014

Ras signaling pathway

6.21E-03

P20827, P49767, P17252, Q15311, P0DP23, P62873, P19174, P17612

EFNA1, VEGFC, PRKCA, RALBP1, CALM1, GNB1, PLCG1, PRKACA

Minaprine

hsa04015

Rap1 signaling pathway

2.98E-02

P20827, P49767, P11215, P0DP23, P17252, P19174

EFNA1, VEGFC, ITGAM, CALM1, PRKCA, PLCG1

Minaprine

hsa04020

Calcium signaling pathway

4.81E-02

P27987, P17252, P19174, P0DP23, P49767

ITPKB, PRKCA, PLCG1, CALM1, VEGFC

Minaprine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.29E-02

P09341, P25024, P25025, P47992, Q9UBD3, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Minaprine

hsa04064

NF-kappa B signaling pathway

3.26E-05

P10415, Q13489, P25963, P51617, O00463, P01375, P29965, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A

Minaprine

hsa04070

Phosphatidylinositol signaling system

1.01E-04

P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCA

Minaprine

hsa04071

Sphingolipid signaling pathway

5.14E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Minaprine

hsa04080

Neuroactive ligand-receptor interaction

3.60E-05

P08311, P28472, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P07550, P35318

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Minaprine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Minaprine

hsa04114

Oocyte meiosis

2.15E-02

P0DP23, P17612, Q13362

CALM1, PRKACA, PPP2R5C

Minaprine

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Minaprine

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Minaprine

hsa04144

Endocytosis

4.07E-03

Q9H444, O75351, P42566, Q15438, Q14161

CHMP4B, VPS4B, EPS15, PSCD1, GIT2

Minaprine

hsa04145

Phagosome

1.78E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Minaprine

hsa04151

PI3K-Akt signaling pathway

4.50E-02

P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252

F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA

Minaprine

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Minaprine

hsa04217

Necroptosis

1.73E-05

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, Q6FI13, Q99878, P10415, Q9H444, O43633, O75351, Q08752

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, VPS4B, PPID

Minaprine

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Minaprine

hsa04261

Adrenergic signaling in cardiomyocytes

2.96E-04

P09493, P07550, P17612, P22694, P18848, Q13362, P0DP23, P17252, P10415

TPM1, ADRB2, PRKACA, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2

Minaprine

hsa04270

Vascular smooth muscle contraction

3.82E-02

P24723, Q04759, Q14643, P22694, P35318

PRKCH, PRKCQ, ITPR1, PRKACB, ADM

Minaprine

hsa04360

Axon guidance

1.53E-02

P16333, P20827, O95631, P17252, P19174

NCK1, EFNA1, NTN1, PRKCA, PLCG1

Minaprine

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Minaprine

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Minaprine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Minaprine

hsa04612

Antigen processing and presentation

6.89E-05

P13765, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375

HLA-DOB, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF

Minaprine

hsa04613

Neutrophil extracellular trap formation

3.86E-06

P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539

PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P17252	PRKCA	Protein kinase C alpha type	-0.706
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P11215	ITGAM	Integrin alpha-M	-0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.821
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.729
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.729
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	O60814	H2BC12	Histone H2B type 1-K	-0.809
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14598	NCF1	Neutrophil cytosol factor 1	0.801
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Minaprine

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Minaprine

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Minaprine

hsa04640

Hematopoietic cell lineage

1.73E-03

P13612, P21926, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, CD9, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Minaprine

hsa04650

Natural killer cell mediated cytotoxicity

1.40E-06

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q07444, Q14953, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Minaprine

hsa04657

IL-17 signaling pathway

5.70E-05

P25963, P08238, O00463, Q07955, Q16539, P49841, P19875, P14780, P04141, P80188, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9

Minaprine

hsa04658

Th1 and Th2 cell differentiation

1.45E-05

P25963, Q04759, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761

NFKBIA, PRKCQ, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3

Minaprine

hsa04659

Th17 cell differentiation

2.92E-03

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, Q9UL17, P23771, P08238, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, HSP90AB1, CD3G, CD247

Minaprine

hsa04660

T cell receptor signaling pathway

1.63E-03

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK

Minaprine

hsa04662

B cell receptor signaling pathway

1.49E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Minaprine

hsa04664

Fc epsilon RI signaling pathway

2.20E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5

Minaprine

hsa04668

TNF signaling pathway

2.13E-04

P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9

Minaprine

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Minaprine

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Minaprine

hsa04713

Circadian entrainment

3.30E-03

P0DP23, P17252, P62873, Q14643, P17612

CALM1, PRKCA, GNB1, ITPR1, PRKACA

Minaprine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Minaprine

hsa04720

Long-term potentiation

6.75E-03

P17252, P0DP23, P17612, Q14643

PRKCA, CALM1, PRKACA, ITPR1

Minaprine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Minaprine

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Minaprine

hsa04724

Glutamatergic synapse

5.94E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Minaprine

hsa04725

Cholinergic synapse

1.90E-03

Q14643, P17252, P62873, P63218, P50151, P42338, P10415

ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2

Minaprine

hsa04727

GABAergic synapse

1.63E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Minaprine

hsa04728

Dopaminergic synapse

2.36E-03

P17612, Q14643, P17252, P62873, Q13362, P0DP23

PRKACA, ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Minaprine

hsa04740

Olfactory transduction

4.53E-04

Q9H255, P0DP23, P17612

OR51E2, CALM1, PRKACA

Minaprine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Minaprine

hsa04744

Phototransduction

9.81E-05

P62873, P0DP23

GNB1, CALM1

Minaprine

hsa04910

Insulin signaling pathway

3.62E-02

P0DP23, P17612

CALM1, PRKACA

Minaprine

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Minaprine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Minaprine

hsa04916

Melanogenesis

2.87E-02

P17612, P0DP23

PRKACA, CALM1

Minaprine

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Minaprine

hsa04921

Oxytocin signaling pathway

1.84E-02

P0DP23, P17612, Q96RR4

CALM1, PRKACA, CAMKK2

Minaprine

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Minaprine

hsa04924

Renin secretion

2.29E-06

P17612, P22694, P07550, Q14643, Q13370, P0DP23

PRKACA, PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Minaprine

hsa04926

Relaxin signaling pathway

3.93E-04

P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407

PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1

Minaprine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Minaprine

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Minaprine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Minaprine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Minaprine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Minaprine

hsa04966

Collecting duct acid secretion

8.41E-04

Q13488, P02730, P00918, Q9Y666

TCIRG1, SLC4A1, CA2, SLC12A7

Minaprine

hsa04970

Salivary secretion

2.49E-04

P07550, P17612, P22694, Q14643, P17252, P0DP23, P49913

ADRB2, PRKACA, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Minaprine

hsa04971

Gastric acid secretion

2.87E-02

P17612, P0DP23

PRKACA, CALM1

Minaprine

hsa04976

Bile secretion

1.74E-03

O43315, P17612, P08183, Q14032

AQP9, PRKACA, ABCB1, BAAT

Minaprine

hsa05010

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Minaprine

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Minaprine

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Minaprine

hsa05022

Pathways of neurodegeneration - multiple diseases

2.00E-04

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1

Minaprine

hsa05031

Amphetamine addiction

3.10E-03

P0DP23, P17612, P22694, P18848, Q13547

CALM1, PRKACA, PRKACB, ATF4, HDAC1

Minaprine

hsa05034

Alcoholism

1.48E-03

P17612, P0DP23, Q96RR4, P62873, Q93077, P62807, O60814

PRKACA, CALM1, CAMKK2, GNB1, HIST1H2AC, HIST1H2BC, H2BC12

Minaprine

hsa05110

Vibrio cholerae infection

1.51E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Minaprine

hsa05131

Shigellosis

2.65E-03

P01375, P25963, O00463, P68431, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32

TNF, NFKBIA, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF

Minaprine

hsa05132

Salmonella infection

1.36E-03

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Minaprine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Minaprine

hsa05140

Leishmaniasis

4.14E-06

P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Minaprine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Minaprine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Minaprine

hsa05145

Toxoplasmosis

1.19E-03

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Minaprine

hsa05146

Amoebiasis

4.49E-04

P09341, P19875, P27930, P01375, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSG

Minaprine

hsa05152

Tuberculosis

1.21E-04

Q13488, P0DP23, P42224, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1

Minaprine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Minaprine

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Minaprine

hsa05163

Human cytomegalovirus infection

2.80E-02

P01375, P49841, P14778, P25025, Q16539, O00463

TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Minaprine

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Minaprine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

5.56E-03

P01568, P42224, P25963, P62873, P19174, Q14643, P04141, P0DP23, Q9UJU2

IFNA21, STAT1, NFKBIA, GNB1, PLCG1, ITPR1, CSF2, CALM1, LEF1

Minaprine

hsa05168

Herpes simplex virus 1 infection

4.39E-02

P25963, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, O75820, Q9UDV6

NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF189, ZNF212

Minaprine

hsa05169

Epstein-Barr virus infection

3.72E-02

Q13547, P42338, P07948, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E

Minaprine

hsa05170

Human immunodeficiency virus 1 infection

1.80E-05

P62873, P0DP23, P01375, P17252, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5

GNB1, CALM1, TNF, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2

Minaprine

hsa05200

Pathways in cancer

6.46E-03

P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, Q9UM47, O75293, P0DP23, P01568, P14784

HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, NOTCH3, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.783
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.734
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P17252	PRKCA	Protein kinase C alpha type	-0.706
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.789
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.754
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.84
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	0.714
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.802
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P0DP23	CALM1	Calmodulin-1	0.775
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.732

Minaprine

hsa05202

Transcriptional misregulation in cancer

1.84E-05

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787

Minaprine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Minaprine

hsa05206

MicroRNAs in cancer

4.24E-02

P30304, P09493, Q9UM47, P20827, P17252, P19174

CDC25A, TPM1, NOTCH3, EFNA1, PRKCA, PLCG1

Minaprine

hsa05212

Pancreatic cancer

2.87E-02

Q15311, P23458

RALBP1, JAK1

Minaprine

hsa05214

Glioma

7.66E-03

P0DP23, P17252, P19174, O75293

CALM1, PRKCA, PLCG1, GADD45B

Minaprine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Minaprine

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Minaprine

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Minaprine

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Minaprine

hsa05231

Choline metabolism in cancer

4.84E-05

Q02750, P09619, Q9GZP0, O15245, Q9Y259, P19174, P23743, P49619, P17252

MAP2K1, PDGFRB, PDGFD, SLC22A1, CHKB, PLCG1, DGKA, DGKG, PRKCA

Minaprine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.09E-02

P07766, P06239, Q9HC35, P01730

CD3E, LCK, EML4, CD4

Minaprine

hsa05310

Asthma

1.22E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Minaprine

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Minaprine

hsa05321

Inflammatory bowel disease

1.07E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Minaprine

hsa05322

Systemic lupus erythematosus

7.03E-05

O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q16778, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Minaprine

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Minaprine

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Minaprine

hsa05332

Graft-versus-host disease

8.53E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Minaprine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Minaprine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Minaprine

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Minaprine

hsa05415

Diabetic cardiomyopathy

1.58E-03

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B

Minaprine

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Minaprine

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Minaprine (S_DC: 5.77)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

SLC6A4

SodiumNonedependent serotonin transporter

Reported

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P42224

STAT1

Signal transducer and activator of transcription 1Nonealpha/beta

Predicted

0.2245

0.0425

1.1973

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

O94782

USP1

Ubiquitin carboxylNoneterminal hydrolase 1

Predicted

0.441

0.0898

0.0213

0.4215

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q92630

DYRK2

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2

Predicted

0.1779

0.3494

0.7877

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

Q8NFZ4

NLGN2

NeuroliginNone2

Predicted

0.566

0.0692

0.1627

0.5841

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

PharmaCoNets of Minaprine (SPCN: 119.13 )

Minaprine regulated-network (SDN: 20.65)

Community members of Minaprine (SDC: 5.77)

PharmaCoNets of Minaprine (S_PCN: 119.13 )

Minaprine regulated-network (S_DN: 20.65)

Community members of Minaprine (S_DC: 5.77)