PharmaCoNets of Miltefosine (SPCN: 13.57 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Miltefosinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Miltefosinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Miltefosinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Miltefosinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Miltefosinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Miltefosinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Miltefosinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Miltefosinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Miltefosinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Miltefosinehsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Miltefosinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Miltefosinehsa04110Cell cycle7.05E-058P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Miltefosinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Miltefosinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Miltefosinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Miltefosinehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Miltefosinehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Miltefosinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Miltefosinehsa04658Th1 and Th2 cell differentiation1.91E-047P07766, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Miltefosinehsa04659Th17 cell differentiation5.09E-036P19174, P01730, P06239, P42224, P14784, P07766PLCG1, CD4, LCK, STAT1, IL2RB, CD3EMore
Miltefosinehsa04660T cell receptor signaling pathway4.08E-025P19174, P16333, P07766, P01730, P06239PLCG1, NCK1, CD3E, CD4, LCKMore
Miltefosinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Miltefosinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Miltefosinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Miltefosinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Miltefosinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Miltefosinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Miltefosinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Miltefosinehsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Miltefosinehsa05231Choline metabolism in cancer4.24E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Miltefosinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.51E-036P19174, P07766, P06239, P42224, Q9HC35, P01730PLCG1, CD3E, LCK, STAT1, EML4, CD4More
Miltefosinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Miltefosinehsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Miltefosine (SDC: 3.56)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Reported10.078810.20522.2446
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)