PharmaCoNets of Milnacipran (SPCN: 18.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levomilnacipranhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Levomilnacipranhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Levomilnacipranhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Levomilnacipranhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Levomilnacipranhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Levomilnacipranhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Levomilnacipranhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Levomilnacipranhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Levomilnacipranhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Levomilnacipranhsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Levomilnacipranhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Levomilnacipranhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Levomilnacipranhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Levomilnacipranhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Levomilnacipranhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Levomilnacipranhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Levomilnacipranhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Levomilnacipranhsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Levomilnacipranhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Levomilnacipranhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Levomilnacipranhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Levomilnacipranhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Levomilnacipranhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Levomilnacipranhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Levomilnacipranhsa04932Non-alcoholic fatty liver disease3.35E-037P49841, Q12933, P01584, P12074, O15239, Q16718, O14521GSK3B, TRAF2, IL1B, COX6A1, NDUFA1, NDUFA5, SDHDMore
Levomilnacipranhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Levomilnacipranhsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Levomilnacipranhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Levomilnacipranhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Levomilnacipranhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Levomilnacipranhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Levomilnacipranhsa05020Prion disease1.94E-0311P01584, P46531, O15239, Q16718, O14521, P05496, P12074, P43686, P49841, Q99941, Q16539IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, PSMC4, GSK3B, CREBL1, MAPK14More
Levomilnacipranhsa05022Pathways of neurodegeneration - multiple diseases2.29E-0415P49841, O15239, Q16718, O14521, P12074, P05496, Q12933, Q13561, Q16539, O15169, P01584, Q08752, Q13557, P62987, P43686GSK3B, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, TRAF2, DCTN2, MAPK14, AXIN1, IL1B, PPID, CAMK2D, UBA52, PSMC4More
Levomilnacipranhsa05133Pertussis4.94E-021P0C0L4C4AMore
Levomilnacipranhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Levomilnacipranhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Levomilnacipranhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Levomilnacipranhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Levomilnacipranhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Levomilnacipranhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Levomilnacipranhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Levomilnacipranhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Levomilnacipranhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Milnacipranhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Milnacipranhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Milnacipranhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Milnacipranhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Milnacipranhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Milnacipranhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Milnacipranhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Milnacipranhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Milnacipranhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Milnacipranhsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Milnacipranhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Milnacipranhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Milnacipranhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Milnacipranhsa04020Calcium signaling pathway9.43E-0612P27987, Q96DU7, Q08828, P21796, Q16566, Q13557, P21860, P30679, O15399, P0DP23, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC1, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Milnacipranhsa04024cAMP signaling pathway1.49E-025P42338, P0DP23, P23634, Q16566, O15399PIK3CB, CALM1, ATP2B4, CAMK4, GRIN2DMore
Milnacipranhsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Milnacipranhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Milnacipranhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Milnacipranhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Milnacipranhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Milnacipranhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Milnacipranhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Milnacipranhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Milnacipranhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Milnacipranhsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Milnacipranhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Milnacipranhsa04713Circadian entrainment9.05E-047O15399, P0DP23, Q13557, Q02153, P63218, P50151, Q08828GRIN2D, CALM1, CAMK2D, GUCY1B3, GNG5, GNG10, ADCY1More
Milnacipranhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Milnacipranhsa04720Long-term potentiation6.32E-046Q16566, P16298, P0DP23, P51812, O15399, Q02750CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1More
Milnacipranhsa04724Glutamatergic synapse4.10E-023O15399, P63218, P50151GRIN2D, GNG5, GNG10More
Milnacipranhsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Milnacipranhsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Milnacipranhsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Milnacipranhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Milnacipranhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Milnacipranhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Milnacipranhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Milnacipranhsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Milnacipranhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Milnacipranhsa04932Non-alcoholic fatty liver disease3.35E-037P49841, Q12933, P01584, P12074, O15239, Q16718, O14521GSK3B, TRAF2, IL1B, COX6A1, NDUFA1, NDUFA5, SDHDMore
Milnacipranhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Milnacipranhsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Milnacipranhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Milnacipranhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Milnacipranhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Milnacipranhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Milnacipranhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Milnacipranhsa05020Prion disease1.94E-0311P01584, P46531, O15239, Q16718, O14521, P05496, P12074, P43686, P49841, Q99941, Q16539IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, PSMC4, GSK3B, CREBL1, MAPK14More
Milnacipranhsa05022Pathways of neurodegeneration - multiple diseases2.29E-0415P49841, O15239, Q16718, O14521, P12074, P05496, Q12933, Q13561, Q16539, O15169, P01584, Q08752, Q13557, P62987, P43686GSK3B, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, TRAF2, DCTN2, MAPK14, AXIN1, IL1B, PPID, CAMK2D, UBA52, PSMC4More
Milnacipranhsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Milnacipranhsa05133Pertussis4.94E-021P0C0L4C4AMore
Milnacipranhsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Milnacipranhsa05167Kaposi sarcoma-associated herpesvirus infection2.44E-039P42338, P62879, P63218, P50151, P16298, Q02750, P07948, P0DP23, P0CG47PIK3CB, GNB2, GNG5, GNG10, PPP3CB, MAP2K1, LYN, CALM1, UBBMore
Milnacipranhsa05170Human immunodeficiency virus 1 infection7.38E-0411P42338, Q02750, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P23528, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, CFL1, TNFRSF1BMore
Milnacipranhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Milnacipranhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Milnacipranhsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Milnacipranhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Milnacipranhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Milnacipranhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Milnacipranhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Milnacipranhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Milnacipranhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Milnacipran (SDC: 2.56)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC5050
SLC6A4P31645IC50320
SLC6A4P31645IC50420