PharmaCoNets of Miglustat (SPCN: 9.12 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Miglustathsa00052Galactose metabolism1.51E-021P16278GLB1More
Miglustathsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Miglustathsa00500Starch and sucrose metabolism2.10E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Miglustathsa00511Other glycan degradation9.09E-031P16278GLB1More
Miglustathsa00531Glycosaminoglycan degradation1.51E-021P16278GLB1More
Miglustathsa00600Sphingolipid metabolism1.81E-021P16278GLB1More
Miglustathsa00604Glycosphingolipid biosynthesis - ganglio series9.09E-031P16278GLB1More
Miglustathsa00970Aminoacyl-tRNA biosynthesis9.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Miglustathsa03030DNA replication1.81E-021P15927RPA2More
Miglustathsa03420Nucleotide excision repair1.51E-021P15927RPA2More
Miglustathsa03430Mismatch repair1.81E-021P15927RPA2More
Miglustathsa03440Homologous recombination1.81E-021P15927RPA2More
Miglustathsa03460Fanconi anemia pathway6.63E-034P15927, P40692, O60673, Q9UNA4RPA2, MLH1, REV3L, POLIMore
Miglustathsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Miglustathsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Miglustathsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Miglustathsa04071Sphingolipid signaling pathway5.54E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Miglustathsa04080Neuroactive ligand-receptor interaction3.70E-027P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADMMore
Miglustathsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Miglustathsa04340Hedgehog signaling pathway2.17E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Miglustathsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Miglustathsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Miglustathsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Miglustathsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Miglustathsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Miglustathsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Miglustathsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Miglustathsa04650Natural killer cell mediated cytotoxicity2.05E-039P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Miglustathsa04658Th1 and Th2 cell differentiation1.27E-049Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21More
Miglustathsa04659Th17 cell differentiation1.64E-0410Q04759, Q16539, P01730, P06239, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Miglustathsa04660T cell receptor signaling pathway6.29E-0410Q04759, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Miglustathsa04662B cell receptor signaling pathway4.88E-024P25963, P13164, P11912, P29350NFKBIA, IFITM1, CD79A, PTPN6More
Miglustathsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Miglustathsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Miglustathsa04912GnRH signaling pathway3.74E-024Q16539, Q9Y6R4, Q14643, P22694MAPK14, MAP3K4, ITPR1, PRKACBMore
Miglustathsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Miglustathsa05120Epithelial cell signaling in Helicobacter pylori infection3.76E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Miglustathsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Miglustathsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Miglustathsa05140Leishmaniasis3.53E-026O75015, O60603, P01375, P29350, Q16539, Q15080FCGR3B, TLR2, TNF, PTPN6, MAPK14, NCF4More
Miglustathsa05146Amoebiasis2.10E-026P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Miglustathsa05202Transcriptional misregulation in cancer3.15E-027P01106, P46527, P35226, O60583, P59665, P59666, P42773MYC, CDKN1B, BMI1, CCNT2, DEFA1; DEFA1B, DEFA3, CDKN2CMore
Miglustathsa05205Proteoglycans in cancer4.51E-029Q14643, P14780, O60603, P01375, Q13635, P22694, Q16539, P29350, P08962ITPR1, MMP9, TLR2, TNF, PTCH1, PRKACB, MAPK14, PTPN6, CD63More
Miglustathsa05206MicroRNAs in cancer2.55E-026P46527, P01106, P26358, Q9UM47, P35226, P63279CDKN1B, MYC, DNMT1, NOTCH3, BMI1, UBE2IMore
Miglustathsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.79E-037P07766, P20963, P09693, P06239, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Miglustathsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore

Community members of Miglustat (SDC: 1.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P35573AGLGlycogen debranching enzymePredicted00.35440.01890.16020.3753
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P06280GLAAlphaNonegalactosidase APredicted10.05930.01240.28140.3358
P16278GLB1BetaNonegalactosidasePredicted10.6880.02440.3220.7148
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)