PharmaCoNets of Midostaurin (SPCN: 280.96 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Midostaurinhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Midostaurinhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Midostaurinhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Midostaurinhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Midostaurinhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Midostaurinhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Midostaurinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Midostaurinhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Midostaurinhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Midostaurinhsa00190Oxidative phosphorylation7.86E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Midostaurinhsa00220Arginine biosynthesis1.55E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Midostaurinhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Midostaurinhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Midostaurinhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Midostaurinhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Midostaurinhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Midostaurinhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Midostaurinhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Midostaurinhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Midostaurinhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Midostaurinhsa00500Starch and sucrose metabolism6.81E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Midostaurinhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Midostaurinhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Midostaurinhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Midostaurinhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Midostaurinhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Midostaurinhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Midostaurinhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Midostaurinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Midostaurinhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Midostaurinhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Midostaurinhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Midostaurinhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Midostaurinhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Midostaurinhsa00630Glyoxylate and dicarboxylate metabolism6.82E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Midostaurinhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Midostaurinhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Midostaurinhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Midostaurinhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Midostaurinhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Midostaurinhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Midostaurinhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Midostaurinhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Midostaurinhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Midostaurinhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Midostaurinhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Midostaurinhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Midostaurinhsa00970Aminoacyl-tRNA biosynthesis2.84E-034O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Midostaurinhsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Midostaurinhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Midostaurinhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Midostaurinhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Midostaurinhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Midostaurinhsa01230Biosynthesis of amino acids1.89E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Midostaurinhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Midostaurinhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Midostaurinhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Midostaurinhsa01523Antifolate resistance2.08E-044P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Midostaurinhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Midostaurinhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Midostaurinhsa03010Ribosome7.89E-1321P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Midostaurinhsa03013RNA transport1.02E-1729P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Midostaurinhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Midostaurinhsa03018RNA degradation2.52E-021Q9NQT4EXOSC5More
Midostaurinhsa03020RNA polymerase5.44E-094P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Midostaurinhsa03040Spliceosome7.91E-0715Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Midostaurinhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Midostaurinhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Midostaurinhsa03430Mismatch repair4.38E-021P20585MSH3More
Midostaurinhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Midostaurinhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Midostaurinhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Midostaurinhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Midostaurinhsa04014Ras signaling pathway2.30E-054P04049, P31751, P08069, P0DP23RAF1, AKT2, IGF1R, CALM1More
Midostaurinhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Midostaurinhsa04020Calcium signaling pathway2.78E-0612Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Midostaurinhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Midostaurinhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Midostaurinhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Midostaurinhsa04061Viral protein interaction with cytokine and cytokine receptor1.29E-049Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Midostaurinhsa04062Chemokine signaling pathway6.90E-0619P25024, P25025, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Midostaurinhsa04064NF-kappa B signaling pathway1.03E-1525P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Midostaurinhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Midostaurinhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Midostaurinhsa04070Phosphatidylinositol signaling system7.50E-0612P19174, P0DP23, Q14643, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Midostaurinhsa04071Sphingolipid signaling pathway1.53E-0511P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, P10415, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Midostaurinhsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Midostaurinhsa04080Neuroactive ligand-receptor interaction1.97E-0411P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Midostaurinhsa04110Cell cycle4.62E-0712Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Midostaurinhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Midostaurinhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Midostaurinhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Midostaurinhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Midostaurinhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Midostaurinhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Midostaurinhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Midostaurinhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Midostaurinhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Midostaurinhsa04145Phagosome4.29E-0611O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Midostaurinhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Midostaurinhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Midostaurinhsa04151PI3K-Akt signaling pathway2.54E-0727P62753, P21860, P25116, O43521, P04637, P27348, P49767, Q13362, P07900, P62873, P61952, P16144, P02452, P24821, Q16363, P22105, O60603, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, F2R, BCL2L11, TP53, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, GNG11, ITGB4, COL1A1, TNC, LAMA4, TNXB, TLR2, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Midostaurinhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Midostaurinhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Midostaurinhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Midostaurinhsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Midostaurinhsa04217Necroptosis1.39E-1220Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Midostaurinhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Midostaurinhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Midostaurinhsa04261Adrenergic signaling in cardiomyocytes6.80E-0915P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Midostaurinhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Midostaurinhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Midostaurinhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Midostaurinhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Midostaurinhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Midostaurinhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Midostaurinhsa04371Apelin signaling pathway1.43E-049P62873, P61952, P31751, P04049, Q08828, P51828, P62753, P0DP23, P0DP24GNB1, GNG11, AKT2, RAF1, ADCY1, ADCY7, RPS6, CALM1, CALM2More
Midostaurinhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Midostaurinhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Midostaurinhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Midostaurinhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Midostaurinhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Midostaurinhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Midostaurinhsa04540Gap junction6.48E-056P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Midostaurinhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Midostaurinhsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Midostaurinhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Midostaurinhsa04612Antigen processing and presentation1.36E-0811P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Midostaurinhsa04613Neutrophil extracellular trap formation1.15E-0625P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, P62807, Q16778, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BAMore
Midostaurinhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Midostaurinhsa04621NOD-like receptor signaling pathway1.92E-0412P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Midostaurinhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Midostaurinhsa04623Cytosolic DNA-sensing pathway1.82E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Midostaurinhsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Midostaurinhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Midostaurinhsa04640Hematopoietic cell lineage7.44E-1017P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Midostaurinhsa04650Natural killer cell mediated cytotoxicity3.34E-1818P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Midostaurinhsa04657IL-17 signaling pathway2.96E-0714P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9, IL1BMore
Midostaurinhsa04658Th1 and Th2 cell differentiation1.82E-3017P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Midostaurinhsa04659Th17 cell differentiation8.49E-2318P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Midostaurinhsa04660T cell receptor signaling pathway7.03E-2019P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Midostaurinhsa04662B cell receptor signaling pathway2.42E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Midostaurinhsa04664Fc epsilon RI signaling pathway1.57E-068P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5More
Midostaurinhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Midostaurinhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Midostaurinhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Midostaurinhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Midostaurinhsa04713Circadian entrainment1.85E-0710P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7More
Midostaurinhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Midostaurinhsa04720Long-term potentiation9.48E-1112P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Midostaurinhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Midostaurinhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Midostaurinhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Midostaurinhsa04724Glutamatergic synapse2.84E-057O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Midostaurinhsa04725Cholinergic synapse3.22E-0713Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Midostaurinhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Midostaurinhsa04727GABAergic synapse7.60E-1010Q08828, P51828, P62873, P63218, P50151, P61952, P78334, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GABRE, GLUL, NSF, PLCL1More
Midostaurinhsa04728Dopaminergic synapse1.32E-0918Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Midostaurinhsa04730Long-term depression3.10E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Midostaurinhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Midostaurinhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Midostaurinhsa04744Phototransduction1.02E-083P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Midostaurinhsa04750Inflammatory mediator regulation of TRP channels8.03E-0911P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Midostaurinhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Midostaurinhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Midostaurinhsa04911Insulin secretion1.04E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Midostaurinhsa04912GnRH signaling pathway1.15E-069P17252, Q08828, P51828, P18848, Q9Y6R4, Q14643, P0DP23, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAP3K4, ITPR1, CALM1, RAF1, MAP2K4More
Midostaurinhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Midostaurinhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Midostaurinhsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Midostaurinhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Midostaurinhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Midostaurinhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Midostaurinhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Midostaurinhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Midostaurinhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Midostaurinhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Midostaurinhsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Midostaurinhsa04924Renin secretion8.24E-075P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Midostaurinhsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Midostaurinhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Midostaurinhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Midostaurinhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Midostaurinhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Midostaurinhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Midostaurinhsa04932Non-alcoholic fatty liver disease4.37E-1212P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Midostaurinhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Midostaurinhsa04934Cushing syndrome5.10E-076Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Midostaurinhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Midostaurinhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Midostaurinhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Midostaurinhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Midostaurinhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Midostaurinhsa04970Salivary secretion2.10E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Midostaurinhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Midostaurinhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Midostaurinhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Midostaurinhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Midostaurinhsa04976Bile secretion1.97E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Midostaurinhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Midostaurinhsa05010Alzheimer disease1.66E-0926P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Midostaurinhsa05012Parkinson disease4.93E-0519O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Midostaurinhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Midostaurinhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Midostaurinhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Midostaurinhsa05020Prion disease1.01E-0623P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P28070, P43686, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Midostaurinhsa05022Pathways of neurodegeneration - multiple diseases7.23E-1035Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Midostaurinhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Midostaurinhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Midostaurinhsa05032Morphine addiction5.68E-032P78334, P32298GABRE, GRK4More
Midostaurinhsa05033Nicotine addiction1.72E-031P78334GABREMore
Midostaurinhsa05034Alcoholism4.25E-0410Q99941, P18848, Q13547, P0DP24, P62873, P61952, P04049, P0C0S5, P62807, Q16778CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2BC, HIST2H2BEMore
Midostaurinhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Midostaurinhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Midostaurinhsa05120Epithelial cell signaling in Helicobacter pylori infection4.31E-1111Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Midostaurinhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Midostaurinhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Midostaurinhsa05132Salmonella infection1.26E-0920P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Midostaurinhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Midostaurinhsa05134Legionellosis2.58E-089P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Midostaurinhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Midostaurinhsa05140Leishmaniasis1.39E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Midostaurinhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Midostaurinhsa05143African trypanosomiasis7.99E-052P69905, P68871HBA2, HBBMore
Midostaurinhsa05144Malaria8.44E-069P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Midostaurinhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Midostaurinhsa05146Amoebiasis1.14E-1412P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Midostaurinhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Midostaurinhsa05152Tuberculosis2.08E-0612P04049, Q13488, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P01568, Q9UDY8, P51617RAF1, TCIRG1, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Midostaurinhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Midostaurinhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Midostaurinhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Midostaurinhsa05163Human cytomegalovirus infection1.17E-1127P31751, P04049, P01375, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769AKT2, RAF1, TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2MMore
Midostaurinhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Midostaurinhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Midostaurinhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Midostaurinhsa05167Kaposi sarcoma-associated herpesvirus infection8.92E-0511P01568, P31751, P42224, P25963, P62873, P19174, Q14643, P04049, P01106, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, PLCG1, ITPR1, RAF1, MYC, CALM1, LEF1More
Midostaurinhsa05168Herpes simplex virus 1 infection4.64E-0317O00463, O60603, P25963, Q05823, Q07955, Q01130, Q16629, Q9Y2A4, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, RNASEL, SFRS1, SFRS2, SFRS7, ZNF443, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Midostaurinhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Midostaurinhsa05170Human immunodeficiency virus 1 infection4.56E-0816P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, P51617, O60603, Q13315, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, IRAK1, TLR2, ATM, BCL2, AP1M2More
Midostaurinhsa05171Coronavirus disease - COVID-194.96E-1121P01584, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23More
Midostaurinhsa05200Pathways in cancer9.39E-0730P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Midostaurinhsa05202Transcriptional misregulation in cancer5.74E-0818Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Midostaurinhsa05203Viral carcinogenesis4.16E-0513Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BEMore
Midostaurinhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Midostaurinhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Midostaurinhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Midostaurinhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Midostaurinhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Midostaurinhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Midostaurinhsa05214Glioma6.68E-066P08069, P0DP23, P04049, P31751, P19174, O75293IGF1R, CALM1, RAF1, AKT2, PLCG1, GADD45BMore
Midostaurinhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Midostaurinhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Midostaurinhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Midostaurinhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Midostaurinhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Midostaurinhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Midostaurinhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Midostaurinhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Midostaurinhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Midostaurinhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Midostaurinhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Midostaurinhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Midostaurinhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Midostaurinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.46E-1417P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Midostaurinhsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Midostaurinhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Midostaurinhsa05321Inflammatory bowel disease6.18E-147O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Midostaurinhsa05322Systemic lupus erythematosus6.78E-0715P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P62807, Q16778, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Midostaurinhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Midostaurinhsa05330Allograft rejection9.93E-044P13765, P29965, P10747, P01375HLA-DOB, CD40LG, CD28, TNFMore
Midostaurinhsa05332Graft-versus-host disease3.29E-115P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Midostaurinhsa05340Primary immunodeficiency4.07E-056P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Midostaurinhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Midostaurinhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Midostaurinhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Midostaurinhsa05415Diabetic cardiomyopathy4.77E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Midostaurinhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Midostaurinhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Midostaurin (SDC: 10.91)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P17252PRKCAProtein kinase C alpha typeReported00.14090.694812.4601
P09619PDGFRBPlateletNonederived growth factor receptor betaReported00.04960.94440.74082.6543
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
O43172PRPF4U4/U6 small nuclear ribonucleoprotein Prp4Predicted00.11220.02640.2850.3939
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q15046KARSLysineNoneNonetRNA ligasePredicted00.10330.0580.00270.1702
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PRKCAP17252Kd720
PDGFRBP09619Kd11
PDGFRBP09619Kd110
PDGFRBP09619Kd380