PharmaCoNets of Midazolam (SPCN: 287.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Midazolamhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Midazolamhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Midazolamhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Midazolamhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Midazolamhsa00052Galactose metabolism8.55E-065P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Midazolamhsa00190Oxidative phosphorylation7.86E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Midazolamhsa00220Arginine biosynthesis8.90E-073P15104, P05089, P49448GLUL, ARG1, GLUD2More
Midazolamhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Midazolamhsa00280Valine, leucine and isoleucine degradation4.31E-022P26440, Q02252IVD, ALDH6A1More
Midazolamhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Midazolamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Midazolamhsa00500Starch and sucrose metabolism5.48E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Midazolamhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Midazolamhsa00520Amino sugar and nucleotide sugar metabolism7.85E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Midazolamhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Midazolamhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Midazolamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Midazolamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Midazolamhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Midazolamhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Midazolamhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Midazolamhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Midazolamhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Midazolamhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Midazolamhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Midazolamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Midazolamhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Midazolamhsa00860Porphyrin and chlorophyll metabolism1.70E-043P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Midazolamhsa00910Nitrogen metabolism2.66E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Midazolamhsa00970Aminoacyl-tRNA biosynthesis9.57E-033O95363, P54136, P14868FARS2, RARS1, DARSMore
Midazolamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Midazolamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Midazolamhsa00983Drug metabolism - other enzymes2.22E-033P04183, P32320, P05164TK1, CDA, MPOMore
Midazolamhsa01100Metabolic pathways2.92E-0339Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRBMore
Midazolamhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Midazolamhsa01230Biosynthesis of amino acids2.34E-046P51854, P60891, Q99707, P50213, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, GLUL, TALDO1More
Midazolamhsa01240Biosynthesis of cofactors3.44E-035Q969G6, P36551, P22557, O60701, Q9Y234RFK, CPOX, ALAS2, UGDH, LIPT1More
Midazolamhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Midazolamhsa01522Endocrine resistance1.69E-024P22694, P04049, P10415, Q13323PRKACB, RAF1, BCL2, BIKMore
Midazolamhsa01523Antifolate resistance1.95E-035P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Midazolamhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Midazolamhsa03008Ribosome biogenesis in eukaryotes2.40E-035P19784, P67870, O14980, O60832, Q9BVP2CSNK2A2, CSNK2B, XPO1, DKC1, GNL3More
Midazolamhsa03013RNA transport1.83E-0820P62826, O14980, P52298, O14893, P61326, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787RAN, XPO1, NCBP2, GEMIN2, MAGOH, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1More
Midazolamhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Midazolamhsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Midazolamhsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Midazolamhsa03050Proteasome9.50E-041P55036PSMD4More
Midazolamhsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Midazolamhsa03410Base excision repair7.59E-031P27695APEX1More
Midazolamhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Midazolamhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Midazolamhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Midazolamhsa04014Ras signaling pathway3.65E-021P04049RAF1More
Midazolamhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Midazolamhsa04020Calcium signaling pathway5.68E-036Q08828, P0DP24, P0DP23, P05141, P51828, P23634ADCY1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Midazolamhsa04022cGMP-PKG signaling pathway1.31E-037P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Midazolamhsa04024cAMP signaling pathway1.48E-0513P63092, Q08828, P51828, P42338, P31751, P26678, P0DP24, P0DP23, P23634, P04049, P61586, Q13370, Q13009GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM2, CALM1, ATP2B4, RAF1, RHOA, PDE3B, TIAM1More
Midazolamhsa04060Cytokine-cytokine receptor interaction1.91E-0519P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P01375, P09341, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNF, CXCL1, CCL8, IL1RN, CD4, TNFRSF25More
Midazolamhsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-0711Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Midazolamhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Midazolamhsa04064NF-kappa B signaling pathway6.85E-1526P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Midazolamhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Midazolamhsa04070Phosphatidylinositol signaling system1.37E-049P0DP23, Q14643, P42338, O14986, P23743, Q16760, P48426, P27987, P17252CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Midazolamhsa04071Sphingolipid signaling pathway6.94E-059P04049, P17252, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2RAF1, PRKCA, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Midazolamhsa04072Phospholipase D signaling pathway2.30E-0514P04049, P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Midazolamhsa04080Neuroactive ligand-receptor interaction2.38E-0411P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Midazolamhsa04110Cell cycle4.61E-048Q9UBD5, P06493, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Midazolamhsa04114Oocyte meiosis7.17E-0712Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Midazolamhsa04120Ubiquitin mediated proteolysis7.08E-046Q14145, Q13042, Q13191, P62837, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, UBE2D2, HERC1, HUWE1More
Midazolamhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Midazolamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Midazolamhsa04140Autophagy - animal5.75E-0411P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Midazolamhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Midazolamhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Midazolamhsa04145Phagosome3.06E-0413O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Midazolamhsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Midazolamhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Midazolamhsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Midazolamhsa04211Longevity regulating pathway9.34E-047Q12778, P31751, Q08828, P51828, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, ADCY1, ADCY7, ATF4, KL, EHMT2More
Midazolamhsa04213Longevity regulating pathway - multiple species4.59E-058P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Midazolamhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Midazolamhsa04217Necroptosis7.23E-0512P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPIDMore
Midazolamhsa04218Cellular senescence8.08E-035P01106, P04049, O75293, P30304, P06493MYC, RAF1, GADD45B, CDC25A, CDK1More
Midazolamhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Midazolamhsa04261Adrenergic signaling in cardiomyocytes3.32E-0612P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP24, P0DP23, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, PRKCA, BCL2, ATP2B4More
Midazolamhsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Midazolamhsa04310Wnt signaling pathway2.00E-044P61586, P17612, P19784, P67870RHOA, PRKACA, CSNK2A2, CSNK2BMore
Midazolamhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Midazolamhsa04340Hedgehog signaling pathway4.58E-055P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Midazolamhsa04360Axon guidance5.32E-035P20827, O95631, P42338, P23528, P04049EFNA1, NTN1, PIK3CB, CFL1, RAF1More
Midazolamhsa04370VEGF signaling pathway6.51E-064P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Midazolamhsa04371Apelin signaling pathway1.24E-025P31751, P04049, Q08828, P51828, P0DP23AKT2, RAF1, ADCY1, ADCY7, CALM1More
Midazolamhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Midazolamhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Midazolamhsa04510Focal adhesion8.84E-034O14986, P61586, Q16363, P04049PIP5K1B, RHOA, LAMA4, RAF1More
Midazolamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Midazolamhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Midazolamhsa04540Gap junction2.13E-046P17252, P22694, Q13509, P68371, P04049, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, RAF1, ITPR1More
Midazolamhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Midazolamhsa04610Complement and coagulation cascades1.19E-062P00734, P0C0L4F2, C4AMore
Midazolamhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Midazolamhsa04612Antigen processing and presentation1.35E-0710P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Midazolamhsa04613Neutrophil extracellular trap formation2.60E-0723P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Midazolamhsa04620Toll-like receptor signaling pathway4.30E-045Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Midazolamhsa04621NOD-like receptor signaling pathway5.35E-037P01568, Q13489, Q13546, P01375, P59665, P59666, P12838IFNA21, BIRC3, RIPK1, TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Midazolamhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Midazolamhsa04623Cytosolic DNA-sensing pathway1.99E-095P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Midazolamhsa04625C-type lectin receptor signaling pathway1.93E-049Q9ULY5, P04049, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Midazolamhsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Midazolamhsa04640Hematopoietic cell lineage9.48E-0814P13612, P21926, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Midazolamhsa04650Natural killer cell mediated cytotoxicity6.44E-1617P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Midazolamhsa04657IL-17 signaling pathway1.07E-067O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Midazolamhsa04658Th1 and Th2 cell differentiation1.32E-1613Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Midazolamhsa04659Th17 cell differentiation4.74E-1419P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Midazolamhsa04660T cell receptor signaling pathway6.71E-1315P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1More
Midazolamhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Midazolamhsa04664Fc epsilon RI signaling pathway7.50E-034P01375, Q16539, Q9UQC2, P04049TNF, MAPK14, GAB2, RAF1More
Midazolamhsa04666Fc gamma R-mediated phagocytosis1.31E-024P42338, P04049, P23528, P14598PIK3CB, RAF1, CFL1, NCF1More
Midazolamhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Midazolamhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Midazolamhsa04713Circadian entrainment4.04E-047P0DP23, P17252, P62873, Q14643, Q08828, P51828, P63092CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7, GNASMore
Midazolamhsa04720Long-term potentiation1.08E-059P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Midazolamhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Midazolamhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Midazolamhsa04723Retrograde endocannabinoid signaling2.51E-035Q14643, P17252, P48169, P62873, Q16718ITPR1, PRKCA, GABRA4, GNB1, NDUFA5More
Midazolamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Midazolamhsa04725Cholinergic synapse7.01E-059Q08828, P51828, P22694, Q14643, P17252, P62873, P18848, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2More
Midazolamhsa04726Serotonergic synapse2.93E-033P63092, P62873, P04049GNAS, GNB1, RAF1More
Midazolamhsa04728Dopaminergic synapse9.19E-048Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Midazolamhsa04730Long-term depression1.16E-021P04049RAF1More
Midazolamhsa04742Taste transduction3.91E-021P17612PRKACAMore
Midazolamhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Midazolamhsa04750Inflammatory mediator regulation of TRP channels2.58E-059P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Midazolamhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Midazolamhsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Midazolamhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Midazolamhsa04912GnRH signaling pathway6.90E-047P17252, Q08828, P51828, P18848, Q14643, P0DP23, P04049PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1, RAF1More
Midazolamhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Midazolamhsa04914Progesterone-mediated oocyte maturation5.30E-058Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Midazolamhsa04915Estrogen signaling pathway7.20E-048P04049, P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788RAF1, ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Midazolamhsa04916Melanogenesis4.54E-034P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Midazolamhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Midazolamhsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Midazolamhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Midazolamhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Midazolamhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Midazolamhsa04924Renin secretion5.53E-065P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Midazolamhsa04925Aldosterone synthesis and secretion3.49E-046P18848, Q08828, P51828, P0DP24, P0DP23, P23634ATF4, ADCY1, ADCY7, CALM2, CALM1, ATP2B4More
Midazolamhsa04926Relaxin signaling pathway6.96E-035P31751, P18848, Q08828, P51828, P04049AKT2, ATF4, ADCY1, ADCY7, RAF1More
Midazolamhsa04927Cortisol synthesis and secretion8.09E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Midazolamhsa04928Parathyroid hormone synthesis, secretion and action2.75E-035Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Midazolamhsa04929GnRH secretion4.98E-031P04049RAF1More
Midazolamhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Midazolamhsa04932Non-alcoholic fatty liver disease9.67E-0712P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Midazolamhsa04933AGE-RAGE signaling pathway in diabetic complications5.84E-047P84022, Q13485, P42224, P10415, Q12778, P49767, P17252SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Midazolamhsa04934Cushing syndrome5.04E-036Q14643, P18848, Q08828, P51828, P22694, P04628ITPR1, ATF4, ADCY1, ADCY7, PRKACB, WNT1More
Midazolamhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Midazolamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Midazolamhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Midazolamhsa04964Proximal tubule bicarbonate reclamation2.61E-033P22748, P00918, P49448CA4, CA2, GLUD2More
Midazolamhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Midazolamhsa04970Salivary secretion1.69E-068P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1More
Midazolamhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Midazolamhsa04972Pancreatic secretion3.95E-045P23634, P63092, P51828, P62491, P61586ATP2B4, GNAS, ADCY7, RAB11A, RHOAMore
Midazolamhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Midazolamhsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Midazolamhsa04976Bile secretion1.36E-056O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Midazolamhsa05010Alzheimer disease5.16E-0520O15239, Q16718, O95298, O14521, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, O95197, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4More
Midazolamhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Midazolamhsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Midazolamhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Midazolamhsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Midazolamhsa05022Pathways of neurodegeneration - multiple diseases3.36E-0418Q14643, Q13509, P68371, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, P0DP23, P28070ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, CALM1, PSMB4More
Midazolamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Midazolamhsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Midazolamhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Midazolamhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Midazolamhsa05120Epithelial cell signaling in Helicobacter pylori infection2.39E-056Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Midazolamhsa05131Shigellosis1.97E-0313P68431, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Midazolamhsa05132Salmonella infection2.30E-0512P25963, P04049, Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371NFKBIA, RAF1, LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Midazolamhsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Midazolamhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Midazolamhsa05140Leishmaniasis1.01E-0712P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Midazolamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Midazolamhsa05143African trypanosomiasis1.53E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Midazolamhsa05144Malaria7.27E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Midazolamhsa05145Toxoplasmosis1.02E-037P25963, P10415, Q13489, P42224, P13765, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Midazolamhsa05146Amoebiasis3.30E-1212P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Midazolamhsa05150Staphylococcus aureus infection5.36E-057P0C0L4, P13646, Q14532, P59665, P59666, P12838, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Midazolamhsa05152Tuberculosis2.44E-0411P04049, Q13488, Q99437, P0DP23, P42224, O60603, P10415, P13765, P25774, P01568, Q9UDY8RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, TLR2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1More
Midazolamhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Midazolamhsa05161Hepatitis B6.38E-045P04049, P25963, Q13485, P10415, P84022RAF1, NFKBIA, SMAD4, BCL2, SMAD3More
Midazolamhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Midazolamhsa05163Human cytomegalovirus infection6.67E-0923P31751, P04049, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2MMore
Midazolamhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Midazolamhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Midazolamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Midazolamhsa05167Kaposi sarcoma-associated herpesvirus infection9.70E-0411P01568, P42224, P62873, P62879, P16298, Q14643, P04049, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, RAF1, MAP2K1, CALM1, UBB, LEF1More
Midazolamhsa05168Herpes simplex virus 1 infection1.95E-0314P25963, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Midazolamhsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Midazolamhsa05170Human immunodeficiency virus 1 infection3.09E-0615P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Midazolamhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Midazolamhsa05200Pathways in cancer6.34E-0318P42338, P08238, P42224, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, O75293, P0DP23, P01568, P14784, P40189PIK3CB, HSP90AB1, STAT1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Midazolamhsa05202Transcriptional misregulation in cancer5.39E-0515Q13315, P14780, P27930, Q15744, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Midazolamhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Midazolamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Midazolamhsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Midazolamhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Midazolamhsa05210Colorectal cancer1.46E-046Q9UKG1, P84022, Q13485, P04049, P10415, P37173APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2More
Midazolamhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Midazolamhsa05212Pancreatic cancer1.49E-059P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Midazolamhsa05213Endometrial cancer4.26E-033O15169, Q02750, P04049AXIN1, MAP2K1, RAF1More
Midazolamhsa05214Glioma1.88E-034P0DP23, P04049, P42338, O75293CALM1, RAF1, PIK3CB, GADD45BMore
Midazolamhsa05215Prostate cancer1.33E-021P04049RAF1More
Midazolamhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Midazolamhsa05218Melanoma6.63E-031P04049RAF1More
Midazolamhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Midazolamhsa05220Chronic myeloid leukemia6.24E-044Q13485, P25963, P84022, P04049SMAD4, NFKBIA, SMAD3, RAF1More
Midazolamhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Midazolamhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Midazolamhsa05223Non-small cell lung cancer6.95E-044P10826, P04049, Q9HC35, O75293RARB, RAF1, EML4, GADD45BMore
Midazolamhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Midazolamhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Midazolamhsa05226Gastric cancer2.93E-046P04049, Q02750, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Midazolamhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Midazolamhsa05231Choline metabolism in cancer4.08E-047P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Midazolamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.22E-0913P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Midazolamhsa05310Asthma2.57E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Midazolamhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Midazolamhsa05321Inflammatory bowel disease1.53E-067O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Midazolamhsa05322Systemic lupus erythematosus6.36E-0915P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P12814ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Midazolamhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Midazolamhsa05330Allograft rejection6.97E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Midazolamhsa05332Graft-versus-host disease3.32E-075P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Midazolamhsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Midazolamhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Midazolamhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Midazolamhsa05415Diabetic cardiomyopathy5.94E-037P17252, P30405, P14598, Q15080, Q16718, O14521, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2More
Midazolamhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Midazolamhsa05418Fluid shear stress and atherosclerosis3.33E-0612Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Midazolam (SDC: 10.05)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
O15151MDM4Protein Mdm4Predicted00.10140.08980.24890.4791
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)