| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Mianserin | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Mianserin | hsa00040 | Pentose and glucuronate interconversions | 4.00E-02 | 1 | P15121 | AKR1B1 | More | | | Mianserin | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Mianserin | hsa00190 | Oxidative phosphorylation | 4.38E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Mianserin | hsa00220 | Arginine biosynthesis | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Mianserin | hsa00240 | Pyrimidine metabolism | 7.14E-04 | 4 | P31350, P21589, P04183, P04818 | RRM2, NT5E, TK1, TYMS | More | | | Mianserin | hsa00250 | Alanine, aspartate and glutamate metabolism | 1.97E-02 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Mianserin | hsa00310 | Lysine degradation | 4.57E-02 | 2 | Q96KQ7, Q02809 | EHMT2, PLOD1 | More | | | Mianserin | hsa00350 | Tyrosine metabolism | 3.40E-02 | 1 | P28332 | ADH6 | More | | | Mianserin | hsa00513 | Various types of N-glycan biosynthesis | 4.96E-02 | 1 | Q9NR34 | MAN1C1 | More | | | Mianserin | hsa00520 | Amino sugar and nucleotide sugar metabolism | 2.24E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Mianserin | hsa00562 | Inositol phosphate metabolism | 2.00E-02 | 4 | P27987, P19174, P42338, Q02252 | ITPKB, PLCG1, PIK3CB, ALDH6A1 | More | | | Mianserin | hsa00564 | Glycerophospholipid metabolism | 4.29E-02 | 2 | Q6P1A2, P23743 | MBOAT5, DGKA | More | | | Mianserin | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Mianserin | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Mianserin | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Mianserin | hsa00600 | Sphingolipid metabolism | 4.77E-02 | 3 | Q9BX95, O14494, P06280 | SGPP1, PLPP1, GLA | More | | | Mianserin | hsa00604 | Glycosphingolipid biosynthesis - ganglio series | 2.87E-03 | 3 | P06865, O15466, Q9H4F1 | HEXA, ST8SIA5, ST6GALNAC4 | More | | | Mianserin | hsa00620 | Pyruvate metabolism | 3.90E-02 | 2 | P07195, P11766 | LDHB, ADH5 | More | | | Mianserin | hsa00630 | Glyoxylate and dicarboxylate metabolism | 4.91E-07 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Mianserin | hsa00670 | One carbon pool by folate | 4.14E-02 | 1 | P04818 | TYMS | More | | | Mianserin | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Mianserin | hsa00790 | Folate biosynthesis | 2.02E-02 | 1 | P15121 | AKR1B1 | More | | | Mianserin | hsa00910 | Nitrogen metabolism | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Mianserin | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Mianserin | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.26E-05 | 4 | P78417, P28332, P09211, P11712 | GSTO1, ADH6, GSTP1, CYP2C9 | More | | | Mianserin | hsa00982 | Drug metabolism - cytochrome P450 | 8.40E-04 | 3 | P11712, P78417, P28332 | CYP2C9, GSTO1, ADH6 | More | | | Mianserin | hsa00983 | Drug metabolism - other enzymes | 3.48E-03 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Mianserin | hsa01100 | Metabolic pathways | 4.11E-02 | 7 | P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6 | PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHE | More | | | Mianserin | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Mianserin | hsa01230 | Biosynthesis of amino acids | 2.60E-02 | 3 | P51854, P60891, P37837 | TKTL1, PRPS1, TALDO1 | More | | | Mianserin | hsa01240 | Biosynthesis of cofactors | 2.52E-02 | 2 | Q9BQB6, P14550 | VKORC1, AKR1A1 | More | | | Mianserin | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa01523 | Antifolate resistance | 3.80E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Mianserin | hsa01524 | Platinum drug resistance | 1.13E-02 | 5 | P10415, Q13489, P78417, P23025, P43246 | BCL2, BIRC3, GSTO1, XPA, MSH2 | More | | | Mianserin | hsa02010 | ABC transporters | 1.66E-04 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Mianserin | hsa03008 | Ribosome biogenesis in eukaryotes | 2.60E-03 | 5 | Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0 | UTP6, RPP38, GNL3, NVL, NXF2; NXF2B | More | | | Mianserin | hsa03010 | Ribosome | 2.25E-04 | 5 | P40429, Q07020, P27635, P05386, P62249 | RPL13A, RPL18, RPL10, RPLP1, RPS16 | More | | | Mianserin | hsa03013 | RNA transport | 1.32E-05 | 13 | P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5 | NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3 | More | | | Mianserin | hsa03020 | RNA polymerase | 3.00E-02 | 3 | P30876, P24928, P62487 | POLR2B, POLR2A, POLR2G | More | | | Mianserin | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Mianserin | hsa03040 | Spliceosome | 1.30E-06 | 12 | Q14562, O43143, O60508, Q99633, P08579, Q13595, Q07955, Q01130, Q13243, Q9UMS4, P11142, O43447 | DHX8, DHX15, CDC40, PRPF18, SNRPB2, TRA2A, SFRS1, SFRS2, SFRS5, PRPF19, HSPA8, PPIH | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.888 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.708 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.819 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.953 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P46091 | GPR1 | Chemerin-like receptor 2 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.816 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.838 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.837 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P46091 | GPR1 | Chemerin-like receptor 2 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.778 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q99633 | PRPF18 | Pre-mRNA-splicing factor 18 | -0.711 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.788 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.702 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.753 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.935 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.882 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.746 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.886 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UMS4 | PRPF19 | Pre-mRNA-processing factor 19 | 0.703 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.746 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.761 |
| | Mianserin | hsa03050 | Proteasome | 1.21E-02 | 1 | P28074 | PSMB5 | More | | | Mianserin | hsa03060 | Protein export | 3.59E-04 | 4 | Q15070, P37108, O76094, Q15005 | OXA1L, SRP14, SRP72, SPCS2 | More | | | Mianserin | hsa03320 | PPAR signaling pathway | 4.33E-02 | 2 | Q6PCB7, Q9UNU6 | SLC27A1, CYP8B1 | More | | | Mianserin | hsa03410 | Base excision repair | 2.52E-02 | 2 | P49005, P29372 | POLD2, MPG | More | | | Mianserin | hsa03450 | Non-homologous end-joining | 1.02E-03 | 2 | P78527, P13010 | PRKDC, XRCC5 | More | | | Mianserin | hsa04010 | MAPK signaling pathway | 1.23E-03 | 3 | P08069, Q9H2K8, Q12933 | IGF1R, TAOK3, TRAF2 | More | | | Mianserin | hsa04012 | ErbB signaling pathway | 2.00E-02 | 4 | P16333, P17252, P19174, P42338 | NCK1, PRKCA, PLCG1, PIK3CB | More | | | Mianserin | hsa04014 | Ras signaling pathway | 4.81E-04 | 11 | P42338, P20827, P49767, P08069, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174 | PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1 | More | | | Mianserin | hsa04015 | Rap1 signaling pathway | 1.67E-05 | 13 | P20827, P49767, P08069, P63261, P11215, P25116, Q8TEU7, Q13009, P42338, P0DP23, P08514, P17252, P19174 | EFNA1, VEGFC, IGF1R, ACTG1, ITGAM, F2R, RAPGEF6, TIAM1, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1 | More | | | Mianserin | hsa04020 | Calcium signaling pathway | 2.66E-04 | 9 | P27987, Q16566, P17252, O15399, P19174, P25116, P0DP23, P23634, P49767 | ITPKB, CAMK4, PRKCA, GRIN2D, PLCG1, F2R, CALM1, ATP2B4, VEGFC | More | | | Mianserin | hsa04024 | cAMP signaling pathway | 4.97E-04 | 9 | P42338, P0DP23, P23634, Q16566, Q13370, O15399, P25963, P25116, Q13009 | PIK3CB, CALM1, ATP2B4, CAMK4, PDE3B, GRIN2D, NFKBIA, F2R, TIAM1 | More | | | Mianserin | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Mianserin | hsa04062 | Chemokine signaling pathway | 7.18E-04 | 14 | P25024, P25025, P09341, P19875, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963 | CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA | More | | | Mianserin | hsa04064 | NF-kappa B signaling pathway | 3.02E-09 | 25 | P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P05164 | MPO | Myeloperoxidase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.821 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P17252 | PRKCA | Protein kinase C alpha type | P29965 | CD40LG | CD40 ligand | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P05164 | MPO | Myeloperoxidase | Q04759 | PRKCQ | Protein kinase C theta type | -0.88 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | P05164 | MPO | Myeloperoxidase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.758 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.869 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.768 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P17252 | PRKCA | Protein kinase C alpha type | Q8WV28 | BLNK | B-cell linker protein | 0.838 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.712 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P05164 | MPO | Myeloperoxidase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.806 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 |
| | Mianserin | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04070 | Phosphatidylinositol signaling system | 6.31E-06 | 8 | P19174, P0DP23, Q14643, P42338, P23743, O14732, P27987, P17252 | PLCG1, CALM1, ITPR1, PIK3CB, DGKA, IMPA2, ITPKB, PRKCA | More | | | Mianserin | hsa04071 | Sphingolipid signaling pathway | 1.55E-09 | 12 | P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q12933, Q02156 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, TRAF2, PRKCE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P17252 | PRKCA | Protein kinase C alpha type | 0.738 | | P05164 | MPO | Myeloperoxidase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.823 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.773 | | P08246 | ELA2 | Neutrophil elastase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.725 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.704 | | P05164 | MPO | Myeloperoxidase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P08246 | ELA2 | Neutrophil elastase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.797 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.809 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | P05164 | MPO | Myeloperoxidase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.799 | | P08246 | ELA2 | Neutrophil elastase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.865 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.712 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | 0.819 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.917 | | P08246 | ELA2 | Neutrophil elastase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.847 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P04637 | TP53 | Cellular tumor antigen p53 | 0.728 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q12933 | TRAF2 | TNF receptor-associated factor 2 | -0.78 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q02156 | PRKCE | Protein kinase C epsilon type | 1 |
| | Mianserin | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Mianserin | hsa04080 | Neuroactive ligand-receptor interaction | 8.77E-05 | 10 | P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550 | CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2 | More | | | Mianserin | hsa04110 | Cell cycle | 2.95E-04 | 7 | P06493, P78527, O75293, P30304, P33981, P42773, P01106 | CDK1, PRKDC, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Mianserin | hsa04114 | Oocyte meiosis | 1.43E-03 | 6 | Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069 | MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R | More | | | Mianserin | hsa04115 | p53 signaling pathway | 6.81E-04 | 7 | P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415 | GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2 | More | | | Mianserin | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Mianserin | hsa04140 | Autophagy - animal | 2.82E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Mianserin | hsa04144 | Endocytosis | 2.89E-03 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Mianserin | hsa04145 | Phagosome | 1.87E-07 | 11 | P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765 | ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB | More | | | Mianserin | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04151 | PI3K-Akt signaling pathway | 2.87E-04 | 21 | P42338, P43657, P25116, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252 | PIK3CB, P2RY5, F2R, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.702 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | -0.789 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P20827 | EFNA1 | Ephrin-A1 | -0.872 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.871 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Q9GZP0 | PDGFD | Platelet-derived growth factor D | 0.736 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.844 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.902 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | P13612 | ITGA4 | Integrin alpha-4 | 0.77 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P16144 | ITGB4 | Integrin beta-4 | -0.705 | | P17252 | PRKCA | Protein kinase C alpha type | P16144 | ITGB4 | Integrin beta-4 | 0.755 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | O15335 | CHAD | Chondroadherin | -0.729 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O15335 | CHAD | Chondroadherin | -0.719 | | P61088 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.794 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.705 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 |
| | Mianserin | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04210 | Apoptosis | 1.53E-03 | 12 | Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643 | ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1 | More | | | Mianserin | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04213 | Longevity regulating pathway - multiple species | 9.82E-04 | 8 | P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | | | Mianserin | hsa04217 | Necroptosis | 9.50E-05 | 13 | P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, P10415, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPID | More | | | Mianserin | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | | Mianserin | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.45E-04 | 10 | P09493, P07550, P22694, P18848, Q13362, Q16537, P0DP23, P17252, P10415, P20020 | TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1 | More | | | Mianserin | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Mianserin | hsa04330 | Notch signaling pathway | 4.84E-04 | 2 | Q92542, P49768 | NCSTN, PSEN1 | More | | | Mianserin | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Mianserin | hsa04350 | TGF-beta signaling pathway | 4.88E-02 | 1 | P37173 | TGFBR2 | More | | | Mianserin | hsa04360 | Axon guidance | 1.16E-04 | 7 | P16333, P20827, O95631, P17252, P42338, P23528, P19174 | NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1 | More | | | Mianserin | hsa04370 | VEGF signaling pathway | 7.52E-05 | 6 | P19174, P16298, P42338, P17252, Q05397, Q02750 | PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1 | More | | | Mianserin | hsa04390 | Hippo signaling pathway | 1.47E-02 | 5 | P63261, Q13485, Q9UJU2, O43623, Q13489 | ACTG1, SMAD4, LEF1, SNAI2, BIRC3 | More | | | Mianserin | hsa04510 | Focal adhesion | 2.79E-04 | 12 | P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P10415, P08069, P49767, P63261 | ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, BCL2, IGF1R, VEGFC, ACTG1 | More | | | Mianserin | hsa04512 | ECM-receptor interaction | 4.41E-02 | 3 | Q13751, P13612, O15335 | LAMB3, ITGA4, CHAD | More | | | Mianserin | hsa04520 | Adherens junction | 2.26E-03 | 5 | Q13485, Q9UJU2, O43623, P08069, P63261 | SMAD4, LEF1, SNAI2, IGF1R, ACTG1 | More | | | Mianserin | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Mianserin | hsa04540 | Gap junction | 1.53E-03 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Mianserin | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa04610 | Complement and coagulation cascades | 1.27E-10 | 2 | P00734, P0C0L4 | F2, C4A | More | | | Mianserin | hsa04611 | Platelet activation | 3.39E-02 | 3 | P25116, P08514, P07359 | F2R, ITGA2B, GP1BA | More | | | Mianserin | hsa04612 | Antigen processing and presentation | 2.53E-05 | 9 | P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Mianserin | hsa04613 | Neutrophil extracellular trap formation | 4.30E-08 | 23 | P17252, O60603, P05164, P08246, Q9UM07, Q92769, P04908, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P17252 | PRKCA | Protein kinase C alpha type | 0.738 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P17252 | PRKCA | Protein kinase C alpha type | P08246 | ELA2 | Neutrophil elastase | -0.735 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P08246 | ELA2 | Neutrophil elastase | -0.706 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q92769 | HDAC2 | Histone deacetylase 2 | 0.702 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P17252 | PRKCA | Protein kinase C alpha type | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.83 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.86 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P33778 | H2BC3 | Histone H2B type 1-B | 0.704 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P17252 | PRKCA | Protein kinase C alpha type | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.783 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.713 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.803 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | | P17252 | PRKCA | Protein kinase C alpha type | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.7 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Mianserin | hsa04614 | Renin-angiotensin system | 1.52E-02 | 1 | P50052 | AGTR2 | More | | | Mianserin | hsa04621 | NOD-like receptor signaling pathway | 2.68E-04 | 14 | Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838 | MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4 | More | | | Mianserin | hsa04622 | RIG-I-like receptor signaling pathway | 2.47E-02 | 1 | Q12933 | TRAF2 | More | | | Mianserin | hsa04623 | Cytosolic DNA-sensing pathway | 1.35E-03 | 4 | P01584, P01568, P25963, Q8NHW4 | IL1B, IFNA21, NFKBIA, CCL4L2 | More | | | Mianserin | hsa04640 | Hematopoietic cell lineage | 1.54E-03 | 9 | P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564 | CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7 | More | | | Mianserin | hsa04650 | Natural killer cell mediated cytotoxicity | 4.54E-07 | 15 | P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715 | PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1 | More | | | Mianserin | hsa04657 | IL-17 signaling pathway | 3.69E-03 | 8 | O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF | More | | | Mianserin | hsa04658 | Th1 and Th2 cell differentiation | 1.54E-05 | 13 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | | Mianserin | hsa04659 | Th17 cell differentiation | 3.49E-05 | 12 | P25963, Q04759, P19174, P06239, P42224, P14784, P14778, P40189, Q9UL17, P08238, P07766, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, HSP90AB1, CD3E, CD247 | More | | | Mianserin | hsa04660 | T cell receptor signaling pathway | 7.14E-06 | 17 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | | Mianserin | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Mianserin | hsa04664 | Fc epsilon RI signaling pathway | 1.19E-03 | 5 | P42338, P17252, P07948, P19174, P09917 | PIK3CB, PRKCA, LYN, PLCG1, ALOX5 | More | | | Mianserin | hsa04666 | Fc gamma R-mediated phagocytosis | 4.32E-05 | 7 | P42338, P19174, P23528, P49006, P06396, P14598, P17252 | PIK3CB, PLCG1, CFL1, MARCKSL1, GSN, NCF1, PRKCA | More | | | Mianserin | hsa04668 | TNF signaling pathway | 2.93E-03 | 9 | P01375, O00463, Q13489, P25963, P18848, P19875, P20749, Q13077, P14780 | TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9 | More | | | Mianserin | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Mianserin | hsa04672 | Intestinal immune network for IgA production | 1.06E-04 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Mianserin | hsa04713 | Circadian entrainment | 8.46E-04 | 6 | O15399, P0DP23, P17252, P62873, P50151, Q14643 | GRIN2D, CALM1, PRKCA, GNB1, GNG10, ITPR1 | More | | | Mianserin | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Mianserin | hsa04720 | Long-term potentiation | 4.44E-06 | 8 | P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643 | PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1 | More | | | Mianserin | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Mianserin | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Mianserin | hsa04724 | Glutamatergic synapse | 4.07E-06 | 6 | O15399, P17252, P62873, P63218, P50151, P15104 | GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL | More | | | Mianserin | hsa04725 | Cholinergic synapse | 3.53E-05 | 9 | P22694, Q14643, P17252, P62873, P63218, P50151, P18848, P42338, P10415 | PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, PIK3CB, BCL2 | More | | | Mianserin | hsa04726 | Serotonergic synapse | 2.54E-02 | 5 | P17252, P62873, P50151, P33260, P09917 | PRKCA, GNB1, GNG10, CYP2C18, ALOX5 | More | | | Mianserin | hsa04727 | GABAergic synapse | 3.12E-05 | 5 | P62873, P63218, P50151, P15104, P17252 | GNB1, GNG5, GNG10, GLUL, PRKCA | More | | | Mianserin | hsa04728 | Dopaminergic synapse | 3.55E-02 | 5 | Q14643, P17252, P62873, Q13362, P0DP23 | ITPR1, PRKCA, GNB1, PPP2R5C, CALM1 | More | | | Mianserin | hsa04730 | Long-term depression | 1.34E-02 | 3 | Q14344, P08069, P07948 | GNA13, IGF1R, LYN | More | | | Mianserin | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | | Mianserin | hsa04742 | Taste transduction | 1.01E-02 | 1 | P30939 | HTR1F | More | | | Mianserin | hsa04744 | Phototransduction | 1.74E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Mianserin | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.85E-04 | 9 | P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | | Mianserin | hsa04912 | GnRH signaling pathway | 3.85E-03 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Mianserin | hsa04913 | Ovarian steroidogenesis | 7.72E-03 | 3 | P42330, P22694, P08069 | AKR1C3, PRKACB, IGF1R | More | | | Mianserin | hsa04914 | Progesterone-mediated oocyte maturation | 2.77E-05 | 10 | P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750 | IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Mianserin | hsa04915 | Estrogen signaling pathway | 2.77E-03 | 10 | P14780, P22694, P18848, Q08828, P51828, P0DMV8, Q14643, P0DP23, Q15788, P10415 | MMP9, PRKACB, ATF4, ADCY1, ADCY7, HSPA1A, ITPR1, CALM1, NCOA1, BCL2 | More | | | Mianserin | hsa04916 | Melanogenesis | 3.55E-02 | 3 | P0DP23, Q9UJU2, P17252 | CALM1, LEF1, PRKCA | More | | | Mianserin | hsa04918 | Thyroid hormone synthesis | 2.88E-03 | 5 | P22694, P17252, P18848, Q14643, P27824 | PRKACB, PRKCA, ATF4, ITPR1, CANX | More | | | Mianserin | hsa04919 | Thyroid hormone signaling pathway | 3.71E-02 | 2 | P26678, P08237 | PLN, PFKM | More | | | Mianserin | hsa04920 | Adipocytokine signaling pathway | 4.49E-02 | 4 | P25963, P33121, Q04759, P01375 | NFKBIA, ACSL1, PRKCQ, TNF | More | | | Mianserin | hsa04921 | Oxytocin signaling pathway | 4.19E-02 | 4 | P0DP23, P17252, Q16566, P63261 | CALM1, PRKCA, CAMK4, ACTG1 | More | | | Mianserin | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Mianserin | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Mianserin | hsa04924 | Renin secretion | 6.30E-05 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Mianserin | hsa04925 | Aldosterone synthesis and secretion | 2.90E-04 | 6 | Q14643, P0DP23, P17252, Q16566, P20020, P23634 | ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4 | More | | | Mianserin | hsa04926 | Relaxin signaling pathway | 2.34E-05 | 12 | P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P17252, P30679, P49407 | NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, PRKCA, GNA15, ARRB1 | More | | | Mianserin | hsa04927 | Cortisol synthesis and secretion | 4.44E-04 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Mianserin | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.13E-02 | 5 | Q14643, P22694, P23771, P18848, P10415 | ITPR1, PRKACB, GATA3, ATF4, BCL2 | More | | | Mianserin | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Mianserin | hsa04930 | Type II diabetes mellitus | 2.47E-02 | 1 | Q02156 | PRKCE | More | | | Mianserin | hsa04932 | Non-alcoholic fatty liver disease | 7.01E-05 | 11 | P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521 | TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD | More | | | Mianserin | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.26E-04 | 8 | Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174 | SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Mianserin | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Mianserin | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 2.68E-02 | 3 | P20020, Q9UEF7, P17252 | ATP2B1, KL, PRKCA | More | | | Mianserin | hsa04962 | Vasopressin-regulated water reabsorption | 1.80E-02 | 2 | P62491, P46459 | RAB11A, NSF | More | | | Mianserin | hsa04964 | Proximal tubule bicarbonate reclamation | 2.17E-03 | 1 | P00918 | CA2 | More | | | Mianserin | hsa04966 | Collecting duct acid secretion | 3.24E-07 | 4 | Q13488, P02730, P00918, Q9Y666 | TCIRG1, SLC4A1, CA2, SLC12A7 | More | | | Mianserin | hsa04970 | Salivary secretion | 1.18E-06 | 10 | P07550, Q08828, P51828, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMP | More | | | Mianserin | hsa04971 | Gastric acid secretion | 4.76E-02 | 3 | P17252, P63261, P0DP23 | PRKCA, ACTG1, CALM1 | More | | | Mianserin | hsa04972 | Pancreatic secretion | 5.75E-04 | 3 | Q14643, P20020, P17252 | ITPR1, ATP2B1, PRKCA | More | | | Mianserin | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Mianserin | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Mianserin | hsa04976 | Bile secretion | 3.14E-03 | 5 | O43315, Q08828, P51828, P08183, Q14032 | AQP9, ADCY1, ADCY7, ABCB1, BAAT | More | | | Mianserin | hsa04978 | Mineral absorption | 3.94E-02 | 2 | P23634, Q9BXS9 | ATP2B4, SLC26A6 | More | | | Mianserin | hsa05010 | Alzheimer disease | 4.45E-03 | 13 | Q16718, O14521, Q14643, O15399, Q9NZJ5, P0DP23, Q13564, Q71U36, Q13509, P68371, P09603, P21796, Q08752 | NDUFA5, SDHD, ITPR1, GRIN2D, EIF2AK3, CALM1, APPBP1, TUBA1A, TUBB3, TUBB2C, CSF1, VDAC1, PPID | More | | | Mianserin | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Mianserin | hsa05014 | Amyotrophic lateral sclerosis | 4.31E-02 | 7 | O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0 | GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B | More | | | Mianserin | hsa05016 | Huntington disease | 2.46E-02 | 9 | O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12 | More | | | Mianserin | hsa05017 | Spinocerebellar ataxia | 2.43E-02 | 1 | P28074 | PSMB5 | More | | | Mianserin | hsa05020 | Prion disease | 2.20E-04 | 11 | Q16718, O14521, Q92736, Q14643, O60282, Q13509, P68371, P49841, P14598, Q15080, Q16539 | NDUFA5, SDHD, RYR2, ITPR1, KIF5C, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14 | More | | | Mianserin | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.00E-04 | 12 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1 | More | | | Mianserin | hsa05031 | Amphetamine addiction | 1.61E-03 | 7 | O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547 | GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1 | More | | | Mianserin | hsa05032 | Morphine addiction | 4.62E-04 | 7 | P62873, P63218, P50151, Q13370, Q07343, P17252, P43250 | GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6 | More | | | Mianserin | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Mianserin | hsa05110 | Vibrio cholerae infection | 3.15E-02 | 3 | Q13488, P17252, P19174 | TCIRG1, PRKCA, PLCG1 | More | | | Mianserin | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Mianserin | hsa05131 | Shigellosis | 5.38E-04 | 16 | P01375, P25963, Q12933, O00463, P68431, Q02156, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32 | TNF, NFKBIA, TRAF2, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF | More | | | Mianserin | hsa05132 | Salmonella infection | 1.01E-08 | 18 | P51617, P25963, P01375, Q9UJU2, P63261, O00471, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, P51808, Q13561, O60282, Q13509, P68371 | IRAK1, NFKBIA, TNF, LEF1, ACTG1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DYNLT3, DCTN2, KIF5C, TUBB3, TUBB2C | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.825 | | P08246 | ELA2 | Neutrophil elastase | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | -0.771 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.736 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.835 | | P46091 | GPR1 | Chemerin-like receptor 2 | P63261 | ACTG1 | Actin, cytoplasmic 2 | 0.776 | | Q9UGN5 | PARP2 | Poly [ADP-ribose] polymerase 2 | O00471 | EXOC5 | Exocyst complex component 5 | 0.74 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O75369 | FLNB | Filamin-B | -0.717 | | P08246 | ELA2 | Neutrophil elastase | Q96A32 | MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform | 0.724 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.701 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.924 | | P08246 | ELA2 | Neutrophil elastase | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | -0.949 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.721 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51808 | DYNLT3 | Dynein light chain Tctex-type 3 | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.809 | | P08246 | ELA2 | Neutrophil elastase | Q13561 | DCTN2 | Dynactin subunit 2 | 0.78 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.781 | | Q9UGN5 | PARP2 | Poly [ADP-ribose] polymerase 2 | O60282 | KIF5C | Kinesin heavy chain isoform 5C | -0.748 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P08246 | ELA2 | Neutrophil elastase | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.724 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.748 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.835 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P46091 | GPR1 | Chemerin-like receptor 2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.751 |
| | Mianserin | hsa05133 | Pertussis | 2.94E-06 | 4 | P0DP23, P23528, P09871, P0C0L4 | CALM1, CFL1, C1S, C4A | More | | | Mianserin | hsa05134 | Legionellosis | 8.80E-04 | 7 | P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | | Mianserin | hsa05135 | Yersinia infection | 3.29E-02 | 4 | Q05397, P51812, Q02750, Q96JJ3 | PTK2, RPS6KA3, MAP2K1, ELMO2 | More | | | Mianserin | hsa05140 | Leishmaniasis | 4.99E-07 | 13 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | | Mianserin | hsa05143 | African trypanosomiasis | 1.11E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Mianserin | hsa05144 | Malaria | 1.44E-03 | 5 | P69905, P68871, P01375, P35443, P26718 | HBA2, HBB, TNF, THBS4, KLRK1 | More | | | Mianserin | hsa05145 | Toxoplasmosis | 1.29E-04 | 12 | P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LG | More | | | Mianserin | hsa05146 | Amoebiasis | 7.00E-06 | 13 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG | More | | | Mianserin | hsa05150 | Staphylococcus aureus infection | 1.31E-02 | 2 | P0C0L4, P13646 | C4A, KRT13 | More | | | Mianserin | hsa05152 | Tuberculosis | 1.03E-06 | 15 | Q13488, Q15075, P0DP23, P42224, P48382, P25208, O60603, P01375, P10415, P13765, Q13651, P01568, P49913, Q9UDY8, P51617 | TCIRG1, EEA1, CALM1, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IL10RA, IFNA21, CAMP, MALT1, IRAK1 | More | | | Mianserin | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Mianserin | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Mianserin | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Mianserin | hsa05163 | Human cytomegalovirus infection | 1.70E-03 | 14 | P42338, P25963, P62873, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P17252, Q13651, P30101, P01568 | PIK3CB, NFKBIA, GNB1, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, PRKCA, IL10RA, PDIA3, IFNA21 | More | | | Mianserin | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Mianserin | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 8.53E-05 | 15 | P01568, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2 | IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1 | More | | | Mianserin | hsa05168 | Herpes simplex virus 1 infection | 2.01E-05 | 16 | Q9UKJ0, P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6, P10415 | PILRB, NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212, BCL2 | More | | | Mianserin | hsa05169 | Epstein-Barr virus infection | 2.83E-03 | 14 | Q13547, Q92769, P04637, Q13546, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P51617, P07766, P09693 | HDAC1, HDAC2, TP53, RIPK1, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, IRAK1, CD3E, CD3G | More | | | Mianserin | hsa05170 | Human immunodeficiency virus 1 infection | 1.50E-09 | 23 | P42338, P62873, P50151, P0DP23, P01375, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P09693, P10415, Q13619, Q93034, Q9Y6Q5 | PIK3CB, GNB1, GNG10, CALM1, TNF, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3G, BCL2, CUL4A, CUL5, AP1M2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.701 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P0DP23 | CALM1 | Calmodulin-1 | -0.734 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P17252 | PRKCA | Protein kinase C alpha type | 0.738 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.739 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P08246 | ELA2 | Neutrophil elastase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.816 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.81 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08246 | ELA2 | Neutrophil elastase | O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | 0.711 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P23528 | CFL1 | Cofilin-1 | -0.853 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.753 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P08246 | ELA2 | Neutrophil elastase | Q13619 | CUL4A | Cullin-4A | -0.707 | | P08246 | ELA2 | Neutrophil elastase | Q93034 | CUL5 | Cullin-5 | -0.744 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.946 | | P08246 | ELA2 | Neutrophil elastase | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.811 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.86 |
| | Mianserin | hsa05171 | Coronavirus disease - COVID-19 | 9.13E-03 | 12 | P25963, P42224, P01568, P62249, P40429, P27635, Q07020, P05386, P40189, P42338, P19174, P17252 | NFKBIA, STAT1, IFNA21, RPS16, RPL13A, RPL10, RPL18, RPLP1, IL6ST, PIK3CB, PLCG1, PRKCA | More | | | Mianserin | hsa05200 | Pathways in cancer | 3.54E-07 | 26 | Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, Q13485, P10826, P14923, P10415, Q13489, P49767, P14921, Q12778, P25116, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD4, RARB, JUP, BCL2, BIRC3, VEGFC, ETS1, FOXO1, F2R, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.705 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.736 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P46091 | GPR1 | Chemerin-like receptor 2 | P17252 | PRKCA | Protein kinase C alpha type | 0.741 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.925 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P46091 | GPR1 | Chemerin-like receptor 2 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.838 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.809 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P10826 | RARB | Retinoic acid receptor beta | 0.779 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14923 | JUP | Junction plakoglobin | -0.716 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P46091 | GPR1 | Chemerin-like receptor 2 | P14923 | JUP | Junction plakoglobin | 0.883 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.747 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.871 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P46091 | GPR1 | Chemerin-like receptor 2 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.718 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14921 | ETS1 | Protein C-ets-1 | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P46091 | GPR1 | Chemerin-like receptor 2 | P25116 | F2R | Proteinase-activated receptor 1 | 0.76 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | -0.703 | | P46091 | GPR1 | Chemerin-like receptor 2 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | 0.738 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.919 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P46091 | GPR1 | Chemerin-like receptor 2 | P0DP23 | CALM1 | Calmodulin-1 | -0.846 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P46091 | GPR1 | Chemerin-like receptor 2 | P01568 | IFNA21 | Interferon alpha-21 | 0.724 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.748 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Mianserin | hsa05202 | Transcriptional misregulation in cancer | 5.78E-09 | 20 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.777 | | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15532 | SS18 | Protein SSXT | 0.763 | | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14923 | JUP | Junction plakoglobin | 0.845 | | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.754 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08246 | ELA2 | Neutrophil elastase | -0.896 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.787 | | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 |
| | Mianserin | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Mianserin | hsa05204 | Chemical carcinogenesis | 1.09E-03 | 3 | P09211, P78417, P11712 | GSTP1, GSTO1, CYP2C9 | More | | | Mianserin | hsa05205 | Proteoglycans in cancer | 1.20E-04 | 15 | Q13009, Q12955, Q14643, O75369, Q14247, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962 | TIAM1, ANK3, ITPR1, FLNB, CTTN, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63 | More | | | Mianserin | hsa05212 | Pancreatic cancer | 2.84E-03 | 4 | P42338, P42224, P37173, O75293 | PIK3CB, STAT1, TGFBR2, GADD45B | More | | | Mianserin | hsa05214 | Glioma | 6.47E-08 | 9 | P08069, P0DP23, Q16566, P17252, P42338, P04637, P19174, P24522, O75293 | IGF1R, CALM1, CAMK4, PRKCA, PIK3CB, TP53, PLCG1, GADD45A, GADD45B | More | | | Mianserin | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa05216 | Thyroid cancer | 1.58E-03 | 5 | P01106, Q9UJU2, P04637, P24522, O75293 | MYC, LEF1, TP53, GADD45A, GADD45B | More | | | Mianserin | hsa05217 | Basal cell carcinoma | 4.42E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Mianserin | hsa05218 | Melanoma | 9.63E-04 | 4 | P08069, P09619, Q9GZP0, Q02750 | IGF1R, PDGFRB, PDGFD, MAP2K1 | More | | | Mianserin | hsa05222 | Small cell lung cancer | 9.25E-04 | 10 | P10826, P42338, Q13751, Q13489, P10415, P25963, Q13077, O00463, P24522, O75293 | RARB, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B | More | | | Mianserin | hsa05223 | Non-small cell lung cancer | 2.07E-04 | 6 | P17252, P42338, P19174, P10826, Q9HC35, O75293 | PRKCA, PIK3CB, PLCG1, RARB, EML4, GADD45B | More | | | Mianserin | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Mianserin | hsa05231 | Choline metabolism in cancer | 1.66E-04 | 9 | Q02750, P42338, P09619, Q9GZP0, O15245, Q9Y259, P19174, P23743, P17252 | MAP2K1, PIK3CB, PDGFRB, PDGFD, SLC22A1, CHKB, PLCG1, DGKA, PRKCA | More | | | Mianserin | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2.99E-04 | 8 | P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730 | PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4 | More | | | Mianserin | hsa05310 | Asthma | 1.58E-04 | 4 | P13765, P29965, P12724, P01375 | HLA-DOB, CD40LG, RNASE3, TNF | More | | | Mianserin | hsa05320 | Autoimmune thyroid disease | 1.05E-04 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Mianserin | hsa05321 | Inflammatory bowel disease | 6.49E-07 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Mianserin | hsa05322 | Systemic lupus erythematosus | 3.08E-06 | 13 | P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | | Mianserin | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Mianserin | hsa05330 | Allograft rejection | 7.91E-05 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Mianserin | hsa05332 | Graft-versus-host disease | 1.10E-07 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | | Mianserin | hsa05340 | Primary immunodeficiency | 1.28E-03 | 4 | P01730, P11912, P07766, P06239 | CD4, CD79A, CD3E, LCK | More | | | Mianserin | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 3.75E-05 | 6 | Q8IZS8, P54284, P14923, P08514, P13612, Q9UJU2 | CACNA2D3, CACNB3, JUP, ITGA2B, ITGA4, LEF1 | More | | | Mianserin | hsa05414 | Dilated cardiomyopathy | 2.58E-03 | 4 | Q8IZS8, P54284, P13612, P26678 | CACNA2D3, CACNB3, ITGA4, PLN | More | | | Mianserin | hsa05415 | Diabetic cardiomyopathy | 1.58E-03 | 7 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B | More | | | Mianserin | hsa05416 | Viral myocarditis | 2.61E-03 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Mianserin | hsa05418 | Fluid shear stress and atherosclerosis | 2.33E-03 | 8 | P42338, P14598, P78417, P63261, P10415, P0DP23, P08238, Q92974 | PIK3CB, NCF1, GSTO1, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2 | More | |
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