PharmaCoNets of Metyrosine (SPCN: 21.08 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Metyrosinehsa00500Starch and sucrose metabolism1.32E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Metyrosinehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Metyrosinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Metyrosinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Metyrosinehsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Metyrosinehsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Metyrosinehsa03050Proteasome3.05E-021P55036PSMD4More
Metyrosinehsa03060Protein export3.28E-022Q15070, O76094OXA1L, SRP72More
Metyrosinehsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Metyrosinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Metyrosinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Metyrosinehsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Metyrosinehsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Metyrosinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Metyrosinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Metyrosinehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Metyrosinehsa04621NOD-like receptor signaling pathway3.15E-0210Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Metyrosinehsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Metyrosinehsa04640Hematopoietic cell lineage1.75E-038P21926, P20023, P11836, P07766, P09693, P01730, P09564, P16871CD9, CR2, MS4A1, CD3E, CD3G, CD4, CD7, IL7RMore
Metyrosinehsa04650Natural killer cell mediated cytotoxicity1.83E-0310P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Metyrosinehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Metyrosinehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Metyrosinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Metyrosinehsa04919Thyroid hormone signaling pathway4.44E-023P60709, Q09472, P01106ACTB, EP300, MYCMore
Metyrosinehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Metyrosinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Metyrosinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Metyrosinehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Metyrosinehsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Metyrosinehsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P41240ATP6V0B, CSKMore
Metyrosinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Metyrosinehsa05144Malaria1.91E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Metyrosinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Metyrosinehsa05163Human cytomegalovirus infection4.07E-029P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Metyrosinehsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Metyrosinehsa05169Epstein-Barr virus infection2.92E-0312P20023, P13765, P01106, Q13547, O00463, Q16539, P24522, P48551, O60603, P29728, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, GADD45A, IFNAR2, TLR2, OAS2, CD3G, CD247More
Metyrosinehsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Metyrosinehsa05211Renal cell carcinoma1.67E-022Q09472, Q99814EP300, EPAS1More
Metyrosinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Metyrosinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Metyrosinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-038P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
Metyrosinehsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Metyrosinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Metyrosinehsa05332Graft-versus-host disease2.02E-035P48023, P10747, P01375, P26715, Q13241FASLG, CD28, TNF, KLRC1, KLRD1More
Metyrosinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore

Community members of Metyrosine (SDC: 3.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07101THTyrosine 3NonemonooxygenaseReported00.04320.08880.49370.6929
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75475PSIP1PC4 and SFRS1Noneinteracting proteinPredicted00.33320.063800.2943
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)