| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Metyrapone | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Metyrapone | hsa00220 | Arginine biosynthesis | 1.26E-03 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Metyrapone | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Metyrapone | hsa00500 | Starch and sucrose metabolism | 8.96E-06 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Metyrapone | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Metyrapone | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Metyrapone | hsa00730 | Thiamine metabolism | 1.44E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Metyrapone | hsa00750 | Vitamin B6 metabolism | 3.56E-02 | 1 | O00764 | PDXK | More | | | Metyrapone | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Metyrapone | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Metyrapone | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Metyrapone | hsa00970 | Aminoacyl-tRNA biosynthesis | 4.29E-04 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Metyrapone | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Metyrapone | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Metyrapone | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.56E-02 | 1 | P50213 | IDH3A | More | | | Metyrapone | hsa01230 | Biosynthesis of amino acids | 5.53E-03 | 2 | P15104, P37837 | GLUL, TALDO1 | More | | | Metyrapone | hsa03008 | Ribosome biogenesis in eukaryotes | 2.99E-02 | 2 | P78345, Q9BVP2 | RPP38, GNL3 | More | | | Metyrapone | hsa03020 | RNA polymerase | 9.80E-05 | 2 | Q9GZM3, P52435 | POLR2J2, POLR2J | More | | | Metyrapone | hsa03050 | Proteasome | 3.05E-02 | 1 | P55036 | PSMD4 | More | | | Metyrapone | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | | Metyrapone | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 5.05E-05 | 9 | P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375 | CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNF | More | | | Metyrapone | hsa04062 | Chemokine signaling pathway | 6.64E-04 | 12 | P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881, P22694, P49841 | CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK, PRKACB, GSK3B | More | | | Metyrapone | hsa04064 | NF-kappa B signaling pathway | 1.44E-03 | 10 | O00463, P14778, P01375, Q04759, Q16548, P07948, P06239, P24522, P09341, Q06643 | TRAF5, IL1R1, TNF, PRKCQ, BCL2A1, LYN, LCK, GADD45A, CXCL1, LTB | More | | | Metyrapone | hsa04080 | Neuroactive ligand-receptor interaction | 1.20E-02 | 8 | P08311, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318 | CTSG, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADM | More | | | Metyrapone | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Metyrapone | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Metyrapone | hsa04140 | Autophagy - animal | 1.62E-02 | 6 | Q9Y4H2, Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759 | IRS2, RRAGD, PRKACB, ITPR1, ATG5, PRKCQ | More | | | Metyrapone | hsa04142 | Lysosome | 2.64E-02 | 2 | Q99437, P25774 | ATP6V0B, CTSS | More | | | Metyrapone | hsa04145 | Phagosome | 3.11E-02 | 2 | Q99437, P25774 | ATP6V0B, CTSS | More | | | Metyrapone | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Metyrapone | hsa04217 | Necroptosis | 2.34E-02 | 4 | P01375, P48023, Q14765, Q99878 | TNF, FASLG, STAT4, H2AC14 | More | | | Metyrapone | hsa04360 | Axon guidance | 1.66E-02 | 3 | P20827, P23528, Q06124 | EFNA1, CFL1, PTPN11 | More | | | Metyrapone | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Metyrapone | hsa04380 | Osteoclast differentiation | 1.02E-02 | 6 | Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149 | GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Metyrapone | hsa04390 | Hippo signaling pathway | 2.30E-02 | 3 | P63261, P04628, O43623 | ACTG1, WNT1, SNAI2 | More | | | Metyrapone | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Metyrapone | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.96E-02 | 3 | P04628, P40189, P14653 | WNT1, IL6ST, HOXB1 | More | | | Metyrapone | hsa04612 | Antigen processing and presentation | 5.27E-04 | 9 | P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Metyrapone | hsa04613 | Neutrophil extracellular trap formation | 1.06E-03 | 15 | O60603, P05164, Q9UM07, Q13547, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539 | TLR2, MPO, PADI4, HDAC1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Metyrapone | hsa04621 | NOD-like receptor signaling pathway | 1.89E-02 | 11 | Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P29728, P01375, P09341, P12838 | MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4 | More | | | Metyrapone | hsa04625 | C-type lectin receptor signaling pathway | 3.87E-02 | 4 | Q9ULY5, P20749, P01375, Q16539 | CLEC4E, BCL3, TNF, MAPK14 | More | | | Metyrapone | hsa04630 | JAK-STAT signaling pathway | 4.43E-02 | 3 | P48551, P40189, Q06124 | IFNAR2, IL6ST, PTPN11 | More | | | Metyrapone | hsa04640 | Hematopoietic cell lineage | 4.61E-07 | 14 | P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603 | ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1 | More | | | Metyrapone | hsa04650 | Natural killer cell mediated cytotoxicity | 2.39E-08 | 14 | P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P11511 | CYP19A1 | Aromatase | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.701 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.769 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.848 | | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.931 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.855 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 |
| | Metyrapone | hsa04657 | IL-17 signaling pathway | 9.10E-04 | 6 | O00463, Q16539, P49841, P09341, P14780, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF | More | | | Metyrapone | hsa04658 | Th1 and Th2 cell differentiation | 7.67E-12 | 13 | Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.756 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.765 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.927 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.769 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 |
| | Metyrapone | hsa04659 | Th17 cell differentiation | 4.65E-09 | 12 | Q04759, Q16539, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963 | PRKCQ, MAPK14, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.823 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.927 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.765 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 |
| | Metyrapone | hsa04660 | T cell receptor signaling pathway | 2.22E-06 | 13 | P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q04759 | PRKCQ | Protein kinase C theta type | -0.807 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.824 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.847 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.783 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.858 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.809 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.794 |
| | Metyrapone | hsa04664 | Fc epsilon RI signaling pathway | 3.98E-02 | 3 | P01375, Q16539, Q9UQC2 | TNF, MAPK14, GAB2 | More | | | Metyrapone | hsa04668 | TNF signaling pathway | 2.21E-02 | 5 | P01375, O00463, Q16539, P20749, P14780 | TNF, TRAF5, MAPK14, BCL3, MMP9 | More | | | Metyrapone | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Metyrapone | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Metyrapone | hsa04723 | Retrograde endocannabinoid signaling | 4.40E-02 | 5 | Q14643, P63218, P50151, P22694, Q16539 | ITPR1, GNG5, GNG10, PRKACB, MAPK14 | More | | | Metyrapone | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.62E-02 | 6 | P14778, P22694, Q16539, Q14643, P24723, Q04759 | IL1R1, PRKACB, MAPK14, ITPR1, PRKCH, PRKCQ | More | | | Metyrapone | hsa04914 | Progesterone-mediated oocyte maturation | 2.94E-02 | 3 | Q17RY0, P51812, Q02750 | CPEB4, RPS6KA3, MAP2K1 | More | | | Metyrapone | hsa04932 | Non-alcoholic fatty liver disease | 2.74E-02 | 3 | P01375, P49841, P48023 | TNF, GSK3B, FASLG | More | | | Metyrapone | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Metyrapone | hsa04976 | Bile secretion | 3.87E-02 | 3 | O43315, P22694, P08183 | AQP9, PRKACB, ABCB1 | More | | | Metyrapone | hsa05016 | Huntington disease | 1.07E-02 | 3 | Q9GZM3, P52435, P55036 | POLR2J2, POLR2J, PSMD4 | More | | | Metyrapone | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Metyrapone | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Metyrapone | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.71E-03 | 5 | Q16539, P09341, P25024, P25025, P07948 | MAPK14, CXCL1, CXCR1, CXCR2, LYN | More | | | Metyrapone | hsa05131 | Shigellosis | 3.15E-02 | 12 | P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796 | TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1 | More | | | Metyrapone | hsa05140 | Leishmaniasis | 4.59E-02 | 5 | O75015, O60603, P01375, Q16539, Q15080 | FCGR3B, TLR2, TNF, MAPK14, NCF4 | More | | | Metyrapone | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Metyrapone | hsa05144 | Malaria | 9.23E-04 | 5 | P60033, O60603, P01375, P35443, P26718 | CD81, TLR2, TNF, THBS4, KLRK1 | More | | | Metyrapone | hsa05146 | Amoebiasis | 1.05E-06 | 9 | P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311 | CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG | More | | | Metyrapone | hsa05152 | Tuberculosis | 4.16E-02 | 2 | Q99437, P25774 | ATP6V0B, CTSS | More | | | Metyrapone | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Metyrapone | hsa05163 | Human cytomegalovirus infection | 7.72E-04 | 11 | P01375, P63218, P50151, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463 | TNF, GNG5, GNG10, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5 | More | | | Metyrapone | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.94E-02 | 4 | P62879, P16298, Q02750, P0CG47 | GNB2, PPP3CB, MAP2K1, UBB | More | | | Metyrapone | hsa05169 | Epstein-Barr virus infection | 8.42E-05 | 14 | P13765, P01106, Q13547, O00463, Q16539, P07948, Q13761, P24522, P01375, O60603, P29728, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, LYN, RUNX3, GADD45A, TNF, TLR2, OAS2, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.748 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13547 | HDAC1 | Histone deacetylase 1 | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q13547 | HDAC1 | Histone deacetylase 1 | -0.727 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.896 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.788 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.849 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.713 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.769 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.805 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P01375 | TNF | Tumor necrosis factor | 0.782 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | -0.72 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.782 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.815 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 |
| | Metyrapone | hsa05170 | Human immunodeficiency virus 1 infection | 6.02E-03 | 5 | Q02750, P62879, P16298, Q05397, P20333 | MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B | More | | | Metyrapone | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Metyrapone | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Metyrapone | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Metyrapone | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Metyrapone | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.30E-04 | 9 | O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730 | RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4 | More | | | Metyrapone | hsa05310 | Asthma | 2.48E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Metyrapone | hsa05321 | Inflammatory bowel disease | 1.68E-02 | 5 | P01375, P13765, Q14765, Q9UL17, P23771 | TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Metyrapone | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Metyrapone | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Metyrapone | hsa05332 | Graft-versus-host disease | 3.48E-04 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Metyrapone | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Metyrapone | hsa05416 | Viral myocarditis | 2.30E-02 | 2 | P10747, P63261 | CD28, ACTG1 | More | | | Metyrapone | hsa05418 | Fluid shear stress and atherosclerosis | 2.92E-04 | 7 | Q16539, Q14145, P10599, P14780, P01375, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2 | More | |
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