PharmaCoNets of Metoclopramide (SPCN: 24.48 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Metoclopramidehsa00030Pentose phosphate pathway1.98E-054P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Metoclopramidehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Metoclopramidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Metoclopramidehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Metoclopramidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Metoclopramidehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Metoclopramidehsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Metoclopramidehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Metoclopramidehsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Metoclopramidehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Metoclopramidehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Metoclopramidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Metoclopramidehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Metoclopramidehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Metoclopramidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Metoclopramidehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Metoclopramidehsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Metoclopramidehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metoclopramidehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Metoclopramidehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Metoclopramidehsa04664Fc epsilon RI signaling pathway2.18E-022P09917, P20292ALOX5, ALOX5APMore
Metoclopramidehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Metoclopramidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Metoclopramidehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Metoclopramidehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Metoclopramidehsa04742Taste transduction1.01E-021P30939HTR1FMore
Metoclopramidehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Metoclopramidehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Metoclopramidehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Metoclopramidehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Metoclopramidehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Metoclopramidehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Metoclopramidehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Metoclopramidehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Metoclopramidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Metoclopramidehsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Metoclopramidehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Metoclopramidehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Metoclopramidehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metoclopramidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Metoclopramidehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Metoclopramidehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Metoclopramidehsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Metoclopramidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Metoclopramidehsa05202Transcriptional misregulation in cancer1.63E-0315Q15532, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Metoclopramidehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metoclopramidehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Metoclopramidehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Metoclopramidehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Metoclopramidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Metoclopramidehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More

Community members of Metoclopramide (SDC: 3.20)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki64