PharmaCoNets

PharmaCoNets of Metixene (S_PCN: 181.93 )

Metixene regulated-network (S_DN: 21.68)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Metixene

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Metixene

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Metixene

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Metixene

hsa00190

Oxidative phosphorylation

1.21E-06

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Metixene

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Metixene

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Metixene

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Metixene

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Metixene

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Metixene

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Metixene

hsa00565

Ether lipid metabolism

3.00E-03

Q8N661

TMEM86B

Metixene

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Metixene

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Metixene

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Metixene

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Metixene

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Metixene

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Metixene

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Metixene

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Metixene

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Metixene

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Metixene

hsa00983

Drug metabolism - other enzymes

4.77E-02

P04183, P32320, P05164

TK1, CDA, MPO

Metixene

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Metixene

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Metixene

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Metixene

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Metixene

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Metixene

hsa03010

Ribosome

2.25E-04

P40429, Q07020, P27635, P05386, P62249

RPL13A, RPL18, RPL10, RPLP1, RPS16

Metixene

hsa03013

RNA transport

2.59E-03

P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812

Metixene

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Metixene

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Metixene

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Metixene

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Metixene

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Metixene

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Metixene

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Metixene

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Metixene

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Metixene

hsa04062

Chemokine signaling pathway

5.65E-04

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Metixene

hsa04064

NF-kappa B signaling pathway

2.43E-04

P10415, Q13489, O00463, P14778, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, TRAF5, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Metixene

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Metixene

hsa04071

Sphingolipid signaling pathway

9.75E-06

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
Q02156	PRKCE	Protein kinase C epsilon type	Q12933	TRAF2	TNF receptor-associated factor 2	-0.78
Q02156	PRKCE	Protein kinase C epsilon type	Q02156	PRKCE	Protein kinase C epsilon type	1

Metixene

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Metixene

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Metixene

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Metixene

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Metixene

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Metixene

hsa04145

Phagosome

1.38E-07

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15080	NCF4	Neutrophil cytosol factor 4	-0.919
P10415	BCL2	Apoptosis regulator Bcl-2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.951
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14598	NCF1	Neutrophil cytosol factor 1	-0.857
P10415	BCL2	Apoptosis regulator Bcl-2	P14598	NCF1	Neutrophil cytosol factor 1	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35443	THBS4	Thrombospondin-4	-0.755
P10415	BCL2	Apoptosis regulator Bcl-2	P35443	THBS4	Thrombospondin-4	-0.765
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754

Metixene

hsa04151

PI3K-Akt signaling pathway

3.84E-05

P62753, P42338, P43657, P25116, O43521, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, F2R, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Metixene

hsa04210

Apoptosis

3.63E-02

O75460, O43521, P18848

ERN1, BCL2L11, ATF4

Metixene

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Metixene

hsa04217

Necroptosis

1.79E-07

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Metixene

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Metixene

hsa04261

Adrenergic signaling in cardiomyocytes

2.31E-03

P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415

TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2

Metixene

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Metixene

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Metixene

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Metixene

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Metixene

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Metixene

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Metixene

hsa04610

Complement and coagulation cascades

4.27E-06

P0C0L4

C4A

Metixene

hsa04612

Antigen processing and presentation

2.31E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Metixene

hsa04613

Neutrophil extracellular trap formation

8.65E-05

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Metixene

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Metixene

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Metixene

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Metixene

hsa04640

Hematopoietic cell lineage

1.54E-03

P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564

CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7

Metixene

hsa04650

Natural killer cell mediated cytotoxicity

5.49E-06

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Metixene

hsa04657

IL-17 signaling pathway

4.97E-04

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Metixene

hsa04658

Th1 and Th2 cell differentiation

1.54E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Metixene

hsa04659

Th17 cell differentiation

9.05E-05

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Metixene

hsa04660

T cell receptor signaling pathway

5.05E-05

P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Metixene

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Metixene

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Metixene

hsa04666

Fc gamma R-mediated phagocytosis

2.42E-02

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Metixene

hsa04668

TNF signaling pathway

2.67E-03

P01375, P18848, P19875, P01584, P14780, P20333

TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B

Metixene

hsa04672

Intestinal immune network for IgA production

1.24E-04

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Metixene

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Metixene

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Metixene

hsa04720

Long-term potentiation

3.89E-02

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Metixene

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Metixene

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Metixene

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Metixene

hsa04724

Glutamatergic synapse

9.51E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Metixene

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Metixene

hsa04727

GABAergic synapse

2.33E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Metixene

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Metixene

hsa04730

Long-term depression

3.72E-02

Q14344, P07948

GNA13, LYN

Metixene

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Metixene

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Metixene

hsa04744

Phototransduction

3.21E-04

P62873, P0DP23

GNB1, CALM1

Metixene

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Metixene

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Metixene

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Metixene

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Metixene

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Metixene

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Metixene

hsa04924

Renin secretion

7.38E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Metixene

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Metixene

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Metixene

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Metixene

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Metixene

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.19E-03

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Metixene

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Metixene

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Metixene

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Metixene

hsa04966

Collecting duct acid secretion

1.26E-04

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Metixene

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Metixene

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Metixene

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Metixene

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Metixene

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Metixene

hsa05010

Alzheimer disease

7.04E-04

Q16718, O14521, P13073, Q14643, O15399, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P01584, P18848, Q71U36, Q13509, P68371, P09603, P05141, P21796, Q08752

NDUFA5, SDHD, COX4I1, ITPR1, GRIN2D, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, TUBB3, TUBB2C, CSF1, SLC25A5, VDAC1, PPID

Metixene

hsa05012

Parkinson disease

4.51E-03

Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371

NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2C

Metixene

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Metixene

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Metixene

hsa05022

Pathways of neurodegeneration - multiple diseases

2.05E-05

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759

Metixene

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Metixene

hsa05032

Morphine addiction

1.34E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Metixene

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Metixene

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Metixene

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Metixene

hsa05132

Salmonella infection

2.23E-05

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766

Metixene

hsa05133

Pertussis

3.02E-03

P0C0L4

C4A

Metixene

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Metixene

hsa05140

Leishmaniasis

8.52E-07

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758

Metixene

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Metixene

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Metixene

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Metixene

hsa05146

Amoebiasis

1.14E-06

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Metixene

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Metixene

hsa05152

Tuberculosis

8.62E-07

Q13488, P0DP23, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P48382	RFX5	DNA-binding protein RFX5	0.797
P10415	BCL2	Apoptosis regulator Bcl-2	P48382	RFX5	DNA-binding protein RFX5	0.856
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	1
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807

Metixene

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Metixene

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Metixene

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Metixene

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.73E-02

P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2

IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1

Metixene

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Metixene

hsa05170

Human immunodeficiency virus 1 infection

9.96E-06

P62873, P0DP23, P17252, Q13546, O00463, Q14643, P01568, P51617, O60603, Q13315, P23528, P10415, Q93034, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, ATM, CFL1, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901

Metixene

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Metixene

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Metixene

hsa05202

Transcriptional misregulation in cancer

2.09E-04

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765

Metixene

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Metixene

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Metixene

hsa05205

Proteoglycans in cancer

8.18E-05

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.711
P10415	BCL2	Apoptosis regulator Bcl-2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.75
P10415	BCL2	Apoptosis regulator Bcl-2	Q12955	ANK3	Ankyrin-3	0.708
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.703
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P04628	WNT1	Proto-oncogene Wnt-1	0.829
P10415	BCL2	Apoptosis regulator Bcl-2	P04628	WNT1	Proto-oncogene Wnt-1	0.703
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13635	PTCH1	Protein patched homolog 1	0.85
P10415	BCL2	Apoptosis regulator Bcl-2	Q13635	PTCH1	Protein patched homolog 1	0.836
P07550	ADRB2	Beta-2 adrenergic receptor	Q13635	PTCH1	Protein patched homolog 1	0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08962	CD63	CD63 antigen	-0.782
P10415	BCL2	Apoptosis regulator Bcl-2	P08962	CD63	CD63 antigen	-0.862

Metixene

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Metixene

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Metixene

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Metixene

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Metixene

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Metixene

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Metixene

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.29E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4

Metixene

hsa05310

Asthma

2.81E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Metixene

hsa05320

Autoimmune thyroid disease

2.92E-05

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Metixene

hsa05321

Inflammatory bowel disease

2.16E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Metixene

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Metixene

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Metixene

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Metixene

hsa05332

Graft-versus-host disease

1.36E-04

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Metixene

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Metixene

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Metixene

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Metixene

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Metixene

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Metixene

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Metixene (S_DC: 8.39)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

PharmaCoNets of Metixene (SPCN: 181.93 )

Metixene regulated-network (SDN: 21.68)

Community members of Metixene (SDC: 8.39)

PharmaCoNets of Metixene (S_PCN: 181.93 )

Metixene regulated-network (S_DN: 21.68)

Community members of Metixene (S_DC: 8.39)